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Conserved domains on  [gi|2183017161|gb|UJP38372|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Hyaena hyaena]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl31798
NADH dehydrogenase subunit 2; Provisional
 1-134 1.24e-62

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00105:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 194.68  E-value: 1.24e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00105  166 GWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLIL 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00105  246 LTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYS 299
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-134 1.24e-62

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 194.68  E-value: 1.24e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00105  166 GWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLIL 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00105  246 LTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYS 299
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 5-134 1.70e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 65.91  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   5 LNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQ-----TWNKTPLI 75
Cdd:COG1007   288 LAQTNVKRMLAYSSIAHAGYLllglAAGTPLGVSAALFYLLAYLFMNLGAFAVILLLSRKGGEAEEIedlagLARRSPLL 367

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183017161  76 TSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIiptmLATTALLN----LYFYMRLTYA 134
Cdd:COG1007   368 ALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYW----LAVIAVLNsvisAYYYLRVVKA 426
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-121 4.92e-11

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.48  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFMLFM-----HNSSTTTSSLSQTWNKTP 73
Cdd:pfam00361 164 AALVQTDIKRLLAYSSISHMGYMlialGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGsviyrRVHTRNIRDYGGLAKTMP 243

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2183017161  74 LITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTA 121
Cdd:pfam00361 244 ILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 3-131 2.74e-09

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.80  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGW----MAAITPYNPTMMILNLTIYIIMTLTTFMLFM------HNSSTTTSSLSQTWNKT 72
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSllrsykDEWIEYISDFAGLFKTN 365

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183017161  73 PLITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRL 131
Cdd:TIGR01770 366 PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-134 1.24e-62

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 194.68  E-value: 1.24e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00105  166 GWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLIL 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00105  246 LTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYS 299
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-134 2.38e-54

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 173.45  E-value: 2.38e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00135  165 GWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTP 244

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00135  245 LILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYA 298
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-134 3.14e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 147.37  E-value: 3.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00070  166 GWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMM 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00070  246 LTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYA 299
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-133 7.99e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 143.81  E-value: 7.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00112  166 GWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTTLM 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:MTH00112  246 LTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTY 298
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-134 1.11e-31

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 114.68  E-value: 1.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00200  166 GWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLG 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00200  246 LTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYL 299
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-133 2.35e-29

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 108.48  E-value: 2.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00041  166 GWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAFLFI 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:MTH00041  246 LSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISF 298
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-134 4.51e-24

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 94.46  E-value: 4.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00011  162 GLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLF 241

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:MTH00011  242 IMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 3-133 2.65e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 86.80  E-value: 2.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLILTL 82
Cdd:MTH00160  160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLN 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2183017161  83 MLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:MTH00160  240 LLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISY 290
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-133 3.39e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 83.78  E-value: 3.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYI-IMTLTTFMLFMHNSSTTTSSLSQtwNKTPLITSLI 79
Cdd:MTH00144  159 SIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIvSSGFLFFSLWSGDSGSMKDLGSL--KPSYKTGLSI 236

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2183017161  80 LTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:MTH00144  237 ISLLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFF 290
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-133 1.84e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 78.95  E-value: 1.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQTWNKTPLITSLIL 80
Cdd:MTH00197  151 GIGGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLG 230

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2183017161  81 TLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:MTH00197  231 LSFLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAY 283
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 5-134 1.70e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 65.91  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   5 LNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFMLFMHNSSTTTSSLSQ-----TWNKTPLI 75
Cdd:COG1007   288 LAQTNVKRMLAYSSIAHAGYLllglAAGTPLGVSAALFYLLAYLFMNLGAFAVILLLSRKGGEAEEIedlagLARRSPLL 367

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2183017161  76 TSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIiptmLATTALLN----LYFYMRLTYA 134
Cdd:COG1007   368 ALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYW----LAVIAVLNsvisAYYYLRVVKA 426
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 3-121 4.92e-11

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.48  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFMLFM-----HNSSTTTSSLSQTWNKTP 73
Cdd:pfam00361 164 AALVQTDIKRLLAYSSISHMGYMlialGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGsviyrRVHTRNIRDYGGLAKTMP 243

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2183017161  74 LITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTA 121
Cdd:pfam00361 244 ILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
3-131 6.09e-10

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 55.60  E-value: 6.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTF-MLFMHNSSTTTSSLSQTWN----KTP 73
Cdd:PRK05777  287 AALSQTNIKRLLAYSSIAHAGYLlvglAAGTAEGYSAVLFYLLAYLFMTLGAFgVISLLRRKGGEAESISDFAglskRSP 366

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2183017161  74 LITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIiptmLATTALLN----LYFYMRL 131
Cdd:PRK05777  367 LLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWW----LAVIGVLNsaigAFYYLRV 424
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 1-131 2.52e-09

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 53.61  E-value: 2.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIM-TLTTFMLFM-------HNSSTTTSSLSQTWNKT 72
Cdd:COG0651   287 ALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNhALAKALLFLaagaierATGTRDLDKLGGLGKRM 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183017161  73 PLITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRL 131
Cdd:COG0651   367 PLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 3-131 2.74e-09

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.80  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMGW----MAAITPYNPTMMILNLTIYIIMTLTTFMLFM------HNSSTTTSSLSQTWNKT 72
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSllrsykDEWIEYISDFAGLFKTN 365

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2183017161  73 PLITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRL 131
Cdd:TIGR01770 366 PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 3-131 4.57e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 50.02  E-value: 4.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMG---WMAAITPYNPTMMIL-NLTIYIIMTLTTF--MLFMHNSSTTTSSLSQTWNKTPLIT 76
Cdd:MTH00199  264 GALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESIQASLiYMIIYVIMSICSFsiILSLKLTKGLIVEVSGLSRKNPVIA 343

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2183017161  77 -SLILTLmLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRL 131
Cdd:MTH00199  344 lTLALTF-LSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
5-95 1.81e-07

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 48.51  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   5 LNQTQLRKILAYSSIAHMGW----MAAITPYNPTMMILNLTIYIIMTLTTFM---LF-MHNSSTTTSSLSQTWNKTPLIT 76
Cdd:PRK02504  295 LAQTSMKRMLAYSSIGQAGFvmigLVAGTEAGYASMVFYLLAYLFMNLGAFAcviLFsLRTGTDQISDYAGLYQKDPLLT 374

                          90       100
                  ....*....|....*....|
gi 2183017161  77 sLILTL-MLSLGGLPPLSGF 95
Cdd:PRK02504  375 -LGLSLcLLSLGGIPPLAGF 393
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 3-131 3.76e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 47.33  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   3 GGLNQTQLRKILAYSSIAHMG---WMAAITPYNPTMM-ILNLTIYIIMTLTTFM--LFMHNSSTTTSSLSQTWNKTPLIT 76
Cdd:MTH00196  169 GALNQTKIKRLLAYSGIGHMGfvlWGIEIGSFESIQAsLVYLFIYIIMSICVFSiiLALNVYKNLIIEFSGLSRRLPILA 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2183017161  77 SLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRL 131
Cdd:MTH00196  249 ITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 7-133 8.82e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 43.81  E-value: 8.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   7 QTQLRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYIIM-TLTTFMLFM-------HNSSTTTSSLSQTWNKTPLITSL 78
Cdd:PRK12667  316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINhAIAKSLLFLasgvfihAAGTRDIDELAGLGRKMPIASFA 395

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2183017161  79 ILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTY 133
Cdd:PRK12667  396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWY 450
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 2-134 1.59e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 42.94  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   2 WGGLNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFM----LFMHNSSTTTSSLSQTWNKTP 73
Cdd:PRK08375  287 LAALGQDDVKRVLAYSTVSQMGYIllglALLTPLALAAGLLHLLHHALMKGALFLaagaIEVTYGTRRLSELSGLGRRMP 366

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2183017161  74 LITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTMLATTALLNLYFYMRLTYA 134
Cdd:PRK08375  367 LTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYR 427
ndhB CHL00049
NADH dehydrogenase subunit 2
 7-95 2.84e-05

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 42.30  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   7 QTQLRKILAYSSIAHMGWM-----AAITPYNPTMMILNLTIYIIMTLTTF---MLF-MHNSSTTTSSLSQTWNKTPLITS 77
Cdd:CHL00049  301 QTSMKRMLAYSSIGQIGYViigiiVGDSNDGYASMITYMLFYIFMNLGTFaciVLFgLRTGTDNIRDYAGLYTKDPFLAL 380

                          90
                  ....*....|....*...
gi 2183017161  78 LILTLMLSLGGLPPLSGF 95
Cdd:CHL00049  381 SLALCLLSLGGIPPLAGF 398
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
71-129 4.41e-04

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 38.78  E-value: 4.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2183017161  71 KTPLITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKN------EMIIIPTMLATTALLNLYFYM 129
Cdd:PRK12663  365 KEPLFGALFLILIFAIGGLPPFSGFWGKVLLVQGALDNgayillALMLITSLITMYSLFRIFFLA 429
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 10-102 1.21e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 37.41  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161  10 LRKILAYSSIAHMGWMAAITPYNPTMMILNLTIYII-MTLTTFMLFM-------HNSSTTTSSLSQTWNKTPLITSLILT 81
Cdd:PRK12662  303 IKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVnHSIVKSALFMvsgsisyHFGTTKLEDCLNLWKSMPKITLAFVL 382

                          90       100
                  ....*....|....*....|.
gi 2183017161  82 LMLSLGGLPPLSGFTPKWMII 102
Cdd:PRK12662  383 LSLSLIGMPPTSGFVAKWYIL 403
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 71-116 1.39e-03

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 37.28  E-value: 1.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2183017161  71 KTPLITSLILTLMLSLGGLPPLSGFTPKWMIIQELTKNEMIIIPTM 116
Cdd:PRK08668  365 KMPFTFAMYLVAIISLAGIPPMSGFASKWLIFEALISKGMPITAFM 410
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 2-102 1.54e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 37.15  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   2 WGGLNQTQLRKILAYSSIAHMGWM----AAITPYNPTMMILNLTIYIIMTLTTFMLFM---------------------H 56
Cdd:MTH00198  372 FGALNQTRIKRLLAYSGIGHIGFIligvSAGTYESLQASWTYAVTYLVSALASFTVICtleefgtrtptsrqrdgsfgnY 451

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2183017161  57 NSSTTTSSLSQTWNKTPLITSLILTLMLSLGGLPPLSGFTPKWMII 102
Cdd:MTH00198  452 NLVRRLVDLTILSRGQPYIAFSLAIVFLSLAGIPPLLGFLGKWFIL 497
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-103 3.08e-03

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 36.07  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   1 GWGGLNQTQLRKILAYSSIAHMGWMA-AITPYNPTMMILNLTIYIIMTLTTFMLFM---------HNssTTTSSLSQTWN 70
Cdd:TIGR01972 284 ALIALAQTDIKRLIAYSSISHMGFVLlGIFSFNELGISGAVFQMISHGLITAALFLlvgvlyeraHT--RDIAKYGGLAN 361

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2183017161  71 KTPLITSLILTLMLSLGGLPPLSGFTPKWMIIQ 103
Cdd:TIGR01972 362 KMPVLAAFFMLFAMASLGLPGTSGFVGEFLILL 394
PRK12650 PRK12650
DUF4040 family protein;
5-98 5.98e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 35.40  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2183017161   5 LNQTQLRKILAYSSIAHMGWMAAI----TPYNPTMMILNLTIYIIMTLTTFMLFM---HNSSTT-TSSLSQTWNKTPLIT 76
Cdd:PRK12650  291 VQKTDLKKLTAYSTVSQLGWIVATigvgTPFALTAAVVHTLAHALFKSSLFMLIGvvdHQAGTRdIRRLGSLWRRMPFTF 370

                          90       100
                  ....*....|....*....|..
gi 2183017161  77 SLILTLMLSLGGLPPLSGFTPK 98
Cdd:PRK12650  371 VSVTIAALSMAAVPPLFGFVSK 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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