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Conserved domains on  [gi|2079607669|gb|QYU72482|]
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vacuolar H+-ATPase SFD subunit, partial [Drosophila qiongzhouensis]

Protein Classification

V-type proton ATPase subunit H( domain architecture ID 230109)

V-type proton ATPase subunit H is subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase); it activates the ATPase activity of V-ATPase and couples ATPase activity to proton flow

Gene Ontology:  GO:0046961|GO:1902600|GO:0000221
PubMed:  15473999|16449553

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VATPase_H super family cl21727
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the ...
 1-114 1.40e-40

VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.


The actual alignment was detected with superfamily member cd00256:

Pssm-ID: 473943 [Multi-domain]  Cd Length: 429  Bit Score: 138.69  E-value: 1.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079607669   1 SQEDFQAISTLDKSRAAYLAQNST--QVVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHETSGkIKQCVWGP 78
Cdd:cd00256    27 SEEDYQFIKALEKKRVKEEILDVLsgQYVKTFVNLLSQIDKDDTVRYVLTLIDDMLQEDDTRVKLFHDDAL-LKKKTWEP 105

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2079607669  79 FLNLLNRQDGFIVNMSSRILAKFACWGHETMPKSDL 114
Cdd:cd00256   106 FFNLLNRQDQFIVHMSFSILAKLACFGLAKMEGSDL 141
 
Name Accession Description Interval E-value
VATPase_H cd00256
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the ...
 1-114 1.40e-40

VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.


Pssm-ID: 238159 [Multi-domain]  Cd Length: 429  Bit Score: 138.69  E-value: 1.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079607669   1 SQEDFQAISTLDKSRAAYLAQNST--QVVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHETSGkIKQCVWGP 78
Cdd:cd00256    27 SEEDYQFIKALEKKRVKEEILDVLsgQYVKTFVNLLSQIDKDDTVRYVLTLIDDMLQEDDTRVKLFHDDAL-LKKKTWEP 105

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2079607669  79 FLNLLNRQDGFIVNMSSRILAKFACWGHETMPKSDL 114
Cdd:cd00256   106 FFNLLNRQDQFIVHMSFSILAKLACFGLAKMEGSDL 141
V-ATPase_H_N pfam03224
V-ATPase subunit H; The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a ...
 1-112 1.04e-29

V-ATPase subunit H; The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.


Pssm-ID: 460852  Cd Length: 314  Bit Score: 108.14  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079607669   1 SQEDFQAISTLDK----SRAAYLAQNSTQVVKTLLNLVSHL-SKDSTIQYILVLLDDLLQEDRSRVDLFHETSGKIKQCV 75
Cdd:pfam03224  27 SEEDLELIKKLDKvpleQRRQLLDSDGDQYVTLFVSLLNKLaSRDDTVQYVLVLIADLLSEDPSRVQLFLSLSKLDDYDP 106

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2079607669  76 WGPFLNLLNRQDGFIVNMSSRILAKFACWGHETMPKS 112
Cdd:pfam03224 107 YSPFLKLLNRQDDFIVLLALYLLAKLLAYGPKKSNEN 143
 
Name Accession Description Interval E-value
VATPase_H cd00256
VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the ...
 1-114 1.40e-40

VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is that of a superhelical spiral, in part the geometry is similar to superhelices composed of armadillo repeat motifs, as found in importins for example.


Pssm-ID: 238159 [Multi-domain]  Cd Length: 429  Bit Score: 138.69  E-value: 1.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079607669   1 SQEDFQAISTLDKSRAAYLAQNST--QVVKTLLNLVSHLSKDSTIQYILVLLDDLLQEDRSRVDLFHETSGkIKQCVWGP 78
Cdd:cd00256    27 SEEDYQFIKALEKKRVKEEILDVLsgQYVKTFVNLLSQIDKDDTVRYVLTLIDDMLQEDDTRVKLFHDDAL-LKKKTWEP 105

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2079607669  79 FLNLLNRQDGFIVNMSSRILAKFACWGHETMPKSDL 114
Cdd:cd00256   106 FFNLLNRQDQFIVHMSFSILAKLACFGLAKMEGSDL 141
V-ATPase_H_N pfam03224
V-ATPase subunit H; The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a ...
 1-112 1.04e-29

V-ATPase subunit H; The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.


Pssm-ID: 460852  Cd Length: 314  Bit Score: 108.14  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079607669   1 SQEDFQAISTLDK----SRAAYLAQNSTQVVKTLLNLVSHL-SKDSTIQYILVLLDDLLQEDRSRVDLFHETSGKIKQCV 75
Cdd:pfam03224  27 SEEDLELIKKLDKvpleQRRQLLDSDGDQYVTLFVSLLNKLaSRDDTVQYVLVLIADLLSEDPSRVQLFLSLSKLDDYDP 106

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2079607669  76 WGPFLNLLNRQDGFIVNMSSRILAKFACWGHETMPKS 112
Cdd:pfam03224 107 YSPFLKLLNRQDDFIVLLALYLLAKLLAYGPKKSNEN 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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