NCBI Conserved Domain Search

Conserved domains on [gi|2456538593|gb|WEI47392|]

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claudin-2, partial [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology: GO:0016020

PubMed: 19706201

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PMP22_Claudin super family

cl21598

PMP-22/EMP/MP20/Claudin family;

6-97

2.73e-06

PMP-22/EMP/MP20/Claudin family;

The actual alignment was detected with superfamily member pfam00822:

Pssm-ID: 473919 Cd Length: 162 Bit Score: 44.28 E-value: 2.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2456538593   6 ISSLACIISVVGMRCTVFCQESRAKDrvaVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSmKFEIGEALYLGII 85
Cdd:pfam00822  75 LSIILGIISLIVFFFQLFTMRKGGRF---KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR-KYSFGYSFILGWV 150

                          90
                  ....*....|..
gi 2456538593  86 SSLFSLIAGIIL 97
Cdd:pfam00822 151 AFALAFIGGVLY 162

Name

Accession

Description

Interval

E-value

PMP22_Claudin

pfam00822

PMP-22/EMP/MP20/Claudin family;

6-97

2.73e-06

PMP-22/EMP/MP20/Claudin family;

Pssm-ID: 395662 Cd Length: 162 Bit Score: 44.28 E-value: 2.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2456538593   6 ISSLACIISVVGMRCTVFCQESRAKDrvaVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSmKFEIGEALYLGII 85
Cdd:pfam00822  75 LSIILGIISLIVFFFQLFTMRKGGRF---KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR-KYSFGYSFILGWV 150

                          90
                  ....*....|..
gi 2456538593  86 SSLFSLIAGIIL 97
Cdd:pfam00822 151 AFALAFIGGVLY 162

Name

Accession

Description

Interval

E-value

PMP22_Claudin

pfam00822

PMP-22/EMP/MP20/Claudin family;

6-97

2.73e-06

PMP-22/EMP/MP20/Claudin family;

Pssm-ID: 395662 Cd Length: 162 Bit Score: 44.28 E-value: 2.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2456538593   6 ISSLACIISVVGMRCTVFCQESRAKDrvaVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSmKFEIGEALYLGII 85
Cdd:pfam00822  75 LSIILGIISLIVFFFQLFTMRKGGRF---KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR-KYSFGYSFILGWV 150

                          90
                  ....*....|..
gi 2456538593  86 SSLFSLIAGIIL 97
Cdd:pfam00822 151 AFALAFIGGVLY 162

Claudin_2

pfam13903

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...

11-97

2.64e-04

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.

Pssm-ID: 372799 [Multi-domain] Cd Length: 191 Bit Score: 38.94 E-value: 2.64e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2456538593  11 CIISVVGMRCTVFC---QESRAKDRVAVAGGVFFILGGLLGFIPVAWN------LHGILRDFYSPLVPDSMKFEIGEALY 81
Cdd:pfam13903  94 AILSLVLIVCGVVCgllALPKQSVFLLLAAGILFLLSGVLGLLGVIVFgqsvklVFEEYFRQWMPEHQNNVRISFGWSFA 173

                          90
                  ....*....|....*.
gi 2456538593  82 LGIISSLFSLIAGIIL 97
Cdd:pfam13903 174 LAWAGVVLSLLAGLLF 189

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01