NCBI Conserved Domain Search

Conserved domains on [gi|506265764|ref|WP_015785539|]

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bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Saccharomonospora viridis]

Protein Classification

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11415140)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH: 3.40.50.720|3.40.430.10

EC: 1.5.1.5|3.5.4.9

Gene Ontology: GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730

PubMed: 8485162

SCOP: 4000102

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-281

2.26e-150

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 421.73 E-value: 2.26e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVdATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALK-AKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY---ADN-- 235
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGInrvEDGkl 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 506265764 236 TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDHEAFR 281
Cdd:COG0190  240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-281

2.26e-150

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 421.73 E-value: 2.26e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVdATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALK-AKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY---ADN-- 235
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGInrvEDGkl 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 506265764 236 TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDHEAFR 281
Cdd:COG0190  240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285

PRK14192

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-274

2.52e-121

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184561 [Multi-domain] Cd Length: 283 Bit Score: 348.37 E-value: 2.52e-121

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14192   1 MMALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14192  81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY----ADNT 236
Cdd:PRK14192 161 HAVVVGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFhprdGGGV 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 237 GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14192 241 GDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAA 278

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-275

5.62e-67

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.

Pssm-ID: 133448 Cd Length: 168 Bit Score: 205.87 E-value: 5.62e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 116 PSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVD 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 196 LAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADN-----TGDVEYEAAAERASYITPVPGGVGPMTIATLL 267
Cdd:cd01080   81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGinrVPDKsggklVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                 ....*...
gi 506265764 268 AQTIKAAR 275
Cdd:cd01080  161 KNTVEAAK 168

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

130-275

1.53e-66

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 204.62 E-value: 1.53e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  130 RMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAA 209
Cdd:pfam02882   7 RLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREADIVVVA 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506265764  210 VGRPGLVRGEWIKPGAVVVDAG--YADN---TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:pfam02882  87 VGKPELIKADWIKPGAVVIDVGinRVGNgklVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAK 157

FolD_Thplmales

NF041156

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-275

2.29e-59

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 469068 [Multi-domain] Cd Length: 277 Bit Score: 190.42 E-value: 2.29e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRsrrIELDA--GITTETLVDH 82
Cdd:NF041156   2 ILDGEEIAEKKMERLKNEIEKIKNKYGIEPKLKLIQIGNDYASTIYANAKIRRGKKLGID---VDLEKydNITMDDLVKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIplSGKHA 162
Cdd:NF041156  79 IKDYSADPDINGIMVESPLPKPINYYDIVKNIPYYKDVDGLSPYNQGNLYLKNEFIAPATARAVVDILDYYGI--KSGNV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG--YADN--TGD 238
Cdd:NF041156 157 CIINRSPVVGRPLSMMLLNRDYTVSVCHSKTVDIKEIARSSDIVVVAVGKPGFLDRSYVTDKSIVIDVGinYVNNkiCGD 236

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:NF041156 237 ANFDNVSEKVKAITPVPGGVGPVTATDIFENFINGAK 273

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-281

2.26e-150

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 421.73 E-value: 2.26e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVdATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALK-AKGITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY---ADN-- 235
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGInrvEDGkl 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 506265764 236 TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDHEAFR 281
Cdd:COG0190  240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285

PRK14192

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-274

2.52e-121

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184561 [Multi-domain] Cd Length: 283 Bit Score: 348.37 E-value: 2.52e-121

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14192   1 MMALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14192  81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY----ADNT 236
Cdd:PRK14192 161 HAVVVGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFhprdGGGV 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 237 GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14192 241 GDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAA 278

PRK14190

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-275

5.62e-114

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184560 [Multi-domain] Cd Length: 284 Bit Score: 329.66 E-value: 5.62e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14190   1 MMAVIIDGKEVAKEKREQLKEEVVK-LKEQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14190  80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG--YADNT-- 236
Cdd:PRK14190 160 HVVVVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGvnRLENGkl 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 506265764 237 -GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14190 240 cGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAK 279

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-277

1.62e-109

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 318.40 E-value: 1.62e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGM-LLLARdATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY--ADN-- 235
Cdd:PRK10792 161 NAVVVGASNIVGRPMSLeLLLAG-CTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGInrLEDgk 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 506265764 236 -TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK10792 240 lVGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEY 282

PRK14177

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-277

3.20e-107

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172665 [Multi-domain] Cd Length: 284 Bit Score: 312.68 E-value: 3.20e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14177   1 MSPILLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14177  81 GVIDKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY-ADNTGDV 239
Cdd:PRK14177 161 NAVVVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYnPGNVGDI 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 240 EYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK14177 241 EISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFKEH 278

PRK14191

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-275

1.92e-97

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172679 [Multi-domain] Cd Length: 285 Bit Score: 287.82 E-value: 1.92e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14191   2 VLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14191  82 KDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADNT--GD 238
Cdd:PRK14191 162 IIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGinrLNDGRlvGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14191 242 VDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAE 278

PRK14189

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

1-274

2.88e-96

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 184559 [Multi-domain] Cd Length: 285 Bit Score: 284.66 E-value: 2.88e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14189   1 MTAQLIDGNALSKQLRAEAAQRAAA-LTARGHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14189  80 ARIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADNT---- 236
Cdd:PRK14189 160 HAVVIGRSNIVGKPMAMLLLQAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDagkl 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 506265764 237 -GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14189 240 cGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAA 278

PRK14186

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

2-271

5.87e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237636 [Multi-domain] Cd Length: 297 Bit Score: 281.95 E-value: 5.87e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   2 TAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVD 81
Cdd:PRK14186   1 MALILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  82 HIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKH 161
Cdd:PRK14186  81 LIAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 162 AVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADNT----- 236
Cdd:PRK14186 161 AVVVGRSILVGKPLALMLLAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRLPssdgk 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 506265764 237 ----GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTI 271
Cdd:PRK14186 241 trlcGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTV 279

PRK14188

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

2-275

3.94e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184558 [Multi-domain] Cd Length: 296 Bit Score: 279.92 E-value: 3.94e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   2 TAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVD 81
Cdd:PRK14188   1 MATIIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  82 HIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKH 161
Cdd:PRK14188  81 LIARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 162 AVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---------Y 232
Cdd:PRK14188 161 AVVIGRSNLVGKPMAQLLLAANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGinripapekG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 506265764 233 ADNT---GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14188 241 EGKTrlvGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAAC 286

PRK14184

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-277

3.88e-92

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237635 [Multi-domain] Cd Length: 286 Bit Score: 274.35 E-value: 3.88e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14184   2 LLLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14184  82 AELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLA----RDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY--ADN-- 235
Cdd:PRK14184 162 VVGRSNIVGKPLALMLGApgkfANATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGInrTDDgl 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 506265764 236 TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK14184 242 VGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKER 283

PRK14183

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-277

4.11e-88

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184555 [Multi-domain] Cd Length: 281 Bit Score: 264.00 E-value: 4.11e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14183   2 QILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14183  82 AMMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY-----ADNTGD 238
Cdd:PRK14183 162 VVGASNIVGKPMAALLLNANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGInrtedGRLVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK14183 242 VDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKNR 280

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-274

6.90e-88

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 263.41 E-value: 6.90e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAA-LKEKGITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14193  80 AVIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLAR--DATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADN--- 235
Cdd:PRK14193 160 HVVVIGRGVTVGRPIGLLLTRRseNATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAgdg 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 506265764 236 --TGDVEyEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14193 240 klVGDVH-PDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERA 279

PRK14174

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-273

3.14e-85

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172662 [Multi-domain] Cd Length: 295 Bit Score: 257.06 E-value: 3.14e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14174   2 LIIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFD--EGGFASATPGGIMALLDAYDIPLSGKH 161
Cdd:PRK14174  82 EDLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGhlDKCFVSCTPYGILELLGRYNIETKGKH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 162 AVVIGRSAILGRPVGMLLL----ARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY----A 233
Cdd:PRK14174 162 CVVVGRSNIVGKPMANLMLqklkESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGInrieD 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 506265764 234 DNT-------GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKA 273
Cdd:PRK14174 242 PSTksgyrlvGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQS 288

PRK14179

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

3-274

1.25e-84

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 237634 [Multi-domain] Cd Length: 284 Bit Score: 255.06 E-value: 1.25e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   3 AQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDH 82
Cdd:PRK14179   2 TEIIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14179  82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADN-----TG 237
Cdd:PRK14179 162 VVIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNRDengklIG 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 238 DVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14179 242 DVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAA 278

PRK14178

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-275

8.26e-84

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172666 [Multi-domain] Cd Length: 279 Bit Score: 252.84 E-value: 8.26e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEfvdaTGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14178   2 ILDGKAVSEKRLELLKEEIIE----SGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVV 164
Cdd:PRK14178  78 RLNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 165 IGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADNT----GDVE 240
Cdd:PRK14178 158 VGRSIDVGRPMAALLLNADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQVNgklcGDVD 237

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 506265764 241 YEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14178 238 FDAVKEIAGAITPVPGGVGPMTIATLMENTFDAAK 272

PRK14176

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-275

2.09e-82

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184553 [Multi-domain] Cd Length: 287 Bit Score: 249.72 E-value: 2.09e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14176  10 IIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVV 164
Cdd:PRK14176  90 SLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAVI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 165 IGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADNT----GDVE 240
Cdd:PRK14176 170 VGHSNVVGKPMAAMLLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITKEEdkvyGDVD 249

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 506265764 241 YEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14176 250 FENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAE 284

PRK14169

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-275

3.67e-81

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184550 [Multi-domain] Cd Length: 282 Bit Score: 246.40 E-value: 3.67e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   3 AQILDGRAVSAKILDRVSREVEEFVDaTGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDH 82
Cdd:PRK14169   1 ATRLDGRAVSKKILADLKQTVAKLAQ-QDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14169  80 VAELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY---ADN--TG 237
Cdd:PRK14169 160 VIVGRSNIVGRPLAGLMVNHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGIsrgADGklLG 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 238 DVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14169 240 DVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAK 277

PRK14173

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-274

8.46e-81

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184551 [Multi-domain] Cd Length: 287 Bit Score: 245.51 E-value: 8.46e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDatgrVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14173   1 MAARELSGPPAAEAVYAELRARLAKLPF----VPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14173  77 ELIARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVD---------AG 231
Cdd:PRK14173 157 EVVVVGRSNIVGKPLAALLLREDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDvginrvggnGG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 506265764 232 YADNTGDVEYEaAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14173 237 RDILTGDVHPE-VAEVAGALTPVPGGVGPMTVAMLMANTVIAA 278

PRK14167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

3-274

2.33e-80

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184549 [Multi-domain] Cd Length: 297 Bit Score: 244.69 E-value: 2.33e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   3 AQILDGRAVSAKILDRVSREVEEFVDAtGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDH 82
Cdd:PRK14167   2 TEIIDGNAVAAQIRDDLTDAIETLEDA-GVTPGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14167  81 IDELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLAR----DATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY----AD 234
Cdd:PRK14167 161 VVVGRSDIVGKPMANLLIQKadggNATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGInrvdAD 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 506265764 235 N------TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14167 241 TekgyelVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAA 286

PRK14185

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-275

2.72e-80

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184556 [Multi-domain] Cd Length: 293 Bit Score: 244.35 E-value: 2.72e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14185   2 QLIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14185  82 RELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLAR----DATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYA------ 233
Cdd:PRK14185 162 VLGRSNIVGKPMAQLMMQKaypgDCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTrvpdat 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 506265764 234 -----DNTGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14185 242 rksgfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGK 288

PRK14166

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-276

1.98e-79

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172654 [Multi-domain] Cd Length: 282 Bit Score: 241.85 E-value: 1.98e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEeFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14166   3 LLDGKALSAKIKEELKEKNQ-FLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFD-EGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14166  82 TLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGlESGFLPCTPLGVMKLLKAYEIDLEGKDAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG-----YADNTGD 238
Cdd:PRK14166 162 IIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGinrleSGKIVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARD 276
Cdd:PRK14166 242 VDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKN 279

PRK14175

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-275

3.12e-78

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184552 [Multi-domain] Cd Length: 286 Bit Score: 239.05 E-value: 3.12e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14175   1 MVAKILDGKQIAKDYRQGLQDQVEA-LKEKGFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14175  80 NELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADN----- 235
Cdd:PRK14175 160 NAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDengkl 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 506265764 236 TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14175 240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEK 279

PRK14172

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-273

2.10e-77

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172660 [Multi-domain] Cd Length: 278 Bit Score: 236.60 E-value: 2.10e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   4 QILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHI 83
Cdd:PRK14172   3 QIINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  84 RELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14172  83 EELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYAD----NTGDV 239
Cdd:PRK14172 163 VIGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSvngkITGDV 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 506265764 240 EYEAAAERASYITPVPGGVGPMTIATLLAQTIKA 273
Cdd:PRK14172 243 NFDKVIDKASYITPVPGGVGSLTTTLLIKNVCEA 276

PLN02616

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

3-281

6.93e-77

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 215332 [Multi-domain] Cd Length: 364 Bit Score: 238.37 E-value: 6.93e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   3 AQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDH 82
Cdd:PLN02616  73 AKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLKF 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFD--EGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PLN02616 153 ISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRgrEPLFVPCTPKGCIELLHRYNVEIKGK 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADNT- 236
Cdd:PLN02616 233 RAVVIGRSNIVGMPAALLLQREDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGinpVEDASs 312

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 506265764 237 -------GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDHEAFR 281
Cdd:PLN02616 313 prgyrlvGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 364

PLN02516

methylenetetrahydrofolate dehydrogenase (NADP+)

2-275

4.19e-74

methylenetetrahydrofolate dehydrogenase (NADP+)

Pssm-ID: 178131 [Multi-domain] Cd Length: 299 Bit Score: 229.01 E-value: 4.19e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   2 TAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVD 81
Cdd:PLN02516   8 VAQIIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELIS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  82 HIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFD--EGGFASATPGGIMALLDAYDIPLSG 159
Cdd:PLN02516  88 KVHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKgrEPLFLPCTPKGCLELLSRSGIPIKG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 160 KHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADNT 236
Cdd:PLN02516 168 KKAVVVGRSNIVGLPVSLLLLKADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGtnaVSDPS 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 506265764 237 --------GDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PLN02516 248 kksgyrlvGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAK 294

PRK14194

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-275

7.63e-73

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172682 [Multi-domain] Cd Length: 301 Bit Score: 225.88 E-value: 7.63e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14194   2 MSAKLIDGKAAAARVLAQVREDVRT-LKAAGIEPALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGK 160
Cdd:PRK14194  81 ALIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 161 HAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY-------- 232
Cdd:PRK14194 161 HAVVIGRSNIVGKPMAALLLQAHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGInridddgr 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 506265764 233 ADNTGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14194 241 SRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAAR 283

PRK14171

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-276

1.12e-72

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172659 [Multi-domain] Cd Length: 288 Bit Score: 224.84 E-value: 1.12e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14171   4 IIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGV--TRTSFARMAFDEgGFASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14171  84 ELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFhpLNVGYLHSGISQ-GFIPCTALGCLAVIKKYEPNLTGKNV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADN--TG 237
Cdd:PRK14171 163 VIIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGinrISGNkiIG 242

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 506265764 238 DVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARD 276
Cdd:PRK14171 243 DVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKD 281

PRK14170

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-275

3.00e-72

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172658 [Multi-domain] Cd Length: 284 Bit Score: 223.80 E-value: 3.00e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   3 AQILDGRAVSAKILDRVSREVEEFVDaTGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDH 82
Cdd:PRK14170   2 GEIIDGKKLAKEIQEKVTREVAELVK-EGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14170  81 VEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADN-----TG 237
Cdd:PRK14170 161 VVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDennklCG 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 506265764 238 DVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14170 241 DVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAK 278

PRK14187

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-274

1.80e-69

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172675 [Multi-domain] Cd Length: 294 Bit Score: 217.00 E-value: 1.80e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14187   4 IIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGG--FASATPGGIMALLDAYDIPLSGKHA 162
Cdd:PRK14187  84 ELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTGQKKncLIPCTPKGCLYLIKTITRNLSGSDA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG--------YAD 234
Cdd:PRK14187 164 VVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGinsieeggVKK 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 506265764 235 NTGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAA 274
Cdd:PRK14187 244 FVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAA 283

PRK14168

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-277

1.83e-69

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237633 [Multi-domain] Cd Length: 297 Bit Score: 217.05 E-value: 1.83e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   1 MTAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLV 80
Cdd:PRK14168   1 MSAKIIKGTEIREEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  81 DHIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAF--DEGGFASATPGGIMALLDAYDIPLS 158
Cdd:PRK14168  81 ALIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIggDEVKFLPCTPAGIQEMLVRSGVETS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 159 GKHAVVIGRSAILGRPVGMLLLAR----DATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY-- 232
Cdd:PRK14168 161 GAEVVVVGRSNIVGKPIANMMTQKgpgaNATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVnr 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 506265764 233 ---------ADNTGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK14168 241 vgtnestgkAILSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSAKFH 294

PRK14180

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-276

3.25e-69

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172668 [Multi-domain] Cd Length: 282 Bit Score: 215.66 E-value: 3.25e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14180   3 LIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAF-DEGGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14180  83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLrDKKCLESCTPKGIMTMLREYGIKTEGAYAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG--YADN--TGDV 239
Cdd:PRK14180 163 VVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGinHVDGkiVGDV 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 240 EYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARD 276
Cdd:PRK14180 243 DFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQE 279

PRK14182

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-275

9.56e-69

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172670 [Multi-domain] Cd Length: 282 Bit Score: 214.50 E-value: 9.56e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEfVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14182   3 LIDGKQIAAKVKGEVATEVRA-LAARGVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFAS-ATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14182  82 RLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVPRpCTPAGVMRMLDEARVDPKGKRAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY---ADN--TGD 238
Cdd:PRK14182 162 VVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMnrlADGklVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PRK14182 242 VEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAK 278

PLN02897

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

2-275

7.80e-68

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 178485 [Multi-domain] Cd Length: 345 Bit Score: 214.44 E-value: 7.80e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   2 TAQILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVD 81
Cdd:PLN02897  55 KTVVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  82 HIRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFD--EGGFASATPGGIMALLDAYDIPLSG 159
Cdd:PLN02897 135 ALRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMRgrEPLFVSCTPKGCVELLIRSGVEIAG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 160 KHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGYADN---- 235
Cdd:PLN02897 215 KNAVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVedss 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 506265764 236 -------TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:PLN02897 295 cefgyrlVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAK 341

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-275

5.62e-67

Pssm-ID: 133448 Cd Length: 168 Bit Score: 205.87 E-value: 5.62e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 116 PSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVD 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 196 LAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG---YADN-----TGDVEYEAAAERASYITPVPGGVGPMTIATLL 267
Cdd:cd01080   81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGinrVPDKsggklVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                 ....*...
gi 506265764 268 AQTIKAAR 275
Cdd:cd01080  161 KNTVEAAK 168

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

130-275

1.53e-66

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 204.62 E-value: 1.53e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  130 RMAFDEGGFASATPGGIMALLDAYDIPLSGKHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAA 209
Cdd:pfam02882   7 RLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREADIVVVA 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506265764  210 VGRPGLVRGEWIKPGAVVVDAG--YADN---TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:pfam02882  87 VGKPELIKADWIKPGAVVIDVGinRVGNgklVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAK 157

PRK14181

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-277

5.37e-62

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172669 [Multi-domain] Cd Length: 287 Bit Score: 197.39 E-value: 5.37e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEefvdATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIR 84
Cdd:PRK14181   2 LLKGAPAAEHILATIKENIS----ASSTAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  85 ELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDE-GGFASATPGGIMALLDAYDIPLSGKHAV 163
Cdd:PRK14181  78 RLNNDPNIHGILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKLLLGEtDGFIPCTPAGIIELLKYYEIPLHGRHVA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 164 VIGRSAILGRPVGMLLLAR----DATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAGY----ADN 235
Cdd:PRK14181 158 IVGRSNIVGKPLAALLMQKhpdtNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTsrvpAAN 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 506265764 236 ------TGDVEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAARDH 277
Cdd:PRK14181 238 pkgyilVGDVDFNNVVPKCRAITPVPGGVGPMTVAMLMRNTWESYLRH 285

FolD_Thplmales

NF041156

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-275

2.29e-59

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 469068 [Multi-domain] Cd Length: 277 Bit Score: 190.42 E-value: 2.29e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764   5 ILDGRAVSAKILDRVSREVEEFVDATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRsrrIELDA--GITTETLVDH 82
Cdd:NF041156   2 ILDGEEIAEKKMERLKNEIEKIKNKYGIEPKLKLIQIGNDYASTIYANAKIRRGKKLGID---VDLEKydNITMDDLVKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764  83 IRELSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVDGVTRTSFARMAFDEGGFASATPGGIMALLDAYDIplSGKHA 162
Cdd:NF041156  79 IKDYSADPDINGIMVESPLPKPINYYDIVKNIPYYKDVDGLSPYNQGNLYLKNEFIAPATARAVVDILDYYGI--KSGNV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 163 VVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLVRGEWIKPGAVVVDAG--YADN--TGD 238
Cdd:NF041156 157 CIINRSPVVGRPLSMMLLNRDYTVSVCHSKTVDIKEIARSSDIVVVAVGKPGFLDRSYVTDKSIVIDVGinYVNNkiCGD 236

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 506265764 239 VEYEAAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:NF041156 237 ANFDNVSEKVKAITPVPGGVGPVTATDIFENFINGAK 273

THF_DHG_CYH

pfam00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

6-121

4.51e-58

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

Pssm-ID: 459930 [Multi-domain] Cd Length: 115 Bit Score: 181.45 E-value: 4.51e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764    6 LDGRAVSAKILDRVSREVEEFVdATGRVPCLATVLVGDDPASHTYVRMKANRCAKVGMRSRRIELDAGITTETLVDHIRE 85
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALK-AGGRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 506265764   86 LSDDPEIDGILLQHPVPSHIDERAAFEAIAPSKDVD 121
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115

NAD_bind_m-THF_DH_Cyclohyd_like

cd05212

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...

137-275

5.55e-28

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133451 Cd Length: 140 Bit Score: 104.90 E-value: 5.55e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 137 GFASATPGGIMALLDAYDIPLSGKHAVVIGRSAILGRPVGMLLLARDATVTYCHSRTVDLAKHVAEADVVVAAVGRPGLV 216
Cdd:cd05212    6 LFVSPVAKAVKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDGATVYSCDWKTIQLQSKVHDADVVVVGSPKPEKV 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 506265764 217 RGEWIKPGAVVVDAGYADNTGDVeyeaAAERASYITPVPGGVGPMTIATLLAQTIKAAR 275
Cdd:cd05212   86 PTEWIKPGATVINCSPTKLSGDD----VKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140

NAD_bind_m-THF_DH

cd01079

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...

116-267

7.73e-09

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133447 [Multi-domain] Cd Length: 197 Bit Score: 54.35 E-value: 7.73e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 116 PSKDVDGVTRTS----FARMAFD--EGGFAS---ATPGGIMALLD---------AYDIPLSGKHAVVIGRSAILGRPVGM 177
Cdd:cd01079    1 PHKDVEGLSHKYifnlYHNIRFLdpENRKKSilpCTPLAIVKILEflgiynkilPYGNRLYGKTITIINRSEVVGRPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506265764 178 LLLARDATV---------TYCHSRTVDLAKHVAEADVVVAAVGRP-------GL------VRGEWIKPGAVVVDAGYADN 235
Cdd:cd01079   81 LLANDGARVysvdingiqVFTRGESIRHEKHHVTDEEAMTLDCLSqsdvvitGVpspnykVPTELLKDGAICINFASIKN 160

                        170       180       190
                 ....*....|....*....|....*....|..
gi 506265764 236 TGDveyeAAAERASYITPVpggVGPMTIATLL 267
Cdd:cd01079  161 FEP----SVKEKASIYVPS---IGKVTIAMLL 185

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01