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Conserved domains on  [gi|1604609570|gb|TFG78391|]
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peptide chain release factor 2 [Thermodesulfobacteriales bacterium]

Protein Classification

PCRF domain-containing protein( domain architecture ID 1750053)

peptide chain release factor (PCRF) domain-containing protein similar to Homo sapiens mitochondrial peptide chain release factor 1 (MTRF1), MTRF1-like and 28S mitochondrial ribosomal protein S35 (MRPS35)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCRF super family cl40670
This domain is found in peptide chain release factors;
4-343 1.63e-175

This domain is found in peptide chain release factors;


The actual alignment was detected with superfamily member TIGR00020:

Pssm-ID: 477417 [Multi-domain]  Cd Length: 364  Bit Score: 491.21  E-value: 1.63e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   4 IFDLPGKESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKL 83
Cdd:TIGR00020  22 SLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  84 SEIEVKVENLEFKRILGEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLV 163
Cdd:TIGR00020 102 KALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 164 KGDYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRI 243
Cdd:TIGR00020 182 KGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 244 THGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFET 323
Cdd:TIGR00020 262 THIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVLHPYSMVKDLRTGYET 341

                         330       340
                  ....*....|....*....|
gi 1604609570 324 GNVDPVLDGDLSEFIKSYLI 343
Cdd:TIGR00020 342 GNVQAVLDGDIDQFIEAYLK 361
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 4-343 1.63e-175

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 491.21  E-value: 1.63e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   4 IFDLPGKESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKL 83
Cdd:TIGR00020  22 SLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  84 SEIEVKVENLEFKRILGEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLV 163
Cdd:TIGR00020 102 KALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 164 KGDYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRI 243
Cdd:TIGR00020 182 KGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 244 THGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFET 323
Cdd:TIGR00020 262 THIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVLHPYSMVKDLRTGYET 341

                         330       340
                  ....*....|....*....|
gi 1604609570 324 GNVDPVLDGDLSEFIKSYLI 343
Cdd:TIGR00020 342 GNVQAVLDGDIDQFIEAYLK 361
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 23-342 8.32e-133

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 381.46  E-value: 8.32e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  23 KPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDAlAEAKAKLSEIEVKVENLEFKRILGEP 102
Cdd:PRK05589    3 EPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDDEMK-KEIISEVKNIKEEIDRFKIETLLSGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 103 EDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGDYAFGYLKAESGVHRLV 182
Cdd:PRK05589   82 YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 183 RISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQ 262
Cdd:PRK05589  162 RISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 263 NKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFETGNVDPVLDGDLSEFIKSYL 342
Cdd:PRK05589  242 NKETAMKMLKSKLVELKERAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGDIDNFITQYL 321
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 11-338 4.04e-108

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 320.02  E-value: 4.04e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  11 ESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKLSEIEVKV 90
Cdd:COG0216    10 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  91 ENLEFK-RIL---GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGD 166
Cdd:COG0216    90 EELEEElKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 167 YAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDsIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHG 246
Cdd:COG0216   170 GVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 247 PSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDElnsTKKE-IGWG--SQ-IRSYVLHPYRmIKDHRTNFE 322
Cdd:COG0216   249 PTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAA---ERKSqVGSGdrSErIRTYNFPQGR-VTDHRINLT 324

                         330
                  ....*....|....*.
gi 1604609570 323 TGNVDPVLDGDLSEFI 338
Cdd:COG0216   325 LYKLDEVMEGDLDELI 340
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 10-200 3.20e-74

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 227.65  E-value: 3.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  10 KESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLeegDEDALAEAKAKLSEIEVK 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  90 VENL--EFKRIL--GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKG 165
Cdd:pfam03462  78 LEELeeELKLLLlpKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1604609570 166 DYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASV 200
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
72-175 2.87e-44

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 147.99  E-value: 2.87e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   72 DEDALAEAKAKLSEievKVENLEFKRIL-GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQE 150
Cdd:smart00937  15 AEEELEELEAELEE---ELEELLKLLLLpKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKVEVLDESE 91

                           90       100
                   ....*....|....*....|....*
gi 1604609570  151 GDEAGLKSATFLVKGDYAFGYLKAE 175
Cdd:smart00937  92 GELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 4-343 1.63e-175

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 491.21  E-value: 1.63e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   4 IFDLPGKESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKL 83
Cdd:TIGR00020  22 SLDPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  84 SEIEVKVENLEFKRILGEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLV 163
Cdd:TIGR00020 102 KALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 164 KGDYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRI 243
Cdd:TIGR00020 182 KGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 244 THGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFET 323
Cdd:TIGR00020 262 THIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVLHPYSMVKDLRTGYET 341

                         330       340
                  ....*....|....*....|
gi 1604609570 324 GNVDPVLDGDLSEFIKSYLI 343
Cdd:TIGR00020 342 GNVQAVLDGDIDQFIEAYLK 361
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 23-342 8.32e-133

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 381.46  E-value: 8.32e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  23 KPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDAlAEAKAKLSEIEVKVENLEFKRILGEP 102
Cdd:PRK05589    3 EPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDDEMK-KEIISEVKNIKEEIDRFKIETLLSGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 103 EDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGDYAFGYLKAESGVHRLV 182
Cdd:PRK05589   82 YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 183 RISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQ 262
Cdd:PRK05589  162 RISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 263 NKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFETGNVDPVLDGDLSEFIKSYL 342
Cdd:PRK05589  242 NKETAMKMLKSKLVELKERAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGDIDNFITQYL 321
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 24-342 1.21e-132

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 381.92  E-value: 1.21e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  24 PEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKLSEIEVKVENLEFKRILGEPE 103
Cdd:PRK07342    6 PSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDALLSGEA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 104 DASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGDYAFGYLKAESGVHRLVR 183
Cdd:PRK07342   86 DANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 184 ISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQN 263
Cdd:PRK07342  166 ISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKN 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1604609570 264 KETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFETGNVDPVLDGDLSEFIKSYL 342
Cdd:PRK07342  246 RAKAWSMLRARLYEEELKKREEATNAAAASKTDIGWGHQIRSYVLQPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAAL 324
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 72-342 8.22e-126

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 363.59  E-value: 8.22e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  72 DEDALAEAKAKLSEIEVKVENLEFKRILGEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEG 151
Cdd:PRK08787   31 DEDTALAVIADLDKYQAHVEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 152 DEAGLKSATFLVKGDYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGG 231
Cdd:PRK08787  111 EVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDNIEIDINPADLRTDVYRSSGAGG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 232 QHVNKTDSAIRITHGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPY 311
Cdd:PRK08787  191 QHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDALEATKSDIGWGSQIRNYVLDQS 270

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1604609570 312 RmIKDHRTNFETGNVDPVLDGDLSEFIKSYL 342
Cdd:PRK08787  271 R-IKDLRTGIERSDTQKVLDGDLDEFVEASL 300
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 26-342 2.78e-117

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 342.48  E-value: 2.78e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  26 FWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKLSEIEVKVENLEFKRILGEPEDA 105
Cdd:PRK06746    6 FWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 106 SNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGDYAFGYLKAESGVHRLVRIS 185
Cdd:PRK06746   86 NNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRIS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 186 PFDSNKRRHTSFASVFISPEIDDSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQNKE 265
Cdd:PRK06746  166 PFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNRE 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1604609570 266 TAMKILRARLYEREREKQREKIDELNSTKKEIGWGSQIRSYVLHPYRMIKDHRTNFETGNVDPVLDGDLSEFIKSYL 342
Cdd:PRK06746  246 HAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYL 322
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 11-338 4.04e-108

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 320.02  E-value: 4.04e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  11 ESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEAKAKLSEIEVKV 90
Cdd:COG0216    10 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELEARL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  91 ENLEFK-RIL---GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKGD 166
Cdd:COG0216    90 EELEEElKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 167 YAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDsIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHG 246
Cdd:COG0216   170 GVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 247 PSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDElnsTKKE-IGWG--SQ-IRSYVLHPYRmIKDHRTNFE 322
Cdd:COG0216   249 PTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAA---ERKSqVGSGdrSErIRTYNFPQGR-VTDHRINLT 324

                         330
                  ....*....|....*.
gi 1604609570 323 TGNVDPVLDGDLSEFI 338
Cdd:COG0216   325 LYKLDEVMEGDLDELI 340
prfA PRK00591
peptide chain release factor 1; Validated
 1-338 2.11e-107

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 318.18  E-value: 2.11e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   1 METIFD-LPGKESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLEEGDEDALAEA 79
Cdd:PRK00591    1 KPSMLDkLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  80 KAKLSEIEVKVENLEFK-RIL---GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAG 155
Cdd:PRK00591   81 KEELKELEERLEELEEElKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 156 LKSATFLVKGDYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASVFISPEIDDsIEVDIDEKDLRIDTYRASGAGGQHVN 235
Cdd:PRK00591  161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEE-VEVEINPKDLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 236 KTDSAIRITHGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKIDELNstKKEIGWGS---QIRSYVlHPYR 312
Cdd:PRK00591  240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATR--KSQVGSGDrseRIRTYN-FPQG 316

                         330       340
                  ....*....|....*....|....*.
gi 1604609570 313 MIKDHRTNFETGNVDPVLDGDLSEFI 338
Cdd:PRK00591  317 RVTDHRINLTLYKLDEVMEGDLDELI 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 10-200 3.20e-74

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 227.65  E-value: 3.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  10 KESRLSELEEITGKPEFWDNADLAQETLREQSLIKQTVEQWQSLTSELEDVEVLEELSLeegDEDALAEAKAKLSEIEVK 89
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570  90 VENL--EFKRIL--GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAGLKSATFLVKG 165
Cdd:pfam03462  78 LEELeeELKLLLlpKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1604609570 166 DYAFGYLKAESGVHRLVRISPFDSNKRRHTSFASV 200
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 208-318 5.61e-69

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 211.13  E-value: 5.61e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 208 DSIEVDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQNKETAMKILRARLYEREREKQREKI 287
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1604609570 288 DELNSTKKEIGWGSQIRSYVLHPYRMIKDHR 318
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKPQSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 202-333 6.54e-54

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 173.78  E-value: 6.54e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 202 ISPEIDdsievdIDEKDLRIDTYRASGAGGQHVNKTDSAIRITH------------GPSGIVVSCQNERSQRQNKETAMK 269
Cdd:COG1186    17 ISPEIE------IPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALK 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1604609570 270 ILRARLYERE-REKQREKIDELNSTKKEIGWGSQIRSyvlhpyrMIKDHRtnfetGNVDpvlDGD 333
Cdd:COG1186    91 RLKALLYEAElEPKERRATKPTRGSKKRRLWGKQIRS-------MVKDLR-----GNVD---DGD 140
PCRF smart00937
This domain is found in peptide chain release factors;
72-175 2.87e-44

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 147.99  E-value: 2.87e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570   72 DEDALAEAKAKLSEievKVENLEFKRIL-GEPEDASNAIVSINAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQE 150
Cdd:smart00937  15 AEEELEELEAELEE---ELEELLKLLLLpKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGWKVEVLDESE 91

                           90       100
                   ....*....|....*....|....*
gi 1604609570  151 GDEAGLKSATFLVKGDYAFGYLKAE 175
Cdd:smart00937  92 GELGGIKEATLKISGEGAYGKLKFE 116
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 112-294 5.00e-31

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 116.41  E-value: 5.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 112 INAGAGGTEAQDWADMLLRMYLRYAERSGFKSEIVEYQEGDEAG-LKSATFLVKGDYAFGYLKAESGVHRLVRISPFDSN 190
Cdd:TIGR03072   5 LSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGtLRSALVSLDGEAAAALADRWEGTLLWICPSPYRPH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 191 KRRHTSFASV--FISPEiddsievDIDEKDLRIDTYRASGAGGQHVNKTDSAIRITHGPSGIVVSCQNERSQRQNKETAm 268
Cdd:TIGR03072  85 HRRKNWFIGVqrFSASE-------EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLA- 156

                         170       180
                  ....*....|....*....|....*.
gi 1604609570 269 kilRARLYEREREKQREKIDELNSTK 294
Cdd:TIGR03072 157 ---TLLLAVRLADLQQEQAAALRAER 179
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
205-275 5.38e-11

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 59.78  E-value: 5.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604609570 205 EIDDSIEvdIDEKDLRIDTYRASGAGGQHVNKTDSAI-------------------------RIThgPSG-IVVSCQNER 258
Cdd:PRK09256    3 RITRRLV--IPENELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerllalaghRIT--KDGvIVIKAQEFR 78

                          90
                  ....*....|....*..
gi 1604609570 259 SQRQNKETAmkilRARL 275
Cdd:PRK09256   79 SQERNREDA----LERL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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