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Conserved domains on  [gi|2028573577|gb|QUA11532|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Ursus rossicus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.64e-45

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.68  E-value: 8.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2028573577 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.64e-45

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.68  E-value: 8.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2028573577 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.31e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 60.66  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  3 VVYVNIFLAFIVSLMGLLiYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2028573577 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.64e-45

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 139.68  E-value: 8.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2028573577 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 2.53e-27

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 95.42  E-value: 2.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577 11 AFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYV 90
Cdd:MTH00126  11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                 ....*...
gi 2028573577 91 QNLNLLQC 98
Cdd:MTH00126  91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.69e-26

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 93.37  E-value: 1.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 2028573577 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.79e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 85.43  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  1 MPVVYVNIFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 2028573577 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.31e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 60.66  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  3 VVYVNIFLAFIVSLMGLLiYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2028573577 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 1.40e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 60.34  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  9 FLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTD 88
Cdd:MTH00181   6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                 ....*...
gi 2028573577 89 YVQNLNLL 96
Cdd:MTH00181  86 HLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 8-97 1.57e-11

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 55.31  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00043   8 ILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVLLSRNHNS 87

                         90
                 ....*....|
gi 2028573577 88 DYVQNLNLLQ 97
Cdd:MTH00043  88 DLVASLNLLQ 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 8-98 5.37e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 51.29  E-value: 5.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLfVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00013   8 LSISPFISMFNLSLQRKHLLMSLLSLEAMILSL-ALFIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVLMTRSYGN 86

                         90
                 ....*....|.
gi 2028573577 88 DYVQNLNLLQC 98
Cdd:MTH00013  87 DMLKSLTSNKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 3.93e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 49.07  E-value: 3.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  9 FLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNnhFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGL--ISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 2028573577 89 YVQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 1.77e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 47.66  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLanMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00188   9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKEL--YLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                         90
                 ....*....|.
gi 2028573577 88 DYVQNLNLLQC 98
Cdd:MTH00188  87 DYVSSLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 8.82e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 45.53  E-value: 8.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVlnNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00162   7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYL--SFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGN 84


                 ....*
gi 2028573577 88 DYVQN 92
Cdd:MTH00162  85 DYFSS 89
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 8-97 4.82e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 33.50  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577  8 IFLAFIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00001   9 VVILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGT 88

                         90
                 ....*....|
gi 2028573577 88 DYVQNLNLLQ 97
Cdd:MTH00001  89 ISLKSLNSLR 98
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 9.12e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 32.70  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028573577 12 FIVSLMGLLIYRSHLMSSLLCLEGMVLSLFVMLTVTVLNNHFTLANMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQ 91
Cdd:MTH00180  13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                 ....*.
gi 2028573577 92 NLNLLQ 97
Cdd:MTH00180  93 SLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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