|
Name |
Accession |
Description |
Interval |
E-value |
| lacY |
PRK09528 |
galactoside permease; Reviewed |
7-411 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 559.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 7 NKAYYWGNRNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLW 86
Cdd:PRK09528 2 ATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 87 AVAIALLFYAPFFIYIFAPMLKTNIWMGAIVGGIYMGFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIA 166
Cdd:PRK09528 82 IISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 167 GILYSKDPDSVFWLGSAGAVVLLVLVALAKPEQNSTASVMAQLGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDI 246
Cdd:PRK09528 162 GILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 247 FDQQFGNFFNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVL 326
Cdd:PRK09528 242 FDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 327 KMLHMFEVPFYLVGLFKYISNVFEVHFSATIYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIF 406
Cdd:PRK09528 322 KLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVF 401
|
....*
gi 517481490 407 TLTGK 411
Cdd:PRK09528 402 TLSGD 406
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
9-411 |
4.86e-164 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 467.71 E-value: 4.86e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 9 AYYWGNRNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAV 88
Cdd:pfam01306 1 MYPLKNTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 89 AIALLFYAPFFIYIFAPMLKTNIWMGAIVGGIYMGFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIAGI 168
Cdd:pfam01306 81 TGLLVLFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 169 LYSKDPDSVFWLGSAGAVVLLVLVALAKPEQNSTASVMAQLGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFD 248
Cdd:pfam01306 161 LFSIDPQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 249 QQFGNFFNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKM 328
Cdd:pfam01306 241 QQFANFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 329 LHMFEVPFYLVGLFKYISNVFEVHFSATIYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIFTL 408
Cdd:pfam01306 321 LHMFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTL 400
|
...
gi 517481490 409 TGK 411
Cdd:pfam01306 401 SGS 403
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
14-409 |
8.76e-163 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 463.83 E-value: 8.76e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 14 NRNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALL 93
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 94 FYAPFFIYIFAPMLKTNIWMGAIVGGIYMGFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIAGILYSKD 173
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 174 PDSVFWLGSAGAVVLLVLVALAKPEQNSTASVMAQLGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFDQQFGN 253
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 254 FFNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMFE 333
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517481490 334 VPFYLVGLFKYISNVFEVHFSATIYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIFTLT 409
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
17-408 |
3.50e-159 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 454.38 E-value: 3.50e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 17 YFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYA 96
Cdd:cd06172 1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 97 PFFIYIFAPMLKTNIWMGAIVGGIYMGFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIAGILYSKDPDS 176
Cdd:cd06172 81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 177 VFWLGSAGAVVLLVLVALAKPEQNSTASVMaqlGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFDQQFGNFFN 256
Cdd:cd06172 161 NFWLGSGFALILLLLLLFAKPEDSDTAAAA---GANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 257 TFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMFEVPF 336
Cdd:cd06172 238 SLFATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPL 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517481490 337 YLVGLFKYISNVFEVHFSATIYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIFTL 408
Cdd:cd06172 318 LLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-406 |
8.97e-21 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 93.03 E-value: 8.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 19 VFSGYFFTYFFIMATCYPFLGIWLGDInGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLW-AVAIALLFYAP 97
Cdd:cd17335 1 RLKLFYFFFFAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLlSLLAAVLFFLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 98 FFIY--IFAPMLktniwmGAIVGGIymgFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIAGIL-----Y 170
Cdd:cd17335 80 LFFVaqIFWLLL------LLVILGA---FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILidrssT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 171 SKDPDSVFWLGSAGAVVLLVLVALAKPEQNSTASvmaqlgantnPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFdqq 250
Cdd:cd17335 151 YKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEP----------NENTGGLLALLRNPRVLAFLLVAFLMGFGHGLI--- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 251 fgNFFNTFFNSKEEGIEV-FGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKML 329
Cdd:cd17335 218 --YSFLFWHLQDLGGSKTlIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 330 HMFEVPFYLVGLFKYISNVFEVHFSATIymvacQFIKQVGNMLASSAVGGW-----YDKFGYQDTYFILGCVALGFTLLS 404
Cdd:cd17335 296 HGLTFALVWAAAVSYASAAAPPGLRATA-----QGLLQGLYFGLGGGLGSLiggylYEAFGARTTFRFFAIAALAGLLAF 370
|
..
gi 517481490 405 IF 406
Cdd:cd17335 371 FL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-407 |
1.40e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.84 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 18 FVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKhmlWAVAIALLFYAP 97
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 98 FFIYIFAPMLKTNIWMGAIVgGIYMGFVFSGGAGASEAYVERvsRQSNFEYGRARMFGMMGWGICASIAGILYSK-DPDS 176
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLL-GIGGGGSFAVGIALVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 177 VFWLGSAGAVVLLVLVALAKPEQnstasvmAQLGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFDQQFGNFFN 256
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDP-------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 257 TFFnskEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATE-AWHVVVLKMLHMFEVP 335
Cdd:COG2223 234 DQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517481490 336 FYLVGLFKYISNVFEVHFSATIYMVAcQFIKQVGNMLASSAVGGWYDKFG-YQDTYFILGCVALGFTLLSIFT 407
Cdd:COG2223 311 GGNGAVFALVPDIFPTKNAGAVYGLV-GAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-406 |
1.09e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 65.91 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 20 FSGYFFTYFFIMATCYPFLGIWLGDINGLTGEErGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYAPFf 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL-GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 100 iyifapMLKTNIWMgAIVGGIYMGFVFSGGAGASEAYVERVS--RQSNFEYGRARMFGMMGWGICASIAGILYSKDPDS- 176
Cdd:cd06174 79 ------AFAPSFWL-LLLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFGw 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 177 --VFWLGSAGAVVLLVLVALAKPEQNSTASvmAQLGANTNPVSLKQAFKLFKLPRFWALLayvVGVACTYDIFDQQFGNF 254
Cdd:cd06174 152 raVFLIAAALALLAAILLLLVVPDPPESAR--AKNEEASSKSVLKLLKRVLKNPGLWLLL---LAIFLVNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 255 FNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINR-MGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMFE 333
Cdd:cd06174 227 PLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517481490 334 VPFYLVGLFKYISNVFEVHFSATiYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIF 406
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGT-AFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
25-399 |
2.34e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.78 E-value: 2.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 25 FTYFFIMatcyPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYApffIYIFA 104
Cdd:cd17329 13 LGFFMVW----PFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA---LLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 105 PMLKTNIWMGAIVgGIYMGFVFSggagASEAYVERVSRQSNFEYGRA--RMFGMMGWGICASIAGILYSKDPDSVFWLGS 182
Cdd:cd17329 86 HSPWLFAIALVLT-GFGGGLFEP----ASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 183 AGAVVLLVLVALAKPEqnsTASVMAQLGANTNPVSLKQAFklfklpRFWALLAYVVGVACTYDIFDQQFGNFFNTFFNSK 262
Cdd:cd17329 161 VLFLLAALVLLFLLPE---TRPKRRAAEKTEILRGYKIVL------RDRAFLLFLLASFLISLIYFQLESTLPVYVVEIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 263 EEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWH----VVVLKMLHMFEVPfyl 338
Cdd:cd17329 232 GLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVlilaMIVLTLGEMLVFP--- 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517481490 339 vglfkyISNVFEVHFSAT----IYMVACQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALG 399
Cdd:cd17329 309 ------AVQTLVAALAPPdkrgSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLI 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-170 |
5.74e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 14 NRNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLW-----AV 88
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIglllsAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 89 AIALLFYAPFFIYIFApmlktniwmGAIVGGIYMGFVFSggagASEAYVERVSRQSNFE--YGRARMFGMMGWGICASIA 166
Cdd:cd17325 278 ALLLLPLATSFWLLLL---------LLALLGLGLGLVFP----ATLALLADIVPPEGRGtaMGLFNTAFSLGMVLGPLLG 344
|
....
gi 517481490 167 GILY 170
Cdd:cd17325 345 GFLY 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-309 |
1.10e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 19 VFSGYFFTYFFIMATcYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFyapf 98
Cdd:pfam07690 1 LFLAAFLAALGRSLL-GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 99 fiyIFAPMLKTNIWM---GAIVGGIYMGFVFSGGAGASEAYVERVSRqsNFEYGRARMFGMMGWGICASIAGILYSK-DP 174
Cdd:pfam07690 76 ---LLLLLFASSLWLllvLRVLQGLGAGALFPAALALIADWFPPEER--GRALGLVSAGFGLGAALGPLLGGLLASLfGW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 175 DSVFWLGSAGAVVLLVLVALAKPEQNSTASVMAQLGANTNPVSLKQafkLFKLPRFWALLAYVVGVACTYdifdqQFGNF 254
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA---LLRDPVLWLLLALLLFGFAFF-----GLLTY 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 517481490 255 FNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTI 309
Cdd:pfam07690 223 LPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
17-169 |
2.14e-07 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 52.63 E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 17 YFVFSGYFFTYFFIMATCYPFLGIWLGDInGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKhmlWAVAIALLFYA 96
Cdd:pfam12832 1 LWRLKGFYFFYFAALGCLLPYWGLYLRSI-GLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRK---AVVRLASILAA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517481490 97 PFFIYIFAPMLKTNIWMGAIVGGIYMGFVFSGGAGASEAYVERVSRQSNfEYGRARMFGMMGWGICASIAGIL 169
Cdd:pfam12832 77 VLFLSVLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRK-DYGRQRLWGSVGFALSVFGLGAL 148
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-406 |
6.13e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 19 VFSGYFFTYFFIMATcYPFLGIWLGDInGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAvaiALLFYAPF 98
Cdd:cd17325 1 LSLALFLDMLGYGII-IPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG---LLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 99 FIYIFApmlkTNIWM---GAIVGGIYMGFVFSggagASEAYVERVSRQSNF--EYGRARMFGMMGWGICASIAGILYSK- 172
Cdd:cd17325 76 LLFAFA----TSYWQlllARFLQGLASAAVWP----AAMALIADIAPPEERgrAMGIFSSAIGLGFLIGPLLGGLLADAl 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 173 DPDSVFWLGSAGAVVLLVLVALAKPEQNSTASvmaqLGANTNPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFDQQFG 252
Cdd:cd17325 148 GYRAPFLVCAALALLALVLALLLLPEPRPPPN----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 253 NFFNTFFNSKEEGIevfGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMF 332
Cdd:cd17325 224 LYAAELGGLSPAQI---GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517481490 333 EVPFYLVGLFKYISNVFEVHFSATIYMVAcQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIF 406
Cdd:cd17325 301 GLGLVFPATLALLADIVPPEGRGTAMGLF-NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-127 |
2.62e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 11 YWGNRNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAI 90
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110
....*....|....*....|....*....|....*..
gi 517481490 91 ALLFYAPFFIYIFAPMLktniWMGAIVGGIYMGFVFS 127
Cdd:COG2814 283 LALGLLLLALAGSLWLL----LLALFLLGFGFGLLFP 315
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
47-357 |
2.94e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 47 GLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYapfFIYIFAPmlktNIWMgAIVGGIYMGFVF 126
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS---LLCALAP----SLWL-LLAARFLQGLGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 127 SGGAGASEAYVERVSRQSNfeygRARMFGMM------GWGICASIAGILYSK-DPDSVFWLGSAGAVVLLVLVALAKPEQ 199
Cdd:COG2814 113 GALFPAALALIADLVPPER----RGRALGLLgaglglGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLPES 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 200 NSTASvmaqlgantnPVSLKQAFKLFKLPRFWALLAYVVGVACTYDIFdqqFGNFFNTFFNSKEEGIEVFGYVTTMGEFL 279
Cdd:COG2814 189 RPAAR----------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVLGLSASAAGLLLALFGLG 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517481490 280 NAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMFEVPFYLVGLFKYISNVFEVHFSATI 357
Cdd:COG2814 256 GVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-426 |
1.14e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 15 RNYFVFSGYFFTYFFIMATCYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVK--KHMLWAVAIAL 92
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 93 LFyAPFFIYIFAPMLKTNIWMGAIVGGIYMGFvFSGGAGASEAYVERVSRQSNFEYGRAR------MFGMMGWGICASIA 166
Cdd:COG2211 90 PL-ALSFVLLFTAPDLSPTGKLIYALVTYLLL-GLAYTLVNIPYSALGAELTPDYEERTRlsswrfAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 167 GILYSKDPDS-------VFWLGSAGAVVLLVLVALAKPEQNSTAsvmaqlganTNPVSLKQAFK-LFKLPRFWALLAYVV 238
Cdd:COG2211 168 PPLVAAFGGDaalgyrlTALIFAVLGLLAFLLTFFGTKERPVPE---------EEKVSLKESLKaLLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 239 GVACTYDIFDQqfgNFFNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYA- 317
Cdd:COG2211 239 LFFLALALVAA---LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLg 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 318 -TEAWHVVVLKMLHMFEVPFYLVGLFKYISNVFEVHFSAT------IYMVACQFIKQVGNMLASSAVGGWYDKFGYQDT- 389
Cdd:COG2211 316 pGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGa 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 517481490 390 -------------YFILGCV--ALGFTLLSIFTLTGKMNMQERYQLHKRNTR 426
Cdd:COG2211 396 aqspsaltgirllFFLLPAVllLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-406 |
2.80e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.93 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 18 FVFSGYFFTYFFIMAtcYPFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYAP 97
Cdd:COG2271 14 LLFLAYFLNYLDRSN--LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 98 FfiyifapMLKTNIWMgAIVGGIYMGFVFSGGAGASEAYVERVSRQSnfEYGRARMFGMMGWGICASIAGILyskdpdsv 177
Cdd:COG2271 92 F-------GFATSFWQ-LLLLRFLLGLGEAGFFPAALKLIAEWFPPK--ERGRALGIFNAGGPLGGALAPPL-------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 178 fwlgsagavvllvlvalakpeqnsTASVMAQLGantnpvsLKQAFKLFKLP-------RFWALLAYVVGVACTYDIFdqq 250
Cdd:COG2271 154 ------------------------LGWLLAAFG-------WRAAFLILGLPglllallRFWLLALAYFLVYFALYGF--- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 251 FGNFFNTFFNSKEEGIEVFGYVTTMGEFLNAAIMFFVPLVINRMGA--KNALLVAGFIMTIRIIGSSYATEAWHVVVLKM 328
Cdd:COG2271 200 LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLF 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517481490 329 LHMFEVPFYLVGLFKYISNVFEVHFSATIYMVAcQFIKQVGNMLASSAVGGWYDKFGYQDTYFILGCVALGFTLLSIF 406
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
18-137 |
4.15e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 18 FVFSGYFFTYFFIMatcypFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYAP 97
Cdd:cd17316 185 LWFFISFGYYGLTT-----FLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 517481490 98 FFIYifapmLKTNIWMGAIVGGIYMGFVFsGGAGASEAYV 137
Cdd:cd17316 260 LFYL-----LSGSPTLLLLLLFILSFFVG-GVWGALYAYL 293
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-135 |
1.17e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 24 FFTYFFIMATcypFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLWAVAIALLFYAPFFiyif 103
Cdd:cd17369 240 ENVLFYLFTT---FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF---- 312
|
90 100 110
....*....|....*....|....*....|..
gi 517481490 104 aPMLKTNIWMGAIVGGIYMGFVFSGGAGASEA 135
Cdd:cd17369 313 -WLLDTGSTWLIVLAAVVVLGVLHGMMYGPQA 343
|
|
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
23-171 |
3.10e-03 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 39.50 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 23 YFFTYFFIMATCYPFLGIWLGDInGLTGEERGIVFAAmsffalcfqpifGYVTDKLG-------VKKHMLWAVAIALLFY 95
Cdd:PRK11128 12 SYFGYFFAYGVFLPFWSVWLKGQ-GYTPETIGLLLGA------------GLVARFLGslliaprVKDPSQLIPALRLLAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517481490 96 APFFIYIFAPMLKTNIWMGAIVGGIYmGFVFSGGAGASEAYVERVSRQSNFEYGRARMFGMMGWGICASIAGILYS 171
Cdd:PRK11128 79 LTLLFAVAFWFGAHSFWLLFVAIGLF-NLFFSPLVPLTDALANTWQKQIGLDYGKVRLWGSIAFVIGSALTGKLVS 153
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
37-121 |
5.17e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.02 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 37 FLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLW------AVAIALLFYAPFfiyifapMLKTN 110
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWfggvgcAISTLLFYYVPQ-------LFGHN 302
|
90
....*....|.
gi 517481490 111 IWMGAIVGGIY 121
Cdd:cd17337 303 YWAALIAAILF 313
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-137 |
6.66e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 17 YFVFSGYFFTYFFIMAtcypFLGIWLGDINGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGvkKHMLWAVAIALLFYA 96
Cdd:COG2271 186 ALAYFLVYFALYGFLT----WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG--RRRKLVLAIGLLLAA 259
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517481490 97 PFfiyIFAPMLKTNIWMGAIVGGIyMGFVFSGGAGASEAYV 137
Cdd:COG2271 260 LA---LLLLALLPSPALAIALLFL-AGFGLGGAFGLLWALA 296
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
20-170 |
6.89e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 20 FSGYFFTYFFIMA--TCYPFLGIWLGDInGLTGEERGIVFAAMSFFALCFQPIFGYVTDKLGVKKHMLwaVAIALLFYAP 97
Cdd:cd17370 202 FWLYLLAVALFALgnFSFAFLILRAQEL-GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI--LGYLSLALAY 278
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517481490 98 FFIYIFAPMlkTNIWMGAIVGGIYMGFVfsggAGASEAYVERVSRQSnfeyGRARMFGM------MGWGICASIAGILY 170
Cdd:cd17370 279 LGFALGSSL--WLLLLGFILWGLYMGAQ----ESIERAAVADLVPAE----LRGTAYGLfntvvgIGWLLASLIAGYLW 347
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| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
283-408 |
7.44e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517481490 283 IMFFVPLVINRMGAKNALLVAGFIMTIRIIGSSYATEAWHVVVLKMLHMFevpfyLVGLFKYISNVF-------EVHFSA 355
Cdd:cd17471 251 IMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAI-----FIGITAGLGISYfqdlmpgQPGLAT 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 517481490 356 TIYMVAcqfiKQVGNMLASSAVGGWYDKFGYQDTYFilgcVALGFTLLSIFTL 408
Cdd:cd17471 326 TLYSNA----SRIGSLLGGLLAGVIAQYFGYRAVFL----VCAVLALLALVLL 370
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