Exportin-2 [Acipenser ruthenus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||||||||||
| PLN03076 super family | cl33628 | ARF guanine nucleotide exchange factor (ARF-GEF); Provisional |
66-1343 | 0e+00 | |||||||||||||||||||
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional The actual alignment was detected with superfamily member PLN03076: Pssm-ID: 215560 [Multi-domain] Cd Length: 1780 Bit Score: 736.25 E-value: 0e+00
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| CAS_CSE1 | pfam03378 | CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ... |
1921-2337 | 0e+00 | |||||||||||||||||||
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins. : Pssm-ID: 367469 Cd Length: 435 Bit Score: 640.89 E-value: 0e+00
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| Cse1 super family | cl38282 | Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ... |
1617-1920 | 1.14e-127 | |||||||||||||||||||
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats. The actual alignment was detected with superfamily member pfam08506: Pssm-ID: 430038 [Multi-domain] Cd Length: 370 Bit Score: 407.07 E-value: 1.14e-127
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| DSRM_STAU1_rpt4 | cd19885 | fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2762-2847 | 1.45e-56 | |||||||||||||||||||
fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. : Pssm-ID: 380714 Cd Length: 86 Bit Score: 191.07 E-value: 1.45e-56
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| Staufen_C | pfam16482 | Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of ... |
2934-3037 | 2.19e-47 | |||||||||||||||||||
Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of an N-terminal Staufen-swapping motif (SSM) comprising two alpha helices, connected by a linker region to a dsRNA-binding-like domain ('RBD'). The 'RBD' has the fold of a functional dsRNA-binding domain, but lacks the residues required to bind RNA. This domain is responsible for dimerization, the SSM from one molecule interacts with the 'RBD' of another. : Pssm-ID: 465131 Cd Length: 110 Bit Score: 165.85 E-value: 2.19e-47
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| DSRM_STAU1_rpt1 | cd19879 | first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2467-2525 | 3.93e-36 | |||||||||||||||||||
first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. : Pssm-ID: 380708 Cd Length: 66 Bit Score: 132.12 E-value: 3.93e-36
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| BIG2_C | pfam20252 | BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ... |
1370-1481 | 3.24e-33 | |||||||||||||||||||
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown. : Pssm-ID: 466403 Cd Length: 178 Bit Score: 127.74 E-value: 3.24e-33
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| DSRM_SF super family | cl00054 | double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 ... |
2669-2735 | 2.62e-28 | |||||||||||||||||||
double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fold. It is not sequence specific, but highly specific for double-stranded RNAs (dsRNAs) of various origin and structure. The DSRM domains are found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila Staufen protein, E. coli RNase III, RNase H1, and dsRNA dependent adenosine deaminases. They are involved in numerous cellular mechanisms ranging from localization and transport of messenger RNAs, through maturation and degradation of RNAs, to viral response and signal transduction. Some members harbor tandem DSRMs that act in small RNA biogenesis. The actual alignment was detected with superfamily member cd19883: Pssm-ID: 444671 Cd Length: 67 Bit Score: 109.72 E-value: 2.62e-28
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| DSRM_SF super family | cl00054 | double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 ... |
2566-2631 | 5.00e-27 | |||||||||||||||||||
double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fold. It is not sequence specific, but highly specific for double-stranded RNAs (dsRNAs) of various origin and structure. The DSRM domains are found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila Staufen protein, E. coli RNase III, RNase H1, and dsRNA dependent adenosine deaminases. They are involved in numerous cellular mechanisms ranging from localization and transport of messenger RNAs, through maturation and degradation of RNAs, to viral response and signal transduction. Some members harbor tandem DSRMs that act in small RNA biogenesis. The actual alignment was detected with superfamily member cd19881: Pssm-ID: 444671 Cd Length: 79 Bit Score: 106.50 E-value: 5.00e-27
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| IBN_N | smart00913 | Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ... |
1490-1563 | 8.47e-15 | |||||||||||||||||||
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport. : Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 71.12 E-value: 8.47e-15
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| Name | Accession | Description | Interval | E-value | |||||||||||||||||||
| PLN03076 | PLN03076 | ARF guanine nucleotide exchange factor (ARF-GEF); Provisional |
66-1343 | 0e+00 | |||||||||||||||||||
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional Pssm-ID: 215560 [Multi-domain] Cd Length: 1780 Bit Score: 736.25 E-value: 0e+00
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| CAS_CSE1 | pfam03378 | CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ... |
1921-2337 | 0e+00 | |||||||||||||||||||
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins. Pssm-ID: 367469 Cd Length: 435 Bit Score: 640.89 E-value: 0e+00
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| Cse1 | pfam08506 | Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ... |
1617-1920 | 1.14e-127 | |||||||||||||||||||
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats. Pssm-ID: 430038 [Multi-domain] Cd Length: 370 Bit Score: 407.07 E-value: 1.14e-127
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| CSE1 | COG5657 | CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ... |
1482-2329 | 7.08e-106 | |||||||||||||||||||
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; Pssm-ID: 227944 [Multi-domain] Cd Length: 947 Bit Score: 364.52 E-value: 7.08e-106
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| DSRM_STAU1_rpt4 | cd19885 | fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2762-2847 | 1.45e-56 | |||||||||||||||||||
fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380714 Cd Length: 86 Bit Score: 191.07 E-value: 1.45e-56
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| Sec7_N | pfam12783 | Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ... |
454-609 | 3.90e-50 | |||||||||||||||||||
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF. Pssm-ID: 463703 Cd Length: 154 Bit Score: 175.38 E-value: 3.90e-50
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| Staufen_C | pfam16482 | Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of ... |
2934-3037 | 2.19e-47 | |||||||||||||||||||
Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of an N-terminal Staufen-swapping motif (SSM) comprising two alpha helices, connected by a linker region to a dsRNA-binding-like domain ('RBD'). The 'RBD' has the fold of a functional dsRNA-binding domain, but lacks the residues required to bind RNA. This domain is responsible for dimerization, the SSM from one molecule interacts with the 'RBD' of another. Pssm-ID: 465131 Cd Length: 110 Bit Score: 165.85 E-value: 2.19e-47
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| DSRM_STAU1_rpt1 | cd19879 | first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2467-2525 | 3.93e-36 | |||||||||||||||||||
first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380708 Cd Length: 66 Bit Score: 132.12 E-value: 3.93e-36
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| BIG2_C | pfam20252 | BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ... |
1370-1481 | 3.24e-33 | |||||||||||||||||||
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown. Pssm-ID: 466403 Cd Length: 178 Bit Score: 127.74 E-value: 3.24e-33
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| DSRM_STAU1_rpt5 | cd19887 | fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2974-3037 | 3.48e-31 | |||||||||||||||||||
fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fifth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380716 Cd Length: 70 Bit Score: 118.23 E-value: 3.48e-31
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| DSRM_STAU1_rpt3 | cd19883 | third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2669-2735 | 2.62e-28 | |||||||||||||||||||
third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380712 Cd Length: 67 Bit Score: 109.72 E-value: 2.62e-28
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| DSRM_STAU1_rpt2 | cd19881 | second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2566-2631 | 5.00e-27 | |||||||||||||||||||
second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380710 Cd Length: 79 Bit Score: 106.50 E-value: 5.00e-27
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2773-2839 | 9.68e-16 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 73.84 E-value: 9.68e-16
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| Sec7 | cd00171 | Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ... |
733-820 | 1.13e-15 | |||||||||||||||||||
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity. Pssm-ID: 238100 Cd Length: 185 Bit Score: 77.65 E-value: 1.13e-15
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| IBN_N | smart00913 | Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ... |
1490-1563 | 8.47e-15 | |||||||||||||||||||
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport. Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 71.12 E-value: 8.47e-15
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| Sec7 | smart00222 | Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ... |
731-820 | 2.72e-12 | |||||||||||||||||||
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors). Pssm-ID: 214569 [Multi-domain] Cd Length: 189 Bit Score: 68.09 E-value: 2.72e-12
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2471-2525 | 4.85e-12 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 63.44 E-value: 4.85e-12
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| Rnc | COG0571 | dsRNA-specific ribonuclease [Transcription]; |
2760-2839 | 1.48e-11 | |||||||||||||||||||
dsRNA-specific ribonuclease [Transcription]; Pssm-ID: 440336 [Multi-domain] Cd Length: 229 Bit Score: 66.66 E-value: 1.48e-11
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2773-2838 | 2.43e-10 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 58.40 E-value: 2.43e-10
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2471-2525 | 2.85e-08 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 52.62 E-value: 2.85e-08
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2672-2715 | 5.51e-08 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 51.88 E-value: 5.51e-08
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| IBN_N | pfam03810 | Importin-beta N-terminal domain; |
1490-1563 | 7.19e-07 | |||||||||||||||||||
Importin-beta N-terminal domain; Pssm-ID: 397745 [Multi-domain] Cd Length: 72 Bit Score: 48.77 E-value: 7.19e-07
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| Rnc | COG0571 | dsRNA-specific ribonuclease [Transcription]; |
2478-2524 | 4.23e-06 | |||||||||||||||||||
dsRNA-specific ribonuclease [Transcription]; Pssm-ID: 440336 [Multi-domain] Cd Length: 229 Bit Score: 50.48 E-value: 4.23e-06
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| RNaseIII | TIGR02191 | ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. ... |
2478-2524 | 8.52e-05 | |||||||||||||||||||
ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing] Pssm-ID: 274024 [Multi-domain] Cd Length: 220 Bit Score: 46.43 E-value: 8.52e-05
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2672-2715 | 1.36e-04 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 42.22 E-value: 1.36e-04
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| Name | Accession | Description | Interval | E-value | |||||||||||||||||||
| PLN03076 | PLN03076 | ARF guanine nucleotide exchange factor (ARF-GEF); Provisional |
66-1343 | 0e+00 | |||||||||||||||||||
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional Pssm-ID: 215560 [Multi-domain] Cd Length: 1780 Bit Score: 736.25 E-value: 0e+00
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| CAS_CSE1 | pfam03378 | CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are ... |
1921-2337 | 0e+00 | |||||||||||||||||||
CAS/CSE protein, C-terminus; Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins. Pssm-ID: 367469 Cd Length: 435 Bit Score: 640.89 E-value: 0e+00
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| Cse1 | pfam08506 | Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the ... |
1617-1920 | 1.14e-127 | |||||||||||||||||||
Cse1; This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats. Pssm-ID: 430038 [Multi-domain] Cd Length: 370 Bit Score: 407.07 E-value: 1.14e-127
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| CSE1 | COG5657 | CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ... |
1482-2329 | 7.08e-106 | |||||||||||||||||||
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; Pssm-ID: 227944 [Multi-domain] Cd Length: 947 Bit Score: 364.52 E-value: 7.08e-106
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| DSRM_STAU1_rpt4 | cd19885 | fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2762-2847 | 1.45e-56 | |||||||||||||||||||
fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380714 Cd Length: 86 Bit Score: 191.07 E-value: 1.45e-56
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| Sec7_N | pfam12783 | Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ... |
454-609 | 3.90e-50 | |||||||||||||||||||
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF. Pssm-ID: 463703 Cd Length: 154 Bit Score: 175.38 E-value: 3.90e-50
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| Staufen_C | pfam16482 | Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of ... |
2934-3037 | 2.19e-47 | |||||||||||||||||||
Staufen C-terminal domain; This is the C-terminal domain of Staufen proteins. It consists of an N-terminal Staufen-swapping motif (SSM) comprising two alpha helices, connected by a linker region to a dsRNA-binding-like domain ('RBD'). The 'RBD' has the fold of a functional dsRNA-binding domain, but lacks the residues required to bind RNA. This domain is responsible for dimerization, the SSM from one molecule interacts with the 'RBD' of another. Pssm-ID: 465131 Cd Length: 110 Bit Score: 165.85 E-value: 2.19e-47
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| DSRM_STAU2_rpt4 | cd19886 | fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2769-2850 | 4.39e-39 | |||||||||||||||||||
fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380715 Cd Length: 86 Bit Score: 141.25 E-value: 4.39e-39
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| DUF1981 | pfam09324 | Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ... |
1160-1241 | 1.33e-38 | |||||||||||||||||||
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins. Pssm-ID: 462756 Cd Length: 84 Bit Score: 139.55 E-value: 1.33e-38
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| DSRM_STAU_rpt4 | cd19860 | fourth double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2772-2839 | 7.41e-38 | |||||||||||||||||||
fourth double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380689 Cd Length: 68 Bit Score: 137.08 E-value: 7.41e-38
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| DCB | pfam16213 | dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ... |
15-202 | 2.21e-36 | |||||||||||||||||||
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis. Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 136.62 E-value: 2.21e-36
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| DSRM_STAU1_rpt1 | cd19879 | first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2467-2525 | 3.93e-36 | |||||||||||||||||||
first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380708 Cd Length: 66 Bit Score: 132.12 E-value: 3.93e-36
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| DSRM_STAU2_rpt1 | cd19880 | first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2465-2525 | 2.20e-33 | |||||||||||||||||||
first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380709 Cd Length: 68 Bit Score: 124.44 E-value: 2.20e-33
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| BIG2_C | pfam20252 | BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ... |
1370-1481 | 3.24e-33 | |||||||||||||||||||
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown. Pssm-ID: 466403 Cd Length: 178 Bit Score: 127.74 E-value: 3.24e-33
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| DSRM_STAU1_rpt5 | cd19887 | fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2974-3037 | 3.48e-31 | |||||||||||||||||||
fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fifth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380716 Cd Length: 70 Bit Score: 118.23 E-value: 3.48e-31
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| DSRM_STAU1_rpt3 | cd19883 | third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2669-2735 | 2.62e-28 | |||||||||||||||||||
third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380712 Cd Length: 67 Bit Score: 109.72 E-value: 2.62e-28
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| DSRM_STAU1_rpt2 | cd19881 | second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2566-2631 | 5.00e-27 | |||||||||||||||||||
second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins; Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 1 contains five double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380710 Cd Length: 79 Bit Score: 106.50 E-value: 5.00e-27
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| DSRM_STAU_rpt1 | cd19857 | first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2470-2525 | 1.19e-26 | |||||||||||||||||||
first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380686 Cd Length: 64 Bit Score: 105.04 E-value: 1.19e-26
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| DSRM_STAU2_rpt3 | cd19884 | third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2669-2735 | 6.57e-24 | |||||||||||||||||||
third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380713 Cd Length: 67 Bit Score: 97.38 E-value: 6.57e-24
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| DSRM_STAU_rpt3 | cd19859 | third double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2671-2735 | 6.96e-23 | |||||||||||||||||||
third double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380688 Cd Length: 65 Bit Score: 94.00 E-value: 6.96e-23
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| Sec7 | pfam01369 | Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ... |
733-820 | 8.21e-23 | |||||||||||||||||||
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family. Pssm-ID: 460178 Cd Length: 183 Bit Score: 98.30 E-value: 8.21e-23
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| SXM1 | COG5656 | Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ... |
1470-2118 | 8.47e-20 | |||||||||||||||||||
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227943 [Multi-domain] Cd Length: 970 Bit Score: 97.62 E-value: 8.47e-20
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| DSRM_STAU_rpt5 | cd19861 | fifth double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2975-3035 | 5.32e-19 | |||||||||||||||||||
fifth double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the fifth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380690 Cd Length: 68 Bit Score: 83.04 E-value: 5.32e-19
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2773-2839 | 9.68e-16 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 73.84 E-value: 9.68e-16
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| Sec7 | cd00171 | Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ... |
733-820 | 1.13e-15 | |||||||||||||||||||
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity. Pssm-ID: 238100 Cd Length: 185 Bit Score: 77.65 E-value: 1.13e-15
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| IBN_N | smart00913 | Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ... |
1490-1563 | 8.47e-15 | |||||||||||||||||||
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport. Pssm-ID: 197981 [Multi-domain] Cd Length: 67 Bit Score: 71.12 E-value: 8.47e-15
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| DSRM_RNAse_III_family | cd10845 | double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ... |
2771-2838 | 2.59e-12 | |||||||||||||||||||
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380682 [Multi-domain] Cd Length: 69 Bit Score: 64.05 E-value: 2.59e-12
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| Sec7 | smart00222 | Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ... |
731-820 | 2.72e-12 | |||||||||||||||||||
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors). Pssm-ID: 214569 [Multi-domain] Cd Length: 189 Bit Score: 68.09 E-value: 2.72e-12
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2471-2525 | 4.85e-12 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 63.44 E-value: 4.85e-12
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| Rnc | COG0571 | dsRNA-specific ribonuclease [Transcription]; |
2760-2839 | 1.48e-11 | |||||||||||||||||||
dsRNA-specific ribonuclease [Transcription]; Pssm-ID: 440336 [Multi-domain] Cd Length: 229 Bit Score: 66.66 E-value: 1.48e-11
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| DSRM_SF | cd00048 | double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 ... |
2779-2835 | 1.72e-11 | |||||||||||||||||||
double-stranded RNA binding motif (DSRM) superfamily; DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fold. It is not sequence specific, but highly specific for double-stranded RNAs (dsRNAs) of various origin and structure. The DSRM domains are found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila Staufen protein, E. coli RNase III, RNase H1, and dsRNA dependent adenosine deaminases. They are involved in numerous cellular mechanisms ranging from localization and transport of messenger RNAs, through maturation and degradation of RNAs, to viral response and signal transduction. Some members harbor tandem DSRMs that act in small RNA biogenesis. Pssm-ID: 380679 [Multi-domain] Cd Length: 57 Bit Score: 61.53 E-value: 1.72e-11
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| DSRM_PRKRA_rpt2 | cd19891 | second double-stranded RNA binding motif of protein activator of the interferon-induced ... |
2772-2835 | 6.08e-11 | |||||||||||||||||||
second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins; PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. PRKRA contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380720 Cd Length: 67 Bit Score: 60.34 E-value: 6.08e-11
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| DSRM_PRKRA-like_rpt2 | cd19863 | second double-stranded RNA binding motif of PRKRA, TARBP2 and similar proteins; The family ... |
2772-2838 | 9.08e-11 | |||||||||||||||||||
second double-stranded RNA binding motif of PRKRA, TARBP2 and similar proteins; The family includes protein activator of the interferon-induced protein kinase (PRKRA) and the RISC-loading complex subunit TARBP2. PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. TARBP2 (also called TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)) participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. The family also includes Drosophila melanogaster Loquacious and similar proteins. Loquacious (Loqs) is a double-stranded RNA-binding domain (dsRBD) protein, a homolog of human TAR RNA binding protein (TRBP) that is a protein first identified as binding the HIV trans-activator RNA (TAR). Loqs interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. PRKRA family proteins contain three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380692 Cd Length: 67 Bit Score: 59.70 E-value: 9.08e-11
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2773-2838 | 2.43e-10 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 58.40 E-value: 2.43e-10
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2471-2525 | 2.85e-08 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 52.62 E-value: 2.85e-08
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| DSRM_RNAse_III_family | cd10845 | double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ... |
2465-2524 | 3.82e-08 | |||||||||||||||||||
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380682 [Multi-domain] Cd Length: 69 Bit Score: 52.49 E-value: 3.82e-08
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| DSRM | smart00358 | Double-stranded RNA binding motif; |
2672-2715 | 5.51e-08 | |||||||||||||||||||
Double-stranded RNA binding motif; Pssm-ID: 214634 [Multi-domain] Cd Length: 67 Bit Score: 51.88 E-value: 5.51e-08
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| DSRM_TARBP2_rpt2 | cd10844 | second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and ... |
2772-2835 | 1.04e-07 | |||||||||||||||||||
second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins; TARBP2 (also known as TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)) participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. TARBP2 contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380681 Cd Length: 67 Bit Score: 51.26 E-value: 1.04e-07
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| DSRM_STAU2_rpt5 | cd19888 | fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2974-3037 | 1.15e-07 | |||||||||||||||||||
fifth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fifth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380717 Cd Length: 68 Bit Score: 51.11 E-value: 1.15e-07
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| DSRM_SON-like | cd19870 | double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known ... |
2770-2840 | 2.02e-07 | |||||||||||||||||||
double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known as Bax antagonist selected in saccharomyces 1 (BASS1), negative regulatory element-binding protein (NRE-binding protein), or protein DBP-5, or SON3) is an RNA-binding protein which acts as an mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. It specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Members of this group contain a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380699 Cd Length: 75 Bit Score: 50.74 E-value: 2.02e-07
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| DSRM_STRBP_RED-like_rpt2 | cd19866 | second double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This ... |
2772-2836 | 2.03e-07 | |||||||||||||||||||
second double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This family includes spermatid perinuclear RNA-binding protein (STRBP) and interleukin enhancer-binding factor 3 (ILF3), as well as two RNA-editing deaminases, RED1 and RED2. STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. RED1 (EC 3.5.4.37; also called double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. RED2 (also called double-stranded RNA-specific editase B2, RNA-dependent adenosine deaminase 3, RNA-editing enzyme 2, dsRNA adenosine deaminase B2, ADAR3, or ADARB2) prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. It is capable of binding to dsRNA but also to ssRNA. RED2 lacks editing activity for currently known substrate RNAs. Members of this group contain two double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380695 Cd Length: 63 Bit Score: 50.24 E-value: 2.03e-07
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| DSRM_PRKRA-like_rpt1 | cd19862 | first double-stranded RNA binding motif of protein activator of the interferon-induced protein ... |
2469-2525 | 3.70e-07 | |||||||||||||||||||
first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins; This family includes protein activator of the interferon-induced protein kinase (PRKRA) and the RISC-loading complex subunit TARBP2. PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. TARBP2 (also called TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)), participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. This family also includes Drosophila melanogaster Loquacious and similar proteins. Loquacious (Loqs) is a double-stranded RNA-binding domain (dsRBD) protein, a homolog of human TAR RNA binding protein (TRBP) that is a protein first identified as binding the HIV trans-activator RNA (TAR). Loqs interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. PRKRA family proteins contain three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380691 [Multi-domain] Cd Length: 70 Bit Score: 49.57 E-value: 3.70e-07
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| IBN_N | pfam03810 | Importin-beta N-terminal domain; |
1490-1563 | 7.19e-07 | |||||||||||||||||||
Importin-beta N-terminal domain; Pssm-ID: 397745 [Multi-domain] Cd Length: 72 Bit Score: 48.77 E-value: 7.19e-07
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| DSRM_STRBP_rpt1 | cd19909 | first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) ... |
2471-2524 | 8.80e-07 | |||||||||||||||||||
first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins; STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. STRBP contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380738 Cd Length: 84 Bit Score: 49.26 E-value: 8.80e-07
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| DSRM_STRBP_rpt2 | cd19911 | second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) ... |
2772-2836 | 3.68e-06 | |||||||||||||||||||
second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins; STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. STRBP contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380740 Cd Length: 64 Bit Score: 46.66 E-value: 3.68e-06
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| Rnc | COG0571 | dsRNA-specific ribonuclease [Transcription]; |
2478-2524 | 4.23e-06 | |||||||||||||||||||
dsRNA-specific ribonuclease [Transcription]; Pssm-ID: 440336 [Multi-domain] Cd Length: 229 Bit Score: 50.48 E-value: 4.23e-06
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| DSRM_STRBP-like_rpt2 | cd19897 | second double-stranded RNA binding motif of STRBP, ILF3 and similar proteins; This family ... |
2772-2836 | 4.64e-06 | |||||||||||||||||||
second double-stranded RNA binding motif of STRBP, ILF3 and similar proteins; This family includes spermatid perinuclear RNA-binding protein (STRBP) and interleukin enhancer-binding factor 3 (ILF3). STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Members of this STRBP/ILF3 group contain an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380726 Cd Length: 64 Bit Score: 46.59 E-value: 4.64e-06
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| DSRM_STAU2_rpt2 | cd19882 | second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen ... |
2559-2632 | 6.11e-06 | |||||||||||||||||||
second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380711 Cd Length: 82 Bit Score: 46.63 E-value: 6.11e-06
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| DSRM_ILF3_rpt2 | cd19912 | second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and ... |
2769-2836 | 6.68e-06 | |||||||||||||||||||
second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins; ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380741 Cd Length: 72 Bit Score: 46.18 E-value: 6.68e-06
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| DSRM_STRBP-like_rpt1 | cd19894 | first double-stranded RNA binding motif of STRBP, ILF3 and similar proteins; This family ... |
2476-2524 | 8.75e-06 | |||||||||||||||||||
first double-stranded RNA binding motif of STRBP, ILF3 and similar proteins; This family includes spermatid perinuclear RNA-binding protein (STRBP) and interleukin enhancer-binding factor 3 (ILF3). STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Members of this STRBP/ILF3 group contain an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380723 Cd Length: 63 Bit Score: 45.45 E-value: 8.75e-06
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| DSRM_STRBP_RED-like_rpt1 | cd19865 | first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This ... |
2771-2836 | 1.00e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This family includes spermatid perinuclear RNA-binding protein (STRBP) and interleukin enhancer-binding factor 3 (ILF3), as well as two RNA-editing deaminases, RED1 and RED2. STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. RED1 (EC 3.5.4.37; also called double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. RED2 (also called double-stranded RNA-specific editase B2, RNA-dependent adenosine deaminase 3, RNA-editing enzyme 2, dsRNA adenosine deaminase B2, ADAR3, or ADARB2) prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. It is capable of binding to dsRNA, but also to ssRNA. RED2 lacks editing activity for currently known substrate RNAs. Members of this group contain two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380694 Cd Length: 63 Bit Score: 45.42 E-value: 1.00e-05
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| DSRM_STRBP_rpt1 | cd19909 | first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) ... |
2769-2840 | 1.40e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins; STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. STRBP contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380738 Cd Length: 84 Bit Score: 45.79 E-value: 1.40e-05
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| DSRM_PRKRA-like_rpt1 | cd19862 | first double-stranded RNA binding motif of protein activator of the interferon-induced protein ... |
2669-2735 | 2.14e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins; This family includes protein activator of the interferon-induced protein kinase (PRKRA) and the RISC-loading complex subunit TARBP2. PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. TARBP2 (also called TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)), participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. This family also includes Drosophila melanogaster Loquacious and similar proteins. Loquacious (Loqs) is a double-stranded RNA-binding domain (dsRBD) protein, a homolog of human TAR RNA binding protein (TRBP) that is a protein first identified as binding the HIV trans-activator RNA (TAR). Loqs interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. PRKRA family proteins contain three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380691 [Multi-domain] Cd Length: 70 Bit Score: 44.56 E-value: 2.14e-05
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| DSRM_ILF3_rpt1 | cd19910 | first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and ... |
2471-2538 | 2.17e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins; ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380739 Cd Length: 73 Bit Score: 44.75 E-value: 2.17e-05
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| DSRM_RED1_rpt1 | cd19895 | first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins; ... |
2471-2524 | 2.41e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins; RED1 (EC 3.5.4.37; also known as double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. It contains two double-stranded RNA binding motifs (DSRMs) and a C-terminal RNA-specific adenosine-deaminase (editase) domain. This model describes the first DSRM. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380724 Cd Length: 72 Bit Score: 44.69 E-value: 2.41e-05
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| DSRM_STAU_rpt3 | cd19859 | third double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2471-2524 | 3.38e-05 | |||||||||||||||||||
third double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380688 Cd Length: 65 Bit Score: 43.93 E-value: 3.38e-05
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| DSRM_SON-like | cd19870 | double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known ... |
2668-2710 | 4.87e-05 | |||||||||||||||||||
double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known as Bax antagonist selected in saccharomyces 1 (BASS1), negative regulatory element-binding protein (NRE-binding protein), or protein DBP-5, or SON3) is an RNA-binding protein which acts as an mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. It specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Members of this group contain a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380699 Cd Length: 75 Bit Score: 43.81 E-value: 4.87e-05
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| DSRM_STRBP_RED-like_rpt1 | cd19865 | first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This ... |
2476-2525 | 4.92e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins; This family includes spermatid perinuclear RNA-binding protein (STRBP) and interleukin enhancer-binding factor 3 (ILF3), as well as two RNA-editing deaminases, RED1 and RED2. STRBP is a double-stranded DNA and RNA binding protein that is involved in spermatogenesis and sperm function. It plays a role in regulation of cell growth. ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. RED1 (EC 3.5.4.37; also called double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. RED2 (also called double-stranded RNA-specific editase B2, RNA-dependent adenosine deaminase 3, RNA-editing enzyme 2, dsRNA adenosine deaminase B2, ADAR3, or ADARB2) prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. It is capable of binding to dsRNA, but also to ssRNA. RED2 lacks editing activity for currently known substrate RNAs. Members of this group contain two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380694 Cd Length: 63 Bit Score: 43.49 E-value: 4.92e-05
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| RNaseIII | TIGR02191 | ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. ... |
2478-2524 | 8.52e-05 | |||||||||||||||||||
ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing] Pssm-ID: 274024 [Multi-domain] Cd Length: 220 Bit Score: 46.43 E-value: 8.52e-05
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| DSRM_DHX9_rpt1 | cd19854 | first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; ... |
2784-2831 | 9.35e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins; DHX9 (EC 3.6.4.13; also known as ATP-dependent RNA helicase A, DExH-box helicase 9 (DDX9), Leukophysin (LKP), nuclear DNA helicase II (NDH II), NDH2, or RNA helicase A) is a multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation, and RNA-mediated gene silencing. It contains two double-stranded RNA binding motifs (DSRMs) at the N-terminal region. This model corresponds to the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380683 Cd Length: 69 Bit Score: 42.64 E-value: 9.35e-05
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| DSRM_EIF2AK2_rpt1 | cd19903 | first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha ... |
2772-2838 | 9.82e-05 | |||||||||||||||||||
first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins; EIF2AK2 (EC 2.7.11.1/EC 2.7.10.2; also known as interferon-induced, double-stranded RNA-activated protein kinase, eIF-2A protein kinase 2, interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, protein kinase RNA-activated (PKR), protein kinase R, tyrosine-protein kinase EIF2AK2, or p68 kinase) acts as an IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380732 Cd Length: 68 Bit Score: 42.76 E-value: 9.82e-05
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| DSRM_RED1_rpt2 | cd19898 | second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar ... |
2769-2835 | 1.02e-04 | |||||||||||||||||||
second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins; RED1 (EC 3.5.4.37; also known as double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. It contains two double-stranded RNA binding motifs (DSRMs) and a C-terminal RNA-specific adenosine-deaminase (editase) domain. This model describes the second DSRM. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380727 Cd Length: 70 Bit Score: 42.87 E-value: 1.02e-04
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| COG5137 | COG5137 | Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ... |
262-365 | 1.19e-04 | |||||||||||||||||||
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics]; Pssm-ID: 227466 [Multi-domain] Cd Length: 279 Bit Score: 46.91 E-value: 1.19e-04
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| DSRM_RED1_rpt1 | cd19895 | first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins; ... |
2773-2835 | 1.35e-04 | |||||||||||||||||||
first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins; RED1 (EC 3.5.4.37; also known as double-stranded RNA-specific editase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADARB1, ADAR2, or DRADA2) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. It contains two double-stranded RNA binding motifs (DSRMs) and a C-terminal RNA-specific adenosine-deaminase (editase) domain. This model describes the first DSRM. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380724 Cd Length: 72 Bit Score: 42.37 E-value: 1.35e-04
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| dsrm | pfam00035 | Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ... |
2672-2715 | 1.36e-04 | |||||||||||||||||||
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. Pssm-ID: 425434 [Multi-domain] Cd Length: 66 Bit Score: 42.22 E-value: 1.36e-04
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| DSRM_RED2_rpt1 | cd19896 | first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins; ... |
2476-2524 | 1.45e-04 | |||||||||||||||||||
first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins; RED2 (also known as double-stranded RNA-specific editase B2, RNA-dependent adenosine deaminase 3, RNA-editing enzyme 2, dsRNA adenosine deaminase B2, ADAR3, or ADARB2) prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. It is capable of binding to dsRNA but also to ssRNA. RED2 contains two double-stranded RNA binding motifs (DSRMs) and a C-terminal RNA-specific adenosine-deaminase (editase) domain. This model describes the first DSRM. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. RED2 lacks editing activity for currently known substrate RNAs, and may have an inactive editase domain. Pssm-ID: 380725 Cd Length: 74 Bit Score: 42.39 E-value: 1.45e-04
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| DSRM_ILF3_rpt1 | cd19910 | first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and ... |
2769-2840 | 1.79e-04 | |||||||||||||||||||
first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins; ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380739 Cd Length: 73 Bit Score: 42.43 E-value: 1.79e-04
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| CobT2 | COG4547 | Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ... |
301-380 | 2.19e-04 | |||||||||||||||||||
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 443611 [Multi-domain] Cd Length: 608 Bit Score: 46.71 E-value: 2.19e-04
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| DSRM_TARBP2_rpt1 | cd19890 | first double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar ... |
2770-2838 | 2.47e-04 | |||||||||||||||||||
first double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins; TARBP2 (also known as TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)), participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. TARBP2 contains three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380719 Cd Length: 72 Bit Score: 41.66 E-value: 2.47e-04
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| DSRM_DRADA | cd19902 | double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) ... |
2772-2835 | 2.81e-04 | |||||||||||||||||||
double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins; DRADA (EC 3.5.4.37; also known as 136 kDa double-stranded RNA-binding protein (p136), interferon-inducible protein 4 (IFI-4), K88DSRBP, ADAR1, G1P1, or ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. DRADA family members contain at least one double-stranded RNA binding motifs (DSRM); vertebrate proteins contain three. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380731 Cd Length: 71 Bit Score: 41.51 E-value: 2.81e-04
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| DSRM_DRADA_rpt2 | cd19914 | second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase ... |
2772-2839 | 2.87e-04 | |||||||||||||||||||
second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins; DRADA (EC 3.5.4.37; also known as 136 kDa double-stranded RNA-binding protein (p136), interferon-inducible protein 4 (IFI-4), K88DSRBP, ADAR1, G1P1, or ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. Vertebrate DRADA contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380743 Cd Length: 71 Bit Score: 41.37 E-value: 2.87e-04
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| DSRM_PRKRA-like_rpt3 | cd19864 | third double-stranded RNA binding motif of PRKRA, TARBP2 and similar proteins; The family ... |
2975-3036 | 4.13e-04 | |||||||||||||||||||
third double-stranded RNA binding motif of PRKRA, TARBP2 and similar proteins; The family includes protein activator of the interferon-induced protein kinase (PRKRA) and the RISC-loading complex subunit TARBP2. PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. TARBP2 (also called TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)) participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. The family also includes Drosophila melanogaster Loquacious and similar proteins. Loquacious (Loqs) is a double-stranded RNA-binding domain (dsRBD) protein, a homolog of human TAR RNA binding protein (TRBP) that is a protein first identified as binding the HIV trans-activator RNA (TAR). Loqs interacts with Dicer1 (dmDcr1) to facilitate miRNA processing. PRKRA family proteins contain three double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380693 Cd Length: 72 Bit Score: 41.06 E-value: 4.13e-04
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| DSRM_RNAse_III_family | cd10845 | double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ... |
2673-2718 | 6.32e-04 | |||||||||||||||||||
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380682 [Multi-domain] Cd Length: 69 Bit Score: 40.55 E-value: 6.32e-04
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| DSRM_PRKRA_rpt1 | cd19889 | first double-stranded RNA binding motif of protein activator of the interferon-induced protein ... |
2469-2525 | 1.36e-03 | |||||||||||||||||||
first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins; PRKRA (also known as interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X (RAX), PKR-associating protein X, protein kinase, interferon-inducible double-stranded RNA-dependent activator, PACT, or HSD14) is a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. PRKRA contains three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380718 [Multi-domain] Cd Length: 71 Bit Score: 39.51 E-value: 1.36e-03
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| DSRM_DCL_plant | cd19869 | double-stranded RNA binding motif of plant Dicer-like proteins; The family includes plant ... |
2486-2516 | 3.86e-03 | |||||||||||||||||||
double-stranded RNA binding motif of plant Dicer-like proteins; The family includes plant Dicer-like (DCL) proteins and other ribonuclease (RNase) III-like (RTL) proteins. DCLs are endoribonucleases involved in RNA-mediated post-transcriptional gene silencing (PTGS). They function in the microRNA (miRNA) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Family members contain a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380698 Cd Length: 70 Bit Score: 38.50 E-value: 3.86e-03
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| DSRM_STAU_rpt1 | cd19857 | first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2672-2715 | 3.87e-03 | |||||||||||||||||||
first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380686 Cd Length: 64 Bit Score: 38.02 E-value: 3.87e-03
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| DSRM_EIF2AK2_rpt1 | cd19903 | first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha ... |
2472-2524 | 4.36e-03 | |||||||||||||||||||
first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins; EIF2AK2 (EC 2.7.11.1/EC 2.7.10.2; also known as interferon-induced, double-stranded RNA-activated protein kinase, eIF-2A protein kinase 2, interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, protein kinase RNA-activated (PKR), protein kinase R, tyrosine-protein kinase EIF2AK2, or p68 kinase) acts as an IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380732 Cd Length: 68 Bit Score: 38.14 E-value: 4.36e-03
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| DSRM_DRADA | cd19902 | double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) ... |
2669-2709 | 4.40e-03 | |||||||||||||||||||
double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins; DRADA (EC 3.5.4.37; also known as 136 kDa double-stranded RNA-binding protein (p136), interferon-inducible protein 4 (IFI-4), K88DSRBP, ADAR1, G1P1, or ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. DRADA family members contain at least one double-stranded RNA binding motifs (DSRM); vertebrate proteins contain three. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380731 Cd Length: 71 Bit Score: 38.04 E-value: 4.40e-03
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| DSRM_STAU_rpt1 | cd19857 | first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein ... |
2772-2835 | 4.49e-03 | |||||||||||||||||||
first double-stranded RNA binding motif of Drosophila melanogaster maternal effect protein Staufen and similar proteins; Staufen is a double-stranded RNA binding protein required both for the localization of maternal determinants to the posterior pole of the egg, oskar (osk) RNA, and for correct localization to the anterior pole, anchoring bicoid (bcd) RNA. The family also includes two Staufen homologs from vertebrates, Staufen 1 and Staufen 2. They are present in distinct ribonucleoprotein complexes and associate with different mRNAs. Staufen 1 may play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. It binds double-stranded RNA (regardless of the sequence) and tubulin. Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen proteins contain five double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380686 Cd Length: 64 Bit Score: 38.02 E-value: 4.49e-03
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| DSRM_STAU2_rpt3 | cd19884 | third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog ... |
2469-2524 | 7.23e-03 | |||||||||||||||||||
third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins; Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the third motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380713 Cd Length: 67 Bit Score: 37.68 E-value: 7.23e-03
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| DSRM_SON-like | cd19870 | double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known ... |
2469-2509 | 9.27e-03 | |||||||||||||||||||
double-stranded RNA binding motif of protein SON and similar proteins; Protein SON (also known as Bax antagonist selected in saccharomyces 1 (BASS1), negative regulatory element-binding protein (NRE-binding protein), or protein DBP-5, or SON3) is an RNA-binding protein which acts as an mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. It specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Members of this group contain a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure. Pssm-ID: 380699 Cd Length: 75 Bit Score: 37.26 E-value: 9.27e-03
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