NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2329660232|gb|UZP17318|]
View 

RNA-dependent RNA polymerase [Peanut stunt virus]

Protein Classification

Bromoviridae_RdRp domain-containing protein( domain architecture ID 10469888)

Bromoviridae_RdRp domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
295-726 0e+00

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


:

Pssm-ID: 395779  Cd Length: 440  Bit Score: 563.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 295 NTDFTTDIDHLTLKQSDLIPK-VDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRFQ 373
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKpKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 374 ESYLNSN-ALAQSNFLNV---VGNFHAYMQKWAASGLSYDDLPDLHAENLQFYEHMVKSDVKPVVADTLNVDRPVPATIT 449
Cdd:pfam00978  81 KSFLDKEkLDKLDPIINTtenVSRWLDKQSGKKAAQLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 450 FHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLNK--HCLEIDLSKFDKSQGELHLMIQEEILNLL 527
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDAseDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 528 GCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFDRMLFSGDDSLAFSLNPI 607
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLEKIDCAAFSGDDSLIFSPKPI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 608 EGKSDWFTSLFNMEAKNMDPPTPYICSKFLLTDELGNtFSVPDPLRELQRLGTKKIPDgglDEAYLKAHYMSFVDRLK-F 686
Cdd:pfam00978 321 EDPASRFATLFNMEAKVFDPSVPYFCSKFLLEVDGGA-FFVPDPLKLLQKLGKKKIPD---DEQHLDEIFTSLCDLTKsF 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2329660232 687 LPRMTHYTVTQLTTFYEMKYKKSGA----ECHAMLGGFSKYSTN 726
Cdd:pfam00978 397 NDDCVVLELLDLAVARYYKYAPEGYaalcALHKALSSFTLFFSL 440
 
Name Accession Description Interval E-value
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
295-726 0e+00

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 563.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 295 NTDFTTDIDHLTLKQSDLIPK-VDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRFQ 373
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKpKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 374 ESYLNSN-ALAQSNFLNV---VGNFHAYMQKWAASGLSYDDLPDLHAENLQFYEHMVKSDVKPVVADTLNVDRPVPATIT 449
Cdd:pfam00978  81 KSFLDKEkLDKLDPIINTtenVSRWLDKQSGKKAAQLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 450 FHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLNK--HCLEIDLSKFDKSQGELHLMIQEEILNLL 527
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDAseDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 528 GCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFDRMLFSGDDSLAFSLNPI 607
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLEKIDCAAFSGDDSLIFSPKPI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 608 EGKSDWFTSLFNMEAKNMDPPTPYICSKFLLTDELGNtFSVPDPLRELQRLGTKKIPDgglDEAYLKAHYMSFVDRLK-F 686
Cdd:pfam00978 321 EDPASRFATLFNMEAKVFDPSVPYFCSKFLLEVDGGA-FFVPDPLKLLQKLGKKKIPD---DEQHLDEIFTSLCDLTKsF 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2329660232 687 LPRMTHYTVTQLTTFYEMKYKKSGA----ECHAMLGGFSKYSTN 726
Cdd:pfam00978 397 NDDCVVLELLDLAVARYYKYAPEGYaalcALHKALSSFTLFFSL 440
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
297-659 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 558.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 297 DFTTDIDHLTLKQSDLIPKVDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRFQESY 376
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWTKPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 377 LNSNALaqsnflnvvgnfhaymqkwaasglsyddlpdlhaenlQFYEHMVKSDVKPVVADTLNVDRPVPATITFHAKGIT 456
Cdd:cd23252    81 IDVDRL-------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGIV 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 457 SQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLN--KHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVS 534
Cdd:cd23252   124 MQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNasKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPFT 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 535 KWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTD--QFDRMLFSGDDSLAFSLNPIEG-KS 611
Cdd:cd23252   204 KWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDdpNFDFVVASGDDSLIGSVEPLPRdDE 283
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2329660232 612 DWFTSLFNMEAKNMDpPTPYICSKFLLTDELG--NTFSVPDPLRELQRLG 659
Cdd:cd23252   284 DLFTTLFNFEAKFPH-NQPFICSKFLLSDEFGdeNVFSVPDPLKLLQRLG 332
 
Name Accession Description Interval E-value
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
295-726 0e+00

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 563.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 295 NTDFTTDIDHLTLKQSDLIPK-VDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRFQ 373
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKpKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 374 ESYLNSN-ALAQSNFLNV---VGNFHAYMQKWAASGLSYDDLPDLHAENLQFYEHMVKSDVKPVVADTLNVDRPVPATIT 449
Cdd:pfam00978  81 KSFLDKEkLDKLDPIINTtenVSRWLDKQSGKKAAQLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 450 FHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLNK--HCLEIDLSKFDKSQGELHLMIQEEILNLL 527
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDAseDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 528 GCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFDRMLFSGDDSLAFSLNPI 607
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLEKIDCAAFSGDDSLIFSPKPI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 608 EGKSDWFTSLFNMEAKNMDPPTPYICSKFLLTDELGNtFSVPDPLRELQRLGTKKIPDgglDEAYLKAHYMSFVDRLK-F 686
Cdd:pfam00978 321 EDPASRFATLFNMEAKVFDPSVPYFCSKFLLEVDGGA-FFVPDPLKLLQKLGKKKIPD---DEQHLDEIFTSLCDLTKsF 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2329660232 687 LPRMTHYTVTQLTTFYEMKYKKSGA----ECHAMLGGFSKYSTN 726
Cdd:pfam00978 397 NDDCVVLELLDLAVARYYKYAPEGYaalcALHKALSSFTLFFSL 440
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
297-659 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 558.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 297 DFTTDIDHLTLKQSDLIPKVDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRFQESY 376
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWTKPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 377 LNSNALaqsnflnvvgnfhaymqkwaasglsyddlpdlhaenlQFYEHMVKSDVKPVVADTLNVDRPVPATITFHAKGIT 456
Cdd:cd23252    81 IDVDRL-------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGIV 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 457 SQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLN--KHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVS 534
Cdd:cd23252   124 MQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNasKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPFT 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 535 KWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTD--QFDRMLFSGDDSLAFSLNPIEG-KS 611
Cdd:cd23252   204 KWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDdpNFDFVVASGDDSLIGSVEPLPRdDE 283
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2329660232 612 DWFTSLFNMEAKNMDpPTPYICSKFLLTDELG--NTFSVPDPLRELQRLG 659
Cdd:cd23252   284 DLFTTLFNFEAKFPH-NQPFICSKFLLSDEFGdeNVFSVPDPLKLLQRLG 332
ps-ssRNAv_Martellivirales_RdRp cd23208
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of ...
420-603 1.15e-80

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Martellivirales, class Alsuviricetes. The order Martellivirales consists of seven families: Bromoviridae, Closteroviridae, Endornaviridae, Kitaviridae, Mayoviridae, Togaviridae, and Virgaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438058 [Multi-domain]  Cd Length: 190  Bit Score: 257.30  E-value: 1.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 420 QFYEHMVKSDVKPVVADTLNVDRPVPATITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVL--- 496
Cdd:cd23208     1 DKYEMMIKSDVKPKLDLTAQQEYPKLQTIVYHDKNITAIFCPIFKELFERLLSCLKKKVVIYTGMMTSAELNDFISAlhl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 497 --NKHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTL 574
Cdd:cd23208    81 esGYYVLEIDFSKFDKSQGALHLLTELLILRRLGVDEPLLVLWEFAHTQSTTRDINNGISFETAYQRKSGDAFTYFGNTL 160
                         170       180
                  ....*....|....*....|....*....
gi 2329660232 575 VTMALFSWCYDTDQFDRMLFSGDDSLAFS 603
Cdd:cd23208   161 VTMAALLDVLDLEKIVCIAFGGDDSLIFS 189
Mayoviridae_RdRp cd23256
RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense ...
377-687 2.33e-65

RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Mayoviridae, order Martellivirales. The Mayoviridae family consists of two genera, Idaeovirus and Pteridovirus. The genus Idaeovirus contains Raspberry bushy dwarf virus (RBDV), named after the host with which it was first associated (red raspberry, Rubus idaeu) and the disease which is characterized by bushiness (stunting and proliferation of canes); RBDV has recently been found causing an infection in grapevines. RBDV occurs in all tissues of the plant, including seed and pollen, and is transmitted in association with pollen, both vertically to the seed and horizontally to the pollinated plant; this is the only known method of natural spread of RBDV. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438106  Cd Length: 329  Bit Score: 221.54  E-value: 2.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 377 LNSNALAQSNFLNVVGNfhaymqkwaasglSYDDLPDLHAENLQFYEHMVKSDVKPVVADTLNVDRPVPATITFHAKGIT 456
Cdd:cd23256     3 VGSSADQIQLYQNKVGN-------------KVNDPVVLALTSLNKYSHMIKRDRKPVLTTAVQSEYTKAATITYHDKDIT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 457 SQFSPLFISLFERFQRCLRGRVVVPVGKISSLEM----DKFSVLNKHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVD 532
Cdd:cd23256    70 QVATPIFRQFKTRLLACKKSNLCIPLDHDHDISGwltnRHLGSENGTFTEIDFSKFDKSQGELHQLIQDLILLRFGCDPE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 533 VSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCY---DTDQFDRMLFSGDDSLAFSLNPIEG 609
Cdd:cd23256   150 FVSLWSTAHRSSSIKDQNVGISFKTDFQRRTGDAFTFLGNSLVTAVMLAYVLsfeDEKKIRYMLVGGDDSLICSYGPISV 229
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2329660232 610 KSDWFTSLFNMEAKNMDPPTPYICSKFLLtdELGNTF-SVPDPLRELQRLGTKKIPDgglDEAYLKAHYMSFVDRLKFL 687
Cdd:cd23256   230 PLEPLSTIFNMSCKLIQPSCPYFASRYII--RVGDEIlCVPDPYKLLVKMGRKDIPD---NEASLEEVRTGLADSAKPL 303
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
425-682 2.34e-58

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 200.09  E-value: 2.34e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 425 MVKSDVKPVVADTLNVDRPVPATITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVG--------KISSLEMDKFSVL 496
Cdd:cd23253     6 MVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGmnleelasLIRSKLGDPLDEY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 497 nkHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVT 576
Cdd:cd23253    86 --KTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFSCRATSDSGVSLELGAQRRTGSPNTWLGNTLVT 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 577 MALFSWCYDTDQFDRMLFSGDDSLAFSLNPIEGKSDWFTSLFNMEAKNMDPPTPYICSKFLLTDElGNTFSVPDPLRELQ 656
Cdd:cd23253   164 LGILSSSYDLDDIDLLLVSGDDSLIFSKKPLPNKANEINLDFGFEAKFIENSVPYFCSKFIIEDR-GKIKVVPDPVKLFE 242
                         250       260
                  ....*....|....*....|....*.
gi 2329660232 657 RLGTKKIPDgglDEAYLKAHYMSFVD 682
Cdd:cd23253   243 KLSVPIRLE---DETLLKERFTSFKD 265
Virgaviridae_RdRp cd23251
RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense ...
293-668 4.37e-54

RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Virgaviridae, order Martellivirales. The Virgaviridae is a family of plant viruses with rod-shaped virions, a (+)ssRNA genome with a 3'-terminal tRNA-like structure and a replication protein similar to those of the alpha-like supergroup. Plants serve as natural hosts. The name of the family is derived from the Latin word virga (rod), as all viruses in this family are rod-shaped. There are currently 59 species in this family, divided among seven genera: Goravirus, Furovirus, Hordeivirus, Pecluvirus, Pomovirus, Tobamovirus, and Tobravirus. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438101  Cd Length: 427  Bit Score: 193.61  E-value: 4.37e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 293 VENTDFTTDIDHLTLKQSDLIPKVDGGNYLRPVLTTGSGSKRLGTTKEVLTAIKKRNADVPELSGSVDLTRISKAVAKRF 372
Cdd:cd23251    16 VATSDINLNVEDCTLDPSKSVKVWQEKEGLKPVLRTAMPEKRQNGLLESLLALIKRNMAAPKLQGAVNEFETIERVIKKA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 373 QESYLNSnALAQSNFLNVVGNFHAYMQKWAASG----LSYD---DLPDLHAenlqfYEHMVKSDVKPVVADTLNVDRPVP 445
Cdd:cd23251    96 KDVFFDE-DLIDRSPLSTRESFLRWWDKQSTTAraqlLADDrvlDEIDVCT-----YNFMIKNDVKPKLDLSPQSEYAAL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 446 ATITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKFSVLNKH----CLEIDLSKFDKSQGELHLMIQE 521
Cdd:cd23251   170 QTVVYPDKIVNALFGPIFKEINERILSALDPHVVFNTRMTAEELNETVEFLDPDeeydALEIDFSKFDKSKTSLHIRAVI 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 522 EILNLLGCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFDRMLFSGDDSLA 601
Cdd:cd23251   250 ELYKLFGLDGMLAFLWEKSQCQTTVKDRQNGIKAYLLYQQKSGNCDTYGSNTWSAALALLSMLPLEKAIFMIFGGDDSLI 329
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329660232 602 F-----SLNPIEGKSdwfTSLFNMEAKNMDPPTPYICSKFLLTDELGNTFsVPDPLRELQRLGTKKIPDGGL 668
Cdd:cd23251   330 LfpkglVIPDPCRRL---ASLWNFECKLFKFKYGYFCGKFLLKHGDGYIF-YPDPLKLITKLGRKDIKDGEH 397
Kitaviridae_RdRp cd23254
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of ...
422-659 1.74e-53

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus leprosis virus C2 (genus Cilevirus); and Hibiscus green spot virus 2 (genus Higrevirus). Although related, there are considerable physical and genetic distinctions between members of the different genera. For example, cile- and higreviruses are associated with a bacilliform virion, whereas a spherical virion has been observed for the lone blunervirus for which microscopy has been reported. Moreover, the replication-associated polyproteins are encoded by a single genomic RNA for cile- and higreviruses, but are split between two genomic RNAs for blunerviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438104  Cd Length: 267  Bit Score: 186.59  E-value: 1.74e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 422 YEHMVKSDVKPVVaDTLNVDR-PVPATITFHAKGITSQFSPLFISLFERFQRCLRGRVVVpVGKISSLEMDKfsVLN--- 497
Cdd:cd23254     3 YSFMIKRNPKPNL-TVDAAYKyPALQTIAYHDKDINAIFCPIFRELKKRLLAVLKPNFVI-FTDMSPEDFEE--LLNrrf 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 498 --------KHCLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTY 569
Cdd:cd23254    79 ppevlsklLHKLEIDISKYDKSQGELALLFECKLMRRFGVPEELVELWFNAHVLTTLYDRTNKLKALVEYQRKSGDASTF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 570 FGNTLVTMALFSWCYDTDQFDRMLFSGDDSLAFSLNPIEGK-SDWFTSLFNMEAKNMDPPTPYICSKFLLTDELGNTFsV 648
Cdd:cd23254   159 FGNTLFLMAVLADLFDLSDLELALFSGDDSLLFGRNLLDYDdSQHFALKFNLESKFLNYKYPYFCSKFLLPVGGRWYF-V 237
                         250
                  ....*....|.
gi 2329660232 649 PDPLRELQRLG 659
Cdd:cd23254   238 PDPVKLLTKLG 248
ps-ssRNAv_Alsuviricetes_RdRp cd23182
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of ...
422-600 5.30e-19

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the class Alsuviricetes, phylum: Kitrinoviricota. Alsuviricetes is a class of [(+)ssRNA] viruses which infect eukaryotes. The name of the group is a syllabic abbreviation of "alpha supergroup" with the suffix -viricetes indicating a virus class. The class Alsuviricetes includes three orders: Hepelivirales, Martellivirales, and Tymovirales. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438032 [Multi-domain]  Cd Length: 187  Bit Score: 85.73  E-value: 5.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 422 YEHMVKSDVKPVVADTLNVDRPVpATITFHAKGITSQFSPLFISLFERFQRCLRgRVVVPVGKISSLEMDKFSVLNKHC- 500
Cdd:cd23182     3 IDFLIKTQQKVSPKTPFNTGKAG-QTIAAHSKSINFVLGPWIRYLEERLRDGSR-THRYSNGLMDEEEAMLSQWKINHVp 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 501 ----LEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVSKWWCDFHRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVT 576
Cdd:cd23182    81 hatfVSNDYTAFDKSHNGESLLLEAAIMRRIGTPAAAPNLFIELHGKRTLRAKVLGGSGELDGMRDSGAAWTYCRNTDYN 160
                         170       180
                  ....*....|....*....|....
gi 2329660232 577 MALFSWCYDTDQFDRmLFSGDDSL 600
Cdd:cd23182   161 LAVMLSLYRLKVKPA-AFSGDDSL 183
Endornaviridae_RdRp cd23255
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of ...
448-625 8.31e-15

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Endornaviridae, order Martellivirales. The family Endornaviridae includes viruses with linear (+)ssRNA genomes that range from 9.7 to 17.6 kb. The family consists of two genera, Alphaendornavirus and Betaendornavirus. Alphaendornavirus includes species whose members infect plants, fungi and oomycetes, while the genus Betaendornavirus includes species whose members infect ascomycete fungi. Plant endornaviruses are transmitted only through the gametes. A conserved RNA-dependent RNA polymerase domain located in the C-terminal region of the polyprotein is a feature common to all endornaviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438105  Cd Length: 237  Bit Score: 74.88  E-value: 8.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 448 ITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGkissLEMDKFSVL------NKHCLEIDLSKFDKsQGELHLM-IQ 520
Cdd:cd23255    61 IVWQRKGICAIFSPIFNEAKKRLKSLLKPKVVYADG----LTPDELSARlrlvknVKYFFEDDLSKQDR-QTDKPIIdVE 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 521 EEILNLLGCPVDVSKWWCDFHRYSYIkdKRAGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDT--DQFDRMLFSGDD 598
Cdd:cd23255   136 MELYKLLGVDPNVIELWREVHENWRF--KGKGVRGVGDAMRLTGQATTALGNVITNLLVHSRLVKRngSNLKLMLVLGDD 213
                         170       180       190
                  ....*....|....*....|....*....|
gi 2329660232 599 SLAFSlnpiegKSDWFTSLFNMEAK---NM 625
Cdd:cd23255   214 NLILT------DTKIDLENLRKEIAeyhNM 237
ps-ssRNAv_Hepelivirales_RdRp cd23209
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of ...
448-602 6.14e-12

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Hepelivirales, class Alsuviricetes. This Hepelivirales order consists of four families: Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438059 [Multi-domain]  Cd Length: 183  Bit Score: 65.20  E-value: 6.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 448 ITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSLEMDKF-SVLNKHCLEIDLSKFDKSQGELHLMIQEEILNL 526
Cdd:cd23209    28 ISAWSKELCFVFGPWFRALEKILRRALKPNVLYANGHEAEPFVDKInQAHSAVFIENDFTEFDSTQNLFSLLVELEILEA 107
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2329660232 527 LGCPVDVSKWWCDFhRYSYIKDKRaGVSMPISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFDRMLFSGDDSLAF 602
Cdd:cd23209   108 CGMPPALAELYRAL-RAKWTLQAR-EGSLEGTCKKTSGEPGTLLHNTIWNMAVMMHMVRGGVRKAAAFKGDDSVVC 181
Gammaflexiviridae_RdRp cd23249
RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense ...
437-633 1.88e-05

RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the RdRp of RNA viruses belonging to the family Gammaflexiviridae, order Tymovirales. Virions within the Gammaflexiviridae family are flexuous filaments of 720 nm modal length and about 13 nm in diameter. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438099  Cd Length: 354  Bit Score: 47.59  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 437 TLNVDRPVPATITFHAKGITSQFSPLFISLFERFQRCLRGRVVVPVGKISSlEMDKFSV----LNKHCLEIDLSKFDKSQ 512
Cdd:cd23249    87 KMGSDATAGQSIASFRAQVLLAWGPLARYLDRRIRALLPPHIYIHSGRTNE-DFERFVAahwdFTRESTEGDYTAFDASQ 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 513 GELHLMIQEEILNLLGCPVDVSKwwcdfhrySYIKDKRAGVSM--PISFQRRTGDAFTYFGNTLVTMALFSWCYDTDQFD 590
Cdd:cd23249   166 DADFLNFETLLMRALGVPLDLIE--------AYLEMKASITSHlgPLAIMRFSGEVWTYLFNTLGNMAYTAAKYEVPPPV 237
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2329660232 591 RMLFSGDDSLAFSLNPIEGKSDWFTSLFNMEAKNMDPPTPYIC 633
Cdd:cd23249   238 PRVYGGDDKSINSRITVRPGWSQLVGQFNLVEKPVVTYEPTFC 280
Togaviridae_RdRp cd23250
RNA-dependent RNA polymerase (RdRp) in the family Togaviridae of positive-sense ...
499-670 3.41e-04

RNA-dependent RNA polymerase (RdRp) in the family Togaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Togaviridae, order Martellivirales. Togaviridae is a family of small, enveloped viruses with [(+)ssRNA] genomes of 10-12 kb, and contains a single genus, Alphavirus. Alphavirus includes a large number of species that are mostly mosquito-borne and pathogenic in their vertebrate hosts. Many are important human and veterinary pathogens (e.g., chikungunya virus, eastern equine encephalitis virus). The genus Alphavirus mainly consists of mosquito-borne viruses although other hematophagous insects, including ticks, lice, and cliff swallow bugs, have been implicated in transmission. Vertebrate hosts include humans, non-human primates, equids, birds, amphibians, reptiles, rodents, and pigs. There are two aquatic alphaviruses, southern elephant seal virus and salmon pancreas disease virus, infecting sea mammals and fish respectively. Interestingly, Eilat virus (EILV) has been shown to only infect insect cells and is incapable of replicating in vertebrate cells. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438100  Cd Length: 458  Bit Score: 43.99  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 499 HCLEIDLSKFDKSQGE----LHLMIQE------EILNLLGCPV-DVSKwwcdFHRYSYIKDKrAGVSMpisfqrRTGDAF 567
Cdd:cd23250   216 KVLETDIASFDKSQDDamalTALMILEdlgvdqELLDLIEAAFgEITS----VHLPTGTRFK-FGAMM------KSGMFL 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 568 TYFGNTLVTMALFSwcydtdqfdRML-----------FSGDDSLAFSLNPIEGKSDWFTSLFNMEAKNMD----PPTPYI 632
Cdd:cd23250   285 TLFVNTVLNIVIAS---------RVLrerltnsrcaaFIGDDNIVHGVVSDKLMADRCATWLNMEVKIIDavigEKPPYF 355
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2329660232 633 CSKFLLTDELGNTFS-VPDPLRELQRLGTKKIPDGGLDE 670
Cdd:cd23250   356 CGGFILYDSVTGTACrVADPLKRLFKLGKPLPADDEQDE 394
ps-ssRNA_RdRp_Tymovirales cd23207
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of ...
500-601 1.00e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Tymovirales. The Tymovirales order contains viruses that mostly infect plants, have a single molecule of (+)ssRNA, and which are united by the similarities in their replication-associated polyproteins. Tymovirales contains five families (Alpha-, Beta-, Delta- and Gammaflexiviridae and Tymoviridae) and groups mostly plant-infecting agents, although a few Tymovirales members have either fungal or insect hosts. Botrytis virus F (BVF), isolated from the fungus Botrytis cinerea, is a flexuous mycovirus that is typical of members of the genus Mycoflexivirus (family Gammaflexiviridae). The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438057 [Multi-domain]  Cd Length: 188  Bit Score: 41.23  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 500 CLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVSKwwcdfhRYSYIKDKRAGVSMPISFQRRTGDAFTYFGNTLVTMAL 579
Cdd:cd23207    90 STANDYTAFDQSQDGEFVVFEVLLMRHLHIPDDLIE------LYVDIKTNAYSHLGPLSIMRLTGEPGTFDFNTDYNLAL 163
                          90       100
                  ....*....|....*....|..
gi 2329660232 580 FSWCYDTDQFDRMLFSGDDSLA 601
Cdd:cd23207   164 TYAKYDLPPGTPICFSGDDSVA 185
Betaflexiviridae_RdRp cd23245
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Betaflexiviridae of ...
489-623 4.04e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Betaflexiviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Betaflexiviridae, order Tymovirales. Virions within the Betaflexiviridae family are flexuous filaments, usually 12#13 nm in diameter (range 10#15 nm) and from 600 to over 1000 nm in length, depending on the genus. They infect plants which share a distinct lineage of alphavirus-like replication proteins. There are 108 species in the family Betaflexiviridae, assigned to 13 genera in two subfamilies (Quinvirinae and Trivirinae). Diseases associated with this family include: mosaic and ringspot symptoms. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides..


Pssm-ID: 438095  Cd Length: 318  Bit Score: 40.13  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329660232 489 EMDKFSVLNKH---CLEIDLSKFDKSQGELHLMIQEEILNLLGCPVDVskwwcdFHRYSYIKDK---RAGvSMPIsfQRR 562
Cdd:cd23245   123 DLNEWVKKYFFdgvCTESDYEAFDASQDHYILAFEVELMKYLGLPEDL------IEDYKFLKTHlgcKLG-NFAI--MRF 193
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329660232 563 TGDAFTYFGNTLVTMaLFSWC-YDTDQFDRMLFSGDDSLAFSLNPIEGKSDWFTSLFNMEAK 623
Cdd:cd23245   194 TGEFSTFLFNTLANM-LFTFLrYDINGDEPICFAGDDMCANGRLRVSKEFESFLDKLKLKAK 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH