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Conserved domains on  [gi|1678143025|gb|TMW51544|]
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hypothetical protein DOY81_003375 [Sarcophaga bullata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Intu_longin_2 super family cl41026
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 449-555 2.09e-13

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


The actual alignment was detected with superfamily member pfam19032:

Pssm-ID: 465951  Cd Length: 120  Bit Score: 67.31  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 449 IYGSVLYYDSFMLASQMPLDMRHYIEVIIRCRGIFDFISKHNT--KDLYIWEEISLPD-----------------TAGRF 509
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKESQrvGRFVTWREVFPTDasdsgedklplnnddtePLGRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1678143025 510 FLAICGRGHLLLAVILKIFTTPdleeeeEKVVPSLFYIEEIQETLD 555
Cdd:pfam19032  81 FLLVYGALHATLCVLLEAGGCT------SKPGPDPFYVEELDATLG 120
Intu_longin_3 super family cl41027
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 727-849 5.06e-09

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


The actual alignment was detected with superfamily member pfam19033:

Pssm-ID: 436913  Cd Length: 98  Bit Score: 54.26  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 727 KNSIYYYIYVDGSNNSVFCPLKSSKES--FPYTTEMYRAFHRIHQVLQKSKQakrdgsrqqngkdvtAVKEHGmtirvrd 804
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQvnGPLDPDFLRLVLDIHSDFSQSLP---------------ELKEHI------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1678143025 805 MKPTSDnkcfeFAVVGRLFlsPPKEVYICHRADI--PQNMVEMAFRL 849
Cdd:pfam19033  59 VKTLND-----YWVVGRKS--NPRELYVILNNKNasLQDINEEAKKL 98
Intu_longin_1 super family cl41025
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 282-361 2.89e-03

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


The actual alignment was detected with superfamily member pfam19031:

Pssm-ID: 436911  Cd Length: 112  Bit Score: 38.37  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 282 NNFLYKARGSFLTLNAVLSEELKTKPTASKLaFENVQYLVFYRNLNGFLVLFAYP--CSMVNLSEGNLRADELLTYIKLM 359
Cdd:pfam19031  32 LNEKLSLRGIFEALVSFTETFSPTQSSPCLL-IELQKYHVAYREVEDDLWLIGSVsnPDNIPDPYYSSVLEQLYRFFKLF 110


                  ..
gi 1678143025 360 FP 361
Cdd:pfam19031 111 YG 112
 
Name Accession Description Interval E-value
Intu_longin_2 pfam19032
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 449-555 2.09e-13

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 465951  Cd Length: 120  Bit Score: 67.31  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 449 IYGSVLYYDSFMLASQMPLDMRHYIEVIIRCRGIFDFISKHNT--KDLYIWEEISLPD-----------------TAGRF 509
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKESQrvGRFVTWREVFPTDasdsgedklplnnddtePLGRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1678143025 510 FLAICGRGHLLLAVILKIFTTPdleeeeEKVVPSLFYIEEIQETLD 555
Cdd:pfam19032  81 FLLVYGALHATLCVLLEAGGCT------SKPGPDPFYVEELDATLG 120
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 727-849 5.06e-09

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 54.26  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 727 KNSIYYYIYVDGSNNSVFCPLKSSKES--FPYTTEMYRAFHRIHQVLQKSKQakrdgsrqqngkdvtAVKEHGmtirvrd 804
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQvnGPLDPDFLRLVLDIHSDFSQSLP---------------ELKEHI------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1678143025 805 MKPTSDnkcfeFAVVGRLFlsPPKEVYICHRADI--PQNMVEMAFRL 849
Cdd:pfam19033  59 VKTLND-----YWVVGRKS--NPRELYVILNNKNasLQDINEEAKKL 98
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 282-361 2.89e-03

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 38.37  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 282 NNFLYKARGSFLTLNAVLSEELKTKPTASKLaFENVQYLVFYRNLNGFLVLFAYP--CSMVNLSEGNLRADELLTYIKLM 359
Cdd:pfam19031  32 LNEKLSLRGIFEALVSFTETFSPTQSSPCLL-IELQKYHVAYREVEDDLWLIGSVsnPDNIPDPYYSSVLEQLYRFFKLF 110


                  ..
gi 1678143025 360 FP 361
Cdd:pfam19031 111 YG 112
 
Name Accession Description Interval E-value
Intu_longin_2 pfam19032
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 449-555 2.09e-13

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 465951  Cd Length: 120  Bit Score: 67.31  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 449 IYGSVLYYDSFMLASQMPLDMRHYIEVIIRCRGIFDFISKHNT--KDLYIWEEISLPD-----------------TAGRF 509
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKESQrvGRFVTWREVFPTDasdsgedklplnnddtePLGRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1678143025 510 FLAICGRGHLLLAVILKIFTTPdleeeeEKVVPSLFYIEEIQETLD 555
Cdd:pfam19032  81 FLLVYGALHATLCVLLEAGGCT------SKPGPDPFYVEELDATLG 120
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 727-849 5.06e-09

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 54.26  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 727 KNSIYYYIYVDGSNNSVFCPLKSSKES--FPYTTEMYRAFHRIHQVLQKSKQakrdgsrqqngkdvtAVKEHGmtirvrd 804
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQvnGPLDPDFLRLVLDIHSDFSQSLP---------------ELKEHI------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1678143025 805 MKPTSDnkcfeFAVVGRLFlsPPKEVYICHRADI--PQNMVEMAFRL 849
Cdd:pfam19033  59 VKTLND-----YWVVGRKS--NPRELYVILNNKNasLQDINEEAKKL 98
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 282-361 2.89e-03

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 38.37  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678143025 282 NNFLYKARGSFLTLNAVLSEELKTKPTASKLaFENVQYLVFYRNLNGFLVLFAYP--CSMVNLSEGNLRADELLTYIKLM 359
Cdd:pfam19031  32 LNEKLSLRGIFEALVSFTETFSPTQSSPCLL-IELQKYHVAYREVEDDLWLIGSVsnPDNIPDPYYSSVLEQLYRFFKLF 110


                  ..
gi 1678143025 360 FP 361
Cdd:pfam19031 111 YG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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