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molecular chaperone HtpG [Microcystis aeruginosa]
Protein Classification
Hsp90 family chaperone protein ( domain architecture ID 11480452 )
Hsp90 (heat shock protein 90) family chaperone protein, such as molecular chaperone HtpG (high-temperature protein G) that facilitates the folding and conformational changes of a wide array of proteins
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
2-655
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 775.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 2 TVL E K G NITIHTENIFPIIKK SLY TDH EIFLRELISN SV DAI S KL KMAS L AGE A - RGEVPEPE I NLAI DKE N RTL S I T DN 80
Cdd:PRK05218 1 MAM E T G EFQAEVKQLLHLMIH SLY SNK EIFLRELISN AS DAI D KL RFEA L TDP A l YEGDGDLK I RISF DKE A RTL T I S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 81 GIGMT G EE IKKYINQV A F S SAE EF IN K Y --- QK SAND LIG H FG L GFYSAFMVA K KV EID T L S YQEG A TP V H W SC DG SP E F 157
Cdd:PRK05218 81 GIGMT R EE VIENLGTI A K S GTK EF LE K L kgd QK KDSQ LIG Q FG V GFYSAFMVA D KV TVI T R S AGPA A EA V R W ES DG EG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 158 ELTDSSRSQI GT T ITL T L MDE E G E Y L EPA RIR QLV K T YSDF ML VPIK IDG --- E V IN QQR ALW KE S PQNL T K E D Y L EFY R 234
Cdd:PRK05218 161 TIEEIEKEER GT E ITL H L KED E D E F L DEW RIR SII K K YSDF IP VPIK LEK eee E T IN SAS ALW TR S KSEI T D E E Y K EFY K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 235 Y L YPFQEE PL L W V H L N TDY PF LLN G I LY F PK LR P ---- DV D v S KG Q LKL FCNQ VF VS D HC EE II P DF L MPLR GVIDS P D I 310
Cdd:PRK05218 241 H L AHDFDD PL F W I H N N VEG PF EYT G L LY I PK KA P fdlf NR D - R KG G LKL YVKR VF IM D DA EE LL P EY L RFVK GVIDS E D L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 311 PLNVSR SA L TK DR T V RR I ADF I A KK IA D R L KS L YNE D AKE Y IRC W GDV G TFI K F G SLKEDKFKQQVEDI L IYRT T YK ple 390
Cdd:PRK05218 320 PLNVSR EI L QE DR V V KK I RKA I T KK VL D E L EK L AKN D REK Y EKF W KEF G PVL K E G LYEDFANREKLAKL L RFAS T HE --- 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 391 tpvqvavqtaegdawqeataktpleaieq EG Y TT L KA Y L ER H KE RHE n RVF Y C T DPR ---- SQ S TYV EL Y K NQ G L E I L FF 466
Cdd:PRK05218 397 ----------------------------- GK Y VS L AE Y V ER M KE GQK - KIY Y I T GDS reaa KN S PHL EL F K KK G I E V L LL 446
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 467 DSF ID T n YF I PF LE REYSD -- VKFT R V D SE L DS tlleqdqaseii DPGSN K TRA E LIK E I F AKA L D -- NSRINI K TEALK 542
Cdd:PRK05218 447 TDP ID E - FW I SY LE EFDGK pf KSVA R G D LD L GK ------------ EDEEE K EEK E EAE E E F KPL L E rl KEALGD K VKDVR 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 543 SDDPQATP PA IVLLP E AM r RLQE M TAMMQQKAMAF PE E - H IL M IN T NHPL iqqiiqisqgsi V TGSGESPSAQLA K M L CQ 621
Cdd:PRK05218 514 LSHRLTDS PA CLVAD E GD - MSTQ M EKLLKAAGQEV PE S k P IL E IN P NHPL ------------ V KKLADEADEAKF K D L AE 580
650 660 670
....*....|....*....|....*....|....
gi 501223703 622 HV YD L AL I A QK G f DA E GMQ AFV E R S N RV L T KL TE 655
Cdd:PRK05218 581 LL YD Q AL L A EG G - SL E DPA AFV K R L N EL L L KL LA 613
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
2-655
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 775.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 2 TVL E K G NITIHTENIFPIIKK SLY TDH EIFLRELISN SV DAI S KL KMAS L AGE A - RGEVPEPE I NLAI DKE N RTL S I T DN 80
Cdd:PRK05218 1 MAM E T G EFQAEVKQLLHLMIH SLY SNK EIFLRELISN AS DAI D KL RFEA L TDP A l YEGDGDLK I RISF DKE A RTL T I S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 81 GIGMT G EE IKKYINQV A F S SAE EF IN K Y --- QK SAND LIG H FG L GFYSAFMVA K KV EID T L S YQEG A TP V H W SC DG SP E F 157
Cdd:PRK05218 81 GIGMT R EE VIENLGTI A K S GTK EF LE K L kgd QK KDSQ LIG Q FG V GFYSAFMVA D KV TVI T R S AGPA A EA V R W ES DG EG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 158 ELTDSSRSQI GT T ITL T L MDE E G E Y L EPA RIR QLV K T YSDF ML VPIK IDG --- E V IN QQR ALW KE S PQNL T K E D Y L EFY R 234
Cdd:PRK05218 161 TIEEIEKEER GT E ITL H L KED E D E F L DEW RIR SII K K YSDF IP VPIK LEK eee E T IN SAS ALW TR S KSEI T D E E Y K EFY K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 235 Y L YPFQEE PL L W V H L N TDY PF LLN G I LY F PK LR P ---- DV D v S KG Q LKL FCNQ VF VS D HC EE II P DF L MPLR GVIDS P D I 310
Cdd:PRK05218 241 H L AHDFDD PL F W I H N N VEG PF EYT G L LY I PK KA P fdlf NR D - R KG G LKL YVKR VF IM D DA EE LL P EY L RFVK GVIDS E D L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 311 PLNVSR SA L TK DR T V RR I ADF I A KK IA D R L KS L YNE D AKE Y IRC W GDV G TFI K F G SLKEDKFKQQVEDI L IYRT T YK ple 390
Cdd:PRK05218 320 PLNVSR EI L QE DR V V KK I RKA I T KK VL D E L EK L AKN D REK Y EKF W KEF G PVL K E G LYEDFANREKLAKL L RFAS T HE --- 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 391 tpvqvavqtaegdawqeataktpleaieq EG Y TT L KA Y L ER H KE RHE n RVF Y C T DPR ---- SQ S TYV EL Y K NQ G L E I L FF 466
Cdd:PRK05218 397 ----------------------------- GK Y VS L AE Y V ER M KE GQK - KIY Y I T GDS reaa KN S PHL EL F K KK G I E V L LL 446
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 467 DSF ID T n YF I PF LE REYSD -- VKFT R V D SE L DS tlleqdqaseii DPGSN K TRA E LIK E I F AKA L D -- NSRINI K TEALK 542
Cdd:PRK05218 447 TDP ID E - FW I SY LE EFDGK pf KSVA R G D LD L GK ------------ EDEEE K EEK E EAE E E F KPL L E rl KEALGD K VKDVR 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 543 SDDPQATP PA IVLLP E AM r RLQE M TAMMQQKAMAF PE E - H IL M IN T NHPL iqqiiqisqgsi V TGSGESPSAQLA K M L CQ 621
Cdd:PRK05218 514 LSHRLTDS PA CLVAD E GD - MSTQ M EKLLKAAGQEV PE S k P IL E IN P NHPL ------------ V KKLADEADEAKF K D L AE 580
650 660 670
....*....|....*....|....*....|....
gi 501223703 622 HV YD L AL I A QK G f DA E GMQ AFV E R S N RV L T KL TE 655
Cdd:PRK05218 581 LL YD Q AL L A EG G - SL E DPA AFV K R L N EL L L KL LA 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
2-655
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 727.30
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 2 TVL E K G NITIHTENIFPIIKK SLY TDH EIFLRELISN SV DAI S KL KMAS L AG - E ARG E VPEPE I NLAI DKE NR TL S I T DN 80
Cdd:COG0326 1 MAK E T G EFQAEVKQLLDLMIH SLY SNK EIFLRELISN AS DAI D KL RFLA L TD p E LKE E DGDLK I RIEV DKE AK TL T I S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 81 GIGMT G EE IKKYINQV A F S SAE EF IN K Y --- QK SAN DLIG H FG L GFYSAFMVA K KVE ID T L S YQ E G A TP V H W SC DG SP E F 157
Cdd:COG0326 81 GIGMT R EE VIENLGTI A K S GTR EF LE K L kgd QK KDS DLIG Q FG V GFYSAFMVA D KVE VV T R S AG E D A EA V R W ES DG DG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 158 ELTDSSRSQI GT T ITL T L MDEEG E Y LE PA R I R QLV K T YSDF ML VPIK ID G -------- E V IN QQR ALW KE S PQNL T K E D Y 229
Cdd:COG0326 161 TIEEAEKAER GT E ITL H L KEDAE E F LE EW R L R EII K K YSDF IP VPIK ME G eeeeteed E T IN SAT ALW TR S KSEI T D E E Y 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 230 L EFY RY L YPFQ E E PL L W V HLN TDY PF LLN G I LY F PK LR P D --- VDVS KG QL KL FCNQ VF VS D HC E EII P DF L MPL RGV I D 306
Cdd:COG0326 241 K EFY KH L FHDF E D PL F W I HLN VEG PF EYT G L LY I PK KA P F dly DRDR KG GI KL YVKR VF IM D DA E DLL P EY L RFV RGV V D 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 307 SPD I PLNVSR SA L TK DR TVRR I ADF I A KK IA D R L KS L YNE D AKE Y IRC W GDV G TFI K F G S L KED K FKQQVE D I L IYRT T Y 386
Cdd:COG0326 321 SPD L PLNVSR EI L QE DR QLKK I RKA I T KK VL D E L EK L AKN D REK Y EKF W KEF G LVL K E G A L EDF K NREKIA D L L RFES T K 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 387 kpletpvqvavqtaegdawqeataktpleaie QE GY T TL KA Y L ER H KE RH e NRVF Y C T DPR ---- S QS TYV E LY K NQ G L E 462
Cdd:COG0326 401 -------------------------------- EG GY V TL AE Y V ER M KE GQ - KKIY Y I T GES reaa E QS PHL E IF K AK G I E 447
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 463 I L FFDSF ID T n YF I PF LE r E YSDV KF TR VDS --- E LD STLLEQDQAS E iidpgsn KTRAELIK E I F AK AL DNSRINIKTE 539
Cdd:COG0326 448 V L LLTDP ID E - FL I SH LE - E FDGK KF KS VDS gdl D LD KLEEKKESEE E ------- EEEFKPLL E R F KE AL GDKVKDVRVS 518
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 540 A LKS D dpqat P PA IVLLP E -- AM RR LQE M TAM M Q Q KAMA fp EEH IL M IN T NHPL iqqiiqisqgsi V TGSGESPSAQ L A K 617
Cdd:COG0326 519 A RLT D ----- S PA CLVAD E gd MS RR MEK M LKA M G Q DMPE -- AKP IL E IN P NHPL ------------ V KKLAAEEDEE L F K 579
650 660 670
....*....|....*....|....*....|....*...
gi 501223703 618 M L CQHV YD L AL I A QK G FDAE g MQ AFV E R S N RV L T K LTE 655
Cdd:COG0326 580 D L AELL YD Q AL L A EG G LLED - PA AFV K R L N KL L E K ALG 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
14-199
1.22e-83
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 260.92
E-value: 1.22e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 14 ENIFPI I KK SLY TDH EIFLRELISN SV DA IS KL KMA SL AGEAR - GEV PE P EI NLAI DKENRTL S I T D N GIGMT G EE IKKY 92
Cdd:cd16927 1 NQLLDL I IH SLY SNK EIFLRELISN AS DA LD KL RYL SL TDPSL l DDD PE L EI RISP DKENRTL T I S D T GIGMT K EE LINN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 93 INQV A F S SAEE F INKY Q -- KSAN DLIG H FG L GFYSAFMVA K KV EID T L S YQ e GATPVH W SC DG SPEFELTDSSRS - QI GT 169
Cdd:cd16927 81 LGTI A R S GTKA F LEAL Q eg AKDS DLIG Q FG V GFYSAFMVA D KV TVT T K S AG - DDEGYR W ES DG GGSYTIEEAEGE l GR GT 159
170 180 190
....*....|....*....|....*....|
gi 501223703 170 T ITL T L MDEEG E Y LE P ARI RQ LVK T YSDF M 199
Cdd:cd16927 160 K ITL H L KEDAK E F LE E ARI KE LVK K YSDF I 189
HSP90
pfam00183 Hsp90 protein;
181-650
5.09e-41
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 156.56
E-value: 5.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 181 EYLE PAR I RQ LVK T YS D F MLV PI KI --------------------------------------------------- DG E V 209
Cdd:pfam00183 1 EYLE EKK I KE LVK K YS E F INF PI YL wvekeeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvw EW E L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 210 I N QQRAL W KES P QNL T K E D Y L EFY RY L YPFQ E E PL LWV H LNTDYPFLLNGI L YF PK LR P ---- DVDVS K GQL KL FCNQ VF 285
Cdd:pfam00183 81 L N KTKPI W TRN P KEV T E E E Y A EFY KS L SKDW E D PL AVK H FSVEGEVEFKSL L FI PK RA P fdlf ENKKK K NNI KL YVRR VF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 286 VS D HC E EI IP DF L MPLR GV I DS P D I PLNVSR SA L TKDRTVRR I ADFIAK K IA D RL K SL y N E DAKE Y IRC W GDV G TFI K F G 365
Cdd:pfam00183 161 IT D DF E DL IP EY L NFVK GV V DS D D L PLNVSR ET L QQNKILKV I KKKLVR K AL D MF K EI - A E EKED Y KKF W KEF G KNL K L G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 366 SLKEDKFKQQVEDI L IYRTTYKPL E tpvqvavqtaegdawqeataktpleaieqeg Y T T L KA Y LE R H KE RHEN r VF Y C T - 444
Cdd:pfam00183 240 IIEDSSNRNKLAKL L RFYSSKSGD E ------------------------------- L T S L DD Y VS R M KE GQKH - IY Y I T g 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 445 --- DPRSQ S TYV E LY K NQ G L E I L FFDSF ID t N Y FIPF L e R E YSDV K FTR V --- DS EL DSTLL E QDQAS E IID pg SNKTRA 518
Cdd:pfam00183 288 esk EEVEN S PFL E RL K KK G Y E V L YLTDP ID - E Y AVQQ L - K E FDGK K LVN V ake GL EL EEDEE E KKKDE E LKK -- EFEPLT 363
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 519 ELI K EIFAK aldnsrini K T E ALKSDDPQATP P AIVLLPE ----- A M R R LQEMT A MMQQKA M AF -- PEEHI L M IN TN HP L 591
Cdd:pfam00183 364 KWL K DVLGD --------- K V E KVVVSNRLVDS P CVLVTSQ ygwsa N M E R IMKAQ A LRKDSS M SS ym SSKKT L E IN PR HP I 434
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 501223703 592 I QQIIQISQ gsivtgsg ESPSAQL AK M L CQHV Y DL AL IAQ k GF DA E GMQA F VE R SN R V L 650
Cdd:pfam00183 435 I KELLKRVE -------- ADKDDKT AK D L ALLL Y ET AL LRS - GF SL E DPAS F AS R IY R M L 484
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
29-175
2.49e-10
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 58.04
E-value: 2.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 29 EIF LR ELI SN SV D AIS K lkmasl AGEAR G EV pep EIN L AI D KENRTLSIT DNG I G MTG E EIK K yinqv A F ssa E E F ink Y 108
Cdd:smart00387 3 PDR LR QVL SN LL D NAI K ------ YTPEG G RI --- TVT L ER D GDHVEITVE DNG P G IPP E DLE K ----- I F --- E P F --- F 62
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501223703 109 Q - KSANDL IG HF GLG FYSAFMVAKKVEI dtlsyqegatpvhwscdgspef E LTDS S RSQI GTT I T L TL 175
Cdd:smart00387 63 R t DKRSRK IG GT GLG LSIVKKLVELHGG ---------------------- E ISVE S EPGG GTT F T I TL 108
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
2-655
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 775.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 2 TVL E K G NITIHTENIFPIIKK SLY TDH EIFLRELISN SV DAI S KL KMAS L AGE A - RGEVPEPE I NLAI DKE N RTL S I T DN 80
Cdd:PRK05218 1 MAM E T G EFQAEVKQLLHLMIH SLY SNK EIFLRELISN AS DAI D KL RFEA L TDP A l YEGDGDLK I RISF DKE A RTL T I S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 81 GIGMT G EE IKKYINQV A F S SAE EF IN K Y --- QK SAND LIG H FG L GFYSAFMVA K KV EID T L S YQEG A TP V H W SC DG SP E F 157
Cdd:PRK05218 81 GIGMT R EE VIENLGTI A K S GTK EF LE K L kgd QK KDSQ LIG Q FG V GFYSAFMVA D KV TVI T R S AGPA A EA V R W ES DG EG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 158 ELTDSSRSQI GT T ITL T L MDE E G E Y L EPA RIR QLV K T YSDF ML VPIK IDG --- E V IN QQR ALW KE S PQNL T K E D Y L EFY R 234
Cdd:PRK05218 161 TIEEIEKEER GT E ITL H L KED E D E F L DEW RIR SII K K YSDF IP VPIK LEK eee E T IN SAS ALW TR S KSEI T D E E Y K EFY K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 235 Y L YPFQEE PL L W V H L N TDY PF LLN G I LY F PK LR P ---- DV D v S KG Q LKL FCNQ VF VS D HC EE II P DF L MPLR GVIDS P D I 310
Cdd:PRK05218 241 H L AHDFDD PL F W I H N N VEG PF EYT G L LY I PK KA P fdlf NR D - R KG G LKL YVKR VF IM D DA EE LL P EY L RFVK GVIDS E D L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 311 PLNVSR SA L TK DR T V RR I ADF I A KK IA D R L KS L YNE D AKE Y IRC W GDV G TFI K F G SLKEDKFKQQVEDI L IYRT T YK ple 390
Cdd:PRK05218 320 PLNVSR EI L QE DR V V KK I RKA I T KK VL D E L EK L AKN D REK Y EKF W KEF G PVL K E G LYEDFANREKLAKL L RFAS T HE --- 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 391 tpvqvavqtaegdawqeataktpleaieq EG Y TT L KA Y L ER H KE RHE n RVF Y C T DPR ---- SQ S TYV EL Y K NQ G L E I L FF 466
Cdd:PRK05218 397 ----------------------------- GK Y VS L AE Y V ER M KE GQK - KIY Y I T GDS reaa KN S PHL EL F K KK G I E V L LL 446
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 467 DSF ID T n YF I PF LE REYSD -- VKFT R V D SE L DS tlleqdqaseii DPGSN K TRA E LIK E I F AKA L D -- NSRINI K TEALK 542
Cdd:PRK05218 447 TDP ID E - FW I SY LE EFDGK pf KSVA R G D LD L GK ------------ EDEEE K EEK E EAE E E F KPL L E rl KEALGD K VKDVR 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 543 SDDPQATP PA IVLLP E AM r RLQE M TAMMQQKAMAF PE E - H IL M IN T NHPL iqqiiqisqgsi V TGSGESPSAQLA K M L CQ 621
Cdd:PRK05218 514 LSHRLTDS PA CLVAD E GD - MSTQ M EKLLKAAGQEV PE S k P IL E IN P NHPL ------------ V KKLADEADEAKF K D L AE 580
650 660 670
....*....|....*....|....*....|....
gi 501223703 622 HV YD L AL I A QK G f DA E GMQ AFV E R S N RV L T KL TE 655
Cdd:PRK05218 581 LL YD Q AL L A EG G - SL E DPA AFV K R L N EL L L KL LA 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
2-655
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 727.30
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 2 TVL E K G NITIHTENIFPIIKK SLY TDH EIFLRELISN SV DAI S KL KMAS L AG - E ARG E VPEPE I NLAI DKE NR TL S I T DN 80
Cdd:COG0326 1 MAK E T G EFQAEVKQLLDLMIH SLY SNK EIFLRELISN AS DAI D KL RFLA L TD p E LKE E DGDLK I RIEV DKE AK TL T I S DN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 81 GIGMT G EE IKKYINQV A F S SAE EF IN K Y --- QK SAN DLIG H FG L GFYSAFMVA K KVE ID T L S YQ E G A TP V H W SC DG SP E F 157
Cdd:COG0326 81 GIGMT R EE VIENLGTI A K S GTR EF LE K L kgd QK KDS DLIG Q FG V GFYSAFMVA D KVE VV T R S AG E D A EA V R W ES DG DG E Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 158 ELTDSSRSQI GT T ITL T L MDEEG E Y LE PA R I R QLV K T YSDF ML VPIK ID G -------- E V IN QQR ALW KE S PQNL T K E D Y 229
Cdd:COG0326 161 TIEEAEKAER GT E ITL H L KEDAE E F LE EW R L R EII K K YSDF IP VPIK ME G eeeeteed E T IN SAT ALW TR S KSEI T D E E Y 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 230 L EFY RY L YPFQ E E PL L W V HLN TDY PF LLN G I LY F PK LR P D --- VDVS KG QL KL FCNQ VF VS D HC E EII P DF L MPL RGV I D 306
Cdd:COG0326 241 K EFY KH L FHDF E D PL F W I HLN VEG PF EYT G L LY I PK KA P F dly DRDR KG GI KL YVKR VF IM D DA E DLL P EY L RFV RGV V D 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 307 SPD I PLNVSR SA L TK DR TVRR I ADF I A KK IA D R L KS L YNE D AKE Y IRC W GDV G TFI K F G S L KED K FKQQVE D I L IYRT T Y 386
Cdd:COG0326 321 SPD L PLNVSR EI L QE DR QLKK I RKA I T KK VL D E L EK L AKN D REK Y EKF W KEF G LVL K E G A L EDF K NREKIA D L L RFES T K 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 387 kpletpvqvavqtaegdawqeataktpleaie QE GY T TL KA Y L ER H KE RH e NRVF Y C T DPR ---- S QS TYV E LY K NQ G L E 462
Cdd:COG0326 401 -------------------------------- EG GY V TL AE Y V ER M KE GQ - KKIY Y I T GES reaa E QS PHL E IF K AK G I E 447
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 463 I L FFDSF ID T n YF I PF LE r E YSDV KF TR VDS --- E LD STLLEQDQAS E iidpgsn KTRAELIK E I F AK AL DNSRINIKTE 539
Cdd:COG0326 448 V L LLTDP ID E - FL I SH LE - E FDGK KF KS VDS gdl D LD KLEEKKESEE E ------- EEEFKPLL E R F KE AL GDKVKDVRVS 518
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 540 A LKS D dpqat P PA IVLLP E -- AM RR LQE M TAM M Q Q KAMA fp EEH IL M IN T NHPL iqqiiqisqgsi V TGSGESPSAQ L A K 617
Cdd:COG0326 519 A RLT D ----- S PA CLVAD E gd MS RR MEK M LKA M G Q DMPE -- AKP IL E IN P NHPL ------------ V KKLAAEEDEE L F K 579
650 660 670
....*....|....*....|....*....|....*...
gi 501223703 618 M L CQHV YD L AL I A QK G FDAE g MQ AFV E R S N RV L T K LTE 655
Cdd:COG0326 580 D L AELL YD Q AL L A EG G LLED - PA AFV K R L N KL L E K ALG 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
14-199
1.22e-83
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 260.92
E-value: 1.22e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 14 ENIFPI I KK SLY TDH EIFLRELISN SV DA IS KL KMA SL AGEAR - GEV PE P EI NLAI DKENRTL S I T D N GIGMT G EE IKKY 92
Cdd:cd16927 1 NQLLDL I IH SLY SNK EIFLRELISN AS DA LD KL RYL SL TDPSL l DDD PE L EI RISP DKENRTL T I S D T GIGMT K EE LINN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 93 INQV A F S SAEE F INKY Q -- KSAN DLIG H FG L GFYSAFMVA K KV EID T L S YQ e GATPVH W SC DG SPEFELTDSSRS - QI GT 169
Cdd:cd16927 81 LGTI A R S GTKA F LEAL Q eg AKDS DLIG Q FG V GFYSAFMVA D KV TVT T K S AG - DDEGYR W ES DG GGSYTIEEAEGE l GR GT 159
170 180 190
....*....|....*....|....*....|
gi 501223703 170 T ITL T L MDEEG E Y LE P ARI RQ LVK T YSDF M 199
Cdd:cd16927 160 K ITL H L KEDAK E F LE E ARI KE LVK K YSDF I 189
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
16-650
7.05e-68
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 235.34
E-value: 7.05e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 16 IFPI I KKSL Y TDH EIFLRELISN SV DA IS K LKMA SL AGEA - R GE V P EPE I NLAI DKEN R TL SIT DNGIGMT GEEIKKYIN 94
Cdd:PTZ00272 14 LMSL I INTF Y SNK EIFLRELISN AS DA CD K IRYQ SL TDPS v L GE S P RLC I RVVP DKEN K TL TVE DNGIGMT KADLVNNLG 93
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 95 QV A F S SAEE F INKYQKSAN - DL IG H FG L GFYSA FM VA KK V EI dt L S YQEGATPVH W SCDGSPE F EL T DSSR S QI -- GT T I 171
Cdd:PTZ00272 94 TI A R S GTKA F MEALEAGGD m SM IG Q FG V GFYSA YL VA DR V TV -- T S KNNSDESYV W ESSAGGT F TI T STPE S DM kr GT R I 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 172 TL T L MDEEG EYLEP A R IRQ L V K TY S D F MLVP I KI ----------------------- DGE -------------------- 208
Cdd:PTZ00272 172 TL H L KEDQM EYLEP R R LKE L I K KH S E F IGYD I EL mvekttekevtdedeedtkkade DGE epkveevkegdegkkkktkk 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 209 --------- V I N QQRA LW KES P QNL TKE D Y LE FY RYLYPFQ E E P LLWV H LNTDYPFLLNG I LYF PK LR P ---- DVDVSKG 275
Cdd:PTZ00272 252 vkevtkeye V Q N KHKP LW TRD P KDV TKE E Y AA FY KAISNDW E D P AATK H FSVEGQLEFRS I MFV PK RA P fdmf EPNKKRN 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 276 QL KL FCNQ VF VS D H CE EII PD F L MPLR GV I DS P D I PLN V SR SA L TKDRTVRR I ADF I A KK IADRLKSL y N E DAKE Y IRCW 355
Cdd:PTZ00272 332 NI KL YVRR VF IM D N CE DLC PD W L GFVK GV V DS E D L PLN I SR EN L QQNKILKV I RKN I V KK CLEMFDEV - A E NKED Y KQFY 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 356 GDV G TF IK F G SLKEDKFKQQVEDI L IYRT T ykpletpvqvavqtaegdawqeataktpl E AI E Q eg Y TTLK A Y LE R H K ER 435
Cdd:PTZ00272 411 EQF G KN IK L G IHEDTANRKKLMEL L RFYS T ----------------------------- E SG E E -- M TTLK D Y VT R M K AG 459
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 436 HEN r VF Y C T - D PRSQ --- S TYV E LYKNQ GLE I LF FDSF ID T ny FIPFLEREYS D V KF --- T RVDSELDSTLL E QD Q AS E i 508
Cdd:PTZ00272 460 QKS - IY Y I T g D SKKK let S PFI E QARRR GLE V LF MTEP ID E -- YVMQQVKDFE D K KF acl T KEGVHFEESEE E KQ Q RE E - 535
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 509 i DPGSNKTRAELI KE IFAK aldnsrini K T E ALKSDDPQA T P P A I VLLP E --------- A MR ---- R LQE M TA - MM QQ K A 574
Cdd:PTZ00272 536 - EKAACEKLCKTM KE VLGD --------- K V E KVIVSERLS T S P C I LVTS E fgwsahmeq I MR nqal R DSS M AQ y MM SK K T 605
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501223703 575 M A fpeehilm I N TN HP L I QQIIQISQ gsivtg SG E SPS A ql A K M L CQHVY D LA L IAQ k GF DA E GMQAFV ER S NR VL 650
Cdd:PTZ00272 606 M E -------- L N PR HP I I KELRRRVG ------ AD E NDK A -- V K D L VFLLF D TS L LTS - GF QL E DPTGYA ER I NR MI 664
PTZ00130
PTZ00130 heat shock protein 90; Provisional
19-591
5.55e-59
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 212.59
E-value: 5.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 19 II KK SLYT DH E I FLRELISN SV DA IS K LKMA SL AG E A - R GE VPEP EI NLAID KE NRT LSITD N GIGMT G E EIKKYINQV A 97
Cdd:PTZ00130 80 II VN SLYT QK E V FLRELISN AA DA LE K IRFL SL SD E S v L GE EKKL EI RISAN KE KNI LSITD T GIGMT K E DLINNLGTI A 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 98 F S SAEE F INKYQ KS AN D -- LIG H FG L GFYSAF M VA K KV EID T LSYQE ga TPVH W SCDGSPE F ELTDSS R SQI --- GT T I T 172
Cdd:PTZ00130 160 K S GTSN F LEAIS KS GG D ms LIG Q FG V GFYSAF L VA D KV IVY T KNNND -- EQYI W ESTADAK F TIYKDP R GST lkr GT R I S 237
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 173 L T L MDEEGEYLEPARIRQ L VKT YS D F MLV PI KIDG E -------------------------------------------- 208
Cdd:PTZ00130 238 L H L KEDATNLMNDKKLVD L ISK YS Q F IQY PI YLLH E nvyteevladiakemendpnydsvkveetddpnkktrtvekkvk 317
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 209 --- VI N Q Q RAL W KES P QN LT K EDY LE F YRY L YP F QE EPL LWV H LNTDYPFLLNGIL Y F P KLR P DVD ---- VSKGQL KL FC 281
Cdd:PTZ00130 318 kwk LM N E Q KPI W LRP P KE LT D EDY KK F FSV L SG F ND EPL YHI H FFAEGEIEFKCLI Y I P SRA P SIN dhlf TKQNSI KL YV 397
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 282 NQ V F V S D HCE E II P DFLMPLR GV I DS P D I PLNVSR SA L TKDRTVRRIADF I AK KI A D RLKS LY N E DA -- KE YI R C wgdvg 359
Cdd:PTZ00130 398 RR V L V A D EFV E FL P RYMSFVK GV V DS D D L PLNVSR EQ L QQNKILKAVSKR I VR KI L D TFRT LY K E GK kn KE TL R A ----- 472
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 360 tfi KFGSLKEDKF K QQVEDILIYRT TYK PLETPVQVAVQ T A -- E G D AWQEATA K TP L - EAIEQEGYTT L KA Y L E r HKERH 436
Cdd:PTZ00130 473 --- ELAKETDEEK K KEIQKKINEPS TYK LIYKEYRKYLK T G cy E D D INRNKIV K LL L f KTMLHPKSIS L DT Y I E - NMKPD 548
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 437 ENRVF Y CTDPR ---- S QSTYVELY K NQGLEIL F FDSFI D TN yfip FLE R -- EY SDV KF TRVDS - E LDST L L E QDQAS E ii 509
Cdd:PTZ00130 549 QKFIY Y ASGDS yeyl S KIPQLQIF K KKNIDVV F LTESV D ES ---- CVQ R vq EY DGK KF KSIQK g E ITFE L T E DEKKK E -- 622
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 510 d PGSN K TRAE LI k EIFAKA L D N SRINIKTEALKS D D P Q A TPPAIVL L PEA M RR L QEMTAMMQQKAM A FPEEH IL M IN TN H 589
Cdd:PTZ00130 623 - EKVK K MYKA LI - DVISDT L R N QIFKVEISRRLV D A P C A VVSTEWG L SGQ M EK L MKINVNNSDQIK A MSGQK IL E IN PD H 700
..
gi 501223703 590 P L 591
Cdd:PTZ00130 701 P I 702
HSP90
pfam00183 Hsp90 protein;
181-650
5.09e-41
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 156.56
E-value: 5.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 181 EYLE PAR I RQ LVK T YS D F MLV PI KI --------------------------------------------------- DG E V 209
Cdd:pfam00183 1 EYLE EKK I KE LVK K YS E F INF PI YL wvekeeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvw EW E L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 210 I N QQRAL W KES P QNL T K E D Y L EFY RY L YPFQ E E PL LWV H LNTDYPFLLNGI L YF PK LR P ---- DVDVS K GQL KL FCNQ VF 285
Cdd:pfam00183 81 L N KTKPI W TRN P KEV T E E E Y A EFY KS L SKDW E D PL AVK H FSVEGEVEFKSL L FI PK RA P fdlf ENKKK K NNI KL YVRR VF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 286 VS D HC E EI IP DF L MPLR GV I DS P D I PLNVSR SA L TKDRTVRR I ADFIAK K IA D RL K SL y N E DAKE Y IRC W GDV G TFI K F G 365
Cdd:pfam00183 161 IT D DF E DL IP EY L NFVK GV V DS D D L PLNVSR ET L QQNKILKV I KKKLVR K AL D MF K EI - A E EKED Y KKF W KEF G KNL K L G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 366 SLKEDKFKQQVEDI L IYRTTYKPL E tpvqvavqtaegdawqeataktpleaieqeg Y T T L KA Y LE R H KE RHEN r VF Y C T - 444
Cdd:pfam00183 240 IIEDSSNRNKLAKL L RFYSSKSGD E ------------------------------- L T S L DD Y VS R M KE GQKH - IY Y I T g 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 445 --- DPRSQ S TYV E LY K NQ G L E I L FFDSF ID t N Y FIPF L e R E YSDV K FTR V --- DS EL DSTLL E QDQAS E IID pg SNKTRA 518
Cdd:pfam00183 288 esk EEVEN S PFL E RL K KK G Y E V L YLTDP ID - E Y AVQQ L - K E FDGK K LVN V ake GL EL EEDEE E KKKDE E LKK -- EFEPLT 363
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 519 ELI K EIFAK aldnsrini K T E ALKSDDPQATP P AIVLLPE ----- A M R R LQEMT A MMQQKA M AF -- PEEHI L M IN TN HP L 591
Cdd:pfam00183 364 KWL K DVLGD --------- K V E KVVVSNRLVDS P CVLVTSQ ygwsa N M E R IMKAQ A LRKDSS M SS ym SSKKT L E IN PR HP I 434
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 501223703 592 I QQIIQISQ gsivtgsg ESPSAQL AK M L CQHV Y DL AL IAQ k GF DA E GMQA F VE R SN R V L 650
Cdd:pfam00183 435 I KELLKRVE -------- ADKDDKT AK D L ALLL Y ET AL LRS - GF SL E DPAS F AS R IY R M L 484
PRK14083
PRK14083 HSP90 family protein; Provisional
24-322
6.76e-34
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 137.00
E-value: 6.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 24 LY TDHEIFL REL IS N S VDAI SKLK ma S L AGE A R G EV pep E I N L a I D KENR TL SIT DNGIG M T G EE IKKYINQVAF SS -- A 101
Cdd:PRK14083 20 LY SSPRVYV REL LQ N A VDAI TARR -- A L DPT A P G RI --- R I E L - T D AGGG TL IVE DNGIG L T E EE VHEFLATIGR SS kr D 93
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 102 E EF inky QKSA ND LI G H FG L G FY S A F M VA KKVEIDTL S y QEGATP V H W -- SC DG SPEFELTDSS R SQI GTT IT L TLMDEE 179
Cdd:PRK14083 94 E NL ---- GFAR ND FL G Q FG I G LL S C F L VA DEIVVVSR S - AKDGPA V E W rg KA DG TYSVRKLETE R AEP GTT VY L RPRPDA 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 180 G E Y LE PARIRQ L V K T Y SDFML VPI KID GE -- VI N QQRAL W KESP -- QNLTK E DY L EFYRY L yp FQEE PL lwvhlnt D Y p F 255
Cdd:PRK14083 169 E E W LE RETVEE L A K K Y GSLLP VPI RVE GE kg GV N ETPPP W TRDY pd PETRR E AL L AYGEE L -- LGFT PL ------- D V - I 238
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 501223703 256 L L N ------- G IL Y FPKLRPDVDVSKGQ l KLFCNQVFV S DHC E EII PD FLMPL R G V IDSPDIPLNV SR S AL TK D 322
Cdd:PRK14083 239 P L D vpsggle G VA Y VLPYAVSPAARRKH - RVYLKRMLL S EEA E NLL PD WAFFV R C V VNTDELRPTA SR E AL YE D 311
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
29-175
2.49e-10
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 58.04
E-value: 2.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 29 EIF LR ELI SN SV D AIS K lkmasl AGEAR G EV pep EIN L AI D KENRTLSIT DNG I G MTG E EIK K yinqv A F ssa E E F ink Y 108
Cdd:smart00387 3 PDR LR QVL SN LL D NAI K ------ YTPEG G RI --- TVT L ER D GDHVEITVE DNG P G IPP E DLE K ----- I F --- E P F --- F 62
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501223703 109 Q - KSANDL IG HF GLG FYSAFMVAKKVEI dtlsyqegatpvhwscdgspef E LTDS S RSQI GTT I T L TL 175
Cdd:smart00387 63 R t DKRSRK IG GT GLG LSIVKKLVELHGG ---------------------- E ISVE S EPGG GTT F T I TL 108
HATPase_TopVIB-like
cd16933 Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
22-137
5.66e-07
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain]
Cd Length: 203
Bit Score: 50.42
E-value: 5.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 22 K SLYT dhei FL REL IS NS V DA I sklkmaslag E AR G EV P EPEINLA - I D K ENRTLSIT DNG I G MTG E E I K K YINQ V AFS S 100
Cdd:cd16933 18 R SLYT ---- TV REL VE NS L DA T ---------- E EA G IL P DIKVEIE e I G K DHYKVIVE DNG P G IPE E Q I P K VFGK V LYG S 83
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 501223703 101 ae EFI NK YQK sandli G HF GLG ----- F YS AFMVA K K VEI DT 137
Cdd:cd16933 84 -- KYH NK QSR ------ G QQ GLG isaav L YS QMTTG K P VEI IS 117
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
29-137
2.56e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 44.24
E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 29 E IF L R ELI S NS V DA ISK lkmaslageargevpep E I NLAID K E --- NRTLS I T D N G I GM TG EE IKKYI n QV A F S saeefi 105
Cdd:pfam13589 2 E GA L A ELI D NS I DA DAT ----------------- N I KIEVN K N rgg GTEIV I E D D G H GM SP EE LINAL - RL A T S ------ 57
90 100 110
....*....|....*....|....*....|...
gi 501223703 106 N K YQ K SANDLI G HF G L G FYS A - FMVAK K VEIDT 137
Cdd:pfam13589 58 A K EA K RGSTDL G RY G I G LKL A s LSLGA K LTVTS 90
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
32-175
1.44e-04
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 41.58
E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 32 L RE L IS N SVDAIS klkmaslageargev PEP EI NLAIDKENR - TL SIT DNGIG MTG E EIKK yinqvafssaee FINKYQK 110
Cdd:pfam02518 10 L SN L LD N ALKHAA --------------- KAG EI TVTLSEGGE l TL TVE DNGIG IPP E DLPR ------------ IFEPFST 62
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501223703 111 SANDLI G HF GLG FYSAFMVAKKV eidtlsyqegatpvhwsc D G spef EL T DS S RSQI GTT I TLTL 175
Cdd:pfam02518 63 ADKRGG G GT GLG LSIVRKLVELL ------------------ G G ---- TI T VE S EPGG GTT V TLTL 105
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
22-128
7.94e-04
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 39.70
E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501223703 22 K S LY T D H E - I F -- LR EL IS N SV DA I sklkmaslage A RG evpepe INLA ID KE N RT ----- LS IT D N G I GMT G EE IKKY I 93
Cdd:cd16931 3 H S NS T T H S w P F ga VA EL VD N AR DA D ----------- A TR ------ LDIF ID DI N LL rggfm LS FL D D G N GMT P EE AHHM I 65
90 100 110
....*....|....*....|....*....|....*
gi 501223703 94 n QVA FS SA eefinky QKSAN D L IG HF G L GF Y S AF M 128
Cdd:cd16931 66 - SFG FS DK ------- RSDDH D H IG RY G N GF K S GS M 92
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
