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Conserved domains on  [gi|2504469302|gb|WHE44938|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Sigaus australis]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-236 4.99e-63

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 199.66  E-value: 4.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKYSMgweSEIIPSMMISSSLLLKI 80
Cdd:MTH00160   25 NSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLML---FNNISSMLINSSLLLKL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  81 GAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLItISSIIIGALGGLNQTSLRQLLAYSSISHIG 160
Cdd:MTH00160  102 GAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIII-ILSAIIGAIGGLNQTSLRKILAYSSINHLG 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2504469302 161 WMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00160  181 WMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLGFLPKW 256
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-236 4.99e-63

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 199.66  E-value: 4.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKYSMgweSEIIPSMMISSSLLLKI 80
Cdd:MTH00160   25 NSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLML---FNNISSMLINSSLLLKL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  81 GAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLItISSIIIGALGGLNQTSLRQLLAYSSISHIG 160
Cdd:MTH00160  102 GAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIII-ILSAIIGAIGGLNQTSLRKILAYSSINHLG 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2504469302 161 WMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00160  181 WMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLGFLPKW 256
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-180 1.87e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 90.07  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSM-TNESSIKYFIVQAMASTMLLFSILMI-----------QMKYSMGWESEIIP 68
Cdd:pfam00361   2 NDLLLMYLGWEAVLLPSYLLIGYWGKSPrSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdeLSKALTGGLNSSGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  69 SM---MISSSLLLKIGAAPFHFWFPEVMSASSWINCLTL-MTWQKIAPMMIL-------SYCIQMSTFMFLITISSIIIG 137
Cdd:pfam00361  82 LLlflLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLLG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2504469302 138 ALGGLNQTSLRQLLAYSSISHIGWMISSLIISENIWELYFIIY 180
Cdd:pfam00361 162 SLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFH 204
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-167 5.67e-15

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 73.23  E-value: 5.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   8 MGLEINLLSFIPLLANNKNSMT-NESSIKYFIVQAMASTMLLFSILM------------IQMKYSMGWESE---IIPSMM 71
Cdd:COG1007   129 LGLELLSLSLYVLVAFRRDDRRsSEAALKYFLLGALSSGFLLYGISLlygatgslnlagIAAALAAGGANSpllLLGLVL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  72 ISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMIL---------SYCIQMSTFMFLITISSIIIGALGGL 142
Cdd:COG1007   209 VLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGLAADWQLLLAVLAVLSMTVGNLAAL 288

                         170       180
                  ....*....|....*....|....*
gi 2504469302 143 NQTSLRQLLAYSSISHIGWMISSLI 167
Cdd:COG1007   289 AQTNVKRMLAYSSIAHAGYLLLGLA 313
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 5-169 1.08e-11

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 63.81  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   5 GVWMGLEINLLSFIPLLANNKNS-MTNESSIKYFIVQAMASTMLLFSILMI----------QMKYSMGWESEIIPSM--- 70
Cdd:TIGR01770 126 SIYLGLELQSLCFYVLAGLKRKSrFSTEAGLKYFILGAFSSGLLLFGISLIygftgslnfeDLLLFLSNGMLNISLLllg 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  71 --MISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIA---PMMILSYCIQMS------TFMFLITISSIIIGAL 139
Cdd:TIGR01770 206 ivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGfseawqIFLAIIAFLSMLIGNF 285

                         170       180       190
                  ....*....|....*....|....*....|
gi 2504469302 140 GGLNQTSLRQLLAYSSISHIGWMISSLIIS 169
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYILIGLLAG 315
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-236 4.99e-63

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 199.66  E-value: 4.99e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKYSMgweSEIIPSMMISSSLLLKI 80
Cdd:MTH00160   25 NSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLML---FNNISSMLINSSLLLKL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  81 GAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLItISSIIIGALGGLNQTSLRQLLAYSSISHIG 160
Cdd:MTH00160  102 GAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIII-ILSAIIGAIGGLNQTSLRKILAYSSINHLG 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2504469302 161 WMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00160  181 WMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLSLGGLPPFLGFLPKW 256
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-180 1.96e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 157.29  E-value: 1.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSIlMIQMKYSMGWE----SEIIPSMMISSSL 76
Cdd:MTH00112   24 NHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSS-TTNAWNTGQWDitqlTNPTSCTLLTLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  77 LLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQM--STFMFLITISSIIIGALGGLNQTSLRQLLAYS 154
Cdd:MTH00112  103 AMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSlnPTLLLTLAILSTLIGGWGGLNQTQLRKIMAFS 182

                         170       180
                  ....*....|....*....|....*.
gi 2504469302 155 SISHIGWMISSLIISENIWELYFIIY 180
Cdd:MTH00112  183 SIAHLGWMIAIITYSPKLTLLTFYIY 208
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-180 7.81e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 150.38  E-value: 7.81e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSIlMIQMKYSMGW----ESEIIPSMMISSSL 76
Cdd:MTH00105   24 SHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAI-IINLMYSGQWtitkLTNPTASTLMTIAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  77 LLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMIL---SYCIQMsTFMFLITISSIIIGALGGLNQTSLRQLLAY 153
Cdd:MTH00105  103 AMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqiSPSINP-NLLLTLAILSILIGGWGGLNQTQLRKILAY 181

                         170       180
                  ....*....|....*....|....*..
gi 2504469302 154 SSISHIGWMISSLIISENIWELYFIIY 180
Cdd:MTH00105  182 SSIAHMGWMTAILPYNPTLTLLNLLIY 208
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-180 3.10e-43

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 148.93  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSIL---MIQMKYSMGWESEIIPSMMISSSLL 77
Cdd:MTH00041   24 NHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALiqaWLSGSWSINGPLNTLSSIIITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  78 LKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLIT--ISSIIIGALGGLNQTSLRQLLAYSS 155
Cdd:MTH00041  104 LKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILcgILSVLVGGWGGLNQTQTRKILAFSS 183

                         170       180
                  ....*....|....*....|....*
gi 2504469302 156 ISHIGWMISSLIISENIWELYFIIY 180
Cdd:MTH00041  184 IAHLGWIIITSAYSPNASIIMFLIY 208
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-236 3.95e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 145.83  E-value: 3.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSIlMIQMKYSMGWE----SEIIPSMMISSSL 76
Cdd:MTH00070   24 NHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSS-TINAWFTGEWTimnmQTPLPTIMLTIAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  77 LLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILsycIQMS-----TFMFLITISSIIIGALGGLNQTSLRQLL 151
Cdd:MTH00070  103 MMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALL---IQIShllnsNLLIIMGLLSTLIGGWGGLNQTQLRKIM 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302 152 AYSSISHIGWMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLG 231
Cdd:MTH00070  180 AYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLTLLSLGGLPPTTG 259


                  ....*
gi 2504469302 232 FMPKW 236
Cdd:MTH00070  260 FIPKW 264
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-236 1.52e-41

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 144.15  E-value: 1.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKYSMgweSEIIPSMMISSSLLLKI 80
Cdd:MTH00011   26 NNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSL---LKNITALMLLVSLMLKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  81 GAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYC--IQMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSSISH 158
Cdd:MTH00011  103 GMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFtsHNILPMMTSMAAMSALAGGLGGMNQTQLRPLLAYSSIGH 182

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2504469302 159 IGWMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00011  183 MGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSLGGLPPFTGFMPKL 260
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 3-195 1.15e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 142.25  E-value: 1.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   3 WFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLF-SILMIQMkySMGWE----SEIIPSMMISSSLL 77
Cdd:MTH00135   26 WLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFaSTTNAWL--TGQWDiqqmSHPLPTTMITLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  78 LKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMmILSYCIQMSTFMFLIT--ISSIIIGALGGLNQTSLRQLLAYSS 155
Cdd:MTH00135  104 LKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPF-ALILQIAPTNPTLLITlgLTSTLVGGWGGLNQTQLRKILAYSS 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2504469302 156 ISHIGWMISSLIISENIWELYFIIYSLLSLILVLLFKQSN 195
Cdd:MTH00135  183 IAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNS 222
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-236 5.65e-40

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 140.49  E-value: 5.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQM---KYSMGWESEIIPSMMISSSLL 77
Cdd:MTH00200   24 SHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWtsgQWGISEMLGPLSETLILLALA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  78 LKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILS--YCIQMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSS 155
Cdd:MTH00200  104 LKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLSVLVGGWGGLNQTQLRKILAYSS 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302 156 ISHIGWMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPK 235
Cdd:MTH00200  184 IAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLLGLTLLSLGGLPPLTGFFPK 263


                  .
gi 2504469302 236 W 236
Cdd:MTH00200  264 W 264
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-236 5.54e-39

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 137.11  E-value: 5.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKYSMgwesEIIPSMMISSSLLLKI 80
Cdd:MTH00197   18 SNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYL----SLLSVVLVILGLLLKL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  81 GAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSSISHIG 160
Cdd:MTH00197   94 GAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQSNIRQLLAYSSIGHTG 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2504469302 161 WMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFLSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00197  174 WMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLGGLPPLSGFFLKW 249
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-236 4.45e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 135.01  E-value: 4.45e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   2 SWFGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIqMKYSMGWESeiipSMMISSSLLLKIG 81
Cdd:MTH00144   25 HWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIM-YNLSFSWFS----MSLLLLGLCLKLG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  82 AAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCI---QMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSSISH 158
Cdd:MTH00144  100 LFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSIGGLNQTQVRALLAYSSISH 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2504469302 159 IGWMISSLIISENIWELYFIIYSLLSLILVLLFKQSNLFFMNQIYSASKMKVEIKFMMFlSLLSLGGLPPFLGFMPKW 236
Cdd:MTH00144  180 TGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIIS-LLLSLGGLPPFLGFCSKL 256
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-180 1.87e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 90.07  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSM-TNESSIKYFIVQAMASTMLLFSILMI-----------QMKYSMGWESEIIP 68
Cdd:pfam00361   2 NDLLLMYLGWEAVLLPSYLLIGYWGKSPrSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdeLSKALTGGLNSSGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  69 SM---MISSSLLLKIGAAPFHFWFPEVMSASSWINCLTL-MTWQKIAPMMIL-------SYCIQMSTFMFLITISSIIIG 137
Cdd:pfam00361  82 LLlflLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLLG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2504469302 138 ALGGLNQTSLRQLLAYSSISHIGWMISSLIISENIWELYFIIY 180
Cdd:pfam00361 162 SLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFH 204
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 1-180 8.07e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 83.93  E-value: 8.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   1 NSWFGVWMGLEINLLSFIPLLANNKNSMTN-ESSIKYFIVQAMASTMLLFSI----------------LMIQMKYSMGWE 63
Cdd:MTH00196   13 SNWLSVYLAIELQTLSLFILIAQNRGSGYSaEAGLKYFVLGALSSGLFLFGCallcgttgglhlsyinLVLNSGQSFSSV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  64 SEIIPSMMISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLITISSIIIGALGGLN 143
Cdd:MTH00196   93 SVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSLFVGAIGALN 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2504469302 144 QTSLRQLLAYSSISHIGWMISSL----IISENIWELYFIIY 180
Cdd:MTH00196  173 QTKIKRLLAYSGIGHMGFVLWGIeigsFESIQASLVYLFIY 213
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 3-180 1.78e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 80.45  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   3 WFGVWMGLEINLLSFIPLLANNKNSM-TNESSIKYFIVQAMASTMLLFSILM---------IQMKYSMGWESeiIPSMMI 72
Cdd:MTH00199  119 WLSIYLAIELQTLTLFILVALKRDSAySTEAGLKYFVLGAVSSGLFLFGCALlygltgetsIQGINSILTGD--VGKILI 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  73 SSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLITISSIIIGALGGLNQTSLRQLLA 152
Cdd:MTH00199  197 TISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIGALNQTKIKRLLA 276

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2504469302 153 YSSISHIGWMISSLIISEN----IWELYFIIY 180
Cdd:MTH00199  277 YSGIGHMGFILFGVAIGSFesiqASLIYMIIY 308
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
8-168 2.31e-16

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 77.55  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   8 MGLEINLLSFIPLLA-NNKNSMTNESSIKYFIVQAMASTMLLFSILMI--------------QMKYSMGWESEIIPSM-M 71
Cdd:PRK05777  130 LGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgslsfagiakALADGSGNSLLLLFGLvF 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  72 ISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMIL---------SYCIQMSTFMFLITISSIIIGALGGL 142
Cdd:PRK05777  210 LLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafgGLSEDWQQVLAIIAIASMLVGNLAAL 289

                         170       180
                  ....*....|....*....|....*.
gi 2504469302 143 NQTSLRQLLAYSSISHIGWMISSLII 168
Cdd:PRK05777  290 SQTNIKRLLAYSSIAHAGYLLVGLAA 315
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-167 5.67e-15

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 73.23  E-value: 5.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   8 MGLEINLLSFIPLLANNKNSMT-NESSIKYFIVQAMASTMLLFSILM------------IQMKYSMGWESE---IIPSMM 71
Cdd:COG1007   129 LGLELLSLSLYVLVAFRRDDRRsSEAALKYFLLGALSSGFLLYGISLlygatgslnlagIAAALAAGGANSpllLLGLVL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  72 ISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMIL---------SYCIQMSTFMFLITISSIIIGALGGL 142
Cdd:COG1007   209 VLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGLAADWQLLLAVLAVLSMTVGNLAAL 288

                         170       180
                  ....*....|....*....|....*
gi 2504469302 143 NQTSLRQLLAYSSISHIGWMISSLI 167
Cdd:COG1007   289 AQTNVKRMLAYSSIAHAGYLLLGLA 313
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 2-163 1.46e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 66.42  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   2 SWFGVWMGLEINLLSFIPL---------LANNKNSMTNESSIKYFIVQAMASTMLLFSI-LMIQMKYSMGWESEIIPS-- 69
Cdd:MTH00198  209 NWLTIYLALEFQTLALFILagegsqpgsHFPSPGNTPPESGLKYWILGAMSSGFYLFGCaLYFGFTGNEGMLGTILSAtl 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  70 --------------MMISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFLITISSII 135
Cdd:MTH00198  289 ettnielrqgslgyLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKLLLSVAIISLV 368

                         170       180
                  ....*....|....*....|....*...
gi 2504469302 136 IGALGGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:MTH00198  369 VGAFGALNQTRIKRLLAYSGIGHIGFIL 396
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 5-169 1.08e-11

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 63.81  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   5 GVWMGLEINLLSFIPLLANNKNS-MTNESSIKYFIVQAMASTMLLFSILMI----------QMKYSMGWESEIIPSM--- 70
Cdd:TIGR01770 126 SIYLGLELQSLCFYVLAGLKRKSrFSTEAGLKYFILGAFSSGLLLFGISLIygftgslnfeDLLLFLSNGMLNISLLllg 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  71 --MISSSLLLKIGAAPFHFWFPEVMSASSWINCLTLMTWQKIA---PMMILSYCIQMS------TFMFLITISSIIIGAL 139
Cdd:TIGR01770 206 ivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILFGfseawqIFLAIIAFLSMLIGNF 285

                         170       180       190
                  ....*....|....*....|....*....|
gi 2504469302 140 GGLNQTSLRQLLAYSSISHIGWMISSLIIS 169
Cdd:TIGR01770 286 GALAQKKVKRLLAYSSISHVGYILIGLLAG 315
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 4-163 8.85e-10

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 57.85  E-value: 8.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   4 FGVWMGLEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKY---SMGWESEIIPSM---------- 70
Cdd:COG0651   130 FNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATgtlNMADLAARLAELdpglllaafa 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  71 MISSSLLLKIGAAPFHFWFPEVMS-ASSWINCL--TLMTwqKIAPMMIL---------SYCIQMSTFMFLITISSIIIGA 138
Cdd:COG0651   210 LLLVGFGIKAALFPLHFWLPDAYPaAPSPVSALlsGLLT--KVGVYAILrvltllfgaDPALFLGTLLLVLGLLTMLVGA 287

                         170       180
                  ....*....|....*....|....*
gi 2504469302 139 LGGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:COG0651   288 LGALAQRDLKRLLAYSSVSQIGYIL 312
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 4-163 1.60e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 54.33  E-value: 1.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302   4 FGVWMGLEINLLSFIPLLA-NNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMKY---SMGW----------ESEIIPS 69
Cdd:PRK08376  144 FNFFVFLEIMSIASYALVAfRNDTWEAIEAGIKYMFVGSLASSMVLLGIALLYGQYgtlNMAYlavkmsenptVVAKIAL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  70 MMISSSLLLKIGAAPFHFWFPEVMSAS-SWINCLTLMTWQ-KIAPMM-----ILSYCIQMSTFMFLITI---SSIIIGAL 139
Cdd:PRK08376  224 ALFIAGLAMKSGAVPVHMWLPDAYPAApSSISAMLLVIKQaGLYALArvlfsIYGPAINLATVGWVIIIlgcLTMFVGVA 303

                         170       180
                  ....*....|....*....|....
gi 2504469302 140 GGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:PRK08376  304 MAVVQKDVKRLLAYHSVSQIGYML 327
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 10-163 7.59e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 52.19  E-value: 7.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  10 LEINLLSFIPLLANNKNSMTNESSIKYFIVQAMASTMLLFSILMIQMK---YSMGWESEIIPSM--------MISSSLLL 78
Cdd:PRK08375  135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVtgtLNMADLAGALAENptvvtafgFVLLALAL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  79 KIGAAPFHFWFPEVMS-ASSWINCLTLMTWQKIAPMMILSYCIQMSTFMFL-----------ITISSIIIGALGGLNQTS 146
Cdd:PRK08375  215 KAAVFPLHTWLPRAYPaAPPVVTALLSGLVTKVAVYALIRIYFTVFGGDFRfalglgwllavLALLSMLVGSLAALGQDD 294

                         170
                  ....*....|....*..
gi 2504469302 147 LRQLLAYSSISHIGWMI 163
Cdd:PRK08375  295 VKRVLAYSTVSQMGYIL 311
PRK12650 PRK12650
DUF4040 family protein;
70-166 1.72e-06

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 48.50  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  70 MMISSSLLLKIGAAPFHFWFPEVMSASSWINC-LTLMTWQKIAPMMILSYCIQMSTFM----FLITISSI--IIGALGGL 142
Cdd:PRK12650  212 VLIAVAAFTKSAQFPFHFWLPEAMAAITPVSAfLHAAAVVKAGIYLLLRFSPVFHDVAvwnwLLIIVGMItaLMGAVFAV 291

                          90       100
                  ....*....|....*....|....
gi 2504469302 143 NQTSLRQLLAYSSISHIGWMISSL 166
Cdd:PRK12650  292 QKTDLKKLTAYSTVSQLGWIVATI 315
ndhB CHL00049
NADH dehydrogenase subunit 2
 30-170 1.92e-05

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 44.99  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  30 NESSIKYFIVQAMASTMLLF--------------------SILMIQMKYSMGwesEIIPSMMISSSLLLKIGAAPFHFWF 89
Cdd:CHL00049  161 NEATMKYLLMGGASSSILVYgfswlyglsggeielqeivnGLINTQMYNSPG---ISIALIFITVGIGFKLSLAPFHQWT 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  90 PEVMSASSWINCLTLMTWQKIAPMM--------ILSYCIQMSTFMF-LITISSIIIGALGGLNQTSLRQLLAYSSISHIG 160
Cdd:CHL00049  238 PDVYEGSPTPVVAFLSVTSKVAASAlatrifdiPFYFSSNEWHLLLeILAILSMILGNLIAITQTSMKRMLAYSSIGQIG 317

                         170
                  ....*....|
gi 2504469302 161 WMISSLIISE 170
Cdd:CHL00049  318 YVIIGIIVGD 327
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
29-168 4.32e-05

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 43.89  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  29 TNESSIKYFIVQAMASTMLLFSI-LMIQMKYSMGWESEIIPSMMISSSLLL-------------KIGAAPFHFWFPEVMS 94
Cdd:PRK02504  159 SNEAALKYLLIGAASSAIFLYGSsLLYGLSGGSTQLSAIALALITSPSLGLalalvfviagiafKISAVPFHQWTPDVYE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  95 ASSWINCLTLMTWQKIA----PMMILSYCIQMST----FMF-LITISSIIIGALGGLNQTSLRQLLAYSSISHIGWMISS 165
Cdd:PRK02504  239 GSPTPVVAFLSVGSKAAgfalAIRLLVTAFPSFDeqwkLLFtALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVMIG 318


                  ...
gi 2504469302 166 LII 168
Cdd:PRK02504  319 LVA 321
PRK12665 PRK12665
putative monovalent cation/H+ antiporter subunit D; Reviewed
 121-163 6.38e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237165 [Multi-domain]  Cd Length: 521  Bit Score: 43.42  E-value: 6.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2504469302 121 QMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:PRK12665  271 GLDTLLMVVALLTMVVGILGAIAQSDIKRLLSFTLVSHIGYMV 313
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 32-163 7.14e-05

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 43.39  E-value: 7.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  32 SSIKYFIVQAMASTMLLFSILMIQMKYSMGWESEIIPSMMISSS----LLLKIGAA--------PFHFWFPEVMSASSWI 99
Cdd:TIGR01972 157 AAMKFFLYTLAGSLLMLLAILGLYFLGGGTFDLLELLNLPLPFGvqtwLFLAFFIAfavkvplfPLHTWLPDAHVEAPTA 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2504469302 100 NCLTLM-TWQKIAPMMILSYCIQM--------STFMFLITISSIIIGALGGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:TIGR01972 237 GSVILAgVLLKMGTYGFLRFNLPLfpdaslyfAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVL 309
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 33-160 4.21e-04

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 40.83  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  33 SIKYFIVQAMASTMLLFSILMI---------------QMKYSMGWESEIIPSMMISssLLLKIGAAPFHFWFPEVMSASS 97
Cdd:COG1008   163 AIKFFLYTLAGSLLMLVAILALyflagaltfdiaelaAAPLPLTAQLLLFLAFFIA--FAVKVPMFPFHTWLPDAHVEAP 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  98 wincltlmtwqkIAPMMILS-------------YCIQM--------STFMFLITISSIIIGALGGLNQTSLRQLLAYSSI 156
Cdd:COG1008   241 ------------TAGSVLLAgvllkmggygllrFALPLfpeasayfAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSV 308


                  ....
gi 2504469302 157 SHIG 160
Cdd:COG1008   309 SHMG 312
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 76-162 1.08e-03

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 39.75  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  76 LLLKIGAA------PFHFWFPEVMSA----SSWINCLT-------LMTwqKIAPMMILSyciqMSTFMFLITISSI--II 136
Cdd:COG1009   215 LLLLLGAFgksaqfPLHFWLPDAMEGptpvSALLHAATmvkagvyLLA--RLSPLFALS----PVWLTVVAIIGAItaLF 288

                          90       100
                  ....*....|....*....|....*.
gi 2504469302 137 GALGGLNQTSLRQLLAYSSISHIGWM 162
Cdd:COG1009   289 AALIALAQTDIKRVLAYSTVSQLGYM 314
PRK12646 PRK12646
DUF4040 family protein;
23-167 7.05e-03

DUF4040 family protein;


Pssm-ID: 183646 [Multi-domain]  Cd Length: 800  Bit Score: 37.43  E-value: 7.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  23 NNKNSMTneSSIKYFIVQAMASTMLLFSILMIQMKYSMGWESEIIPS--------MMISSSLLLKIGAA------PFHFW 88
Cdd:PRK12646  155 NNGDSQF--GAIQSFMITVFGGLALLVGFIMLYIMTGTNNITEILGQadhiknhgLFIPMIFMFLLGAFtksaqfPFHIW 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504469302  89 FPEVMSA----SSWINCLTLMTWQ-----KIAPMMILS-YCIQMSTFMFLITIssiIIGALGGLNQTSLRQLLAYSSISH 158
Cdd:PRK12646  233 LPRAMAAptpvSAYLHSATMVKAGifllfRFTPLLGLSnMYIYIVTFVGLITM---LFGSITALKQWDLKGILAYSTISQ 309


                  ....*....
gi 2504469302 159 IGwMISSLI 167
Cdd:PRK12646  310 LG-MIMAMV 317
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 121-163 8.11e-03

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 37.10  E-value: 8.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2504469302 121 QMSTFMFLITISSIIIGALGGLNQTSLRQLLAYSSISHIGWMI 163
Cdd:PRK05846  275 EFAPIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVT 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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