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Conserved domains on  [gi|1917050899|gb|QOL09939|]
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polymerase [Apple necrotic mosaic virus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
323-695 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


:

Pssm-ID: 438102  Cd Length: 332  Bit Score: 589.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 323 DICLELDKASIDQSVFNDWVpKSGKRLQGVFRTGNFSKRVPTFREAALAIKKRNLNVPDLKQVMFDDDEARKIANRFINT 402
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWT-KPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 403 VIVPNWLpkrsdaisegevgyynkyltgknidpdlfvdpcalvsmDKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKG 482
Cdd:cd23252    80 VIDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKG 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 483 KVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSE 562
Cdd:cd23252   122 IVMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 563 FLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLLDPNITFVIASGDDSLIGSVKPLNRD 642
Cdd:cd23252   202 FTKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRD 281
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1917050899 643 TEFMFTTMFNFEAKFPHNQAFVCSKFLCLLPTksGGKKVLAVPNALKLNIKLG 695
Cdd:cd23252   282 DEDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
323-695 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 589.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 323 DICLELDKASIDQSVFNDWVpKSGKRLQGVFRTGNFSKRVPTFREAALAIKKRNLNVPDLKQVMFDDDEARKIANRFINT 402
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWT-KPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 403 VIVPNWLpkrsdaisegevgyynkyltgknidpdlfvdpcalvsmDKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKG 482
Cdd:cd23252    80 VIDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKG 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 483 KVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSE 562
Cdd:cd23252   122 IVMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 563 FLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLLDPNITFVIASGDDSLIGSVKPLNRD 642
Cdd:cd23252   202 FTKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRD 281
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1917050899 643 TEFMFTTMFNFEAKFPHNQAFVCSKFLCLLPTksGGKKVLAVPNALKLNIKLG 695
Cdd:cd23252   282 DEDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
321-737 9.88e-156

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 462.88  E-value: 9.88e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 321 TDDICLELDKASIDQSVFNDWVPKSGKRLQGVFRTGNFSKRVPTFREAALAIKKRNLNVPDLKQVMFDDDEARKIANRFI 400
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 401 NTVIVPN-WLPKRSDAISEGEVGYYNKYLTGKNID--PDLFVDPCALVSMDKYRHMIKTQLKPAEDTSSVFERSLPATIT 477
Cdd:pfam00978  81 KSFLDKEkLDKLDPIINTTENVSRWLDKQSGKKAAqlKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 478 YHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTAL 557
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 558 GADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLldPNITFVIASGDDSLIGSVK 637
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDL--EKIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 638 PLnRDTEFMFTTMFNFEAKFP-HNQAFVCSKFLCLLPTksggkKVLAVPNALKLNIKLGVKDLA--PEAFDAWYESWLDL 714
Cdd:pfam00978 319 PI-EDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDG-----GAFFVPDPLKLLQKLGKKKIPddEQHLDEIFTSLCDL 392
                         410       420
                  ....*....|....*....|...
gi 1917050899 715 TWYFKHYLVVSMMRDYLSHRYAR 737
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYYK 415
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
323-695 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 589.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 323 DICLELDKASIDQSVFNDWVpKSGKRLQGVFRTGNFSKRVPTFREAALAIKKRNLNVPDLKQVMFDDDEARKIANRFINT 402
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWT-KPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 403 VIVPNWLpkrsdaisegevgyynkyltgknidpdlfvdpcalvsmDKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKG 482
Cdd:cd23252    80 VIDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKG 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 483 KVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSE 562
Cdd:cd23252   122 IVMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 563 FLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLLDPNITFVIASGDDSLIGSVKPLNRD 642
Cdd:cd23252   202 FTKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRD 281
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1917050899 643 TEFMFTTMFNFEAKFPHNQAFVCSKFLCLLPTksGGKKVLAVPNALKLNIKLG 695
Cdd:cd23252   282 DEDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
321-737 9.88e-156

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 462.88  E-value: 9.88e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 321 TDDICLELDKASIDQSVFNDWVPKSGKRLQGVFRTGNFSKRVPTFREAALAIKKRNLNVPDLKQVMFDDDEARKIANRFI 400
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 401 NTVIVPN-WLPKRSDAISEGEVGYYNKYLTGKNID--PDLFVDPCALVSMDKYRHMIKTQLKPAEDTSSVFERSLPATIT 477
Cdd:pfam00978  81 KSFLDKEkLDKLDPIINTTENVSRWLDKQSGKKAAqlKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 478 YHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTAL 557
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 558 GADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLldPNITFVIASGDDSLIGSVK 637
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDL--EKIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 638 PLnRDTEFMFTTMFNFEAKFP-HNQAFVCSKFLCLLPTksggkKVLAVPNALKLNIKLGVKDLA--PEAFDAWYESWLDL 714
Cdd:pfam00978 319 PI-EDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDG-----GAFFVPDPLKLLQKLGKKKIPddEQHLDEIFTSLCDL 392
                         410       420
                  ....*....|....*....|...
gi 1917050899 715 TWYFKHYLVVSMMRDYLSHRYAR 737
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYYK 415
Mayoviridae_RdRp cd23256
RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense ...
423-699 2.99e-69

RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Mayoviridae, order Martellivirales. The Mayoviridae family consists of two genera, Idaeovirus and Pteridovirus. The genus Idaeovirus contains Raspberry bushy dwarf virus (RBDV), named after the host with which it was first associated (red raspberry, Rubus idaeu) and the disease which is characterized by bushiness (stunting and proliferation of canes); RBDV has recently been found causing an infection in grapevines. RBDV occurs in all tissues of the plant, including seed and pollen, and is transmitted in association with pollen, both vertically to the seed and horizontally to the pollinated plant; this is the only known method of natural spread of RBDV. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438106  Cd Length: 329  Bit Score: 232.33  E-value: 2.99e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 423 YYNKylTGKNIDpdlfvDPC--ALVSMDKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLL 500
Cdd:cd23256    13 YQNK--VGNKVN-----DPVvlALTSLNKYSHMIKRDRKPVLTTAVQSEYTKAATITYHDKDITQVATPIFRQFKTRLLA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 501 CLNDKISIPSGKYHQL---FSLDPYAFEmTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIR 577
Cdd:cd23256    86 CKKSNLCIPLDHDHDIsgwLTNRHLGSE-NGTFTEIDFSKFDKSQGELHQLIQDLILLRFGCDPEFVSLWSTAHRSSSIK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 578 DGPCGIGFSVNYQRRTGDACTYLGNTIITLSALAYMYDLLD-PNITFVIASGDDSLIGSVKPLNRDTEfMFTTMFNFEAK 656
Cdd:cd23256   165 DQNVGISFKTDFQRRTGDAFTFLGNSLVTAVMLAYVLSFEDeKKIRYMLVGGDDSLICSYGPISVPLE-PLSTIFNMSCK 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1917050899 657 -FPHNQAFVCSKFLCLLptksgGKKVLAVPNALKLNIKLGVKDL 699
Cdd:cd23256   244 lIQPSCPYFASRYIIRV-----GDEILCVPDPYKLLVKMGRKDI 282
Kitaviridae_RdRp cd23254
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of ...
450-700 2.68e-50

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus leprosis virus C2 (genus Cilevirus); and Hibiscus green spot virus 2 (genus Higrevirus). Although related, there are considerable physical and genetic distinctions between members of the different genera. For example, cile- and higreviruses are associated with a bacilliform virion, whereas a spherical virion has been observed for the lone blunervirus for which microscopy has been reported. Moreover, the replication-associated polyproteins are encoded by a single genomic RNA for cile- and higreviruses, but are split between two genomic RNAs for blunerviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438104  Cd Length: 267  Bit Score: 178.11  E-value: 2.68e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 450 YRHMIKTQLKPAEDTSSVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFS------LDPYA 523
Cdd:cd23254     3 YSFMIKRNPKPNLTVDAAYKYPALQTIAYHDKDINAIFCPIFRELKKRLLAVLKPNFVIFTDMSPEDFEellnrrFPPEV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 524 FEMTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNT 603
Cdd:cd23254    83 LSKLLHKLEIDISKYDKSQGELALLFECKLMRRFGVPEELVELWFNAHVLTTLYDRTNKLKALVEYQRKSGDASTFFGNT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 604 IITLSALAYMYDLLDpnITFVIASGDDSLI-GSVKPLNRDTEFmFTTMFNFEAKFPH-NQAFVCSKFlcLLPTksgGKKV 681
Cdd:cd23254   163 LFLMAVLADLFDLSD--LELALFSGDDSLLfGRNLLDYDDSQH-FALKFNLESKFLNyKYPYFCSKF--LLPV---GGRW 234
                         250
                  ....*....|....*....
gi 1917050899 682 LAVPNALKLNIKLGVKDLA 700
Cdd:cd23254   235 YFVPDPVKLLTKLGRHDLV 253
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
449-696 3.83e-48

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 171.97  E-value: 3.83e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 449 KYRHMIKTQLKPAEDTSSVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFS---------- 518
Cdd:cd23253     2 SFKLMVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGMNLEELAslirsklgdp 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 519 LDPYafemtkEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACT 598
Cdd:cd23253    82 LDEY------KTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFSCRATSDSGVSLELGAQRRTGSPNT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 599 YLGNTIITLSALAYMYDLLDpnITFVIASGDDSLIGSVKPLNRDTEFMfTTMFNFEAKFPHNQA-FVCSKFLCllptkSG 677
Cdd:cd23253   156 WLGNTLVTLGILSSSYDLDD--IDLLLVSGDDSLIFSKKPLPNKANEI-NLDFGFEAKFIENSVpYFCSKFII-----ED 227
                         250
                  ....*....|....*....
gi 1917050899 678 GKKVLAVPNALKLNIKLGV 696
Cdd:cd23253   228 RGKIKVVPDPVKLFEKLSV 246
ps-ssRNAv_Martellivirales_RdRp cd23208
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of ...
448-636 7.02e-45

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Martellivirales, class Alsuviricetes. The order Martellivirales consists of seven families: Bromoviridae, Closteroviridae, Endornaviridae, Kitaviridae, Mayoviridae, Togaviridae, and Virgaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438058 [Multi-domain]  Cd Length: 190  Bit Score: 159.84  E-value: 7.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 448 DKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMT 527
Cdd:cd23208     1 DKYEMMIKSDVKPKLDLTAQQEYPKLQTIVYHDKNITAIFCPIFKELFERLLSCLKKKVVIYTGMMTSAELNDFISALHL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 528 KEFK---EIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTI 604
Cdd:cd23208    81 ESGYyvlEIDFSKFDKSQGALHLLTELLILRRLGVDEPLLVLWEFAHTQSTTRDINNGISFETAYQRKSGDAFTYFGNTL 160
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1917050899 605 ITLSALAYMYDLldPNITFVIASGDDSLIGSV 636
Cdd:cd23208   161 VTMAALLDVLDL--EKIVCIAFGGDDSLIFSK 190
Virgaviridae_RdRp cd23251
RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense ...
304-700 1.88e-44

RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Virgaviridae, order Martellivirales. The Virgaviridae is a family of plant viruses with rod-shaped virions, a (+)ssRNA genome with a 3'-terminal tRNA-like structure and a replication protein similar to those of the alpha-like supergroup. Plants serve as natural hosts. The name of the family is derived from the Latin word virga (rod), as all viruses in this family are rod-shaped. There are currently 59 species in this family, divided among seven genera: Goravirus, Furovirus, Hordeivirus, Pecluvirus, Pomovirus, Tobamovirus, and Tobravirus. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438101  Cd Length: 427  Bit Score: 166.26  E-value: 1.88e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 304 LPGVADVDDRFFQELVETDDICLELDKASIDqsvFNDWVPKSGKR--LQGVFRTGNFSKRVPTFREAALAIKKRNLNVPD 381
Cdd:cd23251     1 FPGNSTRDSDFDGYTVATSDINLNVEDCTLD---PSKSVKVWQEKegLKPVLRTAMPEKRQNGLLESLLALIKRNMAAPK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 382 L-----------------KQVMFDDDearKIANRFINTVI-VPNWLPKRSDAisegevgyynkyLTGKNIDPDLFVDpca 443
Cdd:cd23251    78 LqgavnefetiervikkaKDVFFDED---LIDRSPLSTREsFLRWWDKQSTT------------ARAQLLADDRVLD--- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 444 LVSMDKYRHMIKTQLKPAEDTSSVFERSLPATITYHDKgKVMST-SPIFLMMCNRLLLCLNDKI----SIPSGKYHQLFS 518
Cdd:cd23251   140 EIDVCTYNFMIKNDVKPKLDLSPQSEYAALQTVVYPDK-IVNALfGPIFKEINERILSALDPHVvfntRMTAEELNETVE 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 519 -LDPYAfEMtkEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDAC 597
Cdd:cd23251   219 fLDPDE-EY--DALEIDFSKFDKSKTSLHIRAVIELYKLFGLDGMLAFLWEKSQCQTTVKDRQNGIKAYLLYQQKSGNCD 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 598 TYLGNTIITLSALAYMYDLLDpnITFVIASGDDSLI----GSVKPlnrDTEFMFTTMFNFEAK-FPHNQAFVCSKFLCLL 672
Cdd:cd23251   296 TYGSNTWSAALALLSMLPLEK--AIFMIFGGDDSLIlfpkGLVIP---DPCRRLASLWNFECKlFKFKYGYFCGKFLLKH 370
                         410       420
                  ....*....|....*....|....*...
gi 1917050899 673 ptksgGKKVLAVPNALKLNIKLGVKDLA 700
Cdd:cd23251   371 -----GDGYIFYPDPLKLITKLGRKDIK 393
ps-ssRNAv_Alsuviricetes_RdRp cd23182
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of ...
450-633 3.11e-20

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the class Alsuviricetes, phylum: Kitrinoviricota. Alsuviricetes is a class of [(+)ssRNA] viruses which infect eukaryotes. The name of the group is a syllabic abbreviation of "alpha supergroup" with the suffix -viricetes indicating a virus class. The class Alsuviricetes includes three orders: Hepelivirales, Martellivirales, and Tymovirales. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438032 [Multi-domain]  Cd Length: 187  Bit Score: 89.19  E-value: 3.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 450 YRHMIKTQLKPAEDTSsVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGKYHQLFSLDPYAFEMTK- 528
Cdd:cd23182     3 IDFLIKTQQKVSPKTP-FNTGKAGQTIAAHSKSINFVLGPWIRYLEERLRDGSRTHRYSNGLMDEEEAMLSQWKINHVPh 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 529 -EFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRRTGDACTYLGNTIITl 607
Cdd:cd23182    82 aTFVSNDYTAFDKSHNGESLLLEAAIMRRIGTPAAAPNLFIELHGKRTLRAKVLGGSGELDGMRDSGAAWTYCRNTDYN- 160
                         170       180
                  ....*....|....*....|....*.
gi 1917050899 608 saLAYMYDLLDPNITFVIASGDDSLI 633
Cdd:cd23182   161 --LAVMLSLYRLKVKPAAFSGDDSLL 184
Endornaviridae_RdRp cd23255
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of ...
458-640 5.92e-14

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Endornaviridae, order Martellivirales. The family Endornaviridae includes viruses with linear (+)ssRNA genomes that range from 9.7 to 17.6 kb. The family consists of two genera, Alphaendornavirus and Betaendornavirus. Alphaendornavirus includes species whose members infect plants, fungi and oomycetes, while the genus Betaendornavirus includes species whose members infect ascomycete fungi. Plant endornaviruses are transmitted only through the gametes. A conserved RNA-dependent RNA polymerase domain located in the C-terminal region of the polyprotein is a feature common to all endornaviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438105  Cd Length: 237  Bit Score: 72.18  E-value: 5.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 458 LKpaEDTSSVFERSLPATITYHDKGKVMSTSPIFLMMCNRLLLCLNDKISIPSGkyhqlfsLDP---YA----FEMTKEF 530
Cdd:cd23255    45 LK--EDPIEDFREQKARIIVWQRKGICAIFSPIFNEAKKRLKSLLKPKVVYADG-------LTPdelSArlrlVKNVKYF 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 531 KEIDFSKFDKsqQRLHHLIQ--FHIFTALGADSEFLDMWFGSHEVSHIRdgpcGIGFSVN--YQRRTGDACTYLGNTIIT 606
Cdd:cd23255   116 FEDDLSKQDR--QTDKPIIDveMELYKLLGVDPNVIELWREVHENWRFK----GKGVRGVgdAMRLTGQATTALGNVITN 189
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1917050899 607 LSALAYMYDLLDPNITFVIASGDDSLIGSVKPLN 640
Cdd:cd23255   190 LLVHSRLVKRNGSNLKLMLVLGDDNLILTDTKID 223
ps-ssRNAv_Hepelivirales_RdRp cd23209
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of ...
526-633 2.19e-06

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Hepelivirales, class Alsuviricetes. This Hepelivirales order consists of four families: Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438059 [Multi-domain]  Cd Length: 183  Bit Score: 49.02  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 526 MTKEFKEIDFSKFDKSQQRLHHLIQFHIFTALGADSEFLDMWFG--SHEVSHIRDGpcgiGFSVNYQRRTGDACTYLGNT 603
Cdd:cd23209    77 HSAVFIENDFTEFDSTQNLFSLLVELEILEACGMPPALAELYRAlrAKWTLQAREG----SLEGTCKKTSGEPGTLLHNT 152
                          90       100       110
                  ....*....|....*....|....*....|
gi 1917050899 604 IITLSALAYMYDLLDPniTFVIASGDDSLI 633
Cdd:cd23209   153 IWNMAVMMHMVRGGVR--KAAAFKGDDSVV 180
ps_ssRNAv_Tolivirales_RdRp cd23179
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Toliovirales of ...
520-633 3.83e-04

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Toliovirales of positive-sense single-stranded RNA (+ssRNA) viruses; This family contains the catalytic core domain of RdRp of Tolivirales, an order of (+)ssRNA viruses which infect insects and plants. The virions are non-enveloped, spherical, and have an icosahedral capsid. The name Tolivirales, is derived from "tombusvirus-like" with the suffix -virales indicating a virus order. This order includes two families: Carmotetraviridae and Tombusviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438029  Cd Length: 227  Bit Score: 42.89  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 520 DPYAFEmtkefkeIDFSKFDKS----QQRLHHLIqfhIFTALGADSEFLDM--W----FGSHevshirdgPCGIGFSVNY 589
Cdd:cd23179    82 DPVVFS-------LDASRFDAHvsveLLRLEHSV---YLACYPGDPELRKLlkWqlvnKGRT--------SNGVKYKTRG 143
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1917050899 590 QRRTGDACTYLGNTIITLS-ALAYM------YDLLDpnitfviaSGDDSLI 633
Cdd:cd23179   144 GRMSGDMNTGLGNCLIMLAmVYAVLrelgikYDLLV--------DGDDALV 186
Tymoviridae_RdRp cd23247
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of ...
534-640 8.03e-04

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Tymoviridae, order Tymovirales. Virions of the family Tymoviridae are isometric, non-enveloped, about 30 nm in diameter, and contain a single molecule of (+)ssRNA constituting 25#35% of the particle weight. There are 42 species in this family, assigned to three genera (Maculavirus, Marafivirus, and Tymovirus), with two species unassigned to a genus. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438097  Cd Length: 373  Bit Score: 42.56  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 534 DFSKFDKSQ------------QRL---HHLIQFHIFTALGADSEFldmwfgshevshirdGP--CgigfsvnyQRRTGDA 596
Cdd:cd23247   173 DYTAFDQSQhgeavvferlkmERLsipQHLIDLHVHLKTNVSTQF---------------GPltC--------MRLTGEP 229
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1917050899 597 CTYLGNTIITLSALAYMYDLLDpniTFVIASGDDSLIGSVKPLN 640
Cdd:cd23247   230 GTYDDNTDYNLAVIYSQYDISS---TPIMVSGDDSVIDGVPPER 270
ps-ssRNA_RdRp_Tymovirales cd23207
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of ...
534-636 2.63e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Tymovirales. The Tymovirales order contains viruses that mostly infect plants, have a single molecule of (+)ssRNA, and which are united by the similarities in their replication-associated polyproteins. Tymovirales contains five families (Alpha-, Beta-, Delta- and Gammaflexiviridae and Tymoviridae) and groups mostly plant-infecting agents, although a few Tymovirales members have either fungal or insect hosts. Botrytis virus F (BVF), isolated from the fungus Botrytis cinerea, is a flexuous mycovirus that is typical of members of the genus Mycoflexivirus (family Gammaflexiviridae). The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438057 [Multi-domain]  Cd Length: 188  Bit Score: 39.69  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 534 DFSKFDKSQ------------QRLH---HLIQFHIFTALGADSEFldmwfgshevshirdGPCGIGfsvnyqRRTGDACT 598
Cdd:cd23207    94 DYTAFDQSQdgefvvfevllmRHLHipdDLIELYVDIKTNAYSHL---------------GPLSIM------RLTGEPGT 152
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1917050899 599 YLGNTIITLSALAYMYDLldPNITFVIASGDDSLIGSV 636
Cdd:cd23207   153 FDFNTDYNLALTYAKYDL--PPGTPICFSGDDSVANGT 188
RNA_dep_RNAP cd01699
RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the ...
513-633 4.06e-03

RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are products of processing of polyproteins. Some RdRps consist of one polypeptide chain, and others are complexes of several subunits. The domain organization and the 3D structure of the catalytic center of a wide range of RdRps, including those with a low overall sequence homology, are conserved. The catalytic center is formed by several motifs containing a number of conserved amino acid residues. This subfamily represents the RNA-dependent RNA polymerases from all positive-strand RNA eukaryotic viruses with no DNA stage.


Pssm-ID: 238843 [Multi-domain]  Cd Length: 278  Bit Score: 39.96  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 513 YHQLFSLDPYAFEMtkefkeiDFSKFDKSQQRLhhlIQFHIFTALGADSEFLDMWFGSHEVSHIRDGPCGIGFSVNYQRR 592
Cdd:cd01699    88 ANKLRSFSPVAIAL-------DYSRFDSSLSPQ---LLEAEHSIYNALYDDDDELERRNLLRSLTNNSLHIGFNEVYKVR 157
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1917050899 593 ----TGDACTYLGNTIITLSALAYMYDLLDPNITFVIAS----GDDSLI 633
Cdd:cd01699   158 ggrpSGDPLTSIGNSIINCILVRYAFRKLGGKSFFKNVRllnyGDDCLL 206
ps-ssRNAv_CBPV-like_RdRp cd23174
catalytic core domain of RNA-dependent RNA polymerase (RdRp) chronic bee paralysis virus (CBPV) ...
529-667 5.46e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) chronic bee paralysis virus (CBPV) and related positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of the chronic bee paralysis virus (CBPV) and related (+)ssRNA viruses. The CBPV is the causative agent of severe, usually fatal, paralysis in adult honey bees. CBPV has not been assigned to any group or class of viruses because it has a unique genome organization and virion morphology. However, analyses of the nucleic acid sequence showed similarities between the RdRp of CBPV and the RdRps of Tombusviruses, Nodaviruses, Lake Sinai virus 1 and 2 as well as the Anopheline associated C virus (AACV). CBPV was one of the first viruses in honey bees to be described and isolated as it causes characteristic signs of disease in adult honey bees. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438024  Cd Length: 229  Bit Score: 39.38  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917050899 529 EFKEIDFSKFDksQQRLHHLIQfhIFtalgaDSEFLDMWF--GSHEVSHI-------RDG--PCGIGFSVNYQRRTGDAC 597
Cdd:cd23174    83 RFLEIDFSRFD--MTLMKDLLR--IV-----ELRFLLDPYtqRAHQLFIAfmlytltNVGvsRFGTHYKRDGTRCSGDPH 153
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1917050899 598 TYLGNTIITLSALAYMYDLLDPNITFVIASGDDSLIGSVKPLNRDTEF--MFTTMFNFEAKF----PHNQAFVCSK 667
Cdd:cd23174   154 TSIGNGFLNAFIIWLCLRKLPTNSWQSAHEGDDGIIGLRANVVNQVEYnlKFLSCLGFRAKIrvvsELSQATFCGR 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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