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Conserved domains on  [gi|2287980249|gb|UVD39414|]
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IL-1 receptor-like protein [Lumpy skin disease virus]

Protein Classification

PHA02826 family protein( domain architecture ID 11476097)

PHA02826 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 1-231 4.81e-108

IL-1 receptor-like protein; Provisional


:

Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 310.31  E-value: 4.81e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249   1 MKVINFIILICCFKSAFLSEYCKYRGGILTPVNVNFKDPAFLKCPLDNYKKSIFFKKN-ITSYDITWFQTNSLSFVRNYN 79
Cdd:PHA02826    1 MKVIIFFIIILQFISAFLCLYCKYRGGDLTPVYAKFGDPMVLLCTGKHYKKSIFFDKTfITSYNVTWSKTDSLAFVRDSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  80 DYKNFKKIeVNNENASRvqliGNNLWLYPVINIDDGIYICRFRSHNICEEMSIKLTFldKEETITYRFNEGLNSTVHCMD 159
Cdd:PHA02826   81 ARTKIKKI-THNEIGDR----SENLWIGNVINIDEGIYICTISSGNICEESTIRLTF--DSGTINYQFNSGKDSKLHCYG 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287980249 160 IDLISSYFKNKTLDWYKNNNKVLYDDRIQ--SNELKLVIKNTTHDDSGIYTCNLRINKDSINYDIKRNYNVVVL 231
Cdd:PHA02826  154 TDGISSTFKDYTLTWYKNGNIVLYTDRIQlrNNNSTLVIKSATHDDSGIYTCNLRFNKNSNNYNITKEYKVTII 227
 
Name Accession Description Interval E-value
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 1-231 4.81e-108

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 310.31  E-value: 4.81e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249   1 MKVINFIILICCFKSAFLSEYCKYRGGILTPVNVNFKDPAFLKCPLDNYKKSIFFKKN-ITSYDITWFQTNSLSFVRNYN 79
Cdd:PHA02826    1 MKVIIFFIIILQFISAFLCLYCKYRGGDLTPVYAKFGDPMVLLCTGKHYKKSIFFDKTfITSYNVTWSKTDSLAFVRDSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  80 DYKNFKKIeVNNENASRvqliGNNLWLYPVINIDDGIYICRFRSHNICEEMSIKLTFldKEETITYRFNEGLNSTVHCMD 159
Cdd:PHA02826   81 ARTKIKKI-THNEIGDR----SENLWIGNVINIDEGIYICTISSGNICEESTIRLTF--DSGTINYQFNSGKDSKLHCYG 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287980249 160 IDLISSYFKNKTLDWYKNNNKVLYDDRIQ--SNELKLVIKNTTHDDSGIYTCNLRINKDSINYDIKRNYNVVVL 231
Cdd:PHA02826  154 TDGISSTFKDYTLTWYKNGNIVLYTDRIQlrNNNSTLVIKSATHDDSGIYTCNLRFNKNSNNYNITKEYKVTII 227
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 147-230 8.25e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 45.78  E-value: 8.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249 147 FNEGLNSTVHCMDIDLISSYFKNKTLDWYKNNNKVLYDDRIQSNELKLVIKNTTHDDSGIYTCNLRINKDSINYDIKRNY 226
Cdd:cd05757     7 LPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRTI 86


                  ....
gi 2287980249 227 NVVV 230
Cdd:cd05757    87 SLTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 165-230 1.85e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 1.85e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2287980249  165 SYFKNKTLDWYKNNNK-VLYDDRIQ----SNELKLVIKNTTHDDSGIYTCNLRINkdsiNYDIKRNYNVVV 230
Cdd:smart00410  19 SGSPPPEVTWYKQGGKlLAESGRFSvsrsGSTSTLTISNVTPEDSGTYTCAATNS----SGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 174-209 7.63e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 7.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2287980249 174 WYKNNNKVL----YDDRIQSNELKLVIKNTTHDDSGIYTC 209
Cdd:pfam13927  35 WYKNGEPISsgstRSRSLSGSNSTLTISNVTRSDAGTYTC 74
 
Name Accession Description Interval E-value
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 1-231 4.81e-108

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 310.31  E-value: 4.81e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249   1 MKVINFIILICCFKSAFLSEYCKYRGGILTPVNVNFKDPAFLKCPLDNYKKSIFFKKN-ITSYDITWFQTNSLSFVRNYN 79
Cdd:PHA02826    1 MKVIIFFIIILQFISAFLCLYCKYRGGDLTPVYAKFGDPMVLLCTGKHYKKSIFFDKTfITSYNVTWSKTDSLAFVRDSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  80 DYKNFKKIeVNNENASRvqliGNNLWLYPVINIDDGIYICRFRSHNICEEMSIKLTFldKEETITYRFNEGLNSTVHCMD 159
Cdd:PHA02826   81 ARTKIKKI-THNEIGDR----SENLWIGNVINIDEGIYICTISSGNICEESTIRLTF--DSGTINYQFNSGKDSKLHCYG 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287980249 160 IDLISSYFKNKTLDWYKNNNKVLYDDRIQ--SNELKLVIKNTTHDDSGIYTCNLRINKDSINYDIKRNYNVVVL 231
Cdd:PHA02826  154 TDGISSTFKDYTLTWYKNGNIVLYTDRIQlrNNNSTLVIKSATHDDSGIYTCNLRFNKNSNNYNITKEYKVTII 227
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 1-224 3.62e-07

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 50.01  E-value: 3.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249   1 MKVINFIILICCFKSAFLSEY----CKYRGGILTPVNVNFKDPAFLKCPLDNYKKSIFfkkNItsYDITWFQTNSlsfvr 76
Cdd:PHA02785    1 MSILPVIFLPIFFYSSFVQTFnapeCIDKGQYFASFMELENEPVILPCPQINTLSSGY---NI--LDILWEKRGA----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  77 nyndyKNFKKIEVNNenasrvqliGNNLWLYPVINIDDGIYICRFRSHNICEEMSIKLTFLDKEET----ITYR--FNEG 150
Cdd:PHA02785   71 -----DNDRIIPIDN---------GSNMLILNPTQSDSGIYICITKNETYCDMMSLNLTIVSVSESnidlISYPqiVNER 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2287980249 151 LNSTVHCMDIDLISSYFKNKTLDWykNNNKVLYDDRIQSNELKLV-IKNTTHDDSGIYTCNLRINKDSINYDIKR 224
Cdd:PHA02785  137 STGEMVCPNINAFIASNVNADIIW--SGHRRLRNKRLKQRTPGIItIEDVRKNDAGYYTCVLKYIYGDKTYNVTR 209
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 147-230 8.25e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 45.78  E-value: 8.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249 147 FNEGLNSTVHCMDIDLISSYFKNKTLDWYKNNNKVLYDDRIQSNELKLVIKNTTHDDSGIYTCNLRINKDSINYDIKRNY 226
Cdd:cd05757     7 LPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHNGKQYNVTRTI 86


                  ....
gi 2287980249 227 NVVV 230
Cdd:cd05757    87 SLTV 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 165-230 1.85e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 1.85e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2287980249  165 SYFKNKTLDWYKNNNK-VLYDDRIQ----SNELKLVIKNTTHDDSGIYTCNLRINkdsiNYDIKRNYNVVV 230
Cdd:smart00410  19 SGSPPPEVTWYKQGGKlLAESGRFSvsrsGSTSTLTISNVTPEDSGTYTCAATNS----SGSASSGTTLTV 85
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 39-137 4.49e-06

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 43.95  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  39 PAFLKCPLDNYkksifFKKNITSYDITWfqtnslsfvrnyndYKNFKKIEVNNENASRVQLIGNNLWLYPVINIDDGIYI 118
Cdd:cd05756    17 PDVIKCPLFPN-----FLAQSAGLNLTW--------------YKNDSETPISFEPDSRIHQEKDKLWFVPALLEDSGNYY 77

                          90
                  ....*....|....*....
gi 2287980249 119 CRFRSHNICEEMSIKLTFL 137
Cdd:cd05756    78 CVVRNSTYCSKVSISLEVV 96
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 171-209 1.81e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.85  E-value: 1.81e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2287980249 171 TLDWYKNNNKVL----YDDRIQSNELKLVIKNTTHDDSGIYTC 209
Cdd:cd00096    14 TITWYKNGKPLPpssrDSRRSELGNGTLTISNVTLEDSGTYTC 56
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 174-209 7.63e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 7.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2287980249 174 WYKNNNKVL----YDDRIQSNELKLVIKNTTHDDSGIYTC 209
Cdd:pfam13927  35 WYKNGEPISsgstRSRSLSGSNSTLTISNVTRSDAGTYTC 74
I-set pfam07679
Immunoglobulin I-set domain;
171-209 1.49e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.85  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2287980249 171 TLDWYKNNNKVLYDDRIQ----SNELKLVIKNTTHDDSGIYTC 209
Cdd:pfam07679  31 EVSWFKDGQPLRSSDRFKvtyeGGTYTLTISNVQPDDSGKYTC 73
Ig1_IL1R_like cd20991
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 81-137 1.57e-03

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. IL-1 receptor antagonist (IL-1RA), a naturally occurring cytokine, is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409583  Cd Length: 91  Bit Score: 36.88  E-value: 1.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287980249  81 YKNFKKIEVNNENASRVQLIGNNLWLYPVINIDDGIYICRFRSHNICEEMSIKLTFL 137
Cdd:cd20991    35 YKNDSKTPISMEQDSRIHQYKEKLWFVPAKVEDSGHYYCVVRNSTYCLKIKITAKFV 91
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 41-123 2.34e-03

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 37.01  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287980249  41 FLKCPLDNYKKSIFFKKNITSYDITWFQTNS----LSFVRNYNDYKNFKKIEVNNENASRVQLIGNNLWLYPVINIDDGI 116
Cdd:pfam18452   8 VLFCDLPEPQKTHFYHRSQLSPTQGPHLPCSgskdLSDVQWYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGS 87


                  ....*..
gi 2287980249 117 YICRFRS 123
Cdd:pfam18452  88 YICRPRI 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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