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Conserved domains on  [gi|501156349|ref|WP_012200931|]
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DEAD/DEAH box helicase [Lachnoclostridium phytofermentans]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 153-627 2.90e-68

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 235.89  E-value: 2.90e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTSIVYGAYAYLKNldlndNKKIDRILIIGPLSSFGPWEQEYEeCFGTRTTTKRLISSLKKQDKIDYLysnNTSEI 232
Cdd:COG0553  269 MGLGKTIQALALLLELKE-----RGLARPVLIVAPTSLVGNWQRELA-KFAPGLRVLVLDGTRERAKGANPF---EDADL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 233 TLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:COG0553  340 VITSYGLLRRDIELL---AAVDWDLVILDEAQHIKN-PATKRAKAVRALK--ARHRLALTGTPVENRLEELWSLLDFLNP 413

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 313 skNVMG--------FQINQLKDmsskpNDVRVSRLISSIAPYFIRIKKSDL--NLPSvKIHSPIEVEMGEFQQRIYDLIE 382
Cdd:COG0553  414 --GLLGslkafrerFARPIEKG-----DEEALERLRRLLRPFLLRRTKEDVlkDLPE-KTEETLYVELTPEQRALYEAVL 485

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 383 KKYIESIienkEDDLNDKfKKQLVAAKMIRLMQAATNPTLLrmplkeflydedlsidllknfddtdlLKQILDYKDNeiP 462
Cdd:COG0553  486 EYLRREL----EGAEGIR-RRGLILAALTRLRQICSHPALL--------------------------LEEGAELSGR--S 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 463 AKFIEVKKLVDSIISDGGKVVIWASFVKNIHDLKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkENSE 542
Cdd:COG0553  533 AKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEE-----------RDELVDRFQ-EGPE 600

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 543 FKVIIANPFAVAESISLHkSCHNAIYLERTFNAAHYMQSKDRIHRYGLKAGIETnyYYILSKDSIDEIIHERLNLKERRM 622
Cdd:COG0553  601 APVFLISLKAGGEGLNLT-AADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQV--YKLVAEGTIEEKILELLEEKRALA 677


                 ....*
gi 501156349 623 TEIME 627
Cdd:COG0553  678 ESVLG 682
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 153-627 2.90e-68

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 235.89  E-value: 2.90e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTSIVYGAYAYLKNldlndNKKIDRILIIGPLSSFGPWEQEYEeCFGTRTTTKRLISSLKKQDKIDYLysnNTSEI 232
Cdd:COG0553  269 MGLGKTIQALALLLELKE-----RGLARPVLIVAPTSLVGNWQRELA-KFAPGLRVLVLDGTRERAKGANPF---EDADL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 233 TLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:COG0553  340 VITSYGLLRRDIELL---AAVDWDLVILDEAQHIKN-PATKRAKAVRALK--ARHRLALTGTPVENRLEELWSLLDFLNP 413

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 313 skNVMG--------FQINQLKDmsskpNDVRVSRLISSIAPYFIRIKKSDL--NLPSvKIHSPIEVEMGEFQQRIYDLIE 382
Cdd:COG0553  414 --GLLGslkafrerFARPIEKG-----DEEALERLRRLLRPFLLRRTKEDVlkDLPE-KTEETLYVELTPEQRALYEAVL 485

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 383 KKYIESIienkEDDLNDKfKKQLVAAKMIRLMQAATNPTLLrmplkeflydedlsidllknfddtdlLKQILDYKDNeiP 462
Cdd:COG0553  486 EYLRREL----EGAEGIR-RRGLILAALTRLRQICSHPALL--------------------------LEEGAELSGR--S 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 463 AKFIEVKKLVDSIISDGGKVVIWASFVKNIHDLKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkENSE 542
Cdd:COG0553  533 AKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEE-----------RDELVDRFQ-EGPE 600

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 543 FKVIIANPFAVAESISLHkSCHNAIYLERTFNAAHYMQSKDRIHRYGLKAGIETnyYYILSKDSIDEIIHERLNLKERRM 622
Cdd:COG0553  601 APVFLISLKAGGEGLNLT-AADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQV--YKLVAEGTIEEKILELLEEKRALA 677


                 ....*
gi 501156349 623 TEIME 627
Cdd:COG0553  678 ESVLG 682
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 146-312 3.17e-26

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 105.73  E-value: 3.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 146 NACNFSVPGAGKTSIVYGAYAYLKNLdlndNKKIDRILIIGPLSSFGPWEQEYEECFGTRTTTKrLISSLKKQDKIDYLY 225
Cdd:cd17919   21 GGILADEMGLGKTLQAIAFLAYLLKE----GKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV-YHGSQRERAQIRAKE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 226 SNNTSEITLISYASVATVCDALIWFlknNKVMVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYN 305
Cdd:cd17919   96 KLDKFDVVLTTYETLRRDKASLRKF---RWDLVVVDEAHRLKN-PKSQLSKALKALR--AKRRLLLTGTPLQNNLEELWA 169


                 ....*..
gi 501156349 306 LFKFIWP 312
Cdd:cd17919  170 LLDFLDP 176
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 153-378 3.77e-16

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 79.26  E-value: 3.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  153 PGAGKTSIVYGAYAYLKNLDLNDNKKIdriLIIGPLSSFGPWEQEYEEcFGTRTTTKRLISSLKKQDKIDYLYSNNTSE- 231
Cdd:pfam00176  26 MGLGKTLQTISLLLYLKHVDKNWGGPT---LIVVPLSLLHNWMNEFER-WVSPPALRVVVLHGNKRPQERWKNDPNFLAd 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  232 --ITLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNTsggqsaDAVLKLApfCKS-----RVILTGTPSPNGYDDLY 304
Cdd:pfam00176 102 fdVVITTYETLRKHKELL---KKVHWHRIVLDEGHRLKNS------KSKLSKA--LKSlktrnRWILTGTPLQNNLEELW 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349  305 NLFKFIWPSK--NVMGFQINQLKDMSSKPNDVRVSRLISSIAPYFIRIKKSDL--NLPsVKIHSPIEVEMGEFQQRIY 378
Cdd:pfam00176 171 ALLNFLRPGPfgSLSTFRNWFDRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVekSLP-PKVEYILFCRLSKLQRKLY 247
DEXDc smart00487
DEAD-like helicases superfamily;
153-308 6.66e-10

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 59.04  E-value: 6.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349   153 PGAGKTsIVYGAYAylknLDLNDNKKIDRILIIGPLSSFGP-WEQEYEECFG-TRTTTKRLISSLKKQDKIDYLYSNNTs 230
Cdd:smart00487  33 TGSGKT-LAALLPA----LEALKRGKGGRVLVLVPTRELAEqWAEELKKLGPsLGLKVVGLYGGDSKREQLRKLESGKT- 106

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349   231 EITLISYASVATVCDALIWFLKNNKVmVVLDEAHKIKNTSGGQSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFK 308
Cdd:smart00487 107 DILVTTPGRLLDLLENDKLSLSNVDL-VILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLN 183
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 258-614 2.83e-05

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 47.49  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  258 VVLDEAHKIKNTSGGQSadAVLKLAPfCKSRVILTGTPSPNGYDDLYNLFKFIWPSKNVMGFQINQLKDMSSKPNDVRV- 336
Cdd:PLN03142  295 IIIDEAHRIKNENSLLS--KTMRLFS-TNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVv 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  337 SRLISSIAPYFIRIKKSDL--NLPSVKiHSPIEVEMGEFQQRIYDLIEKKYIESIIENKEddlndkfKKQLVAAKMiRLM 414
Cdd:PLN03142  372 QQLHKVLRPFLLRRLKSDVekGLPPKK-ETILKVGMSQMQKQYYKALLQKDLDVVNAGGE-------RKRLLNIAM-QLR 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  415 QAATNPTLLR--MPLKEFLYDEDLSidllknfddtdllkqildykdnEIPAKFIEVKKLVDSIISDGGKVVIWASFVKNI 492
Cdd:PLN03142  443 KCCNHPYLFQgaEPGPPYTTGEHLV----------------------ENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLL 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  493 HDLKLYLENNGIKcqelYGAIpveqeDMNSDNDtlTREKIVRDFQKENSEFKVIIANPFAVAESISLHKSCHNAIYlERT 572
Cdd:PLN03142  501 DILEDYLMYRGYQ----YCRI-----DGNTGGE--DRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILY-DSD 568

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 501156349  573 FNAAHYMQSKDRIHRYGLKAgiETNYYYILSKDSIDEIIHER 614
Cdd:PLN03142  569 WNPQVDLQAQDRAHRIGQKK--EVQVFRFCTEYTIEEKVIER 608
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 153-627 2.90e-68

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 235.89  E-value: 2.90e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTSIVYGAYAYLKNldlndNKKIDRILIIGPLSSFGPWEQEYEeCFGTRTTTKRLISSLKKQDKIDYLysnNTSEI 232
Cdd:COG0553  269 MGLGKTIQALALLLELKE-----RGLARPVLIVAPTSLVGNWQRELA-KFAPGLRVLVLDGTRERAKGANPF---EDADL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 233 TLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:COG0553  340 VITSYGLLRRDIELL---AAVDWDLVILDEAQHIKN-PATKRAKAVRALK--ARHRLALTGTPVENRLEELWSLLDFLNP 413

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 313 skNVMG--------FQINQLKDmsskpNDVRVSRLISSIAPYFIRIKKSDL--NLPSvKIHSPIEVEMGEFQQRIYDLIE 382
Cdd:COG0553  414 --GLLGslkafrerFARPIEKG-----DEEALERLRRLLRPFLLRRTKEDVlkDLPE-KTEETLYVELTPEQRALYEAVL 485

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 383 KKYIESIienkEDDLNDKfKKQLVAAKMIRLMQAATNPTLLrmplkeflydedlsidllknfddtdlLKQILDYKDNeiP 462
Cdd:COG0553  486 EYLRREL----EGAEGIR-RRGLILAALTRLRQICSHPALL--------------------------LEEGAELSGR--S 532

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 463 AKFIEVKKLVDSIISDGGKVVIWASFVKNIHDLKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkENSE 542
Cdd:COG0553  533 AKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEE-----------RDELVDRFQ-EGPE 600

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 543 FKVIIANPFAVAESISLHkSCHNAIYLERTFNAAHYMQSKDRIHRYGLKAGIETnyYYILSKDSIDEIIHERLNLKERRM 622
Cdd:COG0553  601 APVFLISLKAGGEGLNLT-AADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQV--YKLVAEGTIEEKILELLEEKRALA 677


                 ....*
gi 501156349 623 TEIME 627
Cdd:COG0553  678 ESVLG 682
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 146-312 3.17e-26

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 105.73  E-value: 3.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 146 NACNFSVPGAGKTSIVYGAYAYLKNLdlndNKKIDRILIIGPLSSFGPWEQEYEECFGTRTTTKrLISSLKKQDKIDYLY 225
Cdd:cd17919   21 GGILADEMGLGKTLQAIAFLAYLLKE----GKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV-YHGSQRERAQIRAKE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 226 SNNTSEITLISYASVATVCDALIWFlknNKVMVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYN 305
Cdd:cd17919   96 KLDKFDVVLTTYETLRRDKASLRKF---RWDLVVVDEAHRLKN-PKSQLSKALKALR--AKRRLLLTGTPLQNNLEELWA 169


                 ....*..
gi 501156349 306 LFKFIWP 312
Cdd:cd17919  170 LLDFLDP 176
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 153-378 3.77e-16

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 79.26  E-value: 3.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  153 PGAGKTSIVYGAYAYLKNLDLNDNKKIdriLIIGPLSSFGPWEQEYEEcFGTRTTTKRLISSLKKQDKIDYLYSNNTSE- 231
Cdd:pfam00176  26 MGLGKTLQTISLLLYLKHVDKNWGGPT---LIVVPLSLLHNWMNEFER-WVSPPALRVVVLHGNKRPQERWKNDPNFLAd 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  232 --ITLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNTsggqsaDAVLKLApfCKS-----RVILTGTPSPNGYDDLY 304
Cdd:pfam00176 102 fdVVITTYETLRKHKELL---KKVHWHRIVLDEGHRLKNS------KSKLSKA--LKSlktrnRWILTGTPLQNNLEELW 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349  305 NLFKFIWPSK--NVMGFQINQLKDMSSKPNDVRVSRLISSIAPYFIRIKKSDL--NLPsVKIHSPIEVEMGEFQQRIY 378
Cdd:pfam00176 171 ALLNFLRPGPfgSLSTFRNWFDRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVekSLP-PKVEYILFCRLSKLQRKLY 247
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 154-349 3.14e-14

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 72.40  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKTSIVYgayAYLKNLdlNDNKKIDRILIIGPLSSFGPWEQEYEECfGTRTTTKRLISSLKKQDKIDYLYSNNTSEIT 233
Cdd:cd18001   29 GLGKTVQIC---AFLSGM--FDSGLIKSVLVVMPTSLIPHWVKEFAKW-TPGLRVKVFHGTSKKERERNLERIQRGGGVL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 234 LISYASVATVCDALIWFLKNNKV--MVVLDEAHKIKNTSGgQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIW 311
Cdd:cd18001  103 LTTYGMVLSNTEQLSADDHDEFKwdYVILDEGHKIKNSKT-KSAKSLREIP--AKNRIILTGTPIQNNLKELWALFDFAC 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 501156349 312 P-----SKNV--MGFQ--INQLKDMSSKPNDVRVSRLISS-----IAPYFIR 349
Cdd:cd18001  180 NgsllgTRKTfkMEFEnpITRGRDKDATQGEKALGSEVAEnlrqiIKPYFLR 231
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 183-343 4.82e-14

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 72.32  E-value: 4.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEYEECFGTRTTT---------KRLISSLKKQD-------KIDYLYSNNTSEITLISYASVATVCDA 246
Cdd:cd18008   66 LIVVPLSLLSQWKDEIEKHTKPGSLKvyvyhgskrIKSIEELSDYDivittygTLASEFPKNKKGGGRDSKEKEASPLHR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 247 LIWFlknnkvMVVLDEAHKIKNTSGgQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFI-------WPSKNVmgf 319
Cdd:cd18008  146 IRWY------RVILDEAHNIKNRST-KTSRAVCALK--AERRWCLTGTPIQNSLDDLYSLLRFLrvepfgdYPWFNS--- 213

                        170       180
                 ....*....|....*....|....
gi 501156349 320 QINQLKDMSSKPNDVRVSRLISSI 343
Cdd:cd18008  214 DISKPFSKNDRKALERLQALLKPI 237
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 179-313 1.81e-13

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 70.39  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 179 IDRILIIGPLSSFGPWEQEYEECFGTRTTTKRLISSLKK--QDKIDYLYSNNTSEITLISYASVATVCDALIwflKNNKV 256
Cdd:cd18004   59 AKKALIVCPSSLVGNWKAEFDKWLGLRRIKVVTADGNAKdvKASLDFFSSASTYPVLIISYETLRRHAEKLS---KKISI 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349 257 -MVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWPS 313
Cdd:cd18004  136 dLLICDEGHRLKN-SESKTTKALNSLP--CRRRLLLTGTPIQNDLDEFFALVDFVNPG 190
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 461-589 3.11e-13

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 67.12  E-value: 3.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 461 IPAKFIEVKKLVDSIISDGGKVVIWASFVKNIHDLKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkEN 540
Cdd:cd18793    9 VSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKE-----------RQKLVDRFN-ED 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 501156349 541 SEFKVIIANPFAVAESISLHkSCHNAIYLERTFNAAHYMQSKDRIHRYG 589
Cdd:cd18793   77 PDIRVFLLSTKAGGVGLNLT-AANRVILYDPWWNPAVEEQAIDRAHRIG 124
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 182-349 6.08e-10

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 59.57  E-value: 6.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 182 ILIIGPLSSFGPWEQEYEE-------CFGTRTTTKRLISSLKKQDKIDYLYSNNT---SEITLISYASVATVCDALI--- 248
Cdd:cd17995   53 FLVIAPLSTIPNWQREFETwtdmnvvVYHGSGESRQIIQQYEMYFKDAQGRKKKGvykFDVLITTYEMVIADAEELRkip 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 249 WFLknnkvmVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWPSK--NVMGFQiNQLKD 326
Cdd:cd17995  133 WRV------VVVDEAHRLKN-RNSKLLQGLKKLT--LEHKLLLTGTPLQNNTEELWSLLNFLEPEKfpSSEEFL-EEFGD 202

                        170       180
                 ....*....|....*....|...
gi 501156349 327 MssKPNDvRVSRLISSIAPYFIR 349
Cdd:cd17995  203 L--KTAE-QVEKLQALLKPYMLR 222
DEXDc smart00487
DEAD-like helicases superfamily;
153-308 6.66e-10

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 59.04  E-value: 6.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349   153 PGAGKTsIVYGAYAylknLDLNDNKKIDRILIIGPLSSFGP-WEQEYEECFG-TRTTTKRLISSLKKQDKIDYLYSNNTs 230
Cdd:smart00487  33 TGSGKT-LAALLPA----LEALKRGKGGRVLVLVPTRELAEqWAEELKKLGPsLGLKVVGLYGGDSKREQLRKLESGKT- 106

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349   231 EITLISYASVATVCDALIWFLKNNKVmVVLDEAHKIKNTSGGQSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFK 308
Cdd:smart00487 107 DILVTTPGRLLDLLENDKLSLSNVDL-VILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLN 183
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 154-312 7.32e-10

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 59.67  E-value: 7.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKT----SIVYGAYAYLKNLDLNDNKkidRILIIGPLSSFGPWEQEYE-----------ECFGTRTTTKRLISSLKKQ 218
Cdd:cd17999   29 GLGKTlqtlCILASDHHKRANSFNSENL---PSLVVCPPTLVGHWVAEIKkyfpnaflkplAYVGPPQERRRLREQGEKH 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 219 DkidylysnntseITLISYAsvatVCDALIWFLKNNK-VMVVLDEAHKIKNTSGgQSADAVLKLApfCKSRVILTGTPSP 297
Cdd:cd17999  106 N------------VIVASYD----VLRNDIEVLTKIEwNYCVLDEGHIIKNSKT-KLSKAVKQLK--ANHRLILSGTPIQ 166

                        170
                 ....*....|....*
gi 501156349 298 NGYDDLYNLFKFIWP 312
Cdd:cd17999  167 NNVLELWSLFDFLMP 181
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 154-312 1.10e-09

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 58.49  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKT-SIVygayAYLKNLDLNdNKKIDRILIIGPLSSFGPWEQEYEECF------------GTRTTTKRLISSLKKQDK 220
Cdd:cd18000   29 GLGKTiQII----AFLAALHHS-KLGLGPSLIVCPATVLKQWVKEFHRWWppfrvvvlhssgSGTGSEEKLGSIERKSQL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 221 IDYLYsnNTSEITLISYASVATVCDALiwfLKNNKVMVVLDEAHKIKNtsggqsADAVLKLApfCKS-----RVILTGTP 295
Cdd:cd18000  104 IRKVV--GDGGILITTYEGFRKHKDLL---LNHNWQYVILDEGHKIRN------PDAEITLA--CKQlrtphRLILSGTP 170

                        170
                 ....*....|....*..
gi 501156349 296 SPNGYDDLYNLFKFIWP 312
Cdd:cd18000  171 IQNNLKELWSLFDFVFP 187
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 180-310 1.52e-09

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 59.02  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 180 DRILIIGPLSSFGPWEQEYEECFGTRTTTKRLISSLKKQDKIDYLysnNTSEITLISYASVA----TVCDALIWFLKNNK 255
Cdd:cd18071   72 NFTLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLL---SKYDIVLTTYNTLAsdfgAKGDSPLHTINWLR 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501156349 256 VmvVLDEAHKIKNTSGGQSAdAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFI 310
Cdd:cd18071  149 V--VLDEGHQIRNPNAQQTK-AVLNLS--SERRWVLTGTPIQNSPKDLGSLLSFL 198
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 183-312 3.86e-09

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 57.19  E-value: 3.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEYEECFGTRTTTkrLISSLKKQDKIDYLYSNNtsEITLISYASVAtvcdALIWFLKNNKV-MVVLD 261
Cdd:cd18012   57 LVVAPTSLIYNWEEEAAKFAPELKVL--VIHGTKRKREKLRALEDY--DLVITSYGLLR----RDIELLKEVKFhYLVLD 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 501156349 262 EAHKIKNtSGGQSADAVLKL-APFcksRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18012  129 EAQNIKN-PQTKTAKAVKALkADH---RLALTGTPIENHLGELWSIFDFLNP 176
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 130-310 4.42e-09

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 56.97  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 130 LYELQLLSAYHLAFSQNACNFSVPGAGKTSIVYGAYAYLKNLDlndnkKIDRILIIGPLS-SFGPWEQEYEECFGTRTTT 208
Cdd:cd18013    1 PHPYQKVAINFIIEHPYCGLFLDMGLGKTVTTLTALSDLQLDD-----FTRRVLVIAPLRvARSTWPDEVEKWNHLRNLT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 209 KRLISSLKKQdKIDYLysNNTSEITLISYASVATVCDALI--WFLKnnkvMVVLDEAHKIKNTSGgQSADAVLKLAPFCK 286
Cdd:cd18013   76 VSVAVGTERQ-RSKAA--NTPADLYVINRENLKWLVNKSGdpWPFD----MVVIDELSSFKSPRS-KRFKALRKVRPVIK 147

                        170       180
                 ....*....|....*....|....
gi 501156349 287 SRVILTGTPSPNGYDDLYNLFKFI 310
Cdd:cd18013  148 RLIGLTGTPSPNGLMDLWAQIALL 171
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 463-589 5.03e-09

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 54.14  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  463 AKFIEVKKLVDSiiSDGGKVVIWASFVKNIhDLKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkeNSE 542
Cdd:pfam00271   1 EKLEALLELLKK--ERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEE-----------REEILEDFR--KGK 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 501156349  543 FKVIIA-NpfAVAESISLhKSCHNAIYLERTFNAAHYMQSKDRIHRYG 589
Cdd:pfam00271  65 IDVLVAtD--VAERGLDL-PDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 154-349 1.29e-08

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 56.23  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKT--SIVYGAYAYLKNLDLNDNKKIDRI--------------LIIGPLSSFGPWEQEYEEcFGTRTTTKrlISSLKK 217
Cdd:cd18005   29 GLGKTvqVIAFLAAVLGKTGTRRDRENNRPRfkkkppassakkpvLIVAPLSVLYNWKDELDT-WGHFEVGV--YHGSRK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 218 QDKIDYLYSNNTSEITLISYASVATVCDALiwflknNKV---MVVLDEAHKIKNTSGGQSaDAVLKLApfCKSRVILTGT 294
Cdd:cd18005  106 DDELEGRLKAGRLEVVVTTYDTLRRCIDSL------NSInwsAVIADEAHRIKNPKSKLT-QAMKELK--CKVRIGLTGT 176

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501156349 295 PSPNGYDDLYNLFKFIWPskNVMGFQiNQLKDMSSKP----------------NDVRVSRLISSIAPYFIR 349
Cdd:cd18005  177 LLQNNMKELWCLLDWAVP--GALGSR-SQFKKHFSEPikrgqrhtatarelrlGRKRKQELAVKLSKFFLR 244
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 179-312 1.40e-08

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 56.01  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 179 IDRILIIGPLSSFGPWEQEYEECFGTrtttKRLISSLKKQD-KIDYLYSNNTSEITLISYASVATvCDALIWFLKNNkvM 257
Cdd:cd18066   60 IKRALIVTPGSLVKNWKKEFQKWLGS----ERIKVFTVDQDhKVEEFIASPLYSVLIISYEMLLR-SLDQISKLNFD--L 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 501156349 258 VVLDEAHKIKNTSGgQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18066  133 VICDEGHRLKNTSI-KTTTALTSLS--CERRIILTGTPIQNDLQEFFALIDFVNP 184
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 154-349 5.76e-08

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 53.60  E-value: 5.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKTSIVYGAYAYLKNlDLNDNKKIdriLIIGPLSSFGPWEQEYEEcFGTRTTTKRLISSLKKQ-DKIDYLYSNNTSEI 232
Cdd:cd18006   29 GLGKTCQTISLLWYLAG-RLKLLGPF---LVLCPLSVLDNWKEELNR-FAPDLSVITYMGDKEKRlDLQQDIKSTNRFHV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 233 TLISYASVATVCDALIWFlkNNKVMVVlDEAHKIKNTSGGQSADAVLKLAPFCksrVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18006  104 LLTTYEICLKDASFLKSF--PWASLVV-DEAHRLKNQNSLLHKTLSEFSVDFR---LLLTGTPIQNSLQELYALLSFIEP 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 501156349 313 SKnvmgFQINQLKDMSSKPNDVR-----VSRLISSIAPYFIR 349
Cdd:cd18006  178 NV----FPKDKLDDFIKAYSETDdesetVEELHLLLQPFLLR 215
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 153-310 2.96e-07

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 51.52  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTsIVYGAYA-YLknLDLNDnkkIDRILIIGPLSSFGPWEQEYEECFGTRTTtkRLISSLKKQDKIDYLYSNNTSE 231
Cdd:cd18011   26 VGLGKT-IEAGLIIkEL--LLRGD---AKRVLILCPASLVEQWQDELQDKFGLPFL--ILDRETAAQLRRLIGNPFEEFP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 232 ITLISYASVATVCDALIWFLKNNKVMVVLDEAHKIKNTSGG---QSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFK 308
Cdd:cd18011   98 IVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGGGketKRYKLGRLLAKRARHVLLLTATPHNGKEEDFRALLS 177


                 ..
gi 501156349 309 FI 310
Cdd:cd18011  178 LL 179
HELICc smart00490
helicase superfamily c-terminal domain;
495-589 6.49e-07

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 47.59  E-value: 6.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349   495 LKLYLENNGIKCQELYGAIPVEQedmnsdndtltREKIVRDFQkeNSEFKVIIANPfAVAESISLhKSCHNAIYLERTFN 574
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEE-----------REEILDKFN--NGKIKVLVATD-VAERGLDL-PGVDLVIIYDLPWS 67

                           90
                   ....*....|....*
gi 501156349   575 AAHYMQSKDRIHRYG 589
Cdd:smart00490  68 PASYIQRIGRAGRAG 82
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 183-312 7.48e-07

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 50.28  E-value: 7.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEYEecfgtrtttkRLISSLKKQDKI------DYLYSNNTSeITLISYASVATVCDALIwfLKNNKV 256
Cdd:cd18010   47 LIVCPSSLRLTWADEIE----------RWLPSLPPDDIQvivkskDGLRDGDAK-VVIVSYDLLRRLEKQLL--ARKFKV 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 501156349 257 mVVLDEAHKIKNtSGGQSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18010  114 -VICDESHYLKN-SKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFTQLDALDP 167
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 179-312 9.61e-07

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 50.55  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 179 IDRILIIGPLSSFGPWEQEYEECFGTRTTTKRLISSLKKQDKIDYLYSNN------TSEITLISYASVATVCDALiwflK 252
Cdd:cd18067   59 IDKAIVVSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRKLVQWASqqgrrvSTPVLIISYETFRLHVEVL----Q 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 501156349 253 NNKV-MVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18067  135 KGEVgLVICDEGHRLKN-SDNQTYQALDSLN--TQRRVLLSGTPIQNDLSEYFSLVNFVNP 192
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 153-312 4.07e-06

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 48.44  E-value: 4.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKT--SIVYgAYAYLKNLdlndnKKIDRILIIGPLSSFGPWEQEYEE-------------CFGTRTTTKRLISSLKK 217
Cdd:cd18007   35 MGLGKTlqVITF-LHTYLAAA-----PRRSRPLVLCPASTLYNWEDEFKKwlppdlrpllvlvSLSASKRADARLRKINK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 218 --QDK----IDY-----LYSNNTSEITLISyASVATVCDaliwflkNNKVMVVLDEAHKIKNTSgGQSADAVLKLAPfcK 286
Cdd:cd18007  109 whKEGgvllIGYelfrnLASNATTDPRLKQ-EFIAALLD-------PGPDLLVLDEGHRLKNEK-SQLSKALSKVKT--K 177

                        170       180
                 ....*....|....*....|....*.
gi 501156349 287 SRVILTGTPSPNGYDDLYNLFKFIWP 312
Cdd:cd18007  178 RRILLTGTPLQNNLKEYWTMVDFARP 203
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 154-313 5.65e-06

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 47.88  E-value: 5.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKT--SIVYGAYaylknldLNDNKKI-DRILIIGPLSSFGPWEQE------------YEECFGTRTTTKRLISSlKKQ 218
Cdd:cd18002   29 GLGKTvqSIAVLAH-------LAEEHNIwGPFLVIAPASTLHNWQQEisrfvpqfkvlpYWGNPKDRKVLRKFWDR-KNL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 219 dkidyLYSNNTSEITLISYASVatVCDALiWFLKNNKVMVVLDEAHKIKNTSggqSADAVLKLAPFCKSRVILTGTPSPN 298
Cdd:cd18002  101 -----YTRDAPFHVVITSYQLV--VQDEK-YFQRVKWQYMVLDEAQAIKSSS---SSRWKTLLSFHCRNRLLLTGTPIQN 169

                        170
                 ....*....|....*
gi 501156349 299 GYDDLYNLFKFIWPS 313
Cdd:cd18002  170 SMAELWALLHFIMPT 184
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 258-310 6.96e-06

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 47.86  E-value: 6.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 501156349 258 VVLDEAHKIKNTSGgQSADAVLKLAPFCksRVILTGTPSPNGYDDLYNLFKFI 310
Cdd:cd18072  155 IILDEAHNIKNPKV-QASIAVCKLRAHA--RWALTGTPIQNNLLDMYSLLKFL 204
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 183-349 6.99e-06

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 47.73  E-value: 6.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEyeecFGTRTTTKRLI---SSLKKQDKIDY-LYSNNTS----------EITLISYASVATVCDALi 248
Cdd:cd18058   53 LIIAPLSTITNWERE----FRTWTEMNAIVyhgSQISRQMIQQYeMYYRDEQgnplsgifkfQVVITTFEMILADCPEL- 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 249 wfLKNNKVMVVLDEAHKIKNTSGGQSADavLKLAPFcKSRVILTGTPSPNGYDDLYNLFKFIWPSKnvMGFQINQLKDMS 328
Cdd:cd18058  128 --KKINWSCVIIDEAHRLKNRNCKLLEG--LKLMAL-EHKVLLTGTPLQNSVEELFSLLNFLEPSQ--FPSETTFLEEFG 200

                        170       180
                 ....*....|....*....|.
gi 501156349 329 SKPNDVRVSRLISSIAPYFIR 349
Cdd:cd18058  201 DLKTEEQVKKLQSILKPMMLR 221
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 183-349 1.13e-05

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 46.97  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEYEE-------CFGTRTTTKRLISSLK---KQDKIDYLYSNNTSEITLISYASVATVCDALiwfLK 252
Cdd:cd18060   53 LVIAPLSTITNWEREFNTwtemntiVYHGSLASRQMIQQYEmycKDSRGRLIPGAYKFDALITTFEMILSDCPEL---RE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 253 NNKVMVVLDEAHKIKNTSgGQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWPSKnvMGFQINQLKDMSSKPN 332
Cdd:cd18060  130 IEWRCVIIDEAHRLKNRN-CKLLDSLKHMD--LEHKVLLTGTPLQNTVEELFSLLHFLEPSQ--FPSESEFLKDFGDLKT 204

                        170
                 ....*....|....*..
gi 501156349 333 DVRVSRLISSIAPYFIR 349
Cdd:cd18060  205 EEQVQKLQAILKPMMLR 221
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 127-314 1.44e-05

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 46.92  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 127 NRSLYELQLLSAYHLAFSQNACNFSV----PGAGKTSIVYGAYAYLknldLNDNKKIDRILIIGPLSSFGPWEQEYEEC- 201
Cdd:cd18054   18 NLELRDYQLEGLNWLAHSWCKNNSVIladeMGLGKTIQTISFLSYL----FHQHQLYGPFLLVVPLSTLTSWQREFEIWa 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 202 -----------FGTRTTTKRL--ISSLKKQDKIDYLYSnnTSEITLISYASVATVcdaliwflknNKVMVVLDEAHKIKN 268
Cdd:cd18054   94 peinvvvyigdLMSRNTIREYewIHSQTKRLKFNALIT--TYEILLKDKTVLGSI----------NWAFLGVDEAHRLKN 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 501156349 269 TsggqsaDAVL--KLAPF-CKSRVILTGTPSPNGYDDLYNLFKFIWPSK 314
Cdd:cd18054  162 D------DSLLykTLIDFkSNHRLLITGTPLQNSLKELWSLLHFIMPEK 204
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 153-295 1.90e-05

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 44.99  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTSIVYGAYAYLKNLdlndnkkidRILIIGP-LSSFGPWEQEYEECFGTRTttKRLISSLKKQDKIDylysnntSE 231
Cdd:cd17926   27 TGSGKTLTALALIAYLKEL---------RTLIVVPtDALLDQWKERFEDFLGDSS--IGLIGGGKKKDFDD-------AN 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501156349 232 ITLISYASvATVCDALIWFLKNNKVMVVLDEAHKIkntsGGQSADAVLKLAPfCKSRVILTGTP 295
Cdd:cd17926   89 VVVATYQS-LSNLAEEEKDLFDQFGLLIVDEAHHL----PAKTFSEILKELN-AKYRLGLTATP 146
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 258-614 2.83e-05

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 47.49  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  258 VVLDEAHKIKNTSGGQSadAVLKLAPfCKSRVILTGTPSPNGYDDLYNLFKFIWPSKNVMGFQINQLKDMSSKPNDVRV- 336
Cdd:PLN03142  295 IIIDEAHRIKNENSLLS--KTMRLFS-TNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVv 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  337 SRLISSIAPYFIRIKKSDL--NLPSVKiHSPIEVEMGEFQQRIYDLIEKKYIESIIENKEddlndkfKKQLVAAKMiRLM 414
Cdd:PLN03142  372 QQLHKVLRPFLLRRLKSDVekGLPPKK-ETILKVGMSQMQKQYYKALLQKDLDVVNAGGE-------RKRLLNIAM-QLR 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  415 QAATNPTLLR--MPLKEFLYDEDLSidllknfddtdllkqildykdnEIPAKFIEVKKLVDSIISDGGKVVIWASFVKNI 492
Cdd:PLN03142  443 KCCNHPYLFQgaEPGPPYTTGEHLV----------------------ENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLL 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  493 HDLKLYLENNGIKcqelYGAIpveqeDMNSDNDtlTREKIVRDFQKENSEFKVIIANPFAVAESISLHKSCHNAIYlERT 572
Cdd:PLN03142  501 DILEDYLMYRGYQ----YCRI-----DGNTGGE--DRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILY-DSD 568

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 501156349  573 FNAAHYMQSKDRIHRYGLKAgiETNYYYILSKDSIDEIIHER 614
Cdd:PLN03142  569 WNPQVDLQAQDRAHRIGQKK--EVQVFRFCTEYTIEEKVIER 608
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
82-295 4.35e-05

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 46.56  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349  82 KIILDFYEEEDKFNLFSKKALEIRNNNCEHEEFKAFIEVLSKNI----NNRSLYELQL--LSAYHLAFSQNACNFSV--- 152
Cdd:COG1061   29 SLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDeasgTSFELRPYQQeaLEALLAALERGGGRGLVvap 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 153 PGAGKTSIVYGAYAYLKNldlndnkkIDRILIIGP----LSSfgpWEQEYEECFGtrtttKRLISSLKKQDkidylysnn 228
Cdd:COG1061  109 TGTGKTVLALALAAELLR--------GKRVLVLVPrrelLEQ---WAEELRRFLG-----DPLAGGGKKDS--------- 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501156349 229 TSEITLISYASVATvcDALIWFLKNNKVMVVLDEAHKIkntsGGQSADAVLKLapFCKSRVI-LTGTP 295
Cdd:COG1061  164 DAPITVATYQSLAR--RAHLDELGDRFGLVIIDEAHHA----GAPSYRRILEA--FPAAYRLgLTATP 223
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 183-349 1.05e-04

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 44.27  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 183 LIIGPLSSFGPWEQEYEE-C--------FGTRTTTKRlisslKKQDkidyLYSNNTSEITLISYASVatVCDALIWFLKN 253
Cdd:cd18003   54 LIVVPTSVMLNWEMEFKRwCpgfkiltyYGSAKERKL-----KRQG----WMKPNSFHVCITSYQLV--VQDHQVFKRKK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 254 NKVMVvLDEAHKIKN-TSggQSADAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWPSknvmGFQINQ--------- 323
Cdd:cd18003  123 WKYLI-LDEAHNIKNfKS--QRWQTLLNFN--TQRRLLLTGTPLQNSLMELWSLMHFLMPH----IFQSHQefkewfsnp 193

                        170       180
                 ....*....|....*....|....*....
gi 501156349 324 LKDMSSKPNDVR---VSRLISSIAPYFIR 349
Cdd:cd18003  194 LTAMSEGSQEENeelVRRLHKVLRPFLLR 222
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 154-313 1.76e-04

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 42.76  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKTSIVYGAYAYLKnldlnDNKKIDRILIIGPLSSFGPWEQEY---------EECFGTRTTTKRL-ISSLKKQDKIDy 223
Cdd:cd17998   29 GLGKTIQVIAFLAYLK-----EIGIPGPHLVVVPSSTLDNWLREFkrwcpslkvEPYYGSQEERKHLrYDILKGLEDFD- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 224 lysnntseITLISYaSVATVCDALIWFLKNNKV-MVVLDEAHKIKNtSGGQSADAVLKLApfCKSRVILTGTPSPNGYDD 302
Cdd:cd17998  103 --------VIVTTY-NLATSNPDDRSFFKRLKLnYVVYDEGHMLKN-MTSERYRHLMTIN--ANFRLLLTGTPLQNNLLE 170

                        170
                 ....*....|.
gi 501156349 303 LYNLFKFIWPS 313
Cdd:cd17998  171 LMSLLNFIMPK 181
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 154-336 2.74e-04

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 42.95  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKTSIVYgayAYLKNLDLNDN-KKIDRILIIGPLSSFGPWEQEYEECFGTRTTTKRL----ISSLK-KQDKIDYLY-S 226
Cdd:cd18068   38 GLGKTLQVV---TFLHTVLLCEKlENFSRVLVVCPLNTVLNWLNEFEKWQEGLKDEEKIevneLATYKrPQERSYKLQrW 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 227 NNTSEITLISYA--SVATVCDALIWFLKNNKV-----------MVVLDEAHKIKNTSGGQSaDAVLKLApfCKSRVILTG 293
Cdd:cd18068  115 QEEGGVMIIGYDmyRILAQERNVKSREKLKEIfnkalvdpgpdFVVCDEGHILKNEASAVS-KAMNSIR--TKRRIVLTG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 501156349 294 TPSPNGYDDLYNLFKFIWPS-----KNVMGFQIN-----QLKDmsSKPNDVRV 336
Cdd:cd18068  192 TPLQNNLIEYHCMVNFVKPNllgtiKEFRNRFVNpiqngQCAD--STLVDVRV 242
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 257-338 3.47e-04

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 42.49  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 257 MVVLDEAHKIKNTSGGQSadAVLKlAPFCKSRVILTGTPSPNGYDDLYNLFKFIWPS--------KNVMGFQINQLKDMS 328
Cdd:cd18069  139 VVICDEGHRIKNCHASTS--QALK-NIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDflgtrqefSNMFERPILNGQCVD 215

                         90
                 ....*....|
gi 501156349 329 SKPNDVRVSR 338
Cdd:cd18069  216 STPQDVKLMR 225
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 154-349 4.59e-04

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 42.31  E-value: 4.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 154 GAGKTSIVYGAYAYLKNLdlndnKKID-RILIIGPLSSFGPWEQEYEE--------CF-GTRTTTKRLISSLKKQDKIDY 223
Cdd:cd17997   32 GLGKTLQTISLLGYLKHY-----KNINgPHLIIVPKSTLDNWMREFKRwcpslrvvVLiGDKEERADIIRDVLLPGKFDV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 224 LYSnnTSEITLISYASvatvcdaliwFLKNNKVMVVLDEAHKIKNTSgGQSADAVLKLApfCKSRVILTGTPSPNGYDDL 303
Cdd:cd17997  107 CIT--SYEMVIKEKTV----------LKKFNWRYIIIDEAHRIKNEK-SKLSQIVRLFN--SRNRLLLTGTPLQNNLHEL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 501156349 304 YNLFKFIWPskNVMG--------FQINQLKDmsskPNDVRVSRLISSIAPYFIR 349
Cdd:cd17997  172 WALLNFLLP--DVFTssedfdewFNVNNCDD----DNQEVVQRLHKVLRPFLLR 219
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 250-361 8.56e-04

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 41.57  E-value: 8.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 250 FLKNNKVMVVLDEAHKIKNTSGGQSaDAVLKLApfCKSRVILTGTPSPNGYDDLYNLFKFIWPSKNVMGFQINQLKDMSS 329
Cdd:cd18064  133 FKKFNWRYLVIDEAHRIKNEKSKLS-EIVREFK--TTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNN 209

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 501156349 330 KPNDVR-VSRLISSIAPYFIRIKKSDL--NLPSVK 361
Cdd:cd18064  210 CLGDQKlVERLHMVLRPFLLRRIKADVekSLPPKK 244
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 261-349 1.35e-03

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 40.80  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 261 DEAHKIKNtsggqsADAVL--KLAPF-CKSRVILTGTPSPNGYDDLYNLFKFIWPSKnvmgFQI-NQLKDMSSKPNDVRV 336
Cdd:cd17993  135 DEAHRLKN------DESLLyeALKEFkTNNRLLITGTPLQNSLKELWALLHFLMPGK----FDIwEEFEEEHDEEQEKGI 204

                         90
                 ....*....|...
gi 501156349 337 SRLISSIAPYFIR 349
Cdd:cd17993  205 ADLHKELEPFILR 217
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 257-349 2.89e-03

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 39.34  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 257 MVVLDEAHKIKNTsggQSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFKFIWPSK--NVMGFQiNQLKDMSskpNDV 334
Cdd:cd17994  108 VLVVDEAHRLKNN---QSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERfnNLQGFL-EEFADIS---KED 180

                         90
                 ....*....|....*
gi 501156349 335 RVSRLISSIAPYFIR 349
Cdd:cd17994  181 QIKKLHDLLGPHMLR 195
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 258-349 6.17e-03

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 38.89  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501156349 258 VVLDEAHKIKNTsggQSADAVLKLAPFCKSRVILTGTPSPNGYDDLYNLFKFIWPSK--NVMGFqINQLKDMSSKPndvR 335
Cdd:cd18057  145 LVVDEAHRLKNN---QSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERfnNLEGF-LEEFADISKED---Q 217

                         90
                 ....*....|....
gi 501156349 336 VSRLISSIAPYFIR 349
Cdd:cd18057  218 IKKLHDLLGPHMLR 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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