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Conserved domains on  [gi|2443271263|gb|WCZ56008|]
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MAG: M [Myotis bat alphacoronavirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 6-223 3.69e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


:

Pssm-ID: 394850  Cd Length: 218  Bit Score: 365.82  E-value: 3.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   6 NSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSIL 85
Cdd:cd21564     1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  86 MACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVN 165
Cdd:cd21564    81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2443271263 166 MLPTHVTVAKSYTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPSEVVTESER 223
Cdd:cd21564   161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
 
Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 6-223 3.69e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394850  Cd Length: 218  Bit Score: 365.82  E-value: 3.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   6 NSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSIL 85
Cdd:cd21564     1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  86 MACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVN 165
Cdd:cd21564    81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2443271263 166 MLPTHVTVAKSYTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPSEVVTESER 223
Cdd:cd21564   161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
CoV_M pfam01635
Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins ...
 15-222 9.98e-89

Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The membrane (M) protein is the most abundant structural protein and defines the shape of the viral envelope, being the central organizer of coronavirus assembly. M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many CoVs requires only the M and envelope (E) proteins for efficient virion assembly. Interaction of spike (S) with M is necessary for retention of S in the ER-Golgi intermediate compartment (ERGIC)/Golgi complex and its incorporation into new virions; binding of M to nucleocapsid (N) proteins stabilizes the nucleocapsid. Together, M and E protein make up the viral envelope and their interaction is sufficient for the production and release of virus-like particles (VLPs).


Pssm-ID: 460275  Cd Length: 208  Bit Score: 260.29  E-value: 9.98e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  15 EHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSILMACITAVLW 94
Cdd:pfam01635   1 SHLREWNFAWSIILTLLIVVLQYGYASRSRFLYVLKMILLWLLWPLTLALSIFNAVASYNVNYVYFGFSIIFAVVTFVLW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  95 LMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVNMLPTHVTVA 174
Cdd:pfam01635  81 LMYFVNSIRLYRRTGSWWSFNPETNALLCVSVLGRTVTRPLDEDPTGITLTLLSGTLYVEGQKLARGVSVESLPNYVTVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2443271263 175 KSYTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPSEVVTESE 222
Cdd:pfam01635 161 KPSTTIHYLKKGKSDNVGSNTGWAIYVRSKAGNYSLPSTTTGKLEESA 208
 
Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 6-223 3.69e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394850  Cd Length: 218  Bit Score: 365.82  E-value: 3.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   6 NSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSIL 85
Cdd:cd21564     1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  86 MACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVN 165
Cdd:cd21564    81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2443271263 166 MLPTHVTVAKSYTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPSEVVTESER 223
Cdd:cd21564   161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
CoV_M pfam01635
Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins ...
 15-222 9.98e-89

Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The membrane (M) protein is the most abundant structural protein and defines the shape of the viral envelope, being the central organizer of coronavirus assembly. M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many CoVs requires only the M and envelope (E) proteins for efficient virion assembly. Interaction of spike (S) with M is necessary for retention of S in the ER-Golgi intermediate compartment (ERGIC)/Golgi complex and its incorporation into new virions; binding of M to nucleocapsid (N) proteins stabilizes the nucleocapsid. Together, M and E protein make up the viral envelope and their interaction is sufficient for the production and release of virus-like particles (VLPs).


Pssm-ID: 460275  Cd Length: 208  Bit Score: 260.29  E-value: 9.98e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  15 EHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSILMACITAVLW 94
Cdd:pfam01635   1 SHLREWNFAWSIILTLLIVVLQYGYASRSRFLYVLKMILLWLLWPLTLALSIFNAVASYNVNYVYFGFSIIFAVVTFVLW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  95 LMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVNMLPTHVTVA 174
Cdd:pfam01635  81 LMYFVNSIRLYRRTGSWWSFNPETNALLCVSVLGRTVTRPLDEDPTGITLTLLSGTLYVEGQKLARGVSVESLPNYVTVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2443271263 175 KSYTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPSEVVTESE 222
Cdd:pfam01635 161 KPSTTIHYLKKGKSDNVGSNTGWAIYVRSKAGNYSLPSTTTGKLEESA 208
CoV_M cd21529
coronavirus Membrane (or Matrix) protein; This family contains the Membrane (M) protein of ...
 13-210 2.05e-59

coronavirus Membrane (or Matrix) protein; This family contains the Membrane (M) protein of coronaviruses (CoVs) including three highly pathogenic human CoVs such as Middle East respiratory syndrome (MERS)-related CoV, severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394849 [Multi-domain]  Cd Length: 198  Bit Score: 185.78  E-value: 2.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  13 VIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAWASFNVNWWFFAFSILMACITAV 92
Cdd:cd21529     1 SVSLLEWWNLVLIIILLALIAILQFGYATRSRMIYIIKLIVLWLLWPLTLAVTIWAAVYHGNSKDAVFIISIIMAVLTFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  93 LWLMYFINSFKLYRRSQSWWSFNPETDALL-TCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVNMLPTHV 171
Cdd:cd21529    81 MWLKYWIDSFRLFMRTRSAWSFNPESNALAgIMDPMGQWRCIPIDHMPPVISPVIKHGVLYLHGQELATGVSVHSLPKGI 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2443271263 172 TVAKSYTTIVYQRVGRSVnSASSTGWAFYVKSKNGDYSA 210
Cdd:cd21529   161 TVATPSTTFIYTLVKRIE-STNDRGFAVYIYVKHGASNA 198
betaCoV_M cd21565
betacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein ...
 13-208 1.33e-42

betacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of betacoronaviruses including the M proteins from three highly pathogenic human coronaviruses (CoVs) such as Middle East respiratory syndrome (MERS)-related CoV, severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394851  Cd Length: 208  Bit Score: 142.91  E-value: 1.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  13 VIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAwaSFNVNWWFFAFSILMACITAV 92
Cdd:cd21565     1 IIAIIKDWNFAWSIIFLLITIVLQYGYPSRSMTVYVIKMFVLWLLWPLSIALSVFAA--VYPINLVSQGISGIFAAISAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  93 LWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGiQVNMLPTHVT 172
Cdd:cd21565    79 MWLSYFVQSIRLFRRTGSWWSFNPETNCLLNVPIGGTTVVRPLVEDSTSITAVVTRGHLKMAGMHLGRC-DYDRLPNEVT 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2443271263 173 VAKSYTTIVYQRvGRSVNSASSTGWAFYVKSKNGDY 208
Cdd:cd21565   158 VAKPNVLIAYKM-VKRQRYGTNSGVAIYHRYKAGNY 192
HCoV-like_M cd21568
Membrane (or Matrix) protein from human coronavirus and related betacoronaviruses in the A ...
 11-213 5.57e-37

Membrane (or Matrix) protein from human coronavirus and related betacoronaviruses in the A lineage; This group contains the Membrane (M) protein of human coronaviruses (HCoVs), HCoV-OC43 and HCoV-HKU1, and similar proteins from betacoronaviruses in the embecovirus subgenera (A lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394854  Cd Length: 220  Bit Score: 129.14  E-value: 5.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  11 EEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAwaSFNVNWWFFAFSILMACIT 90
Cdd:cd21568    10 DEAIKFLKEWNFSLGIILLFITIILQFGYTSRSMFVYVIKMIILWLMWPLTIILTIFNC--VYALNNVYLGFSIVFTIVS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  91 AVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVNMLPTH 170
Cdd:cd21568    88 IIMWIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTMYVRPIIEDYHTLTATIIRGHLYIQGVKLGTGYSLSDLPAY 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2443271263 171 VTVAKSYTTIVYQRVGRSVNSASStGWAFYVKSKNGDYSAVSD 213
Cdd:cd21568   168 VTVAKVSHLCTYKRAFLDKIDDTS-GFAVYVKSKVGNYRLPSN 209
MERS-like-CoV_M cd21567
Membrane (or Matrix) protein from Middle East respiratory syndrome-related coronavirus and ...
 4-208 1.45e-35

Membrane (or Matrix) protein from Middle East respiratory syndrome-related coronavirus and related betacoronaviruses in the C lineage; This group contains the Membrane (M) protein of Middle East respiratory syndrome (MERS)-related CoV, bat-CoV HKU5, and similar proteins from betacoronaviruses in the merbecovirus subgenera (C lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394853  Cd Length: 216  Bit Score: 125.39  E-value: 1.45e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   4 SNNSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDawASFNVNWWFFAFS 83
Cdd:cd21567     1 SNMTLTTEQIIAIIKDWNFAWSIIFLLITIVLQYGYPSRSMTVYVFKMFVLWLLWPSSMALSIFS--AVYPIDLASQIIS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  84 ILMACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLngtllvDGYQVATGIQ 163
Cdd:cd21567    79 GILAAISAMMWISYFVQSIRLFMRTGSWWSFNPETNCLLNVPIGGTTVVRPLVEDSTSVTAVVT------NGYLKMAGMH 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2443271263 164 V-----NMLPTHVTVAKSYTTIVYQRVGRSvNSASSTGWAFYVKSKNGDY 208
Cdd:cd21567   153 FgacdyDRLPNEVTVAKPNVLIALKMVKRQ-SYGTNSGVAIYHRYKAGNY 201
batCoV_HKU9-like_M cd21570
Membrane (or Matrix) protein from bat coronavirus HKU9 and related betacoronaviruses in the D ...
 5-208 3.52e-32

Membrane (or Matrix) protein from bat coronavirus HKU9 and related betacoronaviruses in the D lineage; This group contains the Membrane (M) protein of Rousettus bat coronavirus HKU9, and similar proteins from betacoronaviruses in the nobecovirus subgenera (D lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394856  Cd Length: 217  Bit Score: 116.49  E-value: 3.52e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   5 NNSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDAwaSFNVNWWFFAFSI 84
Cdd:cd21570     1 NSTFSREEVFAAVKDWNFAVSVLLLFITILLQWGYPSRCKPLWVVKMFILWLLWPLSIAAAVFAA--VYPINKVAFGFAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  85 LMACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQV 164
Cdd:cd21570    79 AFACISGLMWLSYFISSFRLLCRTGSAWSFMPETNMLLNVPLLGRTVTRPILADSPAIQFLLLRGEIQFDGFKLGRCDPG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2443271263 165 NMlPTHVTVAKSYTTIVYQRvGRSVNSASSTGWAFYVKSKNGDY 208
Cdd:cd21570   159 EM-PDIVTVAKPASLHWYKK-ALTRNIGPKSAIIVYIKYKVGNH 200
SARS-like-CoV_M cd21569
Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, ...
 5-215 3.03e-31

Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, and related betacoronaviruses in the B lineage; This group contains the Membrane (M) protein of Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 (also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus), and related proteins from betacoronaviruses in the sarbecovirus subgenera (B lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394855  Cd Length: 218  Bit Score: 113.94  E-value: 3.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263   5 NNSVPVEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLAlsIFDAWASFNVNWWFFAFSI 84
Cdd:cd21569     1 NGTITVEELKQLLEQWNLVIGFLFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVTLA--CFVLAAVYRINWVTGGIAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  85 LMACITAVLWLMYFINSFKLYRRSQSWWSFNPETDALLTCSVMGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATgIQV 164
Cdd:cd21569    79 AMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLNVPLRGTILTRPLMESELVIGAVIIRGHLRMAGHSLGR-CDI 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2443271263 165 NMLPTHVTVAKSyTTIVYQRVGRSVNSASSTGWAFYVKSKNGDYSAVSDPS 215
Cdd:cd21569   158 KDLPKEITVATS-RTLSYYKLGASQRVGTDSGFAAYNRYRIGNYKLNTDHS 207
gammaCoV_M cd21566
gammacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 10-120 9.96e-19

gammacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of gammacoronavirus including avian infectious bronchitis virus (IBV). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394852  Cd Length: 212  Bit Score: 80.94  E-value: 9.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  10 VEEVIEHLRNWNFSWNVVLTTLLVVLQYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDawASFNVNWWFFAFSILMACI 89
Cdd:cd21566     5 TEQAVELFKEYNLFITAFLLFLTILLQYGYATRSRFIYILKMIVLWCFWPLNIAVGVIS--CIYPPNTGGLVAAIILTVF 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2443271263  90 TAVLWLMYFINSFKLYRRSQSWWSFNPETDA 120
Cdd:cd21566    83 ACLSFVGYWIQSIRLFKRCRSWWSFNPESNA 113
deltaCoV_M cd21594
deltacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 36-182 7.00e-13

deltacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of deltacoronaviruses including porcine deltacoronavirus and Bulbul coronavirus HKU11. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394857  Cd Length: 217  Bit Score: 65.16  E-value: 7.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263  36 QYGHYKYSRFLYGLKMAILWLLWPLVLALSIFDA-WASFNVNWWFFAFSILMACITAVLWLMYFINSFKLYRRSQSWWSF 114
Cdd:cd21594    24 QGGYATRNRMIYVIKLILLWLLQPFTLVVTIWTAvDNGSKKTDAVFIISIIFAVLTFVSWLKYWYDSIRLVMKTKSAWSF 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2443271263 115 NPETdALLTCSV--MGRSICIPVMGAPTGVTLTLLNGTLLVDGYQVATGIQVNMLPTHVTVAKSYTTIVY 182
Cdd:cd21594   104 SPES-RLLAGIMdpMGNWRCIPIDHMAPILTPVVKHGKLKLHGQELATGISVTSPPKDMVVVSPSDTFHY 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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