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Conserved domains on  [gi|2508213537|gb|WHP53179|]
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PR domain-containing 9, partial [Mus musculus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-379 6.25e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 6.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  18 KPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQK--SDLIKHQRTHTGEKPYvcRECGRGFTQKSDLIKHQ 95
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  96 RTHTGEKP-YVCRECGRGFTAKSNLIQH----QRTHTGEKPY---------------------VCRECGRGFTAKSVLIQ 149
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 150 HQRTHTGEKPYVCRECGRgFTQKSDLIKHQRTHTGEKPYVCRECGRGFTAKSNLIQHQRTHTGEKPYVCRECGRGFTEKS 229
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 230 SLIKHQRTHTGE-------KPYVCRECGRGFTAKSNLIQHQRT--HTGE--KPYVCRE--CGRGFTQKSNLIKHQRTHTG 296
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 297 EKPYVCRECGRGFT-------AKSVLIQHQRTHTGEKPYVC--RECGRGFTQKSNLIKHQRTHTGEKPYVCR--ECGWGF 365
Cdd:COG5048   349 ISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410
                  ....*....|....
gi 2508213537 366 TQKSDLIQHQRTHT 379
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-379 6.25e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 6.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  18 KPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQK--SDLIKHQRTHTGEKPYvcRECGRGFTQKSDLIKHQ 95
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  96 RTHTGEKP-YVCRECGRGFTAKSNLIQH----QRTHTGEKPY---------------------VCRECGRGFTAKSVLIQ 149
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 150 HQRTHTGEKPYVCRECGRgFTQKSDLIKHQRTHTGEKPYVCRECGRGFTAKSNLIQHQRTHTGEKPYVCRECGRGFTEKS 229
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 230 SLIKHQRTHTGE-------KPYVCRECGRGFTAKSNLIQHQRT--HTGE--KPYVCRE--CGRGFTQKSNLIKHQRTHTG 296
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 297 EKPYVCRECGRGFT-------AKSVLIQHQRTHTGEKPYVC--RECGRGFTQKSNLIKHQRTHTGEKPYVCR--ECGWGF 365
Cdd:COG5048   349 ISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410
                  ....*....|....
gi 2508213537 366 TQKSDLIQHQRTHT 379
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-283 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 2508213537 258 NLIQHQRTHTGEKPYVCRECGRGFTQ 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 298-346 4.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 4.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2508213537 298 KPYvCRECGRGFTAKSVLIQHQRTHTgekpYVCRECGRGFTQKSNLIKH 346
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-379 6.25e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 6.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  18 KPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQK--SDLIKHQRTHTGEKPYvcRECGRGFTQKSDLIKHQ 95
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  96 RTHTGEKP-YVCRECGRGFTAKSNLIQH----QRTHTGEKPY---------------------VCRECGRGFTAKSVLIQ 149
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 150 HQRTHTGEKPYVCRECGRgFTQKSDLIKHQRTHTGEKPYVCRECGRGFTAKSNLIQHQRTHTGEKPYVCRECGRGFTEKS 229
Cdd:COG5048   190 SNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 230 SLIKHQRTHTGE-------KPYVCRECGRGFTAKSNLIQHQRT--HTGE--KPYVCRE--CGRGFTQKSNLIKHQRTHTG 296
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 297 EKPYVCRECGRGFT-------AKSVLIQHQRTHTGEKPYVC--RECGRGFTQKSNLIKHQRTHTGEKPYVCR--ECGWGF 365
Cdd:COG5048   349 ISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410
                  ....*....|....
gi 2508213537 366 TQKSDLIQHQRTHT 379
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
58-379 6.07e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 6.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  58 TQKSDLIKHQRTHTGE----KPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRG--FTAKSNLIQHQRTHTGEKP 131
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 132 YvcRECGRGFTAKSVLIQHQRTHTGEKP-YVCRECGRGFTQKSDLIKHQ--RTHTGEKPYVCRECGRGF--TAKSNLIQH 206
Cdd:COG5048    92 D--LNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSvnTPQSNSLHP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 207 QRTHTgekpyvcRECGRGFTEKSSLIKHQRTHTGEKPYVCRECGRgFTAKSNLIQHQRTHTGEKPYVCRECGRGFTQKSN 286
Cdd:COG5048   170 PLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 287 LIKHQRTHTGEKPYVCRECGRGFTAKSVLIQHQRTHTGE-------KPYVCRECGRGFTQKSNLIKHQRT--HTGE--KP 355
Cdd:COG5048   242 SQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKP 321

                         330       340
                  ....*....|....*....|....*.
gi 2508213537 356 YVCRE--CGWGFTQKSDLIQHQRTHT 379
Cdd:COG5048   322 FSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-279 2.47e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 2.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537  23 RECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRgFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQKSDLIKHQRTHTGEK 102
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 103 PYVCRECGRGFTAKSNLIQHQRTHTGE-------KPYVCRECGRGFTAKSVLIQHQRT--HTGE--KPYVCRE--CGRGF 169
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLF 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537 170 TQKSDLIKHQRTHTGEKPYVCRECGRGFTAKSNL-------IQHQRTHTGEKPYVC--RECGRGFTEKSSLIKHQRTHTG 240
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2508213537 241 EKPYVCR--ECGRGFTAKSNLIQHQRTHTGEKPYVCRECGR 279
Cdd:COG5048   414 FRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-139 1.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2508213537   1 FSDKSNVNEHQKT--HTGE--KPYVCRE--CGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQKSDLIK-------HQ 67
Cdd:COG5048   299 FSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQY 378

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2508213537  68 RTHTGEKPYVC--RECGRGFTQKSDLIKHQRTHTGEKPYVCR--ECGRGFTAKSNLIQHQRTHTGEKPYVCRECGR 139
Cdd:COG5048   379 KDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-283 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 2508213537 258 NLIQHQRTHTGEKPYVCRECGRGFTQ 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 298-346 4.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 4.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2508213537 298 KPYvCRECGRGFTAKSVLIQHQRTHTgekpYVCRECGRGFTQKSNLIKH 346
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 5.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.15e-03
                          10        20
                  ....*....|....*....|....*
gi 2508213537 118 NLIQHQRTHTGEKPYVCRECGRGFT 142
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 5.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.15e-03
                          10        20
                  ....*....|....*....|....*
gi 2508213537 202 NLIQHQRTHTGEKPYVCRECGRGFT 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 6.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|....*
gi 2508213537 286 NLIKHQRTHTGEKPYVCRECGRGFT 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 272-294 7.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|...
gi 2508213537 272 YVCRECGRGFTQKSNLIKHQRTH 294
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 328-350 7.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|...
gi 2508213537 328 YVCRECGRGFTQKSNLIKHQRTH 350
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-171 7.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.20e-03
                          10        20
                  ....*....|....*....|....*
gi 2508213537 147 LIQHQRTHTGEKPYVCRECGRGFTQ 171
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-339 7.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.20e-03
                          10        20
                  ....*....|....*....|....*
gi 2508213537 315 LIQHQRTHTGEKPYVCRECGRGFTQ 339
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
34-59 7.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 2508213537  34 DLIKHQRTHTGEKPYVCRECGRGFTQ 59
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
62-87 7.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 2508213537  62 DLIKHQRTHTGEKPYVCRECGRGFTQ 87
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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