|
Name |
Accession |
Description |
Interval |
E-value |
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
1-413 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 612.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 1 MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWII 80
Cdd:pfam01306 1 MYPLKNTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 81 TGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGI 160
Cdd:pfam01306 81 TGLLVLFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 161 MFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFD 240
Cdd:pfam01306 161 LFSIDPQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 241 QQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKT 320
Cdd:pfam01306 241 QQFANFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 321 LHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTL 400
Cdd:pfam01306 321 LHMFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTL 400
|
410
....*....|...
gi 446213694 401 SGPGPLSLLRRQV 413
Cdd:pfam01306 401 SGSGPQILLPRPV 413
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
1-417 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 597.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 1 MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWII 80
Cdd:PRK09528 4 MYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWII 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 81 TGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGI 160
Cdd:PRK09528 84 SGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIAGI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 161 MFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFD 240
Cdd:PRK09528 164 LFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDVFD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 241 QQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKT 320
Cdd:PRK09528 244 QQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSILKL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 321 LHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTL 400
Cdd:PRK09528 324 LHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVFTL 403
|
410
....*....|....*..
gi 446213694 401 SGPGPLSLLRRQVNEVA 417
Cdd:PRK09528 404 SGDRELSLLRRQVPEAA 420
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
6-401 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 572.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 6 NTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLV 85
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 86 MFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTIN 165
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 166 NQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFAN 245
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 246 FFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFE 325
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446213694 326 VPFLLVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLS 401
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
22-400 |
0e+00 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 512.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQY 101
Cdd:cd06172 14 IWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFGPFFIFVYGPLLQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 102 NILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILA 181
Cdd:cd06172 94 NILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFALILL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 182 VLLFFAKTDAPSSATvanAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVF 261
Cdd:cd06172 174 LLLLFAKPEDSDTAA---AAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLFATPEQGNRVF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 262 GYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQF 341
Cdd:cd06172 251 GYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHF 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446213694 342 EVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTL 400
Cdd:cd06172 331 DTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-401 |
9.97e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.02 E-value: 9.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 27 FPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGMLVMFAPFFIFIFGPLLqYNILVG 106
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSY-WLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 107 SIVGGIYLGFCFNAGAPAVEAFIEKvsRRSNFEFGRARMFGCVGWALCASIVGIMFTINN-QFVFWLGSGCALILAVLLF 185
Cdd:COG2223 100 GLLLGIGGGGSFAVGIALVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 186 FAKTDAPSSATVAnavganhSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQgtrVFGYVT 265
Cdd:COG2223 178 LFLRDPPAGAAAA-------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA---TAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 266 TMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEV-VILKTLHMFEVPFLLVGCFKYITSQFEVR 344
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446213694 345 FSATIYLVCFCFFkQLAMIFMSVLAGNMYESIG-FQGAYLVLGLVALGFTLISVFTLS 401
Cdd:COG2223 328 NAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-398 |
9.65e-19 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 87.25 E-value: 9.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 20 FFIMGAYFPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGpll 99
Cdd:cd17335 10 FAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQ--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 100 qynILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMFT-----INNQFVFWLGS 174
Cdd:cd17335 86 ---IFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 175 GCALILAVLLFFAKTDAPSSatvanavganHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDqqfaNFFTSFFATG 254
Cdd:cd17335 163 VLMLLALLLALKFPFRPKHP----------EPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIY----SFLFWHLQDL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 255 EQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCF 334
Cdd:cd17335 229 GGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446213694 335 KYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVF 398
Cdd:cd17335 309 SYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-397 |
1.77e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.30 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGMLVMFAPFFIFIFGPLLQY 101
Cdd:cd06174 11 ARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRP---VLLLGLLLFALGALLFAFAPSFWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 102 NILVGSIVGGIYLGFCFNAGAPAVEAFiekVSRRSNFEFGRARMFGCVGWALCASIVGI---MFTINNQFVFWLGSGCAL 178
Cdd:cd06174 87 LLLGRFLLGLGSGLIDPAVLALIADLF---PERERGRALGLLQAFGSVGGILGPLLGGIlasSLGFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 179 ILAVLLFFAKTDAPSSATVANAVgaNHSAFSLKLALELFRQPKLWFLslyVIGVSCTYDVFDQQFANFFTSFFATGEQGT 258
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEE--ASSKSVLKLLKRVLKNPGLWLL---LLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 259 RVFGYVTTMGELLNASIMFFAPLIINR-IGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYI 337
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 338 TSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISV 397
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-398 |
1.49e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.37 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 23 MGAYFPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWiitGMLVMFAPFFIFIFGPLLQYn 102
Cdd:cd17325 12 YGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL---GLLLLAVSTLLFAFATSYWQ- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 103 ILVGSIVGGIYLGFCFnagaPAVEAFIEKVSRRSNF--EFGRARMFGCVGWALCASIVGIMFT-INNQFVFWLGSGCALI 179
Cdd:cd17325 87 LLLARFLQGLASAAVW----PAAMALIADIAPPEERgrAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 180 LAVLLFFAKTDAPSSAtvanAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTr 259
Cdd:cd17325 163 ALVLALLLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 260 vfGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITS 339
Cdd:cd17325 238 --GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446213694 340 QFEVRFSATIYLVcFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVF 398
Cdd:cd17325 316 IVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-188 |
9.85e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 9.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 4 LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGM 83
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP---LILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 84 LVMFAPFFIFIFGPLLqYNILVGSIVGGIYLGFCFnagaPAVEAFIEKVSRRSNFE--FGRARMFGCVGWALCASIVGIM 161
Cdd:cd17325 273 LLSAVALLLLPLATSF-WLLLLLLALLGLGLGLVF----PATLALLADIVPPEGRGtaMGLFNTAFSLGMVLGPLLGGFL 347
|
170 180
....*....|....*....|....*...
gi 446213694 162 F-TINNQFVFWLGSGCALILAVLLFFAK 188
Cdd:cd17325 348 YdAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
24-186 |
6.24e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.32 E-value: 6.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 24 GAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFApFFIFIFGPLLqyni 103
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA-LLGFAHSPWL---- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 104 lvgSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRA--RMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILA 181
Cdd:cd17329 91 ---FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAA 167
|
....*
gi 446213694 182 VLLFF 186
Cdd:cd17329 168 LVLLF 172
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
16-324 |
4.18e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 54.56 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 16 FFFYFFIMGAYFPFFPIWLHDINhISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLlwIITGMLVMFAPFFIFIF 95
Cdd:pfam12832 8 YFFYFAALGCLLPYWGLYLRSIG-LNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAV--VRLASILAAVLFLSVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 96 GPLLQYNILVGSIVGGIYlgFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALCASIVGIMF-TINNQFVFWLGS 174
Cdd:pfam12832 85 IPISLTFWWLALLVVLFS--FFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFdHYSVGLLPSVLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 175 GC--ALILAVLLFFAKTDAPSSATVANavganhsafSLKLALELFRQPKLWFLSLyvigVSCTYDVFDQQFANFFTSFFA 252
Cdd:pfam12832 163 YLfaALMLLSLLLPLAPPEMEYESKGG---------SKAVFWNLLKQPEVIIFFL----AAFLLGFSHGPFYTFLFLYLE 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446213694 253 TGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIG-SSFATSALEVVILKTLHMF 324
Cdd:pfam12832 230 NLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAI 302
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-318 |
8.27e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.58 E-value: 8.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 23 MGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGMLVMFAPFFIFIFGPLLqYN 102
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR---VLLIGLLLFALGLLLLLFASSL-WL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 103 ILVGSIVGGIYLGFCFNAGAPAVEAFIEKvsRRSNFEFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAV 182
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPP--EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 183 LLFFAKTDAPSSATVANAVGANHSAFSLKLAleLFRQPKLWFLSLYVIGVSCTYdvfdqQFANFFTSFFATGEQGTRVFG 262
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVAWKA--LLRDPVLWLLLALLLFGFAFF-----GLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 446213694 263 YVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVIL 318
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-301 |
9.96e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 9.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLR--KYLLWIITGMLVM-FAPFFIFIFGPL 98
Cdd:COG2211 25 AFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLaLSFVLLFTAPDL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 99 LQYNILVGSIVGGIYLGFCFNAGAPAVEAFI----EKVSRRSNFeFGRARMFGCVGWALCASIVGIMFTI-------NNQ 167
Cdd:COG2211 105 SPTGKLIYALVTYLLLGLAYTLVNIPYSALGaeltPDYEERTRL-SSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 168 FVFWLGSGCALILAVLLFFaktdapssaTVANAVGANHSAFSLKLAL-ELFRQPKLWFLSLYVIGVSCTYDVFDQQFANF 246
Cdd:COG2211 184 LTALIFAVLGLLAFLLTFF---------GTKERPVPEEEKVSLKESLkALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446213694 247 FTSFFatgEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSV 301
Cdd:COG2211 255 FKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-398 |
1.67e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 41 SKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLlwiITGMLVM----FAPFFIFIFGPLLQYNILVGSIVGGIYlgf 116
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLL---IAGLLLYgiggVAGLFLDSLYALLASRALLGIGVAGIM--- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 117 cfnAGAPAVEAFIEKVSRRSNFeFGRARMFGCVGWALCASIVGIMFTINNQFVFWL-GSGCALILAVLLFFAKTDAPSSA 195
Cdd:cd17473 107 ---TLATALIGDYFEGEERAKM-LGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVyLLALPVLILVLLFLPEPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 196 TVANAVGANHSafslklalelFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTrvfGYVTTMGELLNASI 275
Cdd:cd17473 183 AASPGAATAAA----------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI---GLALAIASLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 276 MFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITS--QFEVRFSATIYLVC 353
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSlvPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446213694 354 FCFFKQLAMIFMSVLAGNMYEsiGFQGAYLVLGLVALGFTLISVF 398
Cdd:cd17473 330 AFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-396 |
4.26e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 4.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 41 SKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGgiyLGFCFNA 120
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFL---LGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 121 GAPAVEAFIEKVSRRSnfEFGRARMFGCVGWALcASIVG------IMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSS 194
Cdd:cd06173 109 FGPARQALLPELVPKE--QLVRANALNSLATQL-ARIIGpalgglLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 195 ATVANAVGANHSAFSLKLaleLFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGtrvFGYVTTMGELLNAS 274
Cdd:cd06173 186 PGESSSLLLRDLREGLRY---LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG---YGLLLAAFGVGALL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 275 IMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCF 354
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446213694 355 CFFkQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLIS 396
Cdd:cd06173 340 ALN-SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-318 |
6.83e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 6.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 23 MGAYFPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWiitGMLVMFAPFFIFIFGPLLQYn 102
Cdd:COG2814 26 IGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL---GLLLFALGSLLCALAPSLWL- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 103 ILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNfeFGRARMFGCVGWALCASIVGIMFTINN-QFVFWLGSGCALILA 181
Cdd:COG2814 101 LLAARFLQGLGAGALFPAALALIADLVPPERRGRA--LGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVLALLAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 182 VLLFFAKTDAPSSATVAnavganhsafSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQgtrVF 261
Cdd:COG2814 179 LLLLRLLPESRPAARAR----------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS---AA 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446213694 262 GYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVIL 318
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-129 |
5.89e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 3 YLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITG 82
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446213694 83 MLVMFAPFFIFIFGPLLqynilvgsIVGGIYLGFCFNAGAPAVEAFI 129
Cdd:COG2814 283 LALGLLLLALAGSLWLL--------LLALFLLGFGFGLLFPLLQALV 321
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-188 |
7.10e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 29 FFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGlRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSI 108
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG-RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 109 VGGIYLGFCFNAGAPAVEAFIEKVSRRSnfeFGRARMFGCVGWALCASIVGIMFTINN-QFVFWLGSGCALILAVLLFFA 187
Cdd:COG2271 281 AGFGLGGAFGLLWALAAELFPKKARGTA---SGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLL 357
|
.
gi 446213694 188 K 188
Cdd:COG2271 358 L 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-317 |
8.74e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 8.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 24 GAYFPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWiitGMLVMFAPFFIFIFGPLLQYnI 103
Cdd:cd17489 13 YLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI---GLLIFALATLLYLLATSVAL-L 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 104 LVGSIVGGIYLGFCFNAGAPAVEAFIEKvSRRSNfEFGRARMFGCVGWALCASIVGIMFTINN-QFVFWLGSGCALILAV 182
Cdd:cd17489 88 LVLRLIHGIGWGAFTTAAATLVADIIPP-SRRGE-GIGYYGLATTLAMALGPALGLFLYQHLGfAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 183 LLFFAKTDAPSSATVANAVganhsafslKLALELFRQPKLWFLSLYVIGVSCTYDVfdqqFANFFTSFFAtgEQGTRVFG 262
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAG---------TRAFRRLVEKKVLPPALILFLASIAYGA----ISTFLPLYAA--ERGISNAG 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446213694 263 YVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVI 317
Cdd:cd17489 231 LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL 285
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-398 |
2.03e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 39 HISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGMLVMFAPFFIFIFGPLLQYnILVGSIVGGIYLGFCF 118
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRR---VLAIGLLLWGLATLLFGFATSFWQ-LLLLRFLLGLGEAGFF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 119 NAGAPAVEAFIEKvsRRSNFEFGRARMFGCVGWALCASIVGIMFTINN-QFVFWLGSGCALILAVLLFfaktdapssatv 197
Cdd:COG2271 117 PAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwRAAFLILGLPGLLLALLRF------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 198 anavganhsafslklalelfrqpklWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTrvfGYVTTMGELLNASIMF 277
Cdd:COG2271 183 -------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA---GLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 278 FAPLIINRIG--GKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFc 355
Cdd:COG2271 235 LGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN- 313
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446213694 356 FFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVF 398
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
25-398 |
3.37e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 25 AYFPFFPIWLHDINhISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLwIITGMLVMFAPFFIFIFGPllQYNIL 104
Cdd:cd17490 14 VYVPFLSPYAESLG-ASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFI-IIGLLFTVLASLIMILFPS--PWGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 105 VGSIVGGIylgfcfnAGAPAVEAFIEKVSRRSNFEFGRAR---MFGCVGWALCASIVG--IMFTINNQFVFWLGSGCALI 179
Cdd:cd17490 90 IARFLSGI-------AAATWVSFTVLYASYFPPDEAAKAMgliNLVNNLGQLIAFLIGglIAEHFGMRAPFLLAALAGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 180 LAVLLFFAKTDAPSSATVanavganhsAFSLKLALELFRQPKLWFLSLYVIgvsctydvfDQQFANF-----FTSFFATG 254
Cdd:cd17490 163 GFILSLFIKEERREKKPV---------LTELKELLSVLKDKKLLFFSLLAI---------LQQMITFsttfgFTPLIAKQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 255 EQGTRV-FGYVTTMGELLNA-SIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVG 332
Cdd:cd17490 225 LGASSFqLGLLSIIYLLPNAlASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446213694 333 CFKYITSQFEVRFSATIYLVcFCFFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVF 398
Cdd:cd17490 305 LMSLSIEGVPAEQRSTAMGF-FQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
40-127 |
7.49e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 40 ISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFififgPLLQYNILVGSIVGGIYLGFCFN 119
Cdd:cd17369 261 VDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF-----WLLDTGSTWLIVLAAVVVLGVLH 335
|
....*...
gi 446213694 120 AGAPAVEA 127
Cdd:cd17369 336 GMMYGPQA 343
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-185 |
1.38e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 27 FPFFPIWLHDInHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYllwIITGMLVMFAPFFIFIFGPLLqYNILVG 106
Cdd:cd17370 219 FAFLILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL---LILGYLSLALAYLGFALGSSL-WLLLLG 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 107 SIVGGIYLGFcFNAGAPAVEAFIEKVSRRSN----FEFGRArmfgcVGWALCASIVGIMF-TINNQFVFWLGSGCALILA 181
Cdd:cd17370 294 FILWGLYMGA-QESIERAAVADLVPAELRGTayglFNTVVG-----IGWLLASLIAGYLWdLISPSAAFLFSAVLALIAL 367
|
....
gi 446213694 182 VLLF 185
Cdd:cd17370 368 LLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-164 |
1.38e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFpiwLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKylLWIITGMLVMFAPFFIFIFGPLLQY 101
Cdd:COG2211 246 LVAALLLYY---FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK--AFIIGLLLAALGLLLLFFLGPGNLW 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446213694 102 NILVGSIVGGIYLGFcFNAGAPAVEAFIEKVSRRSNFEFGRARMFGC------VGWALCASIVGIMFTI 164
Cdd:COG2211 321 LLLVLAALAGIGLGA-ILVLPWAMLADVVDYDEWKTGRRREGLYFGIftfaikLGQALAGALAGLLLAL 388
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-186 |
3.28e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQ-PLFGLLSDKLGLRKYLLWiitGMLVMFAPFFIFIFGPLLQ 100
Cdd:cd17330 189 AFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRL---GLLLAIIGLLLLPFASSVP 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 101 YnILVGSIVGGIYLGFCFnagaPAVEAFIEKVSRRSNfefgRARMFGC------VGWALCASIVGIMFTI-NNQFVFWLG 173
Cdd:cd17330 266 L-LVLAAAILAFGTGIVF----PALSALLSKSVPSKE----QGKAQGIiqslqsLARIIGPLLAGPLYSFlGPGVPFLLA 336
|
170
....*....|...
gi 446213694 174 SGCALILAVLLFF 186
Cdd:cd17330 337 AGLLLIALFLLSL 349
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
139-294 |
4.38e-03 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 39.15 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 139 EFGRARMFGCVGWALCASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSAtvanavGANHSAFSLkLALELFR 218
Cdd:cd06177 122 DFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIAAGASLLLGLYSLTLPHTPPKKA------GKGVSKRSL-LGLDAFV 194
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446213694 219 QPKLWFLSLYVIG--VSCTYDVFDQQFANFFTSFFATGEQGTRVfgyVTTMGELLNASIMFFAPLIINRIGGKNALLL 294
Cdd:cd06177 195 LLKNPFFAVFFIFsfLLGAPLQFYYTFANPFLNDFGMIVKNPAG---IMSLGQISEILFMLAIPFFLKRLGIKKVMLI 269
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
4-185 |
6.63e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 4 LKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIitGM 83
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI--GL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 84 LVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEkvsRRSNFEFGRARMFGCVGWALCASIVGIMF- 162
Cdd:cd06174 278 LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP---EIRGTAFGLLNTFGFLGGAIGPLLAGFLLa 354
|
170 180
....*....|....*....|....
gi 446213694 163 -TINNQFVFWLGSGCALILAVLLF 185
Cdd:cd06174 355 aTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-113 |
8.11e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 22 IMGAYFPFFPIWLHDiNHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQY 101
Cdd:cd17477 203 LEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL 281
|
90
....*....|....
gi 446213694 102 NI--LVGSIVGGIY 113
Cdd:cd17477 282 VLlfLWGGAAGPLY 295
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
29-136 |
9.00e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.00 E-value: 9.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 29 FFPIWLHDINHISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVmfAPFFIFIFGPLLQYNiLVGSI 108
Cdd:cd17341 227 VLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTI--GAALLSLSLPTSGTN-LVLFL 303
|
90 100
....*....|....*....|....*...
gi 446213694 109 VGGIYLGFCFNAGAPAVEAFIEKVSRRS 136
Cdd:cd17341 304 ALFVALGLGAGAGNGSVFRMVPFIFRRE 331
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-313 |
9.59e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 37.91 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 39 HISKSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKyllWIITGMLVMFAPFFIFIFGPLLQYnILVGSIVGGIYLGFCF 118
Cdd:COG0738 39 GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR---GLLLGLLLMALGLLLFALAPSYPL-LLLALFLLGLGLGLLD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 119 NAGAPAVeAFIEKVSRRSNfeFGRARMFGCVGWALCASIVGIMFTINN----QFVFWLGSGCALILAVLLFFAKTDAPSS 194
Cdd:COG0738 115 VAANPYV-AALGPETAASR--LNLLHAFFSLGALLGPLLGGLLILLGLslswHLPYLILAVLLLLLALLFLRSKLPEIEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446213694 195 ATVANAVGANHSafslklaLELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQgtrVFGYVTTMGELLNAS 274
Cdd:COG0738 192 EEEEAAGSAASL-------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA---TAALGLSLFWGGMTI 261
|
250 260 270
....*....|....*....|....*....|....*....
gi 446213694 275 IMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSAL 313
Cdd:COG0738 262 GRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPW 300
|
|
| |
