|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
9-371 |
4.12e-178 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 499.23 E-value: 4.12e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 9 HIETRLAQAGNRSDdEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQL 88
Cdd:PRK08247 4 TIETKLAQIGNRSD-ERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 89 VFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATA 168
Cdd:PRK08247 83 VMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 169 HAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLR 248
Cdd:PRK08247 163 KKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 249 SLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGRGGMISFYLATGTDVDTFLRALNVISFAESLGGVESLLTVPAVQ 328
Cdd:PRK08247 243 GMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGRGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPATQ 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 503121135 329 THADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRA 371
Cdd:PRK08247 323 THADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
8-368 |
3.75e-154 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 439.10 E-value: 3.75e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 8 LHIETRLAQAGnRSDDEKTGAISAPIYLSTAYRHAGLGQ--------STGFDYPREAQPTRCILERVLAEMEHGIAAYAL 79
Cdd:COG0626 1 MGPATRAVHAG-RDPDPQTGAVSPPIYLTSTFVFPSAEAlaarfageEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 80 TSGMAAIQLV-FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKV 158
Cdd:COG0626 80 ASGMAAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 159 IDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVL 238
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 239 DPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTD-VDT 301
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLpshpghelakrqmsgfGGMLSFELKGGREaARR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503121135 302 FLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:COG0626 320 FLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQAL 386
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
11-368 |
2.78e-144 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 413.55 E-value: 2.78e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 11 ETRLAQAGNRSDdEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAI-QLV 89
Cdd:pfam01053 1 DTLAVHAGQRPD-PQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 90 FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAH 169
Cdd:pfam01053 80 LALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 170 AHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRS 249
Cdd:pfam01053 160 KHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 250 LKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG----------------RGGMISFYLATGTD-VDTFLRALNVISFA 312
Cdd:pfam01053 240 LKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGlpshpghelakrqmkgFGGMLSFELKGGLEaAKKFLDNLKLFSLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503121135 313 ESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:pfam01053 320 VSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQAL 375
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
6-368 |
6.87e-138 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 396.88 E-value: 6.87e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 6 EKLHIETRLAQAGNRSDdEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAA 85
Cdd:PRK07269 3 KDLHINTILAQAGIKSD-EATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 86 IQLVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQatLAALADDQTVALWLETPSNPTMKVIDITATA 165
Cdd:PRK07269 82 IVLAFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEE--LIAAIEEDTDIVYIETPTNPLMVEFDIEKVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 166 ATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWL 245
Cdd:PRK07269 160 KLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 246 LLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGRGGMISFYLATGTDVDTFLRALNVISFAESLGGVESLLTVP 325
Cdd:PRK07269 240 LMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGKGGMISFKVADETRIPHILNSLKVFTFAESLGGVESLITYP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 503121135 326 AVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07269 320 TTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQAL 362
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
27-368 |
1.22e-129 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 376.16 E-value: 1.22e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 27 GAISAPIYLSTAYR--------HAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFTLFNS-GD 97
Cdd:cd00614 1 GAVAPPIYQTSTFVfpspaeaaDLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKaGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 98 KIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIV 177
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 178 DNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRL 257
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 258 HQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATG-TDVDTFLRALNVISFAESLGGVES 320
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPglpshpqhelakkqmsGYGGVFSFELKGGlEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 503121135 321 LLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQAL 368
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
18-368 |
6.69e-121 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 354.41 E-value: 6.69e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 18 GNRSDDEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFTLFNSGD 97
Cdd:PRK07671 10 GGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMMLFSSGD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 98 KIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIV 177
Cdd:PRK07671 90 HVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 178 DNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRL 257
Cdd:PRK07671 170 DNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRM 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 258 HQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTDVDTFLRALNVISFAESLGGVESL 321
Cdd:PRK07671 250 EEHETNSRAIAEFLNNHPAVNKVYYPGLpshpnhelakeqangfGGMISFDVGSEETANKVLERLQYFTLAESLGAVESL 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 503121135 322 LTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07671 330 ISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQAL 376
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
1-368 |
1.38e-115 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 341.24 E-value: 1.38e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQAEKLHIETRLAQAGNRSDDEkTGAISAPIYLSTAYRHAGLGQ-STGFDYPREAQPTRCILERVLAEMEHGIAAYAL 79
Cdd:PRK07811 4 MSDHHANQGFATRAIHAGYEPDPA-TGAVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 80 TSGMAAIQLVF-TLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKV 158
Cdd:PRK07811 83 SSGMAATDCLLrAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 159 IDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVL 238
Cdd:PRK07811 163 TDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 239 DPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTDV-DT 301
Cdd:PRK07811 243 GPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLpshpghevaarqmrgfGGMVSVRLAGGEEAaRD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503121135 302 FLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQskgITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07811 323 FCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDVADLLADLEQAL 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
8-368 |
1.78e-112 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 333.02 E-value: 1.78e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 8 LHIETRLAQAGnRSDDEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQ 87
Cdd:PRK06176 1 MRMQTKLIHGG-ISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 88 LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAAT 167
Cdd:PRK06176 80 AVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 168 AHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLL 247
Cdd:PRK06176 160 AKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 248 RSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTDVDTFLRALNVISF 311
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLpthpnhelakkqmrgfSGMLSFTLKNDSEAVAFVESLKLFIL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 503121135 312 AESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK06176 320 GESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
10-368 |
7.87e-100 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 300.92 E-value: 7.87e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 10 IETRLAQAGNRSDDEkTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLV 89
Cdd:PRK08064 7 IDTLLLHNQYKHDKQ-TGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 90 FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAH 169
Cdd:PRK08064 86 FLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 170 AHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRS 249
Cdd:PRK08064 166 AIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 250 LKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG----------------RGGMISFYLATGTDVDTFLRALNVISFAE 313
Cdd:PRK08064 246 LKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGlqthlgfdiqqsqatsAGAVLSFTLQSEEAVRQFVSHVKLPVFAV 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 503121135 314 SLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK08064 326 SLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQAL 380
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
10-371 |
8.32e-96 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 290.19 E-value: 8.32e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 10 IETRLAQAGNRSDdeKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLV 89
Cdd:TIGR01329 1 LSTLLVNTDNKND--PYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 90 FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAH 169
Cdd:TIGR01329 79 TRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 170 AHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRS 249
Cdd:TIGR01329 159 AQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 250 LKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGTDVDTFLRALNVISFAE 313
Cdd:TIGR01329 239 IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAglpshpgfhlhfsqakGAGSVLSFETGSVALSKRLVEATKLFSITV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503121135 314 SLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRA 371
Cdd:TIGR01329 319 SFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
6-368 |
1.76e-95 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 289.82 E-value: 1.76e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 6 EKLHIETRLAQAGNRSDDEKtGAISAPIYLSTAYRHAGL--------GQSTGFDYPREAQPTRCILERVLAEMEHGIAAY 77
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHK-GSLTPPLFQTSTFTFETAqqgeasfaGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 78 ALTSGMAAIQLV-FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTM 156
Cdd:PRK06767 81 AFGSGMAAISATlIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 157 KVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGA 236
Cdd:PRK06767 161 KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 237 VLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG----------RGGMISFYLATG-TDVDTFLRA 305
Cdd:PRK06767 241 IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEgelasrqmkrGGGVISFSIKGGkEETQAFIND 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503121135 306 LNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK06767 321 LHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQAL 383
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
21-373 |
3.50e-92 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 281.40 E-value: 3.50e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 21 SDDEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFTLF-NSGDKI 99
Cdd:PRK08045 15 NDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFlKPGDLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 100 IVSDDLYGGSYRFFDLLHDH--YHLDFaVWDGQDQATLAALADDQTVALwLETPSNPTMKVIDITATAATAHAHDLKLIV 177
Cdd:PRK08045 95 VAPHDCYGGSYRLFDSLAKRgcYRVLF-VDQGDEQALRAALAEKPKLVL-VESPSNPLLRVVDIAKICHLAREAGAVSVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 178 DNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEF---NLVTTGAVldpFDAWLLLRSLKTLP 254
Cdd:PRK08045 173 DNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWwanNIGVTGGA---FDSYLLLRGLRTLV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 255 LRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGTD-VDTFLRALNVISFAESLGG 317
Cdd:PRK08045 250 PRMELAQRNAQAIVKYLQTQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELDGDEQtLRRFLGGLSLFTLAESLGG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503121135 318 VESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRATK 373
Cdd:PRK08045 330 VESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANK 385
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
27-368 |
2.40e-91 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 279.26 E-value: 2.40e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 27 GAISAPIYLSTAYRHAGLGQST--GFD--YPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQ-LVFTLFNSGDKIIV 101
Cdd:PRK08574 18 GSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIStLFFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 102 SDDLYGGSYRFFDLLhDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTF 181
Cdd:PRK08574 98 PMEAYGTTLRLLKSL-EKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 182 YTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQE 261
Cdd:PRK08574 177 ATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQC 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 262 ANAQELVTVLEADEHVERVLYPG------------------RGGMISFYLATGTD-VDTFLRALNVISFAESLGGVESLL 322
Cdd:PRK08574 257 RNAMAIAEFLSEHPKVAEVYYPGlpsdpyhgvakrlfgkdlYGGVVSFRVKGGRDaVLKFLRSLKLIKPSPSLGGVESLA 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 503121135 323 TVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK08574 337 TYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQAL 382
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-372 |
2.68e-91 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 280.38 E-value: 2.68e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQaeKLHIETRLAQAGNRSDDEkTGAISAPIYLSTAYR-----HA----GLgQSTGFDYPREAQPTRCILERVLAEME 71
Cdd:COG2873 1 MTEK--KYGFETLALHAGQEPDPT-TGARAVPIYQTTSYVfddaeHAadlfAL-KEPGNIYTRIMNPTTDVLEKRIAALE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 72 HGIAAYALTSGMAAIQL-VFTLFNSGDKIIVSDDLYGGSYRFFdllhdHYHL-------DFAvwDGQDQATLAALADDQT 143
Cdd:COG2873 77 GGVAALATASGQAAITLaILNLAEAGDHIVASSSLYGGTYNLF-----AHTLprlgievRFV--DPDDPEAFEAAIDPNT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 144 VALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQAD 223
Cdd:COG2873 150 KAIFGETIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 224 ADA----LEFN----------------------------LVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVL 271
Cdd:COG2873 230 WAAngkfPELTepdpsyhglvyteafgnaafitkarvqlLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 272 EADEHVERVLYP-----------------GRGGMISFYLATGTD-VDTFLRALNVISFAESLGGVESLLTVPAVQTHADL 333
Cdd:COG2873 310 EAHPKVAWVNYPglpshpyhelaqkylpkGAGGVLTFGLKGGREaGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQL 389
|
410 420 430
....*....|....*....|....*....|....*....
gi 503121135 334 TEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRAT 372
Cdd:COG2873 390 SEEEQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
7-368 |
5.86e-91 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 278.31 E-value: 5.86e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 7 KLHIETRLAQAGNRSDDEkTGAISAPIYLSTAYRHAGL--------GQSTGFDYPREAQPTRCILERVLAEMEHGIAAYA 78
Cdd:TIGR01328 1 RMTFATRAIHAGYPPKDQ-FGALTPPIYQTSTFVFDSCeqggnrfaGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 79 LTSGMAAIQ-LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMK 157
Cdd:TIGR01328 80 TSSGMGAIAaTLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 158 VIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVvksqADADALE-FNLVT--- 233
Cdd:TIGR01328 160 LIDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC----GKAELLQqIRMVGikd 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 234 -TGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG----------------RGGMISFYLATG 296
Cdd:TIGR01328 236 mTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGfedhpghdiaakqmrmGGGMITFELKGG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503121135 297 -TDVDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:TIGR01328 316 fAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQAL 388
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
9-371 |
8.68e-89 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 273.40 E-value: 8.68e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 9 HIETRLAQAGNRSDDEKtGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQL 88
Cdd:PRK08776 12 SAATAAVRAGIDRDTAY-GAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 89 VF-TLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLA-ALADDQTVALwLETPSNPTMKVIDITATAA 166
Cdd:PRK08776 91 VLnALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLAdALAQSPKLVL-IETPSNPLLRITDLRFVIE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 167 TAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLL 246
Cdd:PRK08776 170 AAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 247 LRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATG-TDVDTFLRALNVI 309
Cdd:PRK08776 250 LRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLashpghalaarqqkgfGAMLSFELEGGeAAVRAFVDGLRYF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503121135 310 SFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRA 371
Cdd:PRK08776 330 TLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
3-368 |
6.80e-88 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 270.93 E-value: 6.80e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 3 KQAEKLHIETRLAQAGNRSDDeKTGAISAPIYLSTAY----------RHAGlgQSTGFDYPREAQPTRCILERVLAEMEH 72
Cdd:PRK06234 2 ENIKKMGFATKAIHGGHIGDK-QFGSLATPIYQTSTFifdsaeqggrRFAG--EESGYIYSRLGNPTSTEVENKLALLEG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 73 GIAAYALTSGMAAI-QLVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETP 151
Cdd:PRK06234 79 GEAAVVAASGMGAIsSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 152 SNPTMKVIDITATA--ATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKsQADADALEF 229
Cdd:PRK06234 159 ANPTLKVTDIKAISniAHENNKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGK-EEFINQVKL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 230 NLVT--TGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISF 291
Cdd:PRK06234 238 FGIKdmTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLesfeyyelakkqmslpGAMISF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503121135 292 YLATGTDV-DTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK06234 318 ELKGGVEEgKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
23-371 |
1.08e-86 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 267.53 E-value: 1.08e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 23 DEKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFTLFNSGDKIIVS 102
Cdd:PRK08861 18 DSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 103 -DDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATL-AALADDQTVaLWLETPSNPTMKVIDITATAATAHAHDLKLIVDNT 180
Cdd:PRK08861 98 pHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALdAALAKKPKL-ILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 181 FYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQ 260
Cdd:PRK08861 177 FLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVH 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 261 EANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGTD-VDTFLRALNVISFAESLGGVESLLT 323
Cdd:PRK08861 257 EESAQQILAYLQTQSLVGTIYHPslpehpgheiakkqqsGFGSMLSFEFAGSFEqLKVFVKALALFSLAESLGGVESLIC 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 503121135 324 VPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRA 371
Cdd:PRK08861 337 HPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKA 384
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
9-368 |
2.82e-86 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 266.61 E-value: 2.82e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 9 HIETRLAQAGNRsDDEKTGAISAPIYLSTAYRH--------AGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALT 80
Cdd:PRK08249 8 GVGTKAVWAGEK-EYLPYGATQVPVVLSVAYGYddidewydVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 81 SGMAAIQLV-FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVI 159
Cdd:PRK08249 87 TGMAAISNTlYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 160 DITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLaGAVVVKSQADADAL----EFNlvttG 235
Cdd:PRK08249 167 DIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADAL-GGVVCGSKELMEQVyhyrEIN----G 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 236 AVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTD- 298
Cdd:PRK08249 242 ATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLethpnheiakaqmrgfGGILSFVLKGGMDt 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 299 VDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK08249 322 VKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
1-368 |
1.69e-85 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 264.74 E-value: 1.69e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQAEKLHIETRLAQAGNRSDDEKtGAISAPIYLSTAYR----HAG----LGQSTGFDYPREAQPTRCILERVLAEMEH 72
Cdd:PRK07503 1 MRDSHNNTGFSTRAIHHGYDPLDHG-GALVPPVYLTATFAfptaEYGaecfAGEEEGHFYSRISNPTLALLEQRMASLEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 73 GIAAYALTSGMAAIQLVF-TLFNSGDKIIVSDDLYGGSYRFfdlLHdHYHLDFAVW----DGQDQATLAALADDQTVALW 147
Cdd:PRK07503 80 GEAAVALASGMGAITATLwTLLRPGDEVIVDQTLYGCTFAF---LH-HGLGEFGVTvrhvDLTDPAALKAAISDKTRMVY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 148 LETPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGaVVVKSQADADAL 227
Cdd:PRK07503 156 FETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAG-LVVGGKALADRI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 228 EFNLVT--TGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMI 289
Cdd:PRK07503 235 RLEGLKdmTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLpsfaqhalaqrqmalpGGMI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 290 SFYLATGTDVD-TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07503 315 AFELKGGIAAGrRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQAL 394
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
23-368 |
5.07e-81 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 252.44 E-value: 5.07e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 23 DEKTGAISAPIYLSTAYRHAGlGQStgFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLV-FTLFNSGDKIIV 101
Cdd:PRK06460 13 DEATGAITTPIYQTTAYHYPE-GEK--YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTaLALLKPGNSVLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 102 SDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTF 181
Cdd:PRK06460 90 HRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 182 YTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGaVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQE 261
Cdd:PRK06460 170 STPINQKPLELGADIVVHSASKFLAGHNDVIAG-LAAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVIN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 262 ANAQELVTVLEADEHVERVLYPG----------------RGGMISFYLATG-TDVDTFLRALNVISFAESLGGVESLLTV 324
Cdd:PRK06460 249 RNAEQIAEFLEGHPKVVKVYYPGlkshvdyeiarrvlkgFGGVLSFEVNGGqESALKVMKSLKLIIPAQTLGGVNSVISH 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 503121135 325 PAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK06460 329 PATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
6-368 |
4.54e-79 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 250.33 E-value: 4.54e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 6 EKLHIETRLAQAGNRSDdeKTGAISAPIYLSTAYRHAGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAA 85
Cdd:PLN02509 83 EEASVSTLLVNLDNKFD--PFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 86 IQLVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATA 165
Cdd:PLN02509 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIA 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 166 ATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWL 245
Cdd:PLN02509 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 246 LLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLY------PGR----------GGMISFYLATGTDVDTFLRALNVI 309
Cdd:PLN02509 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHhlhfsqakgaGSVFSFITGSVALSKHLVETTKYF 400
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 503121135 310 SFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PLN02509 401 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
12-368 |
3.84e-78 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 245.20 E-value: 3.84e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 12 TRLAQAGNRSDDEkTGAISAPIYLSTAY------RHAGLGQSTG--FDYPREAQPTRCILERVLAEMEHGIAAYALTSGM 83
Cdd:PRK06434 11 TRAVQSGELRDPR-FGNVTTPIFETSTFvypnseKEAYMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 84 AAI-QLVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHY--HLDFAVWDGQDQATLAALADDqtvALWLETPSNPTMKVID 160
Cdd:PRK06434 90 GAItSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLgiHVDYIDTDRLNSLDFDPSNYD---LIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 161 ITATAATAHAHDLklIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDP 240
Cdd:PRK06434 167 IKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 241 FDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------GRGGMISFYLATGTDVDTFLRALNVIS 310
Cdd:PRK06434 245 IQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPdteigkkvlrGFGGMLSFELRSMEDVHKFIRNLEIPM 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503121135 311 FAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK06434 325 VAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
6-368 |
3.94e-78 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 245.30 E-value: 3.94e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 6 EKLHIETRLAQAGNRSDDEktGAISAPIYLSTAYRHAG--------LGQSTGFDYPREAQPTRCILERVLAEMEHGIAAY 77
Cdd:PRK08133 3 DSLGFDTLAVRAGQLRSPF--GEHSEALFLTSSFVFESaaeaaarfAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 78 ALTSGMAAIQ-LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTM 156
Cdd:PRK08133 81 ATASGMAAILaVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 157 KVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFnLVTTGA 236
Cdd:PRK08133 161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGF-LRTAGP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 237 VLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTDVD 300
Cdd:PRK08133 240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLpshpqhelakrqqkggGAIVSFEVKGGREAA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503121135 301 -TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK08133 320 wRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGL 388
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
45-368 |
6.61e-74 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 234.36 E-value: 6.61e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 45 GQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQ-LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLD 123
Cdd:TIGR01325 41 GELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIFaALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 124 FAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATK 203
Cdd:TIGR01325 121 TVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATK 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 204 YLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP 283
Cdd:TIGR01325 201 HIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYP 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 284 GR----------------GGMISFYLATGTDVDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANL 347
Cdd:TIGR01325 281 GLpshpqhelakrqmsggGTVVTFDLDCRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGL 360
|
330 340
....*....|....*....|.
gi 503121135 348 LRLSVGIENSADLAADLKQAL 368
Cdd:TIGR01325 361 VRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
1-368 |
8.67e-72 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 229.26 E-value: 8.67e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQAEKLHIETRLAQAGN-RSDdekTGAISAPIYLSTAYRHAGL--------GQSTGFDYPREAQPTRCILERVLAEME 71
Cdd:PRK07504 2 TTEMARKWRPATRLVHSGTlRSQ---FGETSEALFLTQGFVYDTAeaaearfkGEDPGFIYSRYSNPTVDMFEKRMCALE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 72 HGIAAYALTSGMAAIQL-VFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLET 150
Cdd:PRK07504 79 GAEDARATASGMAAVTAaILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLES 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 151 PSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFN 230
Cdd:PRK07504 159 PTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 231 LVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR--------------GG--MISFYLA 294
Cdd:PRK07504 239 FRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRadhpqadiiakqmtGGstLVAFELK 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503121135 295 TGTDVD-TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07504 319 GGKEAAfRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAAL 393
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
2-373 |
6.04e-71 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 228.10 E-value: 6.04e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 2 TKQAEKLHIETRLAQAGnRSDDEKTGAISAPIYLSTAY-----RHA----GLGQsTGFDYPREAQPTRCILERVLAEMEH 72
Cdd:PRK07812 6 ADPTANWSFETKQIHAG-QTPDPATNARALPIYQTTSYtfddtDHAaalfGLAE-PGNIYTRIMNPTQDVVEQRIAALEG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 73 GIAAYALTSGMAAIQL-VFTLFNSGDKIIVSDDLYGGSYRFFdllhdHYHL-------DFaVWDGQDQATLAALADDQTV 144
Cdd:PRK07812 84 GVAALLLASGQAAETFaILNLAGAGDHIVSSPRLYGGTYNLF-----HYTLpklgievSF-VEDPDDLDAWRAAVRPNTK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 145 ALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADA 224
Cdd:PRK07812 158 AFFAETISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 225 DALEFNLVTT------------------------------GAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEAD 274
Cdd:PRK07812 238 TQGRFPGFTTpdpsyhgvvfaelgppayalkarvqllrdlGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEAR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 275 EHVERVLYP-----------------GRGGMISFYLATGTDV-DTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEE 336
Cdd:PRK07812 318 DEVASVNYAglpsspwyerakrlapkGTGAVLSFELAGGVEAgKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPE 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 503121135 337 QRQSKGITANLLRLSVGIENSADLAADLKQALiRATK 373
Cdd:PRK07812 398 EQLATGVTPGLVRLAVGIEGIDDILADLEAGF-AAAK 433
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
12-368 |
1.78e-67 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 217.17 E-value: 1.78e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 12 TRLAQAGNRsDDEKTGAISAPIYLSTAYrHAGLGQSTGFD-YPREAQPTRCILERVLAEMEhGIAAYALTSGMAAIQ-LV 89
Cdd:PRK07582 6 TRSVHAGGP-EAVPGEPVLPGPVFAAPY-HLSPGEPTGPDtYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITaVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 90 FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFavwdgqDQATLAALADDQ---TVALWLETPSNPTMKVIDITATAA 166
Cdd:PRK07582 83 RALLRPGDTVVVPADGYYQVRALAREYLAPLGVTV------REAPTAGMAEAAlagADLVLAETPSNPGLDVCDLAALAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 167 TAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLL 246
Cdd:PRK07582 157 AAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 247 LRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPGR----------------GGMISFYLATGTDVDTFLRALNVIS 310
Cdd:PRK07582 237 HRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLpgdpahevaarqmrrfGGLVSFELADAAAAERFVAASRLVV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 311 FAESLGGVESlltvpavqthadlTEEQRQSKG--ITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07582 317 AATSFGGVHT-------------SADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERAL 363
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
8-373 |
6.31e-67 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 216.49 E-value: 6.31e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 8 LHIETRLAQAGNRSDDEKTGAISAPIY------------LSTAYRhaglGQSTGFDYPREAQPTRCILERVLAEMEHGIA 75
Cdd:PRK05968 5 LDPFDLAALITAHDEGNAFDAVVPPIFqtslftfdsydeMEDVYA----GEKVRPIYSRGDNPTVRAFEEMLAKLEGAED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 76 AYALTSGMAAIQ-LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVaLWLETPSNP 154
Cdd:PRK05968 81 ARGFASGMAAISsTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPGAKL-LYLESPTSW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 155 TMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTT 234
Cdd:PRK05968 160 VFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 235 GAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP-----------GRGGMISFYLATGTDVDTFL 303
Cdd:PRK05968 240 GAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPalanhppaglsGTSGLFSFIFREGIDVRAFA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503121135 304 RALNVISFAESLGGVESLLtVPA---VQTHADLTEEQRqsKGITANLLRLSVGIENSADLAADLKQALIRATK 373
Cdd:PRK05968 320 DALKLFRLGVSWGGHESLV-VPAevvLQQKAQPNSAAR--FGVSPRSVRLHVGLEGTEALWADLEQALAAASR 389
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
7-371 |
2.13e-64 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 211.07 E-value: 2.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 7 KLHIETRLAQAGnrSDDEKT-GAISAPIYLSTAY------------------RHAGLGQSTGFDYPREAQPTRCILERVL 67
Cdd:PRK07049 15 ELHPETQMLNYG--YDPELSeGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 68 AEMEHGIAAYALTSGMAAIQ-LVFTLFNSGDKIIVSDDLYGGS----YRFFDLLHDHYHlDFAvwDGQDQATLAALADDQ 142
Cdd:PRK07049 93 AVYEGAESAALFSSGMSAIAtTLLAFVRPGDVILHSQPLYGGTetllAKTFRNFGVGAV-GFA--DGLSEAAIGAAAEAA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 143 T----VAL-WLETPSNPTMKVIDITATAATAHAHDLK------LIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDV 211
Cdd:PRK07049 170 AakgrVSLiLIETPANPTNSLVDVAAVRRVADAIEARqghrpiIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 212 LAGAVVvKSQADADALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP-------- 283
Cdd:PRK07049 250 VAGAVL-GRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLpfldpdsa 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 284 ----------GRGGMISFYLATGTDVD-TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSV 352
Cdd:PRK07049 329 ygavykrqctGAGSTFSFDIKGGQAAAfRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSI 408
|
410
....*....|....*....
gi 503121135 353 GIENSADLAADLKQALIRA 371
Cdd:PRK07049 409 GIEHPDDLIADLAQALDAA 427
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
20-368 |
2.01e-63 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 207.66 E-value: 2.01e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 20 RSDDEKTgaiSAPIYLSTAYRH--------AGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAiqlVFT 91
Cdd:PRK07810 27 RSGFEET---AEALYLTSGYVYesaaaaeaAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSA---VFT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 92 ----LFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAAT 167
Cdd:PRK07810 101 algaLLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSEL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 168 AHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNLVTTGAVLDPFDAWLLL 247
Cdd:PRK07810 181 AHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 248 RSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGTDVD-----TFLRAL 306
Cdd:PRK07810 261 KGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPflpshpqydlakrqmsGGGTVVTFELDAPEDAAkkrafEVLDKL 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503121135 307 NVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07810 341 RVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
7-373 |
1.09e-62 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 206.62 E-value: 1.09e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 7 KLHIETRLAQAGNRSDDEkTGAISAPIYLSTAY-----RHA----GLgQSTGFDYPREAQPTRCILERVLAEMEHGIAAY 77
Cdd:PRK08248 6 TFRLETLAIHAGQEIDPT-TGSRAVPIYQTTSYgfrdsEHAanlfSL-KEFGNIYTRIMNPTTDVFEKRIAALEGGIGAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 78 ALTSGMAAIqlVFTLFN---SGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNP 154
Cdd:PRK08248 84 AVSSGQAAI--TYSILNiasAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 155 TMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQAD-ADALEFNLVT 233
Cdd:PRK08248 162 KGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDwKGSGKFPGLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 234 T-------------------------------GAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLY 282
Cdd:PRK08248 242 EpdpsyhglvytdavgeaayitkarvqllrdlGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 283 P-----------------GRGGMISFYLATGTDV-DTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGIT 344
Cdd:PRK08248 322 PglpshpsyelakkylpkGQGAILTFGIKGGVEAgKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVT 401
|
410 420
....*....|....*....|....*....
gi 503121135 345 ANLLRLSVGIENSADLAADLKQALIRATK 373
Cdd:PRK08248 402 PGLVRLSVGTEAIDDILDDLRQAIRQSQT 430
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-373 |
1.58e-62 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 206.13 E-value: 1.58e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 14 LAQAGNRSDDEKTGAISAPIYLSTAY-----RHAGL---GQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAA 85
Cdd:PRK08134 12 LALHAGAAPDPATGARAVPIHLTTSFvfrdsDHAAAlfnLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 86 IQL-VFTLFNSGDKIIVSDDLYGGSYrffDLLH---DHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDI 161
Cdd:PRK08134 92 LHLaIATLMGAGSHIVASSALYGGSH---NLLHytlRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 162 TATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADA--------------- 226
Cdd:PRK08134 169 PTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDWEAsgkfpeltepyagfh 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 227 -LEFN----------------LVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP------ 283
Cdd:PRK08134 249 gMVFAeestvaafllrarregLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPeleshp 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 284 -----------GRGGMISFYLATGTDV-DTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLS 351
Cdd:PRK08134 329 dhalakrllprGAGSVFSFDLKGGRAAgRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLS 408
|
410 420
....*....|....*....|..
gi 503121135 352 VGIENSADLAADLKQALIRATK 373
Cdd:PRK08134 409 IGLEDADDLIDDLKRALKAAEK 430
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
23-368 |
2.63e-61 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 203.02 E-value: 2.63e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 23 DEKTGAISAPIYLSTAY-----RHA----GLgQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVF-TL 92
Cdd:PRK05994 20 DPTTGARATPIYQTTSFvfndaDHAaslfGL-QAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASGHAAQFLVFhTL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 93 FNSGDKIIVSDDLYGGSYRFFDllhdHYHLDF---AVW-DGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATA 168
Cdd:PRK05994 99 LQPGDEFIAARKLYGGSINQFG----HAFKSFgwqVRWaDADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 169 HAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVV-------------------------VKSQAD 223
Cdd:PRK05994 175 HRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwsksgkypmlseprpeyhgLVLHET 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 224 ADALEF-------NLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG------------ 284
Cdd:PRK05994 255 FGNFAFaiaarvlGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGlpddpyhalaqk 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 285 -----RGGMISFYLATGTDVD-TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSA 358
Cdd:PRK05994 335 yspkgAGAVFTFGLKGGYEAGvKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVD 414
|
410
....*....|
gi 503121135 359 DLAADLKQAL 368
Cdd:PRK05994 415 DIIADLEQAL 424
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
27-368 |
3.46e-57 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 191.44 E-value: 3.46e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 27 GAISAPIYLSTAYRHA---GL-----GQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVF-TLFNSGD 97
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEdarDLidvfqGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFlTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 98 KIIVSDDLYGGSYRFFDLLHDhYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIV 177
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFGTLRG-LGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 178 DNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQAD-------------ADALEFNLVTT--------GA 236
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDwsaypnifpayrkGDPQQWGLTQIrkkglrdmGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 237 VLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG----------------RGGMISFYLATGTDVD 300
Cdd:PRK05939 247 TLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGlashpqharatelfrhYGGLLSFELADGIDCF 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503121135 301 TFLRALNVISFAESLGGVESLLtVPAVQT-HADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK05939 327 DFLNRLKLVIKATHLGDTRTLV-IPVAPTiYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQAL 394
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
8-368 |
2.89e-56 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 189.73 E-value: 2.89e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 8 LHIETRLAQAGnRSDDEKTGAISAPIYLSTAY-----RH-AGLG--QSTGFDYPREAQPTRCILERVLAEMEHGIAAYAL 79
Cdd:PRK06084 1 MKLETLAIHAG-YSPDPTTKAVAVPIYQTTSYafddtQHgADLFdlKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 80 TSGMAAIQLVF-TLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKV 158
Cdd:PRK06084 80 ASGMAAITYAIqTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 159 IDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQAD--ADALEFNLVTT-- 234
Cdd:PRK06084 160 IDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPwaEHKERFALLNTpd 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 235 -----------------------------GAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG- 284
Cdd:PRK06084 240 psyhgvtyteafgpaafigrcrvvplrnmGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGl 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 285 ----------------RGGMISFYLATGTDVDT-FLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANL 347
Cdd:PRK06084 320 pdhpehelarrymggkPASILSFGIKGGQAAGArFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDM 399
|
410 420
....*....|....*....|.
gi 503121135 348 LRLSVGIENSADLAADLKQAL 368
Cdd:PRK06084 400 VRLSIGIEHIDDIIADLAQAL 420
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
5-367 |
1.96e-54 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 185.08 E-value: 1.96e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 5 AEKLHIETRLAQAGnRSDDEKTGAISAPIYLSTAY-----RHA----GLgQSTGFDYPREAQPTRCILERVLAEMEHGIA 75
Cdd:PRK05613 9 ADQWGFETRSIHAG-QSVDSDTSARNLPIYQTTSYvfdsaEHAkqrfAL-EDLGPIYSRLTNPTVEALENRIASLEGGVH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 76 AYALTSGMAAIQLVF-TLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFA-VWDGQDQATLAALADDQTVALWLETPSN 153
Cdd:PRK05613 87 AVAFASGQAAETAAIlNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTfVENPDDPESWQAAVQPNTKAFFGETFAN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 154 PTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQ------------ 221
Cdd:PRK05613 167 PQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKfdwtverdgkpv 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 222 ----------------ADADALEFNLVT-------TGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVE 278
Cdd:PRK05613 247 fpyfvtpdpayhglkyADLGAPAFGLKAragllrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 279 RVLYPG-----------------RGGMISFYLATGTDVD-TFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQS 340
Cdd:PRK05613 327 KVNFAGlkdspwyatkeklglkyTGSVLSFDIKGGKDEAwAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLAR 406
|
410 420
....*....|....*....|....*..
gi 503121135 341 KGITANLLRLSVGIENSADLAADLKQA 367
Cdd:PRK05613 407 AGITQATVRLSVGIEDIDDIIADLEGG 433
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-368 |
3.92e-51 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 175.30 E-value: 3.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQAEKLHIETRLAQAgnrSDDEKTG--AISAPIYL-ST-------AYRHAGLGQSTGFDYPREAQPTRCILERVLAEM 70
Cdd:PRK07050 1 MTASTPKRALQTRIVQP---DDQIPPGfrSFVTPVARaSTvvfpdlaTMRALDWRQDVQWRYGLHATPTSLALAQRLAEI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 71 EHGIAAYALTSGMAAIQLV-FTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLE 149
Cdd:PRK07050 78 EGGRHALLQPSGLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 150 TPSNPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEF 229
Cdd:PRK07050 158 APGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 230 NLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYL 293
Cdd:PRK07050 238 ARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPalpdcpghafwmrdftGAGGLFSVVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503121135 294 ATGTD---VDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRqskgitANLLRLSVGIENSADLAADLKQAL 368
Cdd:PRK07050 318 DERYSpaqVDAFVEALELFAIGWSWGGACSLAMPYDVASMRTAKWPHR------GTLVRLYIGLEDEADLIADLEQAL 389
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
44-354 |
5.67e-49 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 170.33 E-value: 5.67e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 44 LGQSTGFD-YPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQLVFT-LFNSGDKIIVSDDLYGGSYRffdLLHDHYH 121
Cdd:PLN02242 61 LGPDRDFYiYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLqLCSSGGHVVASNTLYGGTHA---LLAHFLP 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 122 LDFAVW----DGQD-QATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTFyTPLIQKPLDLGADI 196
Cdd:PLN02242 138 RKCNITttfvDITDlEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADV 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 197 VVHSATKYLAGHNDVLAGAV-----VVKSQADADalEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVL 271
Cdd:PLN02242 217 VVHSISKFISGGADIIAGAVcgpaeLVNSMMDLH--HGALMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRM 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 272 EadEHVERVLYPGR-------------------GGMISFYLATGTDVDTFLRAL-NVISF---AESLGGVESLLTVPAVQ 328
Cdd:PLN02242 295 K--ELGLKVIYPGLedhpqhallksmankgygfGGLLCLDMDTEERANRLMRYLqNSTQFgfmAVSLGYYETLMSCSGSS 372
|
330 340
....*....|....*....|....*.
gi 503121135 329 THADLTEEQRQSKGITANLLRLSVGI 354
Cdd:PLN02242 373 TSSELDPEEKAAAGISPGLVRMSVGY 398
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
12-371 |
1.74e-47 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 165.44 E-value: 1.74e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 12 TRLAQAGNRSDDEKtGAISAPIYLSTA--YRH--AGLGQSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQ 87
Cdd:TIGR01324 1 TRLIHSGRQPRFSQ-GSVNPPLQRASTvlFDShaAQRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 88 L-VFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVIDITATAA 166
Cdd:TIGR01324 80 NsILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 167 TAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEfNLVTTGAVLDPFDAWLL 246
Cdd:TIGR01324 160 AARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLRE-HSYLMGQMVDADDAYTT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 247 LRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGT--DVDTFLRALNV 308
Cdd:TIGR01324 239 LRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPalpscpghefwkrdfsGSSGLFSFVLQRLTqkQVHAFLDHLQL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503121135 309 ISFAESLGGVESLltvpAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALIRA 371
Cdd:TIGR01324 319 FGLGYSWGGYESL----ALCNQPELGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
32-369 |
2.60e-44 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 158.29 E-value: 2.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 32 PIYLSTAYRH------AGLG--QSTGFDYPREAQPTRCILERVLAEMEHGIAAYALTSGMAAIQL-VFTLFNSGDKIIVS 102
Cdd:PRK06702 27 PLYQSTTYKYdtsddlAALFnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLaVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 103 DDLYGGSYRFFDLLHDHYHLDFAVWDGQDQA-TLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNTF 181
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPNLTAdEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 182 YTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFN------------------------------- 230
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNGKYPelvepdpsyhgvsyvqnfgaaayivkarvql 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 231 LVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYPG---------------RG--GMISFYL 293
Cdd:PRK06702 267 LRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGldsnenyslaqkylkKGasGVLTFGI 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503121135 294 ATGTD-VDTFLRALNVISFAESLGGVESLLTVPAVQTHADLTEEQRQSKGITANLLRLSVGIENSADLAADLKQALI 369
Cdd:PRK06702 347 KGGLEaAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAALV 423
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-372 |
3.41e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 157.28 E-value: 3.41e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQA---EKLHIETRLAQAGNRSDDEKtGAISAPI-YLSTA-YRHAGL--GQSTGFDYPREAQPTRCILERVLAEMEHG 73
Cdd:PRK05967 1 MAKKQlktEKAGINTRLAHDGNDPGDYH-GFVNPPVvHASTVlFPDAETmaTRGQKYTYGTRGTPTTDALCKAIDALEGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 74 IAAYALTSGMAAIQLVFTLF-NSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPS 152
Cdd:PRK05967 80 AGTILVPSGLAAVTVPFLGFlSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 153 NPTMKVIDITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVKSQADADALEFNlV 232
Cdd:PRK05967 160 SNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQLLEAH-G 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 233 TTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATG 296
Cdd:PRK05967 239 TLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPalpsfpgheiwkrdfsGASGIFSFVLAAG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 297 T-----DVDTFLRALNVISFAESLGGVESLltvpAVqtHADLTeEQRQSKGITAN-LLRLSVGIENSADLAADLKQALIR 370
Cdd:PRK05967 319 PekgkaKAHAFLDALEIFGLGYSWGGYESL----AL--HVKLG-DRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFAA 391
|
..
gi 503121135 371 AT 372
Cdd:PRK05967 392 AS 393
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
11-370 |
2.10e-37 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 138.71 E-value: 2.10e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 11 ETRLAQAGnRSDDEKTGAISAPIYLSTAY--------RHAGLGQSTG-FDYPREAQPTRCILERVLAEMEHGIAAYALTS 81
Cdd:PRK09028 6 ATKIVSAG-RDKKWTKGVINPPVFRASTVvfdtvaemRHAAKNRANGeMFYGRRGTPTHFAFQAAIVELEGGAGTALYPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 82 GMAAIQ-LVFTLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLETPSNPTMKVID 160
Cdd:PRK09028 85 GAAAISnALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 161 ITATAATAHAHDLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVVkSQADADALEFNLVTTGAVLDP 240
Cdd:PRK09028 165 VPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATA-NEKHWDQLREHSYLMGQCTSP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 241 FDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGMISFYLATGT--DVDTF 302
Cdd:PRK09028 244 DDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPafetcpgheffkrdfsGSNGLFSFVLKQGDpkAVTAL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503121135 303 LRALNVISFAESLGGVESL-LTVPAVqtHADLTEEQRQSKGitaNLLRLSVGIENSADLAADLKQALIR 370
Cdd:PRK09028 324 VEGMQHFKMGFSWGGFESLiLGVFGI--NKLRTATNWDFSK---PLIRLHIGLEDVDDLIADLEAGFER 387
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
1-370 |
1.75e-31 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 122.89 E-value: 1.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 1 MTKQaeklHIETRLAQAGnRSDDEKTGAI-------SAPIYLSTAY-RHAGLGQSTG--FdYPREAQPTRCILERVLAEM 70
Cdd:PRK08114 1 MTDK----KLDTQLVNAG-RSKKYTQGSVnsviqraSSLVFDSVEAkKHATRNRANGelF-YGRRGTLTHFSLQEAMCEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 71 EHGIAAYALTSGMAAIQLVFTLF-NSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQDQATLAALADDQTVALWLE 149
Cdd:PRK08114 75 EGGAGCALYPCGAAAVANAILAFvEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 150 TPSNPTMKVIDITATAATAHAH--DLKLIVDNTFYTPLIQKPLDLGADIVVHSATKYLAGHNDVLAGAVVvksqADA--- 224
Cdd:PRK08114 155 SPGSITMEVHDVPAIVAAVRSVnpDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAV----ANArcw 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 225 DALEFNLVTTGAVLDPFDAWLLLRSLKTLPLRLHQQEANAQELVTVLEADEHVERVLYP----------------GRGGM 288
Cdd:PRK08114 231 EQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPalpgckghefwkrdftGSSGL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 289 ISFYLA---TGTDVDTFLRALNVISFAESLGGVESLLTvpavqthADLTEE---QRQSKGI--TANLLRLSVGIENSADL 360
Cdd:PRK08114 311 FSFVLKkklTDEQLANYLDNFSLFSMAYSWGGFESLIL-------ANQPEEiaaIRPAGEVdfTGTLIRLHIGLEDVDDL 383
|
410
....*....|
gi 503121135 361 AADLKQALIR 370
Cdd:PRK08114 384 IADLAAGFAR 393
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
67-219 |
3.91e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 49.69 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 67 LAEMEHGIAAYALT---------SGMAAIQLVF-TLFNSGDKIIVSDDLYGGSYRFFDLLHDHYHLDFAVWDGQD----- 131
Cdd:cd01494 2 LEELEEKLARLLQPgndkavfvpSGTGANEAALlALLGPGDEVIVDANGHGSRYWVAAELAGAKPVPVPVDDAGYggldv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 132 QATLAALADDQTVALWLETPSNPTMKVIDITATAATAHAHDLKLIVDNT---FYTPLIQ-KPLDLGADIVVHSATKYLAG 207
Cdd:cd01494 82 AILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsagGASPAPGvLIPEGGADVVTFSLHKNLGG 161
|
170
....*....|..
gi 503121135 208 hndVLAGAVVVK 219
Cdd:cd01494 162 ---EGGGVVIVK 170
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
79-222 |
6.73e-07 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 50.80 E-value: 6.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 79 LTSG-MAAIQLVFTLF-NSGDKIIVSDDLYGGSYRFFDLLH---DHYHLDFAVWDGQDQATLAALADDQTVALWLETPSN 153
Cdd:cd00609 64 VTNGaQEALSLLLRALlNPGDEVLVPDPTYPGYEAAARLAGaevVPVPLDEEGGFLLDLELLEAAKTPKTKLLYLNNPNN 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 154 PTMKVID---ITATAATAHAHDLKLIVDNTF----YTPLIQKPLDLGAD----IVVHSATK----------YLAGHNDVL 212
Cdd:cd00609 144 PTGAVLSeeeLEELAELAKKHGILIISDEAYaelvYDGEPPPALALLDAyervIVLRSFSKtfglpglrigYLIAPPEEL 223
|
170
....*....|
gi 503121135 213 AGAVVVKSQA 222
Cdd:cd00609 224 LERLKKLLPY 233
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
77-155 |
4.39e-04 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 42.04 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503121135 77 YALTSGMAAIQLVF-TLFNSGDKIIVSD----------DLYGGSYRFFDLL-HDHYHLDFAvwdgqdqaTLAALADDQTV 144
Cdd:COG0436 94 LVTNGAKEALALALlALLNPGDEVLVPDpgypsyraavRLAGGKPVPVPLDeENGFLPDPE--------ALEAAITPRTK 165
|
90
....*....|.
gi 503121135 145 ALWLETPSNPT 155
Cdd:COG0436 166 AIVLNSPNNPT 176
|
|
| |
