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Conserved domains on  [gi|2438000147|gb|WCH07123|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Poecilimon marmaraensis]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-307 9.27e-68

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 214.69  E-value: 9.27e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLvkqNLFLILI 80
Cdd:MTH00160   17 GTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFN---NISSMLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNtFITLVIISSIIIGSLGGLNQTSLRKLMA 160
Cdd:MTH00160   94 NSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 161 YSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGF 239
Cdd:MTH00160  173 YSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGF 252

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2438000147 240 LPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVKWIEIMPYSFTIYSILMILT 307
Cdd:MTH00160  253 LPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-307 9.27e-68

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 214.69  E-value: 9.27e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLvkqNLFLILI 80
Cdd:MTH00160   17 GTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFN---NISSMLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNtFITLVIISSIIIGSLGGLNQTSLRKLMA 160
Cdd:MTH00160   94 NSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 161 YSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGF 239
Cdd:MTH00160  173 YSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGF 252

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2438000147 240 LPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVKWIEIMPYSFTIYSILMILT 307
Cdd:MTH00160  253 LPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 8-265 3.85e-26

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 104.70  E-value: 3.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   8 STSWFGAWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVILMHL----NDMTLLVK---------- 72
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtLSFDELSKaltgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLIL-MTWQKIAPFMLI-------SYVITMNTFITLVIISSIII 144
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 145 GSLGGLNQTSLRKLMAYSSINHLGWMMAALTAGENM----WLLYFSIYTFLSTSIVFLFQSFQL------YHINQNFLIN 214
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYrrvhtrNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2438000147 215 LNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITT 265
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 1-307 1.73e-15

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 76.69  E-value: 1.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPL-MTNTKNTLSTEASLKYFLIQALASSILLFSVIL-------MHLNDMTLLVK 72
Cdd:COG1007   114 GMMLMASANDLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatgsLNLAGIAAALA 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSSLLL--------KMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLIsYVITMNTFITLVIISSIII 144
Cdd:COG1007   194 AGGANSPLLLLGLVlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAAL-LRLLVEAFPGLAADWQLLL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 145 GSLGGL----------NQTSLRKLMAYSSINHLGWMMAALTAGENMW----LLYFSIYTFLSTSiVFLF------QSFQL 204
Cdd:COG1007   273 AVLAVLsmtvgnlaalAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLG-AFAVilllsrKGGEA 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 205 YHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFS 283
Cdd:COG1007   352 EEIEDlAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDE 431

                         330       340
                  ....*....|....*....|....
gi 2438000147 284 YQEVKWIEIMPYSFTIYSILMILT 307
Cdd:COG1007   432 PEEEAPISAPPGLRVALVIAALLV 455
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-307 8.26e-15

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 74.60  E-value: 8.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVILM-------HLNDMTLLVK 72
Cdd:TIGR01770 114 GIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgslNFEDLLLFLS 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSS--------LLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIA---PFMLISYVITMNTFITLVIISS 141
Cdd:TIGR01770 194 NGMLNISLLLLgivlilvgLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGFSEAWQIFLA 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 142 IIIGSLGGLN------QTSLRKLMAYSSINHLGWMMAALTAGENM----WLLYFSIYTFLSTSIVFLFQSFQLYHINQNF 211
Cdd:TIGR01770 274 IIAFLSMLIGnfgalaQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYKDEWIE 353

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 212 -------LINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLfsY 284
Cdd:TIGR01770 354 yisdfagLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYF--D 431

                         330       340
                  ....*....|....*....|...
gi 2438000147 285 QEVKWIEIMPYSFTIYSILMILT 307
Cdd:TIGR01770 432 KPERRIPSNPQSKAQSLLLSISA 454
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-307 9.27e-68

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 214.69  E-value: 9.27e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLvkqNLFLILI 80
Cdd:MTH00160   17 GTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFN---NISSMLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNtFITLVIISSIIIGSLGGLNQTSLRKLMA 160
Cdd:MTH00160   94 NSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 161 YSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGF 239
Cdd:MTH00160  173 YSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGF 252

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2438000147 240 LPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVKWIEIMPYSFTIYSILMILT 307
Cdd:MTH00160  253 LPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-281 1.80e-51

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 173.11  E-value: 1.80e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVI--LMHLNDMTLLVKQNLFLI 78
Cdd:MTH00105   16 GTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIinLMYSGQWTITKLTNPTAS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  79 LISSS-LLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFML---ISYVITMNTfITLVIISSIIIGSLGGLNQTS 154
Cdd:MTH00105   96 TLMTIaLAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIlyqISPSINPNL-LLTLAILSILIGGWGGLNQTQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 155 LRKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQ-NFLINLNPSLKFCLFFLLLSLGGL 233
Cdd:MTH00105  175 LRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSlSHTWNKTPLMTSLILLTLLSLGGL 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2438000147 234 PPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:MTH00105  255 PPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSL 302
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-278 2.97e-50

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 169.72  E-value: 2.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIL--MHLNDMTLLVKQNLFLI 78
Cdd:MTH00070   16 GTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTInaWFTGEWTIMNMQTPLPT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  79 LISSS-LLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLIsyvITMNTFITLVIISSIIIGSLGG-----LNQ 152
Cdd:MTH00070   96 IMLTIaLMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALL---IQISHLLNSNLLIIMGLLSTLIggwggLNQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 153 TSLRKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLINL-NPSLKFCLFFLLLSLG 231
Cdd:MTH00070  173 TQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSkNPTLTSMMMLTLLSLG 252

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2438000147 232 GLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFA 278
Cdd:MTH00070  253 GLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYA 299
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-277 4.86e-50

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 169.23  E-value: 4.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLN----DMTLLvKQNLF 76
Cdd:MTH00112   16 GTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNtgqwDITQL-TNPTS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  77 LILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLIsyVITMNTFITLVIISSIIIGSLG----GLNQ 152
Cdd:MTH00112   95 CTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLL--LMTSNSLNPTLLLTLAILSTLIggwgGLNQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 153 TSLRKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLI-NLNPSLKFCLFFLLLSLG 231
Cdd:MTH00112  173 TQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSwTKSPTLNTTLMLTLLSLA 252

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2438000147 232 GLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTF 277
Cdd:MTH00112  253 GLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTY 298
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-311 5.43e-49

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 166.64  E-value: 5.43e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLVKQNLFLILI 80
Cdd:MTH00041   16 GTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWSINGPLNTLSS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLL---LKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSIIIGS--LGGLNQTSL 155
Cdd:MTH00041   96 IIITLalaLKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGILSVLVggWGGLNQTQT 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 156 RKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHI-NQNFLINLNPSLKFCLFFLLLSLGGLP 234
Cdd:MTH00041  176 RKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLsHLNKLSQLNPISAFLFILSILSLGGLP 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2438000147 235 PFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVKWIEIMPYSFTIYSILMILTTISS 311
Cdd:MTH00041  256 PLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGNITVYGVILSILS 332
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-288 6.43e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 163.13  E-value: 6.43e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLVkqnlfLILI 80
Cdd:MTH00144   16 GTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS-----MSLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSIIIGSL---GGLNQTSLRK 157
Cdd:MTH00144   91 LLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLSALVgsiGGLNQTQVRA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 158 LMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLINLNPSLKFCLFFLLLSLGGLPPFM 237
Cdd:MTH00144  171 LLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLLLSLGGLPPFL 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2438000147 238 GFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVK 288
Cdd:MTH00144  251 GFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKK 301
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-281 6.21e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 153.42  E-value: 6.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIL-------MHLNDMTllvkQ 73
Cdd:MTH00135   16 GTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTnawltgqWDIQQMS----H 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  74 NLFLILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMN-TFITLVIISSIIIGSLGGLNQ 152
Cdd:MTH00135   92 PLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNpTLLITLGLTSTLVGGWGGLNQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 153 TSLRKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINqnfliNL------NPSLKFCLFFL 226
Cdd:MTH00135  172 TQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKIN-----TLatswtkAPALTALTPLI 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2438000147 227 LLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:MTH00135  247 LLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTL 301
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-283 4.53e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 150.89  E-value: 4.53e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNDMTLLVKQ---NLFL 77
Cdd:MTH00200   16 GTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISEmlgPLSE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  78 ILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITM--NTFITLVIISSIIIGSLGGLNQTSL 155
Cdd:MTH00200   96 TLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPAlnSNILLLLGLLSVLVGGWGGLNQTQL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 156 RKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQ-NFLINLNPSLKFCLFFLLLSLGGLP 234
Cdd:MTH00200  176 RKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSlSSSKTKNPILSMLLGLTLLSLGGLP 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2438000147 235 PFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFS 283
Cdd:MTH00200  256 PLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTL 304
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-283 6.17e-43

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 150.32  E-value: 6.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHlndMTLLVKQNLFLILI 80
Cdd:MTH00011   18 GTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMW---SFPSLLKNITALML 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMN--TFITLVIISSIIIGSLGGLNQTSLRKL 158
Cdd:MTH00011   95 LVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNilPMMTSMAAMSALAGGLGGMNQTQLRPL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 159 MAYSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFM 237
Cdd:MTH00011  175 LAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKIsSMSQTTSMSLFIMLLSLGGLPPFT 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2438000147 238 GFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFS 283
Cdd:MTH00011  255 GFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLS 300
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-305 4.78e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 147.90  E-value: 4.78e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLNdmtlLVKQNLFLILI 80
Cdd:MTH00197   10 GVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSN----LYLSLLSVVLV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  81 SSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSIIIGSLGGLNQTSLRKLMA 160
Cdd:MTH00197   86 ILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQSNIRQLLA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 161 YSSINHLGWMMAALTAGENMWLLYFSIYTFLSTSIVFLFQSFQLYHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGF 239
Cdd:MTH00197  166 YSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQqYSNPESMSSNLVFLGLSFLSLGGLPPLSGF 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2438000147 240 LPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFSYQEVKWIEIMPYSFTIYSILMI 305
Cdd:MTH00197  246 FLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLM 311
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 8-265 3.85e-26

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 104.70  E-value: 3.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   8 STSWFGAWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVILMHL----NDMTLLVK---------- 72
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNytgtLSFDELSKaltgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLIL-MTWQKIAPFMLI-------SYVITMNTFITLVIISSIII 144
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 145 GSLGGLNQTSLRKLMAYSSINHLGWMMAALTAGENM----WLLYFSIYTFLSTSIVFLFQSFQL------YHINQNFLIN 214
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYrrvhtrNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2438000147 215 LNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITT 265
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 1-275 1.41e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 82.00  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTL-STEASLKYFLIQALASSILLFSVILM-------HLN--DMTLL 70
Cdd:MTH00196    5 GILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGySAEAGLKYFVLGALSSGLFLFGCALLcgttgglHLSyiNLVLN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  71 VKQNLFLILISSSLLL-------KMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSII 143
Cdd:MTH00196   85 SGQSFSSVSVPIGYLLiivallfKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSLF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 144 IGSLGGLNQTSLRKLMAYSSINHLGWMMAALTAGE----NMWLLYFSIYTFLStsiVFLFQSFQLYHINQNFLINL---- 215
Cdd:MTH00196  165 VGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMS---ICVFSIILALNVYKNLIIEFsgls 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2438000147 216 --NPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRL 275
Cdd:MTH00196  242 rrLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 1-275 1.03e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 80.06  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTL-STEASLKYFLIQALASSILLFSVILMH-------LNDMTLLVK 72
Cdd:MTH00199  109 GSLLLVSSINWLSIYLAIELQTLTLFILVALKRDSAySTEAGLKYFVLGAVSSGLFLFGCALLYgltgetsIQGINSILT 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSIIIGSLGGLNQ 152
Cdd:MTH00199  189 GDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIGALNQ 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 153 TSLRKLMAYSSINHLGWMMAALTAGEN----MWLLYFSIYTFLSTSIVFLFQSFQLyhiNQNFLINL------NPSLKFC 222
Cdd:MTH00199  269 TKIKRLLAYSGIGHMGFILFGVAIGSFesiqASLIYMIIYVIMSICSFSIILSLKL---TKGLIVEVsglsrkNPVIALT 345

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2438000147 223 LFFLLLSLGGLPPFMGFLPKWLIIQALVdMNNLFLITVM-VITTLLTLFYYLRL 275
Cdd:MTH00199  346 LALTFLSIAGIPPLAGFLSKWLILLSGV-SSGYYLICIIaVLSSVIAGVYYVRV 398
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 1-307 1.73e-15

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 76.69  E-value: 1.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPL-MTNTKNTLSTEASLKYFLIQALASSILLFSVIL-------MHLNDMTLLVK 72
Cdd:COG1007   114 GMMLMASANDLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLlygatgsLNLAGIAAALA 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSSLLL--------KMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLIsYVITMNTFITLVIISSIII 144
Cdd:COG1007   194 AGGANSPLLLLGLVlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAAL-LRLLVEAFPGLAADWQLLL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 145 GSLGGL----------NQTSLRKLMAYSSINHLGWMMAALTAGENMW----LLYFSIYTFLSTSiVFLF------QSFQL 204
Cdd:COG1007   273 AVLAVLsmtvgnlaalAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLG-AFAVilllsrKGGEA 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 205 YHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLFS 283
Cdd:COG1007   352 EEIEDlAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYFDE 431

                         330       340
                  ....*....|....*....|....
gi 2438000147 284 YQEVKWIEIMPYSFTIYSILMILT 307
Cdd:COG1007   432 PEEEAPISAPPGLRVALVIAALLV 455
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 1-307 8.26e-15

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 74.60  E-value: 8.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVILM-------HLNDMTLLVK 72
Cdd:TIGR01770 114 GIFLLVSSNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgslNFEDLLLFLS 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSS--------LLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIA---PFMLISYVITMNTFITLVIISS 141
Cdd:TIGR01770 194 NGMLNISLLLLgivlilvgLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGFSEAWQIFLA 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 142 IIIGSLGGLN------QTSLRKLMAYSSINHLGWMMAALTAGENM----WLLYFSIYTFLSTSIVFLFQSFQLYHINQNF 211
Cdd:TIGR01770 274 IIAFLSMLIGnfgalaQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYKDEWIE 353

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 212 -------LINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFLfsY 284
Cdd:TIGR01770 354 yisdfagLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYF--D 431

                         330       340
                  ....*....|....*....|...
gi 2438000147 285 QEVKWIEIMPYSFTIYSILMILT 307
Cdd:TIGR01770 432 KPERRIPSNPQSKAQSLLLSISA 454
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
1-281 7.59e-14

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 71.78  E-value: 7.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEI-NLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIL-------MHLNDMTLLVK 72
Cdd:PRK05777  115 GMMVMVSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLlygatgsLSFAGIAKALA 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  73 QNLFLILISSS--------LLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLI---------SYVITMNTFIT 135
Cdd:PRK05777  195 DGSGNSLLLLFglvfllvgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafgGLSEDWQQVLA 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 136 LVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWMMAALTAGENM----WLLYFSIYTFLST---SIVFL-----FQSFQ 203
Cdd:PRK05777  275 IIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLgafGVISLlrrkgGEAES 354

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2438000147 204 LYHINQnfLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:PRK05777  355 ISDFAG--LSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVIKLMYF 430
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 15-275 5.49e-08

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 53.61  E-value: 5.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  15 WMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLN----DMTLLVKQNLFLILISSSLLL---- 86
Cdd:COG0651   133 FVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGAtgtlNMADLAARLAELDPGLLLAAFalll 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  87 -----KMGAAPFHFWFPGTM-EGLSWMNCLI--LMTwqKIAPFMLISYVITMNTFITLVIISSIIIGS---------LGG 149
Cdd:COG0651   213 vgfgiKAALFPLHFWLPDAYpAAPSPVSALLsgLLT--KVGVYAILRVLTLLFGADPALFLGTLLLVLglltmlvgaLGA 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 150 LNQTSLRKLMAYSSINHLGWMMAAL---TAGENMWLLYFSIYTFLSTSIVFL--------FQSFQLYHINQnfLINLNPS 218
Cdd:COG0651   291 LAQRDLKRLLAYSSVSQIGYILLGLglgTPLGLAGALFHLLNHALAKALLFLaagaieraTGTRDLDKLGG--LGKRMPL 368

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2438000147 219 LKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRL 275
Cdd:COG0651   369 TAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 1-275 4.92e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 51.01  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147   1 GTLISISSTSWFGAWMGLEINLLSFIPLMTNTKNTLST---------EASLKYFLIQALASSILLF-------------- 57
Cdd:MTH00198  200 GGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFgcalyfgftgnegm 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  58 --SVILMHLNDMTLLVKQNLF-LILISSSLLLKMGAAPFHFWFPGTMEGLSWMNCLILMTWQKIAPFMLISYVITMNTFI 134
Cdd:MTH00198  280 lgTILSATLETTNIELRQGSLgYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKLL 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 135 TLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWMMAALTAGENMWLLyfSIYTFLSTSIVFLFQSFQLYHINQNF--- 211
Cdd:MTH00198  360 LSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQ--ASWTYAVTYLVSALASFTVICTLEEFgtr 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 212 -------------------LINL------NPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALV------DMNNLFLITV 260
Cdd:MTH00198  438 tptsrqrdgsfgnynlvrrLVDLtilsrgQPYIAFSLAIVFLSLAGIPPLLGFLGKWFILVGSIkiafssSLSIYYLVAL 517

                         330
                  ....*....|....*.
gi 2438000147 261 M-VITTLLTLFYYLRL 275
Cdd:MTH00198  518 FaIICTCISAFYYIRI 533
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 18-280 1.34e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 49.49  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  18 LEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVILMHLN----DMTLLVKQ-------NLFLILISSSLLL 86
Cdd:PRK08375  135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVtgtlNMADLAGAlaenptvVTAFGFVLLALAL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  87 KMGAAPFHFWFPGTM-EGLSWMNCLILMTWQKIAPFMLISYVITMNTFITLVIISSIIIGSLGGL-----------NQTS 154
Cdd:PRK08375  215 KAAVFPLHTWLPRAYpAAPPVVTALLSGLVTKVAVYALIRIYFTVFGGDFRFALGLGWLLAVLALlsmlvgslaalGQDD 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 155 LRKLMAYSSINHLGWMM--------AALTAGenmwLLY------FSIYTFLST-SIVFLFQSFQLYHINQnfLINLNPSL 219
Cdd:PRK08375  295 VKRVLAYSTVSQMGYILlglalltpLALAAG----LLHllhhalMKGALFLAAgAIEVTYGTRRLSELSG--LGRRMPLT 368

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2438000147 220 KFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAF 280
Cdd:PRK08375  369 AAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYRAF 429
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 39-281 2.36e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 45.86  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  39 EASLKYFLIQALASSILLFSVIL----------------MHLNdMTLLVKqnLFLILISSSLLLKMGAAPFHFWFP-GTM 101
Cdd:PRK08376  172 EAGIKYMFVGSLASSMVLLGIALlygqygtlnmaylavkMSEN-PTVVAK--IALALFIAGLAMKSGAVPVHMWLPdAYP 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 102 EGLSWMNCLILMTWQ----KIAPFMLISYVITMNTFITLVIISSIIIGSLGGLN-----QTSLRKLMAYSSINHLGWMMA 172
Cdd:PRK08376  249 AAPSSISAMLLVIKQaglyALARVLFSIYGPAINLATVGWVIIILGCLTMFVGVamavvQKDVKRLLAYHSVSQIGYMLL 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 173 ALTAGenmwllYFSIYTFLSTSIVFLFQSFQLYHINQN-------FLI-----------NLN---------PSLKFCLFF 225
Cdd:PRK08376  329 GLGVG------LAALGDPAMASYGEIALAGGIYHIVNHalykallFLTagaviyetgtrNLNelgglartmPKTTIAFLI 402

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2438000147 226 LLLSLGGLPPFMGFLPKWLIIQAlVDMNNLFLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:PRK08376  403 GAAAIVGLPPFNGFASKWLIYES-SALFNPILGVIAMIGSVLTLASFVKVFHTAFF 457
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 152-281 1.00e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 43.81  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 152 QTSLRKLMAYSSINHLGWMMAALTAGENMWLLYFSIYTF---LSTSIVFLFQSFQLYHINQN------FLINLNPSLKFC 222
Cdd:PRK12667  316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIInhaIAKSLLFLASGVFIHAAGTRdidelaGLGRKMPIASFA 395

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2438000147 223 LFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:PRK12667  396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYSLFF 454
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
152-307 4.58e-04

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 41.47  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 152 QTSLRKLMAYSSINHLGWMMAALTAGEN----------------MWLLYFsiytfLSTSIVFLFQSFQLYHINQnfLINL 215
Cdd:PRK12663  293 YKDIRRIAGYQVISSIGFILLGLALGTPagingaifylvhdmvvKTALFL-----IAGSLVRLTGYRSLQYLGG--LYRK 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 216 NPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQALVDMNNLFLITVMVITTLLTLFYYLRLTFAAFlFSYQEVKWIEIMPY 295
Cdd:PRK12663  366 EPLFGALFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRIFFLAY-WGDKDGEEVNFKPI 444

                         170
                  ....*....|..
gi 2438000147 296 SFTIYSILMILT 307
Cdd:PRK12663  445 PLYRKLPLSILA 456
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 234-281 1.18e-03

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 40.52  E-value: 1.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2438000147 234 PPFMGFLPKWLIIQALVDMNNL--FLITVMVITTLLTLFYYLRLTFAAFL 281
Cdd:COG1009   384 PPFAGFFSKEAILEAALEAGGLgpLLLAVALLGAFLTAFYSFRLFFLVFF 433
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
37-191 4.33e-03

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 38.49  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147  37 STEASLKYFLIQALASSILLFSVILM--------HLNDMTLLVKQNLFLILISSSLLL------KMGAAPFHFWFPGTME 102
Cdd:PRK02504  159 SNEAALKYLLIGAASSAIFLYGSSLLyglsggstQLSAIALALITSPSLGLALALVFViagiafKISAVPFHQWTPDVYE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2438000147 103 GLSWMNCLILMTWQKIAPFML-ISYVITM--------NTFITLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWMMAA 173
Cdd:PRK02504  239 GSPTPVVAFLSVGSKAAGFALaIRLLVTAfpsfdeqwKLLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVMIG 318

                         170       180
                  ....*....|....*....|..
gi 2438000147 174 LTAGEN----MWLLYFSIYTFL 191
Cdd:PRK02504  319 LVAGTEagyaSMVFYLLAYLFM 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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