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Conserved domains on  [gi|547930171|ref|WP_022332133|]
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MULTISPECIES: triose-phosphate isomerase [Alistipes]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-246 2.41e-149

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 416.38  E-value: 2.41e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIA 80
Cdd:COG0149    1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADL-ADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEIS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  81 ASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEY 160
Cdd:COG0149   80 AAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 161 KNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGA-AAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALK 239
Cdd:COG0149  160 ANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAeVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                 ....*..
gi 547930171 240 AEDFLGI 246
Cdd:COG0149  240 AEDFLAI 246
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-246 2.41e-149

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 416.38  E-value: 2.41e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIA 80
Cdd:COG0149    1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADL-ADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEIS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  81 ASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEY 160
Cdd:COG0149   80 AAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 161 KNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGA-AAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALK 239
Cdd:COG0149  160 ANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAeVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                 ....*..
gi 547930171 240 AEDFLGI 246
Cdd:COG0149  240 AEDFLAI 246
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-252 1.29e-143

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 401.81  E-value: 1.29e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   2 RKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIAA 81
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA-DGVEVAVAPPFTALASVKEALKGSNIKLGAQNVHPEDSGAFTGEISA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  82 SMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEYK 161
Cdd:PRK00042  80 EMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 162 NLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAE 241
Cdd:PRK00042 160 NLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGEVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239

                        250
                 ....*....|.
gi 547930171 242 DFLGIGKGFAK 252
Cdd:PRK00042 240 DFLAIVKAAAA 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-246 8.28e-128

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 361.85  E-value: 8.28e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   4 KIVAGNWKMNTLPAEGVELAKGIAAGRGEVCScVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIAASM 83
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDESG-VEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  84 IAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLteEEYKNL 163
Cdd:cd00311   80 LKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLAPV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 164 VIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDF 243
Cdd:cd00311  158 VIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAESF 237


                 ...
gi 547930171 244 LGI 246
Cdd:cd00311  238 LDI 240
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-246 1.67e-124

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 353.35  E-value: 1.67e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171    4 KIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALkGSDIALGAQDCATEAKGAYTGEIAASM 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADE-SGVEVVVAPPFTYLSAVAELL-GSNIKVGAQNVDPEESGAFTGEISAEM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   84 IAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEyKNL 163
Cdd:pfam00121  79 LKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-KNL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  164 VIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDF 243
Cdd:pfam00121 158 VIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEDF 237


                  ...
gi 547930171  244 LGI 246
Cdd:pfam00121 238 LDI 240
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-241 6.85e-40

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 136.86  E-value: 6.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171    5 IVAGNWKM--NTLPAEGVELAKgIAAGRGEVCSCvNFIVCPPFTHLSQVAEALKgsdIALGAQDCATEAKGAYTGEIAAS 82
Cdd:TIGR00419   1 LVIGNWKTynESRGMRALEVAK-IAEEVASEAGV-AVAVAPPFVDLPMIKREVE---IPVYAQHVDAVLSGAHTGEISAE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   83 MIAALGCKYVILGHSERRQyygeTSATLNKKMAQAYANGLTPIYCVgENLEEREAGKHFDvvkaqieevvynlteeeykN 162
Cdd:TIGR00419  76 MLKDIGAKGTLINHSERRM----KLADIEKKIARLKELGLTSVVCT-NNVLTTAAAAALE-------------------P 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547930171  163 LVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVlaakfGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAE 241
Cdd:TIGR00419 132 DVVAVEPPELIGTGIPVSPAQPEVVHGSVRAV-----KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-246 2.41e-149

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 416.38  E-value: 2.41e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIA 80
Cdd:COG0149    1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADL-ADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEIS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  81 ASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEY 160
Cdd:COG0149   80 AAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 161 KNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGA-AAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALK 239
Cdd:COG0149  160 ANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAeVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLD 239


                 ....*..
gi 547930171 240 AEDFLGI 246
Cdd:COG0149  240 AEDFLAI 246
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-252 1.29e-143

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 401.81  E-value: 1.29e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   2 RKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIAA 81
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA-DGVEVAVAPPFTALASVKEALKGSNIKLGAQNVHPEDSGAFTGEISA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  82 SMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEYK 161
Cdd:PRK00042  80 EMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 162 NLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAE 241
Cdd:PRK00042 160 NLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGEVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239

                        250
                 ....*....|.
gi 547930171 242 DFLGIGKGFAK 252
Cdd:PRK00042 240 DFLAIVKAAAA 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-246 8.28e-128

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 361.85  E-value: 8.28e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   4 KIVAGNWKMNTLPAEGVELAKGIAAGRGEVCScVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIAASM 83
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDESG-VEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  84 IAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLteEEYKNL 163
Cdd:cd00311   80 LKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLAPV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 164 VIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDF 243
Cdd:cd00311  158 VIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAESF 237


                 ...
gi 547930171 244 LGI 246
Cdd:cd00311  238 LDI 240
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-246 1.67e-124

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 353.35  E-value: 1.67e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171    4 KIVAGNWKMNTLPAEGVELAKGIAAGRGEVcSCVNFIVCPPFTHLSQVAEALkGSDIALGAQDCATEAKGAYTGEIAASM 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADE-SGVEVVVAPPFTYLSAVAELL-GSNIKVGAQNVDPEESGAFTGEISAEM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   84 IAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEyKNL 163
Cdd:pfam00121  79 LKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-KNL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  164 VIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDF 243
Cdd:pfam00121 158 VIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEDF 237


                  ...
gi 547930171  244 LGI 246
Cdd:pfam00121 238 LDI 240
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 1-250 9.31e-111

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 332.46  E-value: 9.31e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGVE----LAKGIAAGRGEVcscvnfIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYT 76
Cdd:PRK13962 396 PRKPIIAGNWKMNKTPAEAKEfvneLKKYVKDAQAEV------VVCPPFTALPSVKEAVDGSNIKLGAQNVFYEEKGAYT 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  77 GEIAASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLT 156
Cdd:PRK13962 470 GEISGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNGLS 549

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 157 EEEYKNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFG-AAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGG 235
Cdd:PRK13962 550 AEQVKKVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGeEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGG 629

                        250
                 ....*....|....*
gi 547930171 236 AALKAEDFLGIGKGF 250
Cdd:PRK13962 630 ASLKAQEFAAIANYF 644
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-252 5.78e-98

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 286.43  E-value: 5.78e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVCScVNFIVCPPFTHLSQVAEALKGSDIALGAQDCATEAKGAYTGEIA 80
Cdd:PTZ00333   3 KRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPNN-VDVVVAPPSLHIPLVQEKLKNKNFKISSQNVSLTGSGAFTGEIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  81 ASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTEEEY 160
Cdd:PTZ00333  82 AEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDEAW 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 161 KNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAA-AQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALK 239
Cdd:PTZ00333 162 DNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADvAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASLK 241

                        250
                 ....*....|...
gi 547930171 240 aEDFLGIGKGFAK 252
Cdd:PTZ00333 242 -PDFVDIIKSAEQ 253
PLN02561 PLN02561
triosephosphate isomerase
 2-248 1.68e-68

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 211.60  E-value: 1.68e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   2 RKKIVAGNWKMNTLPAEGVELAKGIAAGRGEVCSCVNFIVCPPFTHLSQVAEALKgSDIALGAQDCATEAKGAYTGEIAA 81
Cdd:PLN02561   3 RKFFVGGNWKCNGTVEEVKKIVTTLNEAEVPSEDVVEVVVSPPFVFLPLVKSLLR-PDFQVAAQNCWVKKGGAFTGEISA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  82 SMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVYNLTeeEYK 161
Cdd:PLN02561  82 EMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVS--DWA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 162 NLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKFGAA-AQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKA 240
Cdd:PLN02561 160 NVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEvAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASLKP 239


                 ....*...
gi 547930171 241 EdFLGIGK 248
Cdd:PLN02561 240 E-FIDIIK 246
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 5-246 9.92e-57

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 181.11  E-value: 9.92e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   5 IVAgNWKMNTLPAEGVELAKGIAAGRGEVCSCVNFIVCPPFTHLSQVAEalKGSDIALGAQDCATEAKGAYTGEIAASMI 84
Cdd:PRK14565   5 IVA-NWKMNGDFSLFSSFLKELSNKLANNEITLKLVICPPFTAMSSFVE--CNPNIKLGAQNCFYGSSGGYTGEISAKML 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  85 AALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVynlteEEYKNLV 164
Cdd:PRK14565  82 KECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCL-----PKHGEFI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 165 IAYEPVWAIGTGKTASAEQAQEIHAYIRQVLAAKfgaaaqdtAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDFL 244
Cdd:PRK14565 157 IAYEPVWAIGGSTIPSNDAIAEAFEIIRSYDSKS--------HIIYGGSVNQENIRDLKSINQLSGVLVGSASLDVDSFC 228


                 ..
gi 547930171 245 GI 246
Cdd:PRK14565 229 KI 230
PLN02429 PLN02429
triosephosphate isomerase
 37-246 9.32e-56

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 181.14  E-value: 9.32e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  37 VNFIVCPPFTHLSQVAEALKgSDIALGAQDCATEAKGAYTGEIAASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQ 116
Cdd:PLN02429  97 VDVVVSPPFVYIDQVKSSLT-DRIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAY 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 117 AYANGLTPIYCVGENLEEREAGKHFDVVKAQIEevVYNLTEEEYKNLVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVLA 196
Cdd:PLN02429 176 ALSEGLGVIACIGEKLEEREAGKTFDVCFAQLK--AFADAVPSWDNIVVAYEPVWAIGTGKVASPQQAQEVHVAVRGWLK 253

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 547930171 197 AKFG-AAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAEDFLGI 246
Cdd:PLN02429 254 KNVSeEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATI 304
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 1-249 5.68e-51

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 167.09  E-value: 5.68e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKMNTLPAEGV-------ELAKGIAAGRGevcscVNFIVCPPFTHLSQVAEALKGSD----IALGAQDCAT 69
Cdd:PRK15492   1 MKKIYFGTNLKMYKGIADATdflaklsELADDIPADKD-----IELFVIPSFTAIQDAIAATLAIPhdhpIIIGAQNMNP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  70 EAKGAYTGEIAASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIE 149
Cdd:PRK15492  76 NDNGQFTGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 150 EVVYNLTEEEYKNLVIAYEPVWAIGT-GKTASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDV 228
Cdd:PRK15492 156 IGLHGINPDQLAKLRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIELFGDAGDDIPVFYGGSVNAENANELFGQPHI 235

                        250       260
                 ....*....|....*....|.
gi 547930171 229 DGGLIGGAALKAEDFLGIGKG 249
Cdd:PRK15492 236 DGLFIGRSAWDADKFFAIIEG 256
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 1-243 3.98e-46

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 157.50  E-value: 3.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAG-NWKMNTLPAEGVELAKGIAAGRGEVCS--CVNFIVCPPFTHLSQVAEALKG----SDIALGAQDCATEAKG 73
Cdd:PRK14905   1 MAKKIYFGtNLKMYKGNAETVDYLSELLAFAEKFKSdyDIELFVIPSYIALKDAVEAAASetghPKIKIGAQNMNAKDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171  74 AYTGEIAASMIAALGCKYVILGHSERRQYYGETSATLNKKMAQAYANGLTPIYCVGENLEEREAGKHFDVVKAQIEEVVY 153
Cdd:PRK14905  81 QFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171 154 NLTEEEYKNLVIAYEPVWAIGTGKT-ASAEQAQEIHAYIRQVLAAKFGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGL 232
Cdd:PRK14905 161 GVSAEQLPHLFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAEESKKIPVLYGGSVNLENANELIMKPHIDGLF 240

                        250
                 ....*....|.
gi 547930171 233 IGGAALKAEDF 243
Cdd:PRK14905 241 IGRSAWDAQCF 251
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-241 6.85e-40

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 136.86  E-value: 6.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171    5 IVAGNWKM--NTLPAEGVELAKgIAAGRGEVCSCvNFIVCPPFTHLSQVAEALKgsdIALGAQDCATEAKGAYTGEIAAS 82
Cdd:TIGR00419   1 LVIGNWKTynESRGMRALEVAK-IAEEVASEAGV-AVAVAPPFVDLPMIKREVE---IPVYAQHVDAVLSGAHTGEISAE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   83 MIAALGCKYVILGHSERRQyygeTSATLNKKMAQAYANGLTPIYCVgENLEEREAGKHFDvvkaqieevvynlteeeykN 162
Cdd:TIGR00419  76 MLKDIGAKGTLINHSERRM----KLADIEKKIARLKELGLTSVVCT-NNVLTTAAAAALE-------------------P 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547930171  163 LVIAYEPVWAIGTGKTASAEQAQEIHAYIRQVlaakfGAAAQDTAILYGGSCKPSNAPELFAKEDVDGGLIGGAALKAE 241
Cdd:TIGR00419 132 DVVAVEPPELIGTGIPVSPAQPEVVHGSVRAV-----KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 1-128 1.15e-10

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 59.50  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547930171   1 MRKKIVAGNWKM--NTLPAEGVELAKGIAAGRGEvcSCVNFIVCPPFTHLSQVAEALkgsDIALGAQDCATEAKGAYTGE 78
Cdd:PRK04302   1 MKYPIILVNFKTypEATGKDALEIAKAAEKVSKE--TGVRIAVAPQALDIRRVAEEV---DIPVYAQHVDPVEPGSHTGH 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 547930171  79 IAASMIAALGCKYVILGHSERRQYYGETSATLNKkmaqAYANGLTPIYCV 128
Cdd:PRK04302  76 ILPEAVKDAGAVGTLINHSERRLTLADIEAVVER----AKKLGLESVVCV 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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