|
Name |
Accession |
Description |
Interval |
E-value |
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
22-573 |
0e+00 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 555.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 22 ESFREAMNRIAAAL---------KDDDQHFADFRDALLGMRFLPAGRIQSAMGSTRQVTPYNCYVsgtinDSFVDGEGSI 92
Cdd:TIGR02504 17 ESPEDLFRRVARALaaaedkynsPVWKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFV-----LPVEDSMEDI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 93 MVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFI 172
Cdd:TIGR02504 92 FEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWHPDIEEFI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 173 HAKQpgkdvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLTFEgRT--YREVDARAL 250
Cdd:TIGR02504 172 EAKA-----------------------------KEGKLQNFNISVGVTDEFMEAVENDEEYELRNP-RTgeYKEVDAREL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 251 WDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIFKDGAGRYAFDWDQYRED 330
Cdd:TIGR02504 222 WDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLLPYESCNLGSINLAKFVKNDFGDEASFDFERLREV 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 331 IPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKV 410
Cdd:TIGR02504 302 VRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIADAAYRASAELAKE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 411 KGSFPKFDKDKYLQG-----QFIKTLREDVRDAIAKYGIRNSHLTSIAPTGTISLCADnVSSGIEPVFAYSFDRTVIEfs 485
Cdd:TIGR02504 382 RGAFPLYDASKYPMGramgaRIPSALPAEIREAIRKYGIRNAQLTTIAPTGTISLIAG-TSSGIEPVFALVYFRNVTV-- 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 486 GPRVETVEDY---GARVFG-----VRGKACSRVTVQEH----------VAALTV----------AAQR-VDSAVSKTCNV 536
Cdd:TIGR02504 459 GGELLEVNPLvelALRELGyysdeIVKYVDEKGTVEGApgpeelpkvfVTAMDIspedhvlmqaAIQPwVDSSISKTINM 538
|
570 580 590
....*....|....*....|....*....|....*..
gi 1898303842 537 PSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKRSGIL 573
Cdd:TIGR02504 539 PSDATVEDVKAVYLEAWKLGLKGITVYRDGSRSSQVL 575
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
42-566 |
0e+00 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 549.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 42 FADFRDALLGMRFLPAGRIQSAMGSTRQVTPYNCYVSGTINDSFvdgeGSIMVRAAEAAATMRMGGGIGYDFSTLRPRGD 121
Cdd:cd02888 1 ADEFFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDDSI----EGIFDALKEAALIFKRGGGVGYNFSRLRPKGD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 122 LIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK-QPGKDVQplwdlvaelpegaqkqql 200
Cdd:cd02888 77 IVKSTGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKmKEEKTVV------------------ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 201 vmslqqtlkLTGFNVSVAITDKFMECVASGEPFPLTF-----EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRM 275
Cdd:cd02888 139 ---------LQNFNISVAVTDAFMEAVENDEPWELRNprepdTGKVYRTVPARELWDKIVEAAWDSADPGVLFIDTINRW 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 276 NNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIfKDGAGRYAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQE 355
Cdd:cd02888 210 NPLPGLGRINATNPCGEQPLLPYESCNLGSINLSKFV-KNPFGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 356 AKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQFI---KTLR 432
Cdd:cd02888 289 TKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASRYLMLKVIvnaKELP 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 433 EDVRDAIAKYGIRNSHLTSIAPTGTISLCADnVSSGIEPVFAYsfdrtviefsgprvetvedygarvfgvrgkacsrvtv 512
Cdd:cd02888 369 DDVLEEIEKYGIRNAHLTTIAPTGTISLIAG-TSSGIEPIFSP------------------------------------- 410
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1898303842 513 QEHVAALTVAAQRVDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLG 566
Cdd:cd02888 411 EDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKGITVYRDG 464
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
22-578 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 530.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 22 ESFREAMNRIAAAL-----KDDDQHFAD-FRDALLGMRFLPAGRIQSAMGSTRQvTPYNCYVSgTINDSFvdgeGSIMVR 95
Cdd:COG0209 72 ETPQDLFMRVAMGLaaaekPEDREEWAKeFYDLLSSLRFLPATPTLFNAGTPRG-QLSSCFVL-PVEDSL----ESIFDA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 96 AAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK 175
Cdd:COG0209 146 LKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLK 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 176 QPGKDvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLTF------------------ 237
Cdd:COG0209 226 KNNGD-------------------------ERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSprevpdlyglygeefeea 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 238 ------EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYG----ACLLGSFN 307
Cdd:COG0209 281 yeeyeaDGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYEsedaSCNLGSIN 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 308 LVKYIfKDGAgryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLA 387
Cdd:COG0209 361 LAKFV-KDGE----FDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARE 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 388 FEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF------------IKTLREDVRDAIAKYGIRNSHLTSIAPT 455
Cdd:COG0209 436 LADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILpfdkylddllipTTLDWDALREDIKKHGLRNSTLTAIAPT 515
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 456 GTISLCAdNVSSGIEPVFAYSFDRTVI---EFsgPRVETVEDYGARVFG-----VRGKACSRVTVQEH-----------V 516
Cdd:COG0209 516 GTISLIA-GTTSGIEPIFSLVYVRKVLdggEF--TVVNPYLVRALKELGlwdeeLVEKIKEDGSVQDIdelpeelkelyV 592
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1898303842 517 AALTV----------AAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKRSGILVVKDD 578
Cdd:COG0209 593 TAYEIdpewhidmqaARQKhVDQAISKTLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
74-563 |
1.40e-128 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 386.56 E-value: 1.40e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 74 NCYVsGTINDSFVdgegSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHR 153
Cdd:pfam02867 2 SCFL-LSVEDSLD----SIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 154 RGAQMGVMRVDHPDIEEFIHAKQPGKDvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPF 233
Cdd:pfam02867 77 RGAAAVYLEVWHPDIEEFLDLKKNNGD-------------------------EEVRARNLNLGVWVPDLFMERVEADEDW 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 234 PLTF-------------------------EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATN 288
Cdd:pfam02867 132 TLFSpreapdledlygeefekeyyereenEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 289 PCGEQPLPPYGA----CLLGSFNLVKYIFKDGAgryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGL 364
Cdd:pfam02867 212 LCTEIVQPTSPSeiavCNLASINLAKFVEFGGT----FDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 365 GITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF-------------IKTL 431
Cdd:pfam02867 288 GVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILqfdkyvktdfapkASKT 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 432 RED---VRDAIAKYGIRNSHLTSIAPTGTISLcADNVSSGIEPVFAYSFDRTVI-EFSGPRVETVEDYGarvfgvrgkac 507
Cdd:pfam02867 368 REDweeLREDIKKYGLRNSQLTAIAPTGSISQ-IAGATESIEPIFSNVYSRKVLsEETKEYYKTAYDID----------- 435
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1898303842 508 srvtvQEHVAALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTF 563
Cdd:pfam02867 436 -----QKAHIDMAAARQPfVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
106-605 |
6.53e-121 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 375.43 E-value: 6.53e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 106 GGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQpgkdvqplw 185
Cdd:PRK08665 123 GGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRVDHPDIMEFITCKE--------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 186 dlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLT--FEGRTYREVDARALWDAIMRGTWDWAE 263
Cdd:PRK08665 194 --------------------DNGELTNFNISVAITEAFMEAVEADEEYDLInpRTGEVVGRLNAREVFDLIVEMAWENGE 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 264 PGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYiFKDGAgryaFDWDQYREDIPQVVRAMDNVVD 343
Cdd:PRK08665 254 PGIVFIDRINRDNPTPHLGEIESTNPCGEQPLLPYESCNLGSINLSKM-VKNGD----VDWEKLREVVHLAVRFLDNVID 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 344 RAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYL 423
Cdd:PRK08665 329 ANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYD 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 424 QgqfiktlredvrDAIAKYgiRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRTV------IEFSGPRVETVEDYG- 496
Cdd:PRK08665 409 K------------DGLGPM--RNATVTTIAPTGTISIIA-GCSSGIEPLFALSFTRNVmdgerlVEVNPVFEAAAKEEGf 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 497 ---------ARVFGVRG-----KACSRVTV-------QEHVaALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWE 554
Cdd:PRK08665 474 yseelmekiAEKGSIQDidevpEDVRRVFVtahdispEWHV-RMQAAFQKhTDNAVSKTVNFPNEATIEDVREVYRLAYE 552
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1898303842 555 GGAKGCTTFRLGGKRSGILVVKdDGGEPEADAPAEEPASQC----RIDPATGRRE 605
Cdd:PRK08665 553 LGCKGVTIYRDGSRDEQVLSTG-KKEKKEEEPAAAVEPKKLeprpRPKVTKGFTE 606
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
22-573 |
0e+00 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 555.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 22 ESFREAMNRIAAAL---------KDDDQHFADFRDALLGMRFLPAGRIQSAMGSTRQVTPYNCYVsgtinDSFVDGEGSI 92
Cdd:TIGR02504 17 ESPEDLFRRVARALaaaedkynsPVWKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFV-----LPVEDSMEDI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 93 MVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFI 172
Cdd:TIGR02504 92 FEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWHPDIEEFI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 173 HAKQpgkdvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLTFEgRT--YREVDARAL 250
Cdd:TIGR02504 172 EAKA-----------------------------KEGKLQNFNISVGVTDEFMEAVENDEEYELRNP-RTgeYKEVDAREL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 251 WDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIFKDGAGRYAFDWDQYRED 330
Cdd:TIGR02504 222 WDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLLPYESCNLGSINLAKFVKNDFGDEASFDFERLREV 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 331 IPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKV 410
Cdd:TIGR02504 302 VRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIADAAYRASAELAKE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 411 KGSFPKFDKDKYLQG-----QFIKTLREDVRDAIAKYGIRNSHLTSIAPTGTISLCADnVSSGIEPVFAYSFDRTVIEfs 485
Cdd:TIGR02504 382 RGAFPLYDASKYPMGramgaRIPSALPAEIREAIRKYGIRNAQLTTIAPTGTISLIAG-TSSGIEPVFALVYFRNVTV-- 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 486 GPRVETVEDY---GARVFG-----VRGKACSRVTVQEH----------VAALTV----------AAQR-VDSAVSKTCNV 536
Cdd:TIGR02504 459 GGELLEVNPLvelALRELGyysdeIVKYVDEKGTVEGApgpeelpkvfVTAMDIspedhvlmqaAIQPwVDSSISKTINM 538
|
570 580 590
....*....|....*....|....*....|....*..
gi 1898303842 537 PSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKRSGIL 573
Cdd:TIGR02504 539 PSDATVEDVKAVYLEAWKLGLKGITVYRDGSRSSQVL 575
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
42-566 |
0e+00 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 549.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 42 FADFRDALLGMRFLPAGRIQSAMGSTRQVTPYNCYVSGTINDSFvdgeGSIMVRAAEAAATMRMGGGIGYDFSTLRPRGD 121
Cdd:cd02888 1 ADEFFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDDSI----EGIFDALKEAALIFKRGGGVGYNFSRLRPKGD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 122 LIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK-QPGKDVQplwdlvaelpegaqkqql 200
Cdd:cd02888 77 IVKSTGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKmKEEKTVV------------------ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 201 vmslqqtlkLTGFNVSVAITDKFMECVASGEPFPLTF-----EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRM 275
Cdd:cd02888 139 ---------LQNFNISVAVTDAFMEAVENDEPWELRNprepdTGKVYRTVPARELWDKIVEAAWDSADPGVLFIDTINRW 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 276 NNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIfKDGAGRYAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQE 355
Cdd:cd02888 210 NPLPGLGRINATNPCGEQPLLPYESCNLGSINLSKFV-KNPFGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 356 AKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQFI---KTLR 432
Cdd:cd02888 289 TKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASRYLMLKVIvnaKELP 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 433 EDVRDAIAKYGIRNSHLTSIAPTGTISLCADnVSSGIEPVFAYsfdrtviefsgprvetvedygarvfgvrgkacsrvtv 512
Cdd:cd02888 369 DDVLEEIEKYGIRNAHLTTIAPTGTISLIAG-TSSGIEPIFSP------------------------------------- 410
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1898303842 513 QEHVAALTVAAQRVDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLG 566
Cdd:cd02888 411 EDHVRMQAALQPWVDGAISKTINLPNDATVEDVEAVYLLAWKLGLKGITVYRDG 464
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
22-578 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 530.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 22 ESFREAMNRIAAAL-----KDDDQHFAD-FRDALLGMRFLPAGRIQSAMGSTRQvTPYNCYVSgTINDSFvdgeGSIMVR 95
Cdd:COG0209 72 ETPQDLFMRVAMGLaaaekPEDREEWAKeFYDLLSSLRFLPATPTLFNAGTPRG-QLSSCFVL-PVEDSL----ESIFDA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 96 AAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK 175
Cdd:COG0209 146 LKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLK 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 176 QPGKDvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLTF------------------ 237
Cdd:COG0209 226 KNNGD-------------------------ERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSprevpdlyglygeefeea 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 238 ------EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYG----ACLLGSFN 307
Cdd:COG0209 281 yeeyeaDGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYEsedaSCNLGSIN 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 308 LVKYIfKDGAgryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLA 387
Cdd:COG0209 361 LAKFV-KDGE----FDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARE 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 388 FEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF------------IKTLREDVRDAIAKYGIRNSHLTSIAPT 455
Cdd:COG0209 436 LADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILpfdkylddllipTTLDWDALREDIKKHGLRNSTLTAIAPT 515
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 456 GTISLCAdNVSSGIEPVFAYSFDRTVI---EFsgPRVETVEDYGARVFG-----VRGKACSRVTVQEH-----------V 516
Cdd:COG0209 516 GTISLIA-GTTSGIEPIFSLVYVRKVLdggEF--TVVNPYLVRALKELGlwdeeLVEKIKEDGSVQDIdelpeelkelyV 592
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1898303842 517 AALTV----------AAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKRSGILVVKDD 578
Cdd:COG0209 593 TAYEIdpewhidmqaARQKhVDQAISKTLNLPNDATVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
74-563 |
1.40e-128 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 386.56 E-value: 1.40e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 74 NCYVsGTINDSFVdgegSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHR 153
Cdd:pfam02867 2 SCFL-LSVEDSLD----SIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 154 RGAQMGVMRVDHPDIEEFIHAKQPGKDvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPF 233
Cdd:pfam02867 77 RGAAAVYLEVWHPDIEEFLDLKKNNGD-------------------------EEVRARNLNLGVWVPDLFMERVEADEDW 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 234 PLTF-------------------------EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATN 288
Cdd:pfam02867 132 TLFSpreapdledlygeefekeyyereenEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 289 PCGEQPLPPYGA----CLLGSFNLVKYIFKDGAgryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGL 364
Cdd:pfam02867 212 LCTEIVQPTSPSeiavCNLASINLAKFVEFGGT----FDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 365 GITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF-------------IKTL 431
Cdd:pfam02867 288 GVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILqfdkyvktdfapkASKT 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 432 RED---VRDAIAKYGIRNSHLTSIAPTGTISLcADNVSSGIEPVFAYSFDRTVI-EFSGPRVETVEDYGarvfgvrgkac 507
Cdd:pfam02867 368 REDweeLREDIKKYGLRNSQLTAIAPTGSISQ-IAGATESIEPIFSNVYSRKVLsEETKEYYKTAYDID----------- 435
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1898303842 508 srvtvQEHVAALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTF 563
Cdd:pfam02867 436 -----QKAHIDMAAARQPfVDQSISKTLFLPNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
106-605 |
6.53e-121 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 375.43 E-value: 6.53e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 106 GGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQpgkdvqplw 185
Cdd:PRK08665 123 GGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRVDHPDIMEFITCKE--------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 186 dlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECVASGEPFPLT--FEGRTYREVDARALWDAIMRGTWDWAE 263
Cdd:PRK08665 194 --------------------DNGELTNFNISVAITEAFMEAVEADEEYDLInpRTGEVVGRLNAREVFDLIVEMAWENGE 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 264 PGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYiFKDGAgryaFDWDQYREDIPQVVRAMDNVVD 343
Cdd:PRK08665 254 PGIVFIDRINRDNPTPHLGEIESTNPCGEQPLLPYESCNLGSINLSKM-VKNGD----VDWEKLREVVHLAVRFLDNVID 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 344 RAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYL 423
Cdd:PRK08665 329 ANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYD 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 424 QgqfiktlredvrDAIAKYgiRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRTV------IEFSGPRVETVEDYG- 496
Cdd:PRK08665 409 K------------DGLGPM--RNATVTTIAPTGTISIIA-GCSSGIEPLFALSFTRNVmdgerlVEVNPVFEAAAKEEGf 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 497 ---------ARVFGVRG-----KACSRVTV-------QEHVaALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWE 554
Cdd:PRK08665 474 yseelmekiAEKGSIQDidevpEDVRRVFVtahdispEWHV-RMQAAFQKhTDNAVSKTVNFPNEATIEDVREVYRLAYE 552
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1898303842 555 GGAKGCTTFRLGGKRSGILVVKdDGGEPEADAPAEEPASQC----RIDPATGRRE 605
Cdd:PRK08665 553 LGCKGVTIYRDGSRDEQVLSTG-KKEKKEEEPAAAVEPKKLeprpRPKVTKGFTE 606
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
7-580 |
2.55e-117 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 361.42 E-value: 2.55e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 7 PYSQELHAQKYRGSGESFREAM-NRIAAALK-----DDDQHFAD--FRDALLGMrfLPAGRIQSAMGSTRQVTPYNCYVS 78
Cdd:PRK06948 14 PICDAVFADRYALPGETSRAQVfARVARALAlaeppDTRAGAARrfYRNLLNGA--IGAGRIMANAGAAPDQTMVNCFVH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 79 GTINDSFVDGEGSIMVRA-AEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQ 157
Cdd:PRK06948 92 PIRAPAALTAVHPNLDRAlDDARLTLLMGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 158 MGVMRVDHPDIEEFIHAKQPGKdvqplwdlvaelpegaqkqqlvmslqqtlKLTGFNVSVAITDKFMECVASGEPFPLTF 237
Cdd:PRK06948 172 MAVLRCDHPDLLAFVAAKRGRA-----------------------------RWTTFNLSVAVTDAFMQAVAQDLPWALRH 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 238 EGR----------------TYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGAC 301
Cdd:PRK06948 223 RAPprraaggalrgadgawTYATVPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEQPLPPYGSC 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 302 LLGSFNLVKYI---FKDGaGRYAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGH 378
Cdd:PRK06948 303 VLGPIDLSRFVrhpFGVG-GEPRFDFAALATAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRL 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 379 EYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQG-QFIKTLREDVRDAIAKYGIRNSHLTSIAPTGT 457
Cdd:PRK06948 382 RYDSPAAREMARYIASDLRHHAYAASAALAAERGAYPLCDPAAHLDAlRAGPPLPHAVCHAIARHGLRNSHLLSFAPVGS 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 458 ISLC-ADNVSSGIEPVFAYSFDRTV-IEFSGPRVETVEDYGARVF-GVRGK---------ACSRVTVQEHVAALTVAAQR 525
Cdd:PRK06948 462 VSLAfGDNCSPGIEPARAWIEHRPVrAGAGGARGMRAENHAYRLFrSLRGEraalpdyfvTAADVAPADHLAMRAALQPY 541
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1898303842 526 VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKRSGilVVKDDGG 580
Cdd:PRK06948 542 VDAGISKTVTLPNHYSLAEVDALLFQAWRAGLKGITIFRPDPALDA--VPSDDDA 594
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
31-596 |
2.84e-101 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 326.80 E-value: 2.84e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 31 IAAALKDDDQ---HFADFRDALLGMRFLPAGRIQSAMGSTRQVTPYNCYVSGTINDSfvdGEGsIMVRAAEAAATMRMGG 107
Cdd:PRK08115 142 LAAVEKTEEKrkeSFEKFYQELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPFVKDS---REG-ISEHRKQVMEIMSRGG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 108 GIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQPGKDV------ 181
Cdd:PRK08115 218 GVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFIISKMQNPRIlrylle 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 182 -----------------QPLWDLVAEL-----------PEGAQKQQLVMSLQQTLK------------LTGFNVSVAITD 221
Cdd:PRK08115 298 ntedeqikrlvkeklkfTPLSEVEEAMyqaivnyknieGQGGFDTKVIKEAENKLRtggtytvnnpefLTGANISVCLTK 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 222 KFMECVASGEPFPLTFEG--------------------------------RTYREVDARALWDAIMRGTWDWAEPGVLFI 269
Cdd:PRK08115 378 EFMEAVENDEEYELRFPDvenyteeemeiyneewhevgdvrewekmgypvRTYRKIKAKELWNLINICATYSAEPGIFFI 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 270 DAINRMNNL-WYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIFKDgagRYAFDWDQYREDIPQVVRAMDNVVDRAIYP 348
Cdd:PRK08115 458 DNANEMTNAkAYGQKVVATNPCGEQPLAPYSVCNLAAINLANMADKE---TKTVDYEKLKRTVEVGVRMQDNVIDATPYF 534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 349 LPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFP----------KFD 418
Cdd:PRK08115 535 LEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPflvgqteeetAKL 614
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 419 KDKYLQGQFIKTLREDVRDAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRT--VIEFSGPRVETVEDYG 496
Cdd:PRK08115 615 REAFINTGYMKKMPEDIREDILKYGIRNSHLLTVAPTGSTGTMV-GVSTGLEPYFSFSYYRSgrLGKFIEVKADIVQEYL 693
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 497 ARVFGVRGKACSRVTV-------QEHVAALTVAAQRVDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLGGKR 569
Cdd:PRK08115 694 DKHPEADENHLPEWFIsamelkpEAHADVQCIIQRWVDSSLSKTVNAPKGYTVEQVQKVYERLYRGGAKGGTVYVDGSRD 773
|
650 660 670
....*....|....*....|....*....|
gi 1898303842 570 SGILVVK---DDGGEPEADAPAEEPASQCR 596
Cdd:PRK08115 774 AQVLTLKaeeNDLDEQLLLLPEELEEEETK 803
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
23-583 |
1.09e-96 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 312.56 E-value: 1.09e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 23 SFREAMNRIAAALKDDDQHFADFRDALLGMRFLP-AGRIQSAMGSTRQVTPynCYVSgTINDSFVDgegsIMVRAAEAAA 101
Cdd:PRK06406 201 DFEEFLDFLKTKWDSIEEYINKFEEVMSNLKFVPnSPTLMNAGTKLGQLSA--CFVL-PVPDSIEG----IFNALKYTAM 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 102 TMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQPGKDV 181
Cdd:PRK06406 274 IHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKDSENKV 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 182 qplwdlvaelpegaqkqqlvmslqqtlkLTGFNVSVAITDKFMECVASGEPFPLT--FEGRTYREVDARALWDAIMRGTW 259
Cdd:PRK06406 354 ----------------------------LSNFNISVAVTDEFFDKLDNDDYYPLRnpRNGKEVKRIKARQVWDLIITQAW 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 260 DWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPLPPYGACLLGSFNLVKYIfKDGagryAFDWDQYREDIPQVVRAMD 339
Cdd:PRK06406 406 KTGDPGVIFLDEINRKNPVKNLGEIESTNPCGEQPLLPYESCNLGSINLSKFV-ENG----KIDWDRLRETVHIATRFLD 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 340 NVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDK 419
Cdd:PRK06406 481 NVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYG 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 420 DKYlQGQFIKtlredvrdaiakygIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRTVIE---------------- 483
Cdd:PRK06406 561 SEW-EKKGIK--------------MRNSTTTTIAPTGTISIIA-GCSSSIEPLFAIAFVRHVLNgqellevnplfeeitr 624
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 484 ----FSGPRVETVEDYGA-----------RVFgvrgKACSRVTVQEHVaALTVAAQR-VDSAVSKTCNVPSDISWEDFKN 547
Cdd:PRK06406 625 krglYSEELMRKVAETGNlqnidvpedikRIF----VTAHEIDPQWHV-LMQATFQRyCDSGVSKTINLRYDATPEDIAK 699
|
570 580 590
....*....|....*....|....*....|....*.
gi 1898303842 548 VYVSAWEGGAKGCTTFRLGGKRSGILVVKDDGGEPE 583
Cdd:PRK06406 700 AYRLAKDLHCKGITVYRDKSKTVQVLYAGTKTTKKE 735
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
16-562 |
6.02e-73 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 245.76 E-value: 6.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 16 KYRGSGESFREAMNRIAAAL------KDDDQHFADFRDALLGMRFLPAGRIQSAMGSTRQVTPyNCYVSgTINDSFVDge 89
Cdd:TIGR02506 17 ATGAIYESPQEAYMRVAMGLaslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLS-SCFLL-DVTDDTLE-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 90 gSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIE 169
Cdd:TIGR02506 93 -SIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAAVYLEVWHPDIE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 170 EFIHAKQPGKDvqplwdlvaelpegaqkqqlvmslqQTLKLTGFNVSVAITDKFMECV-------------------ASG 230
Cdd:TIGR02506 172 EFLDLKKNNGD-------------------------ERRRCDNLFYGLWIPDLFMKRVeedkdwylfspydvpglygLYG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 231 EPFPLTFE--------GRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINR-MNNLWYCETIAATNPCGEQPLPPY--- 298
Cdd:TIGR02506 227 EEFEEEYErlekdveaRKKIRKVSARDLMKDILRTRVETGRPYILFKDAVNKhNPFKTGGGAIKMSNLCTEITQPTDdsh 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 299 ----GACLLGSFNLVKYIFKDGagryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAE 374
Cdd:TIGR02506 307 kgetAVCNLASVNLANFVMEDK-----FDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 375 ALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQ-FIKT-------------LRED---VRD 437
Cdd:TIGR02506 382 KLGLPYDSEEARDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWlHPDTwektidpktsmapTEEDweaLRE 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 438 AIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDR--TVIEFSGPR---VETVEDYGARVFGVRGKACSRVTV 512
Cdd:TIGR02506 462 RIKEYGLRNSQLTALMPTASSSQLT-GVTESIEPVFSNIFTKktLSGEFLIPNkylMKELEELGLWDADRRGDIVENVGS 540
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1898303842 513 ----------------------QEHVAALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEggaKGCTT 562
Cdd:TIGR02506 541 pqpiaaipetlkykyktayeldQEALIDMAADRQKfVDQSISLNLFLTEEVTAKDLLKLLLLAWK---KGLKT 610
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
91-603 |
2.75e-65 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 230.63 E-value: 2.75e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 91 SIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLirkLQS--HSSGPISFMHIFDAICKCVASSGH-RRGAQMGVMRVDHPD 167
Cdd:PRK06556 163 SILNWYKEEGMLFKGGSGTGTNLSRIRSSKEL---LSGggTASGPVSFMRGADASAGTIKSGGAtRRAAKMVILDVDHPD 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 168 IEEFIHAKqpGKDVQPLWDLVaelpegaqKQQLVMSLQ----QTLKLTGFNVSVAITDKFMECVASGEPFPLT--FEGRT 241
Cdd:PRK06556 240 IEEFIETK--AKEEDKIRALR--------DAGYDMDLGgeaySSVQYQNANNSVRVSDEFMRAVENDGEFGLRarTDGEV 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 242 YREVDARALWDAIMRGTWDWAEPGVLFIDAINRmnnlWY-C-ET--IAATNPCGEqplppY-----GACLLGSFNLVKYI 312
Cdd:PRK06556 310 IETVDAKELFRKIAEAAWECADPGIQYDDTIND----WHtCpESgrINASNPCSE-----YmfldnSSCNLASLNLMKFL 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 313 FKDGAgryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEV 392
Cdd:PRK06556 381 RDDGT----FDVESFRHAVELVITAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAI 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 393 LDTLRDESYLASAHIAKVKGSFPKFDKDKylqGQFIKTLRE--DVRDAI-------------------------AKYGIR 445
Cdd:PRK06556 457 TSLMTGEAYRRSAELAGVVGPFEGYARNA---EPHLRVMRKhaAANDAIrplgevdaalleaakeawddalelgEKNGYR 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 446 NSHLTSIAPTGTISLCADNVSSGIEPVFA----------------------------YSFDRT--VIEFSGpRVETVED- 494
Cdd:PRK06556 534 NAQASVLAPTGTIGFMMDCDTTGIEPDFAlvkykklvgggsmkivnqtvpralkklgYSEEQIeaIVEYIA-EHGHIEGa 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 495 ------------------YGARVFGVRGkacsrvtvqeHVaALTVAAQRVDS-AVSKTCNVPSDISWEDFKNVYVSAWEG 555
Cdd:PRK06556 613 pglkpehyavfdcamkpaSGERSISPMG----------HV-RMMAAVQPFLSgAISKTVNMPEDATVEDIEEVYLEGWKL 681
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 1898303842 556 GAKGCTTFRLGGKRSGIL-VVKDDGGEPEADAPAEEPASQCRIDPATGR 603
Cdd:PRK06556 682 GLKALAIYRDNCKVGQPLnTSKKEKEDKEAEAAAEAELLAKVKELQKYR 730
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
30-562 |
2.08e-56 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 197.00 E-value: 2.08e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 30 RIAAALKDDDQHFA-DFRDALLGMRFLPAGRIQSAMGSTR-QvtPYNCYVSgTINDSFvdgeGSIMVRAAEAAATMRMGG 107
Cdd:cd01679 7 RVALGLASGDLEWAkEFYDLLSKQRFTPATPTLFNAGTPRgQ--LSSCFLL-TVDDSL----ESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 108 GIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQP-GKDVQPLWD 186
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNnGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 187 LvaelpegaqkqqlvmslqqtlkltgfNVSVAITDKFMECVAsgepfpltfegrtyrevdaRALWDAIMRGTWDWAEPGV 266
Cdd:cd01679 160 L--------------------------FYGVWIPDLFMERVE-------------------RDLWRKILESQFETGYPYI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 267 LFIDAINRMNNLWYCETIAATNPCGE--QPLPPYGA-------CLLGSFNLVKYIfkdgagryafDWDQYREDIPQVVRA 337
Cdd:cd01679 195 LFKDTCNRKNPQKHLGTIKSSNLCTEilQPTSPSEDepgedavCNLASINLGNFV----------TFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 338 MDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGsfpkf 417
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 418 dkdkylqgqfiktlredvrdaiakyGIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRTVIEFSGPRV-----ETV 492
Cdd:cd01679 340 -------------------------GLRNSLLLAIAPTASISQIL-GATPSIEPITSNIYVRRVLSGEFPVVnphleKDL 393
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1898303842 493 EDYGAR--VFGVRgkacsrvtvQEHVAALTVAAQR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEggaKGCTT 562
Cdd:cd01679 394 WEYGLYktAYEID---------QRWLIDLAADRQKhIDQGQSLNLFLTPPATTRDLNSLYFYAWK---KGLKT 454
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
21-559 |
3.13e-55 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 197.10 E-value: 3.13e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 21 GESFREAMNRIAAALKDDDQHFAD-FRDALLGMRFLPAGRIQSAMGSTRQVtPYNCYVSgTINDSFvdgEGsIMVRAAEA 99
Cdd:PRK09102 37 GESYQDLFARIAEAYADIDPEHAQrFYDYMSRGWFMPATPVLSNGGTDRGL-PISCFLN-YVEDSL---EG-IVNTWNEN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 100 AATMRMGGGIGYDFSTLRPRGDLIRkLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQPGK 179
Cdd:PRK09102 111 VWLAKRGGGIGSYWGNVRSIGEPIR-NNGKSSGIIPFIKVMDSLTLAISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPTG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 180 DVQplwdlvaelpegaQKQQLVMslqqtlklTGfnvsVAITDKFMECVASGEPFPLT--FEGRTYREVDARALWDAIMRG 257
Cdd:PRK09102 190 DPN-------------RKALNLH--------HG----VCVTDEFMEAVEDGDEWDLIspKDKSVIRTVKARDLWAKILET 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 258 TWDWAEPGVLFIDAINRM-------NNLwyceTIAATNPCGEQPLPPYGA---------CLLGSFNLVKYifkdgagrya 321
Cdd:PRK09102 245 RIETGEPYLLFIDNVNRAlpevykdLGL----KVKASNLCSEITLPTGIDhlgedrtavCCLSSLNLEYY---------- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 322 FDWDQYREDIPQVVRAMDNV----VDRAIYPLPQQKQEAKDKRRMGLGITGLanaaealgHEY----GSPaFLAFEAEVL 393
Cdd:PRK09102 311 DEWKDTDAFIEDLMRFLDNVlqdfIDKAPDEMERAKYSAMRERSVGLGVMGF--------HSYlqskMIP-FESVMAKQW 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 394 D-----TLRDESYLASAHIAKVKGSFPkfdkdkylqgqfiktlredvrDAiAKYGI--RNSHLTSIAPTGTISLCADNVS 466
Cdd:PRK09102 382 NkkifkHIREQADKASKELAKEKGECP---------------------DA-AGYGVmrRFSTKMAIAPTASISIILGNTS 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 467 SGIEPVFAYSF--DRTVIEFsgprveTVED-YGARVFGVRGKACSRV---------TVQeHVAALT-------------- 520
Cdd:PRK09102 440 PGIEPIAANYYthKTLKGSF------TVKNkYLEKLLEEKGKDTDEVwssiltnegSVQ-HLDFLSeeekdvfktafeid 512
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 1898303842 521 ------VAAQR---VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKG 559
Cdd:PRK09102 513 qrwiieLAADRqkyIDQAQSLNLFLPANVPKRDLNKLHFEAWKKGVKS 560
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
290-566 |
5.31e-42 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 163.40 E-value: 5.31e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 290 CGEQPLPPYGACLLGSFNLVKYIFKDGAGRYAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGL 369
Cdd:PRK08332 1297 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGL 1376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 370 ANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF---------IKTLRED-VRDAI 439
Cdd:PRK08332 1377 ADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELpvegfyhpeIWNLPWDkLVEEI 1456
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 440 AKYGIRNSHLTSIAPTGTISLCADNvSSGIEPVFAYSFDR--TVIEF-----------------SGPRVETVEDYGARVF 500
Cdd:PRK08332 1457 KKYGVRNAMVTTCPPTGSVSMIADT-SSGIEPIFALVYKKsvTVGEFyyvdpvfeaelkkrglySEELLKKISDNYGSVQ 1535
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1898303842 501 GVRG--KACSRVTVQ-------EHV-AALTVAAQRVDSAvSKTCNVPSDISWEDFKNVYVSAWEGGAKGCTTFRLG 566
Cdd:PRK08332 1536 GLEEipEDMQRVFVTaldihwlDHIlAQANIQMWLTDSA-SKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDG 1610
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
30-596 |
5.22e-38 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 150.46 E-value: 5.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 30 RIAAAL----KDDDQHFADFRDALLGMRFLPAGRIQSAMGstrqvTPY----NCYVSGTINDSfvdgeGSIMVRAAEAAA 101
Cdd:PRK06539 179 RIAMGLslneDDPTSSALAFYEKMSKLEYLAAGSTLVNAG-----TPYpqlsNCFVMEMQDDI-----EHIAKTTRDVMW 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 102 TMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQPGKDV 181
Cdd:PRK06539 249 LTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 182 --------QPLWdLVAELPEGAQKQQ--LVMSLQQTLKLTGFNVSvAITDKFMECVASGEPFPLtfegRTYREVDARALW 251
Cdd:PRK06539 329 yrrtrtanTAVW-ISDEFMKRVQNDEdwYLFDPLETPDLNELYGK-AFSKRYAQYVEQAEAGRI----RMFKRITAREQF 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 252 DAIMRGTWDWAEPGVLFIDAINR--MNNlwYCETIAATNPCGEQPLPP----YGACLLGSFNLVKYiFKDGAgryaFDWD 325
Cdd:PRK06539 403 RAILMSLQTTSHPWLTWKDTINNraLNN--NTGTIHLSNLCTEICLPQdrdnVSVCNLASINLSRH-LADGE----LDWA 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 326 QYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLrdeSYLA-- 403
Cdd:PRK06539 476 QLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHI---SYAAid 552
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 404 -SAHIAKVKGSFPKFDKDKYLQGQF----IKTLRED----------VR---DAI---AKYGIRNSHLTSIAPTGTISLCA 462
Cdd:PRK06539 553 eSADLAAERGAYPNFEGSRWSRGMVpvdsIALLEADrgvpvdvnrtTRldwDALrakVRGGMRNATLMAIAPTASIGLVA 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 463 dNVSSGIEPVFAYSFDRTV-----IEFSGPRVETVEDYG------ARVFGVRG------------KACSRVTVQ-EHVAA 518
Cdd:PRK06539 633 -GTTPGLDPQFSQIFSRSTssgkfLEVNRNLVADLKELGlwetvrEEILRSQGdiqeiaaipdeiKALYRTSFQlSPYAF 711
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 519 LTVAAQR---VDSAVSKTCNVPS-DISweDFKNVYVSAWEGGAKgcTTFRL----------------------GGKRSG- 571
Cdd:PRK06539 712 LEVAARAqkwVDQAISRNMYLESrDIG--DMMDIYTAAWEMGVK--TTYYLhmkprhtaeqstvkvnksaerrGGPRRGf 787
|
650 660 670
....*....|....*....|....*....|....*
gi 1898303842 572 --------ILVVKD--DGGEPEADAPAEEPASQCR 596
Cdd:PRK06539 788 agfgagvpPAVSADliPGASCPVDAQAPQQCESCR 822
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
45-493 |
2.69e-36 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 145.47 E-value: 2.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 45 FRDALLGMRFLPAGRIQSAMGsTRQVTPYNCYVSgTINDSFVDgegsIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIR 124
Cdd:PRK12365 428 FYNLLSTFRYTPATPTLFNSG-MRHSQLSSCYLS-TVQDDLVH----IYKVISDNAMLSKWAGGIGNDWTAVRATGALIK 501
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 125 KLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIH-AKQPGKDVQPLWDL--VAELPEGAQKQqlv 201
Cdd:PRK12365 502 GTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFLElRKNTGDERRRTHDIntASWIPDLFFKR--- 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 202 msLQQTLKLTGFN------VSVAITDKFMECVASGEPFPLTFEGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRM 275
Cdd:PRK12365 579 --LQQKGTWTLFSpddvpgLHEAYGEEFEKLYEEYERKVDTGEIRLYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIR 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 276 NNLWYCETIAATNPCGEQPL----PPYGACLLGSFNLVKYIFKDGagryaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQ 351
Cdd:PRK12365 657 SAQDHKGVVRCSNLCTEILLncseTETAVCNLGSINLVEHIVNDG-----LDEEKLSETISIAIRILDNVIDINFYPTKE 731
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 352 QKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQG------ 425
Cdd:PRK12365 732 AKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGylpidt 811
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 426 -QFIKTLR---------------EDVRDAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFDRTVI--EFSGP 487
Cdd:PRK12365 812 iELLKEYRgeanllmdtssrkdwEPVRSLIKEYGMRNSQLMAIAPTATISNII-GVTQSIEPTYKHLFVKSNLsgEFTIP 890
|
....*.
gi 1898303842 488 RVETVE 493
Cdd:PRK12365 891 NVYLIE 896
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
110-290 |
5.27e-34 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 138.75 E-value: 5.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 110 GYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAKQP--GKDVqplwdl 187
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKniGTNV------ 830
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 188 vaelpegaqkqqlvmslqqtlkLTGFNVSVAITDKFMECVASGEPFPLT--FEGRTYREVDARALWDAIMRGTWDWAEPG 265
Cdd:PRK08332 831 ----------------------LSNFNISVGIWEDFWEALKEGKKYPLInpRTGEVVKEIDPKSLFEELAYMAWAKADPG 888
|
170 180
....*....|....*....|....*..
gi 1898303842 266 VLFIDAINRMNNLWYC--ETIAATNPC 290
Cdd:PRK08332 889 VIFFDVINRRNVLKEAkgGPIRATNPC 915
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
72-474 |
1.10e-31 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 131.62 E-value: 1.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 72 PYNCYVSGtINDSFVDgEGSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDlirKLQS--HSSGPISFMHIFDAICKCVAS 149
Cdd:PRK07562 196 PHACFIQS-VEDDLVN-EGGIMDLWVREARLFKYGSGTGSNFSNLRGEGE---KLSGggKSSGLMSFLKIGDRAAGAIKS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 150 SGH-RRGAQMGVMRVDHPDIEEFIHAKQpgKDVQPLWDLVAELPEGAQKQQLVM--------------------SLQQTL 208
Cdd:PRK07562 271 GGTtRRAAKMVIVDIDHPDIEEFIDWKV--KEEQKVAALVTGSKIVSKHLKAIMkacvncegdgddcfdpaknpALKREI 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 209 KLT-------------------GF-------------------------NVSVAITDKFMECVASGEPFPLTF--EGRTY 242
Cdd:PRK07562 349 KAAkkalvpenyikrviqfarqGYtdidfptydtdwdseayltvsgqnsNNSVRVTDEFLRAVENDGDWNLTArtDGKVA 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 243 REVDARALWDAIMRGTWDWAEPGVLFIDAINRmnnlWY-CET---IAATNPCGEQPLPPYGACLLGSFNLVKyiFKDGAG 318
Cdd:PRK07562 429 KTLKARDLWEKIGYAAWASADPGLQFNTTIND----WHtCPAsgpIRASNPCSEYMFLDDTACNLASLNLLT--FRDEDT 502
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 319 RyAFDWDQYRedipQVVRAMDNV----VDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLD 394
Cdd:PRK07562 503 K-RFDVEAYE----HACRLWTVVleisVLMAQFPSKEIAELSYEFRTLGLGYANIGGLLMTMGIPYDSDEGRAICGALSA 577
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 395 TLRDESYLASAHIAKVKGSFPKFDKDK----------------------------------YL-QGQFIKTLREDVRDAI 439
Cdd:PRK07562 578 IMTGVAYATSAEMAKELGPFPGYEKNAdhmlrvirnhrraahgesegyeglsvnpvpldhaNCpDQDLVAHAKAAWDKAL 657
|
490 500 510
....*....|....*....|....*....|....*...
gi 1898303842 440 A---KYGIRNSHLTSIAPTGTISLCADNVSSGIEPVFA 474
Cdd:PRK07562 658 ElgeKHGYRNAQVTVIAPTGTIGLVMDCDTTGIEPDFA 695
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
64-558 |
1.16e-25 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 112.21 E-value: 1.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 64 MGSTRqvTPY----NCYVSgTINDSFvdgeGSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHI 139
Cdd:PRK07088 226 LSNAG--TPFyqlsSCFIS-VVDDNL----WSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 140 FDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK-------QPGKDVQP---LWDLVAELPEGAQKQQLvMSLQQTLK 209
Cdd:PRK07088 299 YNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKtnngddrRKAHDIFPgvsYPDLFMKRLEKRENWSL-FDPHEIKK 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 210 LTGFNV--------SVAITDKFMECVASGEpfpltFEGRTyreVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYC 281
Cdd:PRK07088 378 VKGYSLedyydeedRKEFTKKYLECEEDTN-----IPRRT---VPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHK 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 282 ETIAATNPCGEQplppygACLLGSFNLVKYIFKDGAGRYAF----------------------DWDQYREDIPQVVRAMD 339
Cdd:PRK07088 450 GMIYSSNLCHEI------AQNMSESELLEEEIIDENGYYEVvqkikagdmvtcnlnsivlgnvDDEELEEVIPTQIRMLD 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 340 NVVDRAIYPLPQQKQEAKDKRRMGLGITG----LANAaealGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFP 415
Cdd:PRK07088 524 NVISLNYYPVPEAEITSDKYRAIGLGTSGyhhmLANN----KIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYP 599
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 416 KFDKDKYLQGQFIKtLRE-------DVRDAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEPVFAYSFdrtVIEFSGPR 488
Cdd:PRK07088 600 AFKGSEWETGKYFE-RRGynserwkKLKEEIKKYGMRNGYITAVAPTGSTSNIA-NTTAGIDPVFKRFF---MEEKKGSF 674
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1898303842 489 V-ETVEDYGARVFGVRGKACSrVTVQEHVAALTVAAQRVDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAK 558
Cdd:PRK07088 675 TpKTAPDLNEENFWYYKEAHT-IDQQWSIKACGVRQRHIDQAQSFNLYITPEYKAKQILNLYIEAWKQGVK 744
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
75-563 |
1.30e-24 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 109.05 E-value: 1.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 75 CYVSgTINDSFVdgegSIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRR 154
Cdd:PRK09209 237 CFID-TVDDSLQ----GIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRK 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 155 GAQMGVMRVDHPDIEEFIHAK-------QPGKDVQP---LWDLVAELPEgAQKQQLVMSLQQTLKLTGFNV--------- 215
Cdd:PRK09209 312 GAIAVYLDVWHKDIESFLDLRlnngderLRAHDVFTgvcIPDLFMEAVE-RRGDWYLFDPHEVKKVMGWYLedfydekkg 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 216 SVAITDKFMECVAsgepfpltfEGRTYRE-VDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGE-- 292
Cdd:PRK09209 391 DGSFREKYEECVA---------DERLSRKtVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEim 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 293 QPLPP---------------------YGACLLGSFNLvkyifkdgaGRyAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQ 351
Cdd:PRK09209 462 QNMSPtvmiqeiisggqivitkqpgdFVVCNLSSINL---------GR-AVTADVLERLIPIQVRMLDNVIDLNQLPVPQ 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 352 QKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLrdeSYL---ASAHIAKVKGSFPKFDKDKYLQGQFI 428
Cdd:PRK09209 532 ATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERI---NYLtiqASMELAKEKGAYPVFKGSDWQTGEYF 608
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 429 K----------TLREDVrdaiAKYGIRNSHLTSIAPTGTISLCADNVSSgIEPVFAYSFDRTVIEFSGPrvETVEDYGAR 498
Cdd:PRK09209 609 ErrgynspqwdELAAQV----AENGVRNAYLMAVAPNMSTAQIAGSTAS-IDPIYSAFYYEEKKDYRRP--VTAPDLSLD 681
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1898303842 499 VFGVRGKacSRVTVQEHVAALTVAA-QR-VDSAVSKTCNVPSDISWEDFKNVYVSAWEGGAKgcTTF 563
Cdd:PRK09209 682 TWPYYEK--GAYKVDQFWSIRQNAArQRhVDQSISFNFYVPSTIRASELLDLHMTAWKEGLK--TTY 744
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
98-459 |
1.36e-23 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 105.98 E-value: 1.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 98 EAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCV-ASSGHRRGAQMGVMRVDHPDIEEFIH-AK 175
Cdd:PLN02437 237 ECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVdQGGGKRKGAFAIYLEPWHADIFEFLDlRK 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 176 QPGKdvqplwdlvaelpEGAQKQQLVMSLQqtlkltgfnvsvaITDKFMECVAS-------------------GEPFPLT 236
Cdd:PLN02437 317 NHGK-------------EEHRARDLFYALW-------------IPDLFMERVQSngdwslfcpneapgladcwGEEFERL 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 237 F-----EGRTYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEqpLPPYGA------CLLGS 305
Cdd:PLN02437 371 YtkyerEGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTE--IIEYTSptetavCNLAS 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 306 FNLVKYIFKDG----------------AGRYaFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGL 369
Cdd:PLN02437 449 IALPRFVREKGvpleshpsklvgslgsKNRY-FDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGL 527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 370 ANAAEALGHEYGSPAFLAFEAEVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF-------IKTLRED---VRDAI 439
Cdd:PLN02437 528 ADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILqpdmwgvTPSGRWDwaaLREMI 607
|
410 420
....*....|....*....|
gi 1898303842 440 AKYGIRNSHLTSIAPTGTIS 459
Cdd:PLN02437 608 SKNGVRNSLLVAPMPTASTS 627
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
64-558 |
5.09e-23 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 104.06 E-value: 5.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 64 MGSTRQVT-----------PYN----CYVSgTINDSfVDGegsIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQS 128
Cdd:PRK12364 290 MLSKLKVTmatptlsnarkPFHqlssCFID-TVPDS-LDG---IYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQG 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 129 HSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIHAK-------QPGKDVQP-------LWDLVAELPEG 194
Cdd:PRK12364 365 VAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRtnngddrMKAHDVFPavcypdlFWKMVRDDINQ 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 195 aqkQQLVMSLQQTLKLTGFNVSVAITD----KFMECVASgepfpltfEGRTYREVDARALWDAIMRgtwDWAEPGVLFI- 269
Cdd:PRK12364 445 ---SWYLFCPHEILTVKGYALEDYYGEewekRYLDCVND--------ARISKRSIPIKDLVRLILK---SAVETGTPFTf 510
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 270 --DAINRMNNLWYCETIAATNPCGE--QPLPP-------------------------YGACLLGSFNLVKYIFKDGAgry 320
Cdd:PRK12364 511 nrDTVNRANPNKHKGMIYCSNLCTEiaQNMSAietvsteietedgdtvvvtttrpgdFVVCNLASLSLGNIDLEDEE--- 587
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 321 afdwdQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEVLDTLRDES 400
Cdd:PRK12364 588 -----ELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAA 662
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 401 YLASAHIAKVKGSFPKFDKDKYLQGQFIKtLR-------EDVRDAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEPVF 473
Cdd:PRK12364 663 IKASMEIAKEKGAYGYFEGSDWQTGAYFR-KRgytseewQRLAREVAENGMRNAYLLAVAPTSSTSIIA-GTTAGVDPVM 740
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 474 AYSFdrtVIEFSG---PRV----------------ETVEDYGARVFGVRgkacsrvtvQEHvaaltvaaqrVDSAVSKTC 534
Cdd:PRK12364 741 KRYF---LEEKKGalmPRVapelsdktfwlyknahLIDQKWSIRAAGVR---------QRH----------IDQAQSVNL 798
|
570 580
....*....|....*....|....
gi 1898303842 535 NVPSDISWEDFKNVYVSAWEGGAK 558
Cdd:PRK12364 799 YITNEFTMRQVLDLYLLAWEEGVK 822
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
75-473 |
9.74e-22 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 99.80 E-value: 9.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 75 CYVsGTINDSFvdgEGsIMVRAAEAAATMRMGGGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRR 154
Cdd:PRK08447 216 CYI-GSTPDNI---EG-IFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRK 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 155 GAQMGVMRVDHPDIEEFIH-AKQPGKDVQPLWDLVAELpegaqkqqlvmslqqtlkltgfnvsvAITDKFMECVASGEPF 233
Cdd:PRK08447 291 GAIAVYLEPWHMDISDFIDlRKNSGEERRRAHDLFPAL--------------------------WINDLFMKRVEEDAMW 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 234 PL---------------TFEGRtYRE-----------VDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAAT 287
Cdd:PRK08447 345 TLfdpyeckdltelygeEFEKR-YLEyekdekiikeyINAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSS 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 288 NPCGE--QPLPPygacllgSFNLVKYIFKDGA------------------------------GRYAFDWDQY-------- 327
Cdd:PRK08447 424 NLCTEifQNTAP-------NHYKIKIEFEDGSieffeeeelvtvdsgitkkakkitsldslkGKKIYIVEKEkkdgktav 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 328 -------------REDIPQVV----RAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEA 390
Cdd:PRK08447 497 cnlasinlskintKEDIERVVpiaiRMLDNVIDLNFYPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKID 576
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 391 EVLDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF--------IKTLRED------------VRDAIAKYGIRNSHLT 450
Cdd:PRK08447 577 EIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFpidkaneeAKKLVERgglfdsacdwegLREKVKKDGMRNGYLM 656
|
490 500
....*....|....*....|...
gi 1898303842 451 SIAPTGTISLCADNVSSgIEPVF 473
Cdd:PRK08447 657 AIAPTSSISILVGTTQT-IEPVY 678
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
16-471 |
2.92e-21 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 98.25 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 16 KY----RGSGESFRE---AMNRIAAALKDDD------QHFADFRDALLGMRF-LPAGRIQSAMGSTRQVTpyNCYV--SG 79
Cdd:PHA02572 152 KYlvqdRSTGEIYETpqfAYMLIAMALHQDEpkedrlEHVIRFYNAVSTRKIsLPTPIMAGVRTPTRQFS--SCVVieSG 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 80 TINDSFVDGEGSIMVRAAEAAatmrmggGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMG 159
Cdd:PHA02572 230 DSLDSINKTAMAIVKYISKRA-------GIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 160 VMRVDHPDIEEFIHAKQpGKDVQPlwDLVAELPEGAQKQQLVMS-LQQTLKLTGFNVSV----------AITDKFMECVA 228
Cdd:PHA02572 303 YYPIWHLEVEDLLVLKN-NKGVEE--NRIRHLDYGVQINDLMYErFIKNDYITLFSPHDvggelydayfADQDRFRELYE 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 229 SGEPFPLTFEGRtyreVDARALWDAIMRgtwDWAEPGVLFIDAINRMNNLW-YCETIAATNPCGEQPLPPY--------- 298
Cdd:PHA02572 380 ALEKDPSVRKKR----IKAQELFLLLLK---ERSETGRIYIMFIDHCNNHSpFKDPIRQSNLCCEIALPTKplnhidgeg 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 299 --GACLLGSFNLVKyiFKDgagryafdWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQeAKDKRRMGLGITGLANAAEAL 376
Cdd:PHA02572 453 eiALCTLSAIVLGN--FED--------QDEIEELAEVAVRALDNLLDYQDYPVPAALK-AKKRRSLGVGVTNYAHYLAKN 521
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 377 GHEYGSPAflafeAEVLDTL--RDESYL--ASAHIAKVKGSFPKFDKDKYLQGQF-IKTLREDV---------------R 436
Cdd:PHA02572 522 FASYEDAN-----ADLVHELfeRLQYYLikASNKLAKEKGACEYFSDTKYSRGELpIDWYKKKVdelvapkyncdweslR 596
|
490 500 510
....*....|....*....|....*....|....*
gi 1898303842 437 DAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEP 471
Cdd:PHA02572 597 EDLKKYGIRNSTLSALMPCESSSQVS-NSTNGIEP 630
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
107-473 |
1.32e-19 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 93.49 E-value: 1.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 107 GGIGYDFSTLRPRGDLIRKLQSHSSGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDHPDIEEFIH-AKQPGKDVQPLW 185
Cdd:PRK07207 401 GGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLElRKNTGDDRRRTH 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 186 DLvaelpegaqkqqlvmslqqtlkltgfNVSVAITDKFMECVASGEPFPL---------------TFEGR---------- 240
Cdd:PRK07207 481 DM--------------------------NTANWIPDLFMKRVMEDGEWTLfspsevpdlhdlfgkAFEEAytayeakaar 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 241 ----TYREVDARALWDAIMRGTWDWAEPGVLFIDAINRMNNLWYCETIAATNPCGEQPL----PPYGACLLGSFNLVKYI 312
Cdd:PRK07207 535 geikLFKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLntsdDEIAVCNLGSVNLVAHI 614
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 313 fKDGAgryAFDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYGSPAFLAFEAEV 392
Cdd:PRK07207 615 -KDGA---KLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRS 690
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 393 LDTLRDESYLASAHIAKVKGSFPKFDKDKYLQGQF----IKTLRED-----------------VRDAIAKYGIRNSHLTS 451
Cdd:PRK07207 691 MEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILpidsLKLLAEArggylevdrsstldwdaLRARIKKHGMRNSNCMA 770
|
410 420
....*....|....*....|...
gi 1898303842 452 IAPTGTIS-LCAdnVSSGIEPVF 473
Cdd:PRK07207 771 IAPTATISnIIG--VSQSIEPTY 791
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
301-471 |
1.77e-14 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 76.95 E-value: 1.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 301 CLLGSFNLvkyifkdGAGRyafDWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLAN--------- 371
Cdd:PRK09103 459 CTLSAFNL-------GAIN---SLDELEELADLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYylakngvry 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 372 ---AAEALGHEygspaflAFEAEvldtlrdESYL--ASAHIAKVKGSFPKFDKDKYLQGQF-IKTLREDV---------- 435
Cdd:PRK09103 529 sdgSANNLTHK-------TFEAI-------QYYLlkASNELAKEQGACPWFNETTYAQGILpIDTYKKDLdaicneplhy 594
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1898303842 436 -----RDAIAKYGIRNSHLTSIAPTGTISLCAdNVSSGIEP 471
Cdd:PRK09103 595 dwetlREEIKTHGLRNSTLSALMPSETSSQIS-NATNGIEP 634
|
|
| RTPR |
TIGR02505 |
ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
111-499 |
2.44e-12 |
|
ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (RNR) related to the characterized species from Lactococcus leichmannii. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Thus model identifies NrdJ enzymes only in cyanobacteria, lactococcus and certain bacteriophage. A separate model (TIGR02504) identifies a larger group of divergent B12-dependent RNR's. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274169 [Multi-domain] Cd Length: 713 Bit Score: 69.95 E-value: 2.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 111 YDFSTLRPRGDLIRKLQSHSSGPISF------------------------MHIFDAICKCVASSGHRRGAQMGVMRVDHP 166
Cdd:TIGR02505 212 LDLSDIRPAGAELKGFGGTASGPVPLakmltdvaeilsnkaggrltavdaADICNLIGKAVVAGNVRRSAEMALFSNDDP 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 167 DIEEFIHAKQpgKDVQPLWDLvaelpegaqkqqlvmslqqtlkltgfNVSVAITDKFmECVASGEPFPLTFEGRTYREVD 246
Cdd:TIGR02505 292 EFESFKQAKE--KLMHHRWAS--------------------------NNSVAVDSAF-SGLARSAADILENGEPGQVNLD 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 247 ARALWDAIMRGTWDWAEPgvlfidainrmnnlwycETIAATNPCGEQPLPPYGACLLGSFNLVKYifkDGAGryafdWDQ 326
Cdd:TIGR02505 343 LSKSEGRIVNGRYQAGED-----------------GDVEGTNPCGEILLANGEPCNLFEVNLLAF---EEDG-----WGL 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 327 YRedipqVVRAMDNVVDRAIY-PLPQQK-QEAKDK-RRMGLGITGLanaAEALGHEYGSPAFLAFEAEVLDTLrdesyla 403
Cdd:TIGR02505 398 QR-----AFALAARYAKRVTFsPYDDEIsREIIQKnRRIGVSMSGI---QDFLLLRGGTGFKDDFDPETHEAI------- 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 404 sahiakvkgSFPKFDKdkyLQGQFIKTLREDVRDAIAKY----GI-RNSHLTSIAPTGTISLCAdNVSSGIEPVFA-YSF 477
Cdd:TIGR02505 463 ---------KVRVYDK---RAAKFLDRMYKIVVKAAQDYskelGCpEPIKHTTVKPSGTISKLA-GASEGIHPPYGaYLI 529
|
410 420
....*....|....*....|..
gi 1898303842 478 DRTVIEFSGPRVETVEDYGARV 499
Cdd:TIGR02505 530 RRITFSKSDPLAPALKACGYTV 551
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
91-381 |
4.35e-10 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 61.78 E-value: 4.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 91 SIMVRAAEAAATMRMGGGIGYDF--STLRPRGDLIRKLQSHS-SGPISFMHIFDAICKCVASSGHRRGAQMGVMRVDH-- 165
Cdd:cd00576 53 QKTYQIIALAASNQNGGGVSFARasSILSPYGSRDYAKGSGTeTDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHkg 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 166 ---PDIEEFIHAKQpgkdvqplwdlvAELPEGAQKQQlvmslqqtlkltgFNVSVAITDKFMEcvasgepfpltfegrty 242
Cdd:cd00576 133 kgdKISQEFLNLAL------------ANGGEGIPLNF-------------PNLSVRVSSDKPG----------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898303842 243 REVDARALWDAIMRGTWDWAEPGVLFidaiNRMnnlwycetiaatnpcgeqplppygaCLLGSFNLVKYIFKDGAGRYAF 322
Cdd:cd00576 171 ILVKAVELKQLIAEEARKTGSPGIFN----DEL-------------------------CNLVSLNLARIMEKAINGSMDV 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1898303842 323 DWDQYREDIPQVVRAMDNVVDRAIYPLPQQKQEAKDKRRMGLGITGLANAAEALGHEYG 381
Cdd:cd00576 222 VLEELEELAFLAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKV 280
|
|
| |
