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Conserved domains on  [gi|1967465496|gb|QQY96590|]
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E [Transmissible gastroenteritis virus]

Protein Classification

envelope protein( domain architecture ID 10497897)

envelope (E) protein is the envelope small membrane protein that plays a central role in virus morphogenesis and assembly, such as the E proteins from three highly pathogenic human coronaviruses (CoVs) such as Middle East respiratory syndrome (MERS) CoV, Severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoV_E pfam02723
Coronavirus small envelope protein E; This family includes E proteins, well conserved among ...
 6-77 2.15e-15

Coronavirus small envelope protein E; This family includes E proteins, well conserved among Coronavirus strains. They are small, integral membrane proteins involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They act as a viroporin by oligomerizing after insertion in host membranes to create a hydrophilic pore that allows ion transport,. SARS-CoV E protein forms a Ca2+ permeable channel in the endoplasmic reticulum Golgi apparatus intermediate compartment (ERGIC)/Golgi membranes. The E protein ion channel activity alters Ca2+ homeostasis within cells boosting the activation of the NLRP3 inflammasome, leading to the overproduction of IL-beta. SARS-CoV overstimulates the NF-kappaB inflammatory pathway, triggering p38 MARK activation.


:

Pssm-ID: 460662  Cd Length: 75  Bit Score: 63.80  E-value: 2.15e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1967465496  6 ALTVIDDNGMVINIIFWFLLIIIFILLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPD 77
Cdd:pfam02723  1 LLFVINDTGLVVNIILWLLVCIVVLLVSIAFLTLIKLCFQCCRLCNTLVYSPVIYVYNAYKDYMQIEPLPPV 72
 
Name Accession Description Interval E-value
CoV_E pfam02723
Coronavirus small envelope protein E; This family includes E proteins, well conserved among ...
 6-77 2.15e-15

Coronavirus small envelope protein E; This family includes E proteins, well conserved among Coronavirus strains. They are small, integral membrane proteins involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They act as a viroporin by oligomerizing after insertion in host membranes to create a hydrophilic pore that allows ion transport,. SARS-CoV E protein forms a Ca2+ permeable channel in the endoplasmic reticulum Golgi apparatus intermediate compartment (ERGIC)/Golgi membranes. The E protein ion channel activity alters Ca2+ homeostasis within cells boosting the activation of the NLRP3 inflammasome, leading to the overproduction of IL-beta. SARS-CoV overstimulates the NF-kappaB inflammatory pathway, triggering p38 MARK activation.


Pssm-ID: 460662  Cd Length: 75  Bit Score: 63.80  E-value: 2.15e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1967465496  6 ALTVIDDNGMVINIIFWFLLIIIFILLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPD 77
Cdd:pfam02723  1 LLFVINDTGLVVNIILWLLVCIVVLLVSIAFLTLIKLCFQCCRLCNTLVYSPVIYVYNAYKDYMQIEPLPPV 72
 
Name Accession Description Interval E-value
CoV_E pfam02723
Coronavirus small envelope protein E; This family includes E proteins, well conserved among ...
 6-77 2.15e-15

Coronavirus small envelope protein E; This family includes E proteins, well conserved among Coronavirus strains. They are small, integral membrane proteins involved in several aspects of the virus' life cycle, such as assembly, budding, envelope formation, and pathogenesis. They act as a viroporin by oligomerizing after insertion in host membranes to create a hydrophilic pore that allows ion transport,. SARS-CoV E protein forms a Ca2+ permeable channel in the endoplasmic reticulum Golgi apparatus intermediate compartment (ERGIC)/Golgi membranes. The E protein ion channel activity alters Ca2+ homeostasis within cells boosting the activation of the NLRP3 inflammasome, leading to the overproduction of IL-beta. SARS-CoV overstimulates the NF-kappaB inflammatory pathway, triggering p38 MARK activation.


Pssm-ID: 460662  Cd Length: 75  Bit Score: 63.80  E-value: 2.15e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1967465496  6 ALTVIDDNGMVINIIFWFLLIIIFILLSIALLNIIKLCMVCCNLGRTVIIVPAQHAYDAYKNFMRIKAYNPD 77
Cdd:pfam02723  1 LLFVINDTGLVVNIILWLLVCIVVLLVSIAFLTLIKLCFQCCRLCNTLVYSPVIYVYNAYKDYMQIEPLPPV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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