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Conserved domains on  [gi|2458278134|gb|WEL32827|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Pentaspinula unispinula]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 1-89 5.56e-23

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.05  E-value: 5.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIR 80
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2458278134 81 SHGNDFFNS 89
Cdd:MTH00162  81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 1-89 5.56e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.05  E-value: 5.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIR 80
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2458278134 81 SHGNDFFNS 89
Cdd:MTH00162  81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-91 3.78e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 41.40  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  4 FFISLLIFMSGVYVFSSkRKHLMLVLLSLEYIVISLFLMIILYLLFFNNEL--YFVIIFMIMSVCEGVLGLSILVSMIRS 81
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLpqALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|
gi 2458278134 82 HGNDFFNSFS 91
Cdd:pfam00420 82 HGTDDVDSLN 91
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 1-89 5.56e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.05  E-value: 5.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIR 80
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2458278134 81 SHGNDFFNS 89
Cdd:MTH00162  81 SHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 4-95 2.90e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 57.29  E-value: 2.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  4 FFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIRSHG 83
Cdd:MTH00188   6 ILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSLIRSHG 85

                         90
                 ....*....|..
gi 2458278134 84 NDFFNSFSFSLC 95
Cdd:MTH00188  86 SDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-95 3.91e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 54.08  E-value: 3.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIR 80
Cdd:MTH00149   3 FMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIR 82

                         90
                 ....*....|....*
gi 2458278134 81 SHGNDFFNSFSFSLC 95
Cdd:MTH00149  83 LHGNDYVSSLSSLKF 97
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 2-95 1.40e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 47.53  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  2 LSFFISLLIFMSGvyvFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFV--IIFMIMSVCEGVLGLSILVSMI 79
Cdd:MTH00125   6 FSLYTAFMLSLLG---LSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPmpIILLTFSACEAGTGLALLVATT 82

                         90
                 ....*....|....*.
gi 2458278134 80 RSHGNDFFNSFSFSLC 95
Cdd:MTH00125  83 RTHGSDHLKNLNLLQC 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-95 6.71e-07

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 43.20  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNN-ELYFVIIFMIMSVCEGVLGLSILVSMI 79
Cdd:MTH00013   2 MSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQvNGMLAIVLLTFGACEASLGLSLLVLMT 81

                         90
                 ....*....|....*.
gi 2458278134 80 RSHGNDFFNSFSFSLC 95
Cdd:MTH00013  82 RSYGNDMLKSLTSNKC 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-91 3.78e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 41.40  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  4 FFISLLIFMSGVYVFSSkRKHLMLVLLSLEYIVISLFLMIILYLLFFNNEL--YFVIIFMIMSVCEGVLGLSILVSMIRS 81
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLpqALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|
gi 2458278134 82 HGNDFFNSFS 91
Cdd:pfam00420 82 HGTDDVDSLN 91
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-91 1.33e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 39.93  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  4 FFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLF--LMIILYLLFFNNELYFVIIFMIMSVCEGVLGLSILVSMIRS 81
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFllLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|
gi 2458278134 82 HGNDFFNSFS 91
Cdd:MTH00181  82 HGSDHLLKFN 91
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-85 4.31e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 38.82  E-value: 4.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFV--IIFMIMSVCEGVLGLSILVSM 78
Cdd:MTH00067   2 SPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSlpMFMLTFSACEASTGLALMVAT 81


                 ....*..
gi 2458278134 79 IRSHGND 85
Cdd:MTH00067  82 TRTHGTD 88
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-95 6.09e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 38.41  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134 11 FMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFV--IIFMIMSVCEGVLGLSILVSMIRSHGNDFFN 88
Cdd:MTH00126  12 FILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAapMLLLAFSACEASAGLALLVATARTHGTDRLQ 91


                 ....*..
gi 2458278134 89 SFSFSLC 95
Cdd:MTH00126  92 NLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-86 3.77e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 36.06  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLifmsGVYVFsskRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELYFV--IIFMIMSVCEGVLGLSILVSM 78
Cdd:MTH00107   9 MLAFTISLL----GLLMY---RSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMmpIILLVFAACEAAVGLALLVMV 81


                 ....*...
gi 2458278134 79 IRSHGNDF 86
Cdd:MTH00107  82 SNTYGTDY 89
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-91 4.70e-04

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 36.05  E-value: 4.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458278134  1 MLSFFISLLIFMSGVYVFSSKRKHLMLVLLSLEYIVISLFLMIILYLLFFNNELY--FVIIFMIMSVCEGVLGLSILVSM 78
Cdd:MTH00043   2 NIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNlsFSLLLLTLSACEASIGLSLMVLL 81

                         90
                 ....*....|...
gi 2458278134 79 IRSHGNDFFNSFS 91
Cdd:MTH00043  82 SRNHNSDLVASLN 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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