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Conserved domains on  [gi|493927261|ref|WP_006872011|]
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polyhydroxyalkanoate synthesis regulator DNA-binding domain-containing protein [Legionella drancourtii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5394 super family cl34994
Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary ...
 1-101 7.34e-36

Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary metabolites biosynthesis, transport and catabolism, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5394:

Pssm-ID: 444154 [Multi-domain]  Cd Length: 181  Bit Score: 121.16  E-value: 7.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261   1 MTRLIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAGATQFLSADILRQIISLA 80
Cdd:COG5394    6 EPRVIKKYPNRRLYDTETSSYVTLEDVAQLVKDGEEFQVVDAKTGEDLTRSILLQIILEEESKGQPLLSIDFLRQLIRFY 85

                         90       100
                 ....*....|....*....|....*....
gi 493927261  81 NHPMQ--------ASLKTMMEQMFQVMEK 101
Cdd:COG5394   86 GDSMQgfvpsyleKSLQAFADQQEKMREQ 114
 
Name Accession Description Interval E-value
COG5394 COG5394
Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary ...
 1-101 7.34e-36

Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary metabolites biosynthesis, transport and catabolism, Signal transduction mechanisms];


Pssm-ID: 444154 [Multi-domain]  Cd Length: 181  Bit Score: 121.16  E-value: 7.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261   1 MTRLIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAGATQFLSADILRQIISLA 80
Cdd:COG5394    6 EPRVIKKYPNRRLYDTETSSYVTLEDVAQLVKDGEEFQVVDAKTGEDLTRSILLQIILEEESKGQPLLSIDFLRQLIRFY 85

                         90       100
                 ....*....|....*....|....*....
gi 493927261  81 NHPMQ--------ASLKTMMEQMFQVMEK 101
Cdd:COG5394   86 GDSMQgfvpsyleKSLQAFADQQEKMREQ 114
PHA_reg_PhaR TIGR01848
polyhydroxyalkanoate synthesis repressor PhaR; Poly-B-hydroxyalkanoates are lipidlike carbon ...
 3-101 1.41e-29

polyhydroxyalkanoate synthesis repressor PhaR; Poly-B-hydroxyalkanoates are lipidlike carbon/energy storage polymers found in granular inclusions. PhaR is a regulatory protein found in general near other proteins associated with polyhydroxyalkanoate (PHA) granule biosynthesis and utilization. It is found to be a DNA-binding homotetramer that is also capable of binding short chain hydroxyalkanoic acids and PHA granules. PhaR may regulate the expression of itself, of the phasins that coat granules, and of enzymes that direct carbon flux into polymers stored in granules. The C-terminal region is poorly conserved in this family and is not part of this model.//GO terms added 12/6/04 [SS] [Fatty acid and phospholipid metabolism, Biosynthesis, Regulatory functions, DNA interactions]


Pssm-ID: 130907 [Multi-domain]  Cd Length: 107  Bit Score: 102.87  E-value: 1.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261    3 RLIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAGATQFLSADILRQIISLANH 82
Cdd:TIGR01848   1 RIIKKYPNRRLYDTETSSYVTLEDIRDLVREGREFQVVDSKSGDDLTRSILLQIIAEEESGGEPVLSTDFLTQIIRFYGG 80

                          90
                  ....*....|....*....
gi 493927261   83 PMQASLKTMMEQMFQVMEK 101
Cdd:TIGR01848  81 SMQSFVPQYLEASLEMFAK 99
PHB_acc_N pfam07879
PHB/PHA accumulation regulator DNA-binding domain; This domain is found at the N-terminus of ...
 4-63 8.20e-29

PHB/PHA accumulation regulator DNA-binding domain; This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA. The invariant nature of this domain compared to the C-terminal pfam05233 domain(s) suggests that it contains the DNA-binding function.


Pssm-ID: 429710  Cd Length: 61  Bit Score: 99.51  E-value: 8.20e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261    4 LIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAG 63
Cdd:pfam07879   1 IIKKYPNRRLYDTETSRYITLEDIAQLVREGEDFQVVDAKTGEDITRSVLTQIILEEESK 60
 
Name Accession Description Interval E-value
COG5394 COG5394
Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary ...
 1-101 7.34e-36

Polyhydroxyalkanoate (PHA) synthesis regulator protein, binds DNA and PHA [Secondary metabolites biosynthesis, transport and catabolism, Signal transduction mechanisms];


Pssm-ID: 444154 [Multi-domain]  Cd Length: 181  Bit Score: 121.16  E-value: 7.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261   1 MTRLIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAGATQFLSADILRQIISLA 80
Cdd:COG5394    6 EPRVIKKYPNRRLYDTETSSYVTLEDVAQLVKDGEEFQVVDAKTGEDLTRSILLQIILEEESKGQPLLSIDFLRQLIRFY 85

                         90       100
                 ....*....|....*....|....*....
gi 493927261  81 NHPMQ--------ASLKTMMEQMFQVMEK 101
Cdd:COG5394   86 GDSMQgfvpsyleKSLQAFADQQEKMREQ 114
PHA_reg_PhaR TIGR01848
polyhydroxyalkanoate synthesis repressor PhaR; Poly-B-hydroxyalkanoates are lipidlike carbon ...
 3-101 1.41e-29

polyhydroxyalkanoate synthesis repressor PhaR; Poly-B-hydroxyalkanoates are lipidlike carbon/energy storage polymers found in granular inclusions. PhaR is a regulatory protein found in general near other proteins associated with polyhydroxyalkanoate (PHA) granule biosynthesis and utilization. It is found to be a DNA-binding homotetramer that is also capable of binding short chain hydroxyalkanoic acids and PHA granules. PhaR may regulate the expression of itself, of the phasins that coat granules, and of enzymes that direct carbon flux into polymers stored in granules. The C-terminal region is poorly conserved in this family and is not part of this model.//GO terms added 12/6/04 [SS] [Fatty acid and phospholipid metabolism, Biosynthesis, Regulatory functions, DNA interactions]


Pssm-ID: 130907 [Multi-domain]  Cd Length: 107  Bit Score: 102.87  E-value: 1.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261    3 RLIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAGATQFLSADILRQIISLANH 82
Cdd:TIGR01848   1 RIIKKYPNRRLYDTETSSYVTLEDIRDLVREGREFQVVDSKSGDDLTRSILLQIIAEEESGGEPVLSTDFLTQIIRFYGG 80

                          90
                  ....*....|....*....
gi 493927261   83 PMQASLKTMMEQMFQVMEK 101
Cdd:TIGR01848  81 SMQSFVPQYLEASLEMFAK 99
PHB_acc_N pfam07879
PHB/PHA accumulation regulator DNA-binding domain; This domain is found at the N-terminus of ...
 4-63 8.20e-29

PHB/PHA accumulation regulator DNA-binding domain; This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA. The invariant nature of this domain compared to the C-terminal pfam05233 domain(s) suggests that it contains the DNA-binding function.


Pssm-ID: 429710  Cd Length: 61  Bit Score: 99.51  E-value: 8.20e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493927261    4 LIKKYKNRRLYDTETSQYITIEQLQHYVVDGVKFKVEDSNTGKDLTNSILLQIIVEMEAG 63
Cdd:pfam07879   1 IIKKYPNRRLYDTETSRYITLEDIAQLVREGEDFQVVDAKTGEDITRSVLTQIILEEESK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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