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Conserved domains on  [gi|2073491183|gb|QYA73735|]
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RNA-dependent RNA polymerase [Sweet potato chlorotic stunt virus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
197-464 7.26e-162

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


:

Pssm-ID: 438103  Cd Length: 266  Bit Score: 459.72  E-value: 7.26e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 197 STMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPL 276
Cdd:cd23253     1 TSFKLMVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGMNLEELASLIRSKLGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 277 PLDSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEAYVNIETTEYF-CRFKSASGITGELGAQRRTGSPNTWLSNT 355
Cdd:cd23253    81 PLDEYKTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFsCRATSDSGVSLELGAQRRTGSPNTWLGNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 356 LVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLENKTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRF 435
Cdd:cd23253   161 LVTLGILSSSYDLDDIDLLLVSGDDSLIFSKKPLPNKANEINLDFGFEAKFIENSVPYFCSKFIIEDRGKIKVVPDPVKL 240
                         250       260
                  ....*....|....*....|....*....
gi 2073491183 436 FEKLSVPVRLSDflsETTLRERFTSYKDL 464
Cdd:cd23253   241 FEKLSVPIRLED---ETLLKERFTSFKDL 266
 
Name Accession Description Interval E-value
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
197-464 7.26e-162

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 459.72  E-value: 7.26e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 197 STMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPL 276
Cdd:cd23253     1 TSFKLMVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGMNLEELASLIRSKLGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 277 PLDSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEAYVNIETTEYF-CRFKSASGITGELGAQRRTGSPNTWLSNT 355
Cdd:cd23253    81 PLDEYKTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFsCRATSDSGVSLELGAQRRTGSPNTWLGNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 356 LVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLENKTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRF 435
Cdd:cd23253   161 LVTLGILSSSYDLDDIDLLLVSGDDSLIFSKKPLPNKANEINLDFGFEAKFIENSVPYFCSKFIIEDRGKIKVVPDPVKL 240
                         250       260
                  ....*....|....*....|....*....
gi 2073491183 436 FEKLSVPVRLSDflsETTLRERFTSYKDL 464
Cdd:cd23253   241 FEKLSVPIRLED---ETLLKERFTSFKDL 266
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
75-512 6.64e-131

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 387.77  E-value: 6.64e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183  75 PVGDLTIDLSKSKPYISGE--FVTSGVMGKGERSRPDTWRQAIASLSHRNFSAPRVNERLDTFKTAELLCESLLKAFDMS 152
Cdd:pfam00978   7 DLDDCRLDPSKSKPKPKDKepYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFKKSFLDK 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 153 RLFENYDYIIPDIYKIDQWLSDRDVSKFNRIKRDMNHNLMYEQFSTMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIV 232
Cdd:pfam00978  87 EKLDKLDPIINTTENVSRWLDKQSGKKAAQLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTITYHDKGV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 233 SMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPlpldSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKF 312
Cdd:pfam00978 167 TAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDA----SEDFLEIDFSKFDKSQGELHLLVQLEILKLLGL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 313 SEEAYVNIET-TEYFCRFKSASGITGELGAQRRTGSPNTWLSNTLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLEN 391
Cdd:pfam00978 243 DPELADLWFKfHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLEKIDCAAFSGDDSLIFSPKPIED 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 392 KTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRFFEKLSVPVRLSDflsETTLRERFTSYKDLMSEYDND 471
Cdd:pfam00978 323 PASRFATLFNMEAKVFDPSVPYFCSKFLLEVDGGAFFVPDPLKLLQKLGKKKIPDD---EQHLDEIFTSLCDLTKSFNDD 399
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2073491183 472 SVCLLVDSLISKRYSLPLMTSYAALCFIHCLCANFSSFRKI 512
Cdd:pfam00978 400 CVVLELLDLAVARYYKYAPEGYAALCALHKALSSFTLFFSL 440
 
Name Accession Description Interval E-value
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
197-464 7.26e-162

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 459.72  E-value: 7.26e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 197 STMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPL 276
Cdd:cd23253     1 TSFKLMVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGMNLEELASLIRSKLGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 277 PLDSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEAYVNIETTEYF-CRFKSASGITGELGAQRRTGSPNTWLSNT 355
Cdd:cd23253    81 PLDEYKTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFsCRATSDSGVSLELGAQRRTGSPNTWLGNT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 356 LVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLENKTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRF 435
Cdd:cd23253   161 LVTLGILSSSYDLDDIDLLLVSGDDSLIFSKKPLPNKANEINLDFGFEAKFIENSVPYFCSKFIIEDRGKIKVVPDPVKL 240
                         250       260
                  ....*....|....*....|....*....
gi 2073491183 436 FEKLSVPVRLSDflsETTLRERFTSYKDL 464
Cdd:cd23253   241 FEKLSVPIRLED---ETLLKERFTSFKDL 266
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
75-512 6.64e-131

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 387.77  E-value: 6.64e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183  75 PVGDLTIDLSKSKPYISGE--FVTSGVMGKGERSRPDTWRQAIASLSHRNFSAPRVNERLDTFKTAELLCESLLKAFDMS 152
Cdd:pfam00978   7 DLDDCRLDPSKSKPKPKDKepYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFKKSFLDK 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 153 RLFENYDYIIPDIYKIDQWLSDRDVSKFNRIKRDMNHNLMYEQFSTMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIV 232
Cdd:pfam00978  87 EKLDKLDPIINTTENVSRWLDKQSGKKAAQLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTITYHDKGV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 233 SMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPlpldSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKF 312
Cdd:pfam00978 167 TAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDA----SEDFLEIDFSKFDKSQGELHLLVQLEILKLLGL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 313 SEEAYVNIET-TEYFCRFKSASGITGELGAQRRTGSPNTWLSNTLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLEN 391
Cdd:pfam00978 243 DPELADLWFKfHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLEKIDCAAFSGDDSLIFSPKPIED 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 392 KTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRFFEKLSVPVRLSDflsETTLRERFTSYKDLMSEYDND 471
Cdd:pfam00978 323 PASRFATLFNMEAKVFDPSVPYFCSKFLLEVDGGAFFVPDPLKLLQKLGKKKIPDD---EQHLDEIFTSLCDLTKSFNDD 399
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2073491183 472 SVCLLVDSLISKRYSLPLMTSYAALCFIHCLCANFSSFRKI 512
Cdd:pfam00978 400 CVVLELLDLAVARYYKYAPEGYAALCALHKALSSFTLFFSL 440
Kitaviridae_RdRp cd23254
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of ...
201-439 7.91e-55

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus leprosis virus C2 (genus Cilevirus); and Hibiscus green spot virus 2 (genus Higrevirus). Although related, there are considerable physical and genetic distinctions between members of the different genera. For example, cile- and higreviruses are associated with a bacilliform virion, whereas a spherical virion has been observed for the lone blunervirus for which microscopy has been reported. Moreover, the replication-associated polyproteins are encoded by a single genomic RNA for cile- and higreviruses, but are split between two genomic RNAs for blunerviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438104  Cd Length: 267  Bit Score: 185.04  E-value: 7.91e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 201 MMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLP--LPL 278
Cdd:cd23254     5 FMIKRNPKPNLTVDAAYKYPALQTIAYHDKDINAIFCPIFRELKKRLLAVLKPNFVIFTDMSPEDFEELLNRRFPpeVLS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 279 DSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEaYVNI-----ETTEYFCRfksASGITGELGAQRRTGSPNTWLS 353
Cdd:cd23254    85 KLLHKLEIDISKYDKSQGELALLFECKLMRRFGVPEE-LVELwfnahVLTTLYDR---TNKLKALVEYQRKSGDASTFFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 354 NTLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQLENK-TNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDP 432
Cdd:cd23254   161 NTLFLMAVLADLFDLSDLELALFSGDDSLLFGRNLLDYDdSQHFALKFNLESKFLNYKYPYFCSKFLLPVGGRWYFVPDP 240

                  ....*..
gi 2073491183 433 VRFFEKL 439
Cdd:cd23254   241 VKLLTKL 247
ps-ssRNAv_Martellivirales_RdRp cd23208
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of ...
200-386 6.37e-48

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Martellivirales, class Alsuviricetes. The order Martellivirales consists of seven families: Bromoviridae, Closteroviridae, Endornaviridae, Kitaviridae, Mayoviridae, Togaviridae, and Virgaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438058 [Multi-domain]  Cd Length: 190  Bit Score: 164.46  E-value: 6.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 200 KMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGM-NLETLSRVVKSKLPLpl 278
Cdd:cd23208     4 EMMIKSDVKPKLDLTAQQEYPKLQTIVYHDKNITAIFCPIFKELFERLLSCLKKKVVIYTGMmTSAELNDFISALHLE-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 279 DSYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEAYVNIETteyFCRFKSASGITGELGA----QRRTGSPNTWLSN 354
Cdd:cd23208    82 SGYYVLEIDFSKFDKSQGALHLLTELLILRRLGVDEPLLVLWEF---AHTQSTTRDINNGISFetayQRKSGDAFTYFGN 158
                         170       180       190
                  ....*....|....*....|....*....|..
gi 2073491183 355 TLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSK 386
Cdd:cd23208   159 TLVTMAALLDVLDLEKIVCIAFGGDDSLIFSK 190
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
202-439 3.50e-47

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 167.02  E-value: 3.50e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 202 MIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGM--NLETL--SRVVKSKlplp 277
Cdd:cd23252    92 MIKSDLKPVEDDSLHVERPVPATITYHKKGIVMQFSPLFLAAFERLLRCLRSKIVIPSGKihQLFMIdpSVLNASK---- 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 278 ldsyYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEeayvniETTEYFCRFKSAS-------GITGELGAQRRTGSPNT 350
Cdd:cd23252   168 ----HFKEIDFSKFDKSQGELHHEIQEHILNALGCPA------PFTKWWFDFHRRSyisdrraGVGFSVDFQRRTGDAFT 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 351 WLSNTLVTMGMLLNVYDLDD--IDLMLVSGDDSLIFSKKQLENKTNELNIN-FGFEAKFIENsVPYFCSKF-IIDDRGSI 426
Cdd:cd23252   238 YLGNTLVTLAELAYVYDLDDpnFDFVVASGDDSLIGSVEPLPRDDEDLFTTlFNFEAKFPHN-QPFICSKFlLSDEFGDE 316
                         250
                  ....*....|....*
gi 2073491183 427 KV--VPDPVRFFEKL 439
Cdd:cd23252   317 NVfsVPDPLKLLQRL 331
Virgaviridae_RdRp cd23251
RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense ...
76-463 1.01e-42

RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Virgaviridae, order Martellivirales. The Virgaviridae is a family of plant viruses with rod-shaped virions, a (+)ssRNA genome with a 3'-terminal tRNA-like structure and a replication protein similar to those of the alpha-like supergroup. Plants serve as natural hosts. The name of the family is derived from the Latin word virga (rod), as all viruses in this family are rod-shaped. There are currently 59 species in this family, divided among seven genera: Goravirus, Furovirus, Hordeivirus, Pecluvirus, Pomovirus, Tobamovirus, and Tobravirus. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438101  Cd Length: 427  Bit Score: 157.40  E-value: 1.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183  76 VGDLTIDLSKS-KPYISGEFVTSGVMGKGERSRPDTWRQAIASLSHRNFSAPRVNERLDTFKTAEllcESLLKAFDMsrl 154
Cdd:cd23251    25 VEDCTLDPSKSvKVWQEKEGLKPVLRTAMPEKRQNGLLESLLALIKRNMAAPKLQGAVNEFETIE---RVIKKAKDV--- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 155 FENYDYIIPDIYKIDQ----WLSDRDVSKFNRIKRDmNHNLMYEQFSTMKMMIKGDMKPKMDLSCYTTYAPPANIIYYKH 230
Cdd:cd23251    99 FFDEDLIDRSPLSTREsflrWWDKQSTTARAQLLAD-DRVLDEIDVCTYNFMIKNDVKPKLDLSPQSEYAALQTVVYPDK 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 231 IVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVkSKLPlPLDSYYTLEIDFSKFDKSQ-----GCVFKLYEGM 305
Cdd:cd23251   178 IVNALFGPIFKEINERILSALDPHVVFNTRMTAEELNETV-EFLD-PDEEYDALEIDFSKFDKSKtslhiRAVIELYKLF 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 306 -IYRFLKFSEEA---------YVNietteyfcrfksasGITGELGAQRRTGSPNTWLSNTLVTMGMLLNVYDLDDIDLML 375
Cdd:cd23251   256 gLDGMLAFLWEKsqcqttvkdRQN--------------GIKAYLLYQQKSGNCDTYGSNTWSAALALLSMLPLEKAIFMI 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 376 VSGDDSLIFSKKQL--ENKTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPVRFFEKLSVP-VRLSDFLSE- 451
Cdd:cd23251   322 FGGDDSLILFPKGLviPDPCRRLASLWNFECKLFKFKYGYFCGKFLLKHGDGYIFYPDPLKLITKLGRKdIKDGEHLSEi 401
                         410
                  ....*....|...
gi 2073491183 452 -TTLRERFTSYKD 463
Cdd:cd23251   402 fVSICDNYKSYRD 414
Mayoviridae_RdRp cd23256
RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense ...
200-485 9.23e-39

RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Mayoviridae, order Martellivirales. The Mayoviridae family consists of two genera, Idaeovirus and Pteridovirus. The genus Idaeovirus contains Raspberry bushy dwarf virus (RBDV), named after the host with which it was first associated (red raspberry, Rubus idaeu) and the disease which is characterized by bushiness (stunting and proliferation of canes); RBDV has recently been found causing an infection in grapevines. RBDV occurs in all tissues of the plant, including seed and pollen, and is transmitted in association with pollen, both vertically to the seed and horizontally to the pollinated plant; this is the only known method of natural spread of RBDV. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438106  Cd Length: 329  Bit Score: 144.12  E-value: 9.23e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 200 KMMIKGDMKPKMDLSCYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLEtLSRVVKSKLpLPLD 279
Cdd:cd23256    36 SHMIKRDRKPVLTTAVQSEYTKAATITYHDKDITQVATPIFRQFKTRLLACKKSNLCIPLDHDHD-ISGWLTNRH-LGSE 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 280 SYYTLEIDFSKFDKSQGCVFKLYEGMIyrFLKFS-EEAYVNIETTEY-FCRFKSAS-GITGELGAQRRTGSPNTWLSNTL 356
Cdd:cd23256   114 NGTFTEIDFSKFDKSQGELHQLIQDLI--LLRFGcDPEFVSLWSTAHrSSSIKDQNvGISFKTDFQRRTGDAFTFLGNSL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 357 VTMGMLLNVYDLDD---IDLMLVSGDDSLIFSKKQLENKTNELNINFGFEAKFIENSVPYFCSKFIIDDRGSIKVVPDPV 433
Cdd:cd23256   192 VTAVMLAYVLSFEDekkIRYMLVGGDDSLICSYGPISVPLEPLSTIFNMSCKLIQPSCPYFASRYIIRVGDEILCVPDPY 271
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2073491183 434 RFFEKLSvpvRLSDFLSETTLRERFTSYKDLMSEYDNDSVCLLVDSLISKRY 485
Cdd:cd23256   272 KLLVKMG---RKDIPDNEASLEEVRTGLADSAKPLFDDEVKQKLSILVQIRY 320
Endornaviridae_RdRp cd23255
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of ...
232-392 5.33e-16

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Endornaviridae, order Martellivirales. The family Endornaviridae includes viruses with linear (+)ssRNA genomes that range from 9.7 to 17.6 kb. The family consists of two genera, Alphaendornavirus and Betaendornavirus. Alphaendornavirus includes species whose members infect plants, fungi and oomycetes, while the genus Betaendornavirus includes species whose members infect ascomycete fungi. Plant endornaviruses are transmitted only through the gametes. A conserved RNA-dependent RNA polymerase domain located in the C-terminal region of the polyprotein is a feature common to all endornaviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438105  Cd Length: 237  Bit Score: 77.58  E-value: 5.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 232 VSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSklpLPLDSYYtLEIDFSKFDK--SQGCVfkLYEGMIYRF 309
Cdd:cd23255    68 ICAIFSPIFNEAKKRLKSLLKPKVVYADGLTPDELSARLRL---VKNVKYF-FEDDLSKQDRqtDKPII--DVEMELYKL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 310 LKFSEEAyVNI--ETTEYFcRFKSaSGITGELGAQRRTGSPNTWLSNTLVTMG--MLLNVYDLDDIDLMLVSGDDSLIFS 385
Cdd:cd23255   142 LGVDPNV-IELwrEVHENW-RFKG-KGVRGVGDAMRLTGQATTALGNVITNLLvhSRLVKRNGSNLKLMLVLGDDNLILT 218

                  ....*..
gi 2073491183 386 KKQLENK 392
Cdd:cd23255   219 DTKIDLE 225
ps-ssRNAv_Alsuviricetes_RdRp cd23182
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of ...
202-383 1.53e-12

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the class Alsuviricetes, phylum: Kitrinoviricota. Alsuviricetes is a class of [(+)ssRNA] viruses which infect eukaryotes. The name of the group is a syllabic abbreviation of "alpha supergroup" with the suffix -viricetes indicating a virus class. The class Alsuviricetes includes three orders: Hepelivirales, Martellivirales, and Tymovirales. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438032 [Multi-domain]  Cd Length: 187  Bit Score: 66.08  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 202 MIKGDMKPKMDLScYTTYAPPANIIYYKHIVSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLET--LSRVVKSKLPlpld 279
Cdd:cd23182     6 LIKTQQKVSPKTP-FNTGKAGQTIAAHSKSINFVLGPWIRYLEERLRDGSRTHRYSNGLMDEEEamLSQWKINHVP---- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 280 SYYTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSEEAYVNIETTEYFCRFK-SASGITGELGAQRRTGSPNTWLSNTLVT 358
Cdd:cd23182    81 HATFVSNDYTAFDKSHNGESLLLEAAIMRRIGTPAAAPNLFIELHGKRTLRaKVLGGSGELDGMRDSGAAWTYCRNTDYN 160
                         170       180
                  ....*....|....*....|....*
gi 2073491183 359 MGMLLNVYDLDDIdLMLVSGDDSLI 383
Cdd:cd23182   161 LAVMLSLYRLKVK-PAAFSGDDSLL 184
Gammaflexiviridae_RdRp cd23249
RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense ...
232-415 4.58e-09

RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the RdRp of RNA viruses belonging to the family Gammaflexiviridae, order Tymovirales. Virions within the Gammaflexiviridae family are flexuous filaments of 720 nm modal length and about 13 nm in diameter. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438099  Cd Length: 354  Bit Score: 57.99  E-value: 4.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 232 VSMFFSPLFLEVFDRITYCLSNKVVMYSGMNLETLSRVVKSKLPLPLDSYytlEIDFSKFDKSQGCVFKLYEGMIYRFLK 311
Cdd:cd23249   105 VLLAWGPLARYLDRRIRALLPPHIYIHSGRTNEDFERFVAAHWDFTREST---EGDYTAFDASQDADFLNFETLLMRALG 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 312 FSE---EAYVNIETteyfcrfkSASGITGELGAQRRTGSPNTWLSNTLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQ 388
Cdd:cd23249   182 VPLdliEAYLEMKA--------SITSHLGPLAIMRFSGEVWTYLFNTLGNMAYTAAKYEVPPPVPRVYGGDDKSINSRIT 253
                         170       180
                  ....*....|....*....|....*..
gi 2073491183 389 LENKTNELNINFGFEAKFIENSVPYFC 415
Cdd:cd23249   254 VRPGWSQLVGQFNLVEKPVVTYEPTFC 280
ps-ssRNA_RdRp_Tymovirales cd23207
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of ...
196-383 1.04e-07

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Tymovirales. The Tymovirales order contains viruses that mostly infect plants, have a single molecule of (+)ssRNA, and which are united by the similarities in their replication-associated polyproteins. Tymovirales contains five families (Alpha-, Beta-, Delta- and Gammaflexiviridae and Tymoviridae) and groups mostly plant-infecting agents, although a few Tymovirales members have either fungal or insect hosts. Botrytis virus F (BVF), isolated from the fungus Botrytis cinerea, is a flexuous mycovirus that is typical of members of the genus Mycoflexivirus (family Gammaflexiviridae). The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438057 [Multi-domain]  Cd Length: 188  Bit Score: 52.02  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 196 FSTMKMMIKGDMKPKMDlSCYTTYAPPANIIYYKHIVSMFFSPL--FLEVFDRI-----TYClsnkvvmYSGMNLETLSR 268
Cdd:cd23207     8 FNVVKIFIKGQHKKKDE-KIFSDAKAGQTLALFHDQIILRFGPYarYMRRFINAdlppnIYI-------HCGKTPEDLSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 269 VVKSKL-PLPldsyyTLEIDFSKFDKSQGCVFKLYEGMIYRFLKFSE---EAYVNIETteyfcrfkSASGITGELGAQRR 344
Cdd:cd23207    80 WCKEHWqHGP-----STANDYTAFDQSQDGEFVVFEVLLMRHLHIPDdliELYVDIKT--------NAYSHLGPLSIMRL 146
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2073491183 345 TGSPNTWLSNTLVTMGMLLNVYDLDDIDLMLVSGDDSLI 383
Cdd:cd23207   147 TGEPGTFDFNTDYNLALTYAKYDLPPGTPICFSGDDSVA 185
ps-ssRNAv_Hepelivirales_RdRp cd23209
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of ...
285-384 1.67e-07

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Hepelivirales, class Alsuviricetes. This Hepelivirales order consists of four families: Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438059 [Multi-domain]  Cd Length: 183  Bit Score: 51.34  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 285 EIDFSKFDKSQGCVFKLYEGMIYRFL---KFSEEAYVNIETtEYFCRFKSASGitgELGAQRRTGSPNTWLSNTLVTMGM 361
Cdd:cd23209    83 ENDFTEFDSTQNLFSLLVELEILEACgmpPALAELYRALRA-KWTLQAREGSL---EGTCKKTSGEPGTLLHNTIWNMAV 158
                          90       100
                  ....*....|....*....|...
gi 2073491183 362 LLNVYDLDDIDLMLVSGDDSLIF 384
Cdd:cd23209   159 MMHMVRGGVRKAAAFKGDDSVVC 181
Matonaviridae_RdRp cd23260
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Matonaviridae of ...
280-415 1.38e-04

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Matonaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Matonaviridae, order Hepelivirales. Members of the family Matonaviridae have a (+)ssRNA genome enclosed by an icosahedral capsid. Matonaviridae has a single genus, Rubivirus, which contains three species: Rubivirus rubella (commonly called rubella virus), Rubivirus ruteetense (commonly called ruhugu virus), and Rubivirus strelense (commonly called rustrela virus). Rubella virus (RuV) is the etiologic agent of the disease rubella (also called German measles). RuV is transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome (severe congenital birth defects, miscarriage, and stillbirth) when infection occurs during the first trimester of pregnancy. In vitro studies with cell lines showed that RuV has an apoptotic effect on certain cell types; there is evidence for a p53-dependent mechanism. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438110  Cd Length: 257  Bit Score: 43.81  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 280 SYYT---LEIDFSKFDKSQGCVFKLYEGMIYRFLKF--SEEAYVNIETTEYfCRFKSASgiTGELGAQRRTGSPNTWLSN 354
Cdd:cd23260    74 AHYSpnaVEVDFTEFDMNQTLATRDVELEISASLLGlpSAEDYRALRAGSY-CLLRDLA--STETGCERTSGEPATLLHN 150
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073491183 355 TLVTMGMLLNVYDLDDIDLMLVSGDDSLIFSKKQ-----LENKTNELNInFGFE--AKFIENSVPYFC 415
Cdd:cd23260   151 TLVAMCMAMRMVPKGVRWAGIFQGDDMVIFLPEGarraaLRWTPAELGL-FGFHipVKHVATATPSFC 217
Tymoviridae_RdRp cd23247
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of ...
287-451 2.50e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Tymoviridae, order Tymovirales. Virions of the family Tymoviridae are isometric, non-enveloped, about 30 nm in diameter, and contain a single molecule of (+)ssRNA constituting 25#35% of the particle weight. There are 42 species in this family, assigned to three genera (Maculavirus, Marafivirus, and Tymovirus), with two species unassigned to a genus. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438097  Cd Length: 373  Bit Score: 40.25  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 287 DFSKFDKSQG---CVFKLY--------EGMI--YRFLKfseeayVNIETteyfcRFksasgitGELGAQRRTGSPNTWLS 353
Cdd:cd23247   173 DYTAFDQSQHgeaVVFERLkmerlsipQHLIdlHVHLK------TNVST-----QF-------GPLTCMRLTGEPGTYDD 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073491183 354 NTLVTMGMLLNVYDLDDIDLMlVSGDDSLIFSKKQLENKTNELNINFGFEAKFIENSVPYFCSKFIiddrGSIKVVPDPV 433
Cdd:cd23247   235 NTDYNLAVIYSQYDISSTPIM-VSGDDSVIDGVPPERPSWPAIKPLLHLRFKTETTRYPLFCGYYV----GPAGAIRNPL 309
                         170       180
                  ....*....|....*....|....*
gi 2073491183 434 RFFEKL-------SVPVRLSDFLSE 451
Cdd:cd23247   310 ALFAKLmiavddgSLPDKLLSYLTE 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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