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Conserved domains on  [gi|506605313|ref|WP_016069287|]
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SprT-like domain-containing protein [Brucella melitensis]

Protein Classification

SprT family zinc-dependent metalloprotease( domain architecture ID 141001)

SprT family zinc-dependent metalloprotease, which contains an HExxH motif characteristic of zinc metallopeptidases

CATH:  3.30.2010.10
EC:  3.4.-.-
Gene Ontology:  GO:0008237|GO:0006508|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SprT-like super family cl46348
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 22-107 2.02e-13

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


The actual alignment was detected with superfamily member pfam10263:

Pssm-ID: 480688  Cd Length: 106  Bit Score: 63.06  E-value: 2.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506605313   22 GLISNGWTFRINGRITKTLGRCSYTKK-LIELSGRHVAEDIYEDILDTLLHEIAHALV----GRGYEHGKVWQAMALRLG 96
Cdd:pfam10263  15 GFLLPGVSVRWSKRLRTTAGRAHLKRKnEIRLSEPLLDENPEEFLRETLLHEMIHAYLfvlfGRRRGHGPEFKAWMERIN 94

                          90
                  ....*....|.
gi 506605313   97 AKPSPSKTTTK 107
Cdd:pfam10263  95 EAQTGLPITTY 105
 
Name Accession Description Interval E-value
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 22-107 2.02e-13

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 63.06  E-value: 2.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506605313   22 GLISNGWTFRINGRITKTLGRCSYTKK-LIELSGRHVAEDIYEDILDTLLHEIAHALV----GRGYEHGKVWQAMALRLG 96
Cdd:pfam10263  15 GFLLPGVSVRWSKRLRTTAGRAHLKRKnEIRLSEPLLDENPEEFLRETLLHEMIHAYLfvlfGRRRGHGPEFKAWMERIN 94

                          90
                  ....*....|.
gi 506605313   97 AKPSPSKTTTK 107
Cdd:pfam10263  95 EAQTGLPITTY 105
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 33-99 6.06e-13

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 63.11  E-value: 6.06e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506605313    33 NGRITKTLGRCSYTKKLIELSGRHVAEDIYEDILDTLLHEIAHALV---GRGYEHGKVWQAMALRLGAKP 99
Cdd:smart00731  27 NKRLRKTGGRCLLKSAEIRLNPKLLTENGRDRLRETLLHELCHAALylfGRGYGHGDEWKRWMRQVNGLF 96
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
28-100 4.96e-07

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 47.19  E-value: 4.96e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506605313  28 WTFRINGRITkTLGRCSYTKKLIELSGRHVAEDIYEDILDTLLHEIAHALV----GRGYEHGKVWQAMALRLGAKPS 100
Cdd:COG3091   30 PEVRFNLRGT-TAGRAHLQSHEIRLNPKLLEENGEEFLIEVVPHELAHYHLyqefGRVRPHGKEWRELMEKVGGLPP 105
 
Name Accession Description Interval E-value
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 22-107 2.02e-13

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 63.06  E-value: 2.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506605313   22 GLISNGWTFRINGRITKTLGRCSYTKK-LIELSGRHVAEDIYEDILDTLLHEIAHALV----GRGYEHGKVWQAMALRLG 96
Cdd:pfam10263  15 GFLLPGVSVRWSKRLRTTAGRAHLKRKnEIRLSEPLLDENPEEFLRETLLHEMIHAYLfvlfGRRRGHGPEFKAWMERIN 94

                          90
                  ....*....|.
gi 506605313   97 AKPSPSKTTTK 107
Cdd:pfam10263  95 EAQTGLPITTY 105
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 33-99 6.06e-13

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 63.11  E-value: 6.06e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506605313    33 NGRITKTLGRCSYTKKLIELSGRHVAEDIYEDILDTLLHEIAHALV---GRGYEHGKVWQAMALRLGAKP 99
Cdd:smart00731  27 NKRLRKTGGRCLLKSAEIRLNPKLLTENGRDRLRETLLHELCHAALylfGRGYGHGDEWKRWMRQVNGLF 96
SprT COG3091
Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];
28-100 4.96e-07

Predicted Zn-dependent metalloprotease, SprT family [General function prediction only];


Pssm-ID: 442325  Cd Length: 159  Bit Score: 47.19  E-value: 4.96e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506605313  28 WTFRINGRITkTLGRCSYTKKLIELSGRHVAEDIYEDILDTLLHEIAHALV----GRGYEHGKVWQAMALRLGAKPS 100
Cdd:COG3091   30 PEVRFNLRGT-TAGRAHLQSHEIRLNPKLLEENGEEFLIEVVPHELAHYHLyqefGRVRPHGKEWRELMEKVGGLPP 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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