NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2519790159|gb|WIW75310|]
View 

NADH dehydrogenase subunit 4L (mitochondrion) [Mecostethus sp.]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 3.71e-23

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.82  E-value: 3.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  3 MFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2519790159 83 SYGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 3.71e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.82  E-value: 3.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  3 MFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2519790159 83 SYGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-94 7.39e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 43.32  E-value: 7.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  4 FSMLTSLLIYFSGIYIFSSkRKHLLMVLLSLEYIVLSLFMFIIIFLVKFN--CDYFFPVVFLVFSVCEGALGLSILVSMI 81
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTAdpLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|...
gi 2519790159 82 RSYGNDFFNSFFL 94
Cdd:pfam00420 80 RTHGTDDVDSLNL 92
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 3.71e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 84.82  E-value: 3.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  3 MFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2519790159 83 SYGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-97 2.38e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 59.99  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  1 MFMFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSM 80
Cdd:MTH00188   1 MFFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSL 80

                         90
                 ....*....|....*..
gi 2519790159 81 IRSYGNDFFNSFFLSLC 97
Cdd:MTH00188  81 IRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-92 2.87e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 54.47  E-value: 2.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  1 MFMFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSM 80
Cdd:MTH00149   1 SMFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSL 80

                         90
                 ....*....|..
gi 2519790159 81 IRSYGNDFFNSF 92
Cdd:MTH00149  81 IRLHGNDYVSSL 92
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 3-97 9.59e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 50.61  E-value: 9.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  3 MFSMLTSLLIYFS-GIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFF--PVVFLVFSVCEGALGLSILVS 79
Cdd:MTH00125   1 MTPTHFSLYTAFMlSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTpmPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 2519790159 80 MIRSYGNDFFNSFFLSLC 97
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 2-97 9.94e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 50.91  E-value: 9.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  2 FMFSMLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNC-DYFFPVVFLVFSVCEGALGLSILVSM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQvNGMLAIVLLTFGACEASLGLSLLVLM 80

                         90
                 ....*....|....*..
gi 2519790159 81 IRSYGNDFFNSFFLSLC 97
Cdd:MTH00013  81 TRSYGNDMLKSLTSNKC 97
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 24-97 1.28e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 45.34  E-value: 1.28e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519790159 24 RKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYF--FPVVFLVFSVCEGALGLSILVSMIRSYGNDFFNSFFLSLC 97
Cdd:MTH00126  23 RTHLLSALLCLEGMMLSLFIALSLWALQLESTSFsaAPMLLLAFSACEASAGLALLVATARTHGTDRLQNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 24-97 3.56e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 44.15  E-value: 3.56e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2519790159 24 RKHLLMVLLSLEYIVLSLFMF--IIIFLVKFNCDYFFPVVFLVFSVCEGALGLSILVSMIRSYGNDFFNSFFLSLC 97
Cdd:MTH00107  23 RSHLMSSLLCLEGMMLSLFIMatLTILNTHFTLASMMPIILLVFAACEAAVGLALLVMVSNTYGTDYVQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 4-97 7.39e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 43.44  E-value: 7.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  4 FSMLTSLLIYFSGIyifSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYFF--PVVFLVFSVCEGALGLSILVSMI 81
Cdd:MTH00067   6 FTFYSAFLLGLMGL---AFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFslPMFMLTFSACEASTGLALMVATT 82

                         90
                 ....*....|....*.
gi 2519790159 82 RSYGNDFFNSFFLSLC 97
Cdd:MTH00067  83 RTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-94 7.39e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 43.32  E-value: 7.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  4 FSMLTSLLIYFSGIYIFSSkRKHLLMVLLSLEYIVLSLFMFIIIFLVKFN--CDYFFPVVFLVFSVCEGALGLSILVSMI 81
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTAdpLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|...
gi 2519790159 82 RSYGNDFFNSFFL 94
Cdd:pfam00420 80 RTHGTDDVDSLNL 92
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 6-95 5.05e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 41.08  E-value: 5.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159  6 MLTSLLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNC--DYFFPVVFLVFSVCEGALGLSILVSMIRS 83
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSssMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|..
gi 2519790159 84 YGNDFFNSFFLS 95
Cdd:MTH00181  82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 10-91 7.73e-04

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 35.28  E-value: 7.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2519790159 10 LLIYFSGIYIFSSKRKHLLMVLLSLEYIVLSLFMFIIIFLVKFNCDYF--FPVVFLVFSVCEGALGLSILVSMIRSYGND 87
Cdd:MTH00043   9 LSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNlsFSLLLLTLSACEASIGLSLMVLLSRNHNSD 88


                 ....
gi 2519790159 88 FFNS 91
Cdd:MTH00043  89 LVAS 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH