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Conserved domains on  [gi|551338846|ref|WP_022958266|]
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VWA domain-containing protein [Spongiibacter tropicus]

Protein Classification

vWFA and TPR domain-containing protein( domain architecture ID 10208665)

vWFA and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 15-281 6.71e-20

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


:

Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 6.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  15 WLRPELVWIALPMLLALLWLARRQRPQRGWQQHIDAELLPYLLDDSEQRPRRLWPAALAALICWLALMGPSWEKVPSPVL 94
Cdd:COG1240   10 LLLLALALLLLALLLPLLPLLLLPLPLDLLLALPLAGLALLLGLAGLGLLALLLAALLLLLAVLLLLLALALAPLALARP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  95 EDRSGLVIVLDLSPSMLAQDvqpsRLERAKYTIRDLLR-LRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGmm 173
Cdd:COG1240   90 QRGRDVVLVVDASGSMAAEN----RLEAAKGALLDFLDdYRPRDRVGLVAFGGEAEVLLPLTRDREALKRALDELPPG-- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 174 plPGSNPLAGLTLAAELLARGGSA-NGHILLIGDG---FSASQLTGLKGFARNSQYPLSILAVGSErgapiplpeggfvk 249
Cdd:COG1240  164 --GGTPLGDALALALELLKRADPArRKVIVLLTDGrdnAGRIDPLEAAELAAAAGIRIYTIGVGTE-------------- 227

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551338846 250 dsqgktvlaSVPTGLMKSLSRDSGGQYAQLDS 281
Cdd:COG1240  228 ---------AVDEGLLREIAEATGGRYFRADD 250
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 408-441 8.09e-09

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


:

Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 51.29  E-value: 8.09e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 551338846   408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPNM 441
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
371-449 7.88e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 7.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 371 DPGSAATQFvdpmWRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAK 445
Cdd:COG0457   38 DPDDAEALY----NLGLAYLRLGRYEEALADyeqalELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113


                 ....
gi 551338846 446 ANKA 449
Cdd:COG0457  114 YNLG 117
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-613 2.66e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 709 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDsDSDSDSDSDSDSD 787

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQEQWLRNIPDS 613
Cdd:NF033609 788 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 856
 
Name Accession Description Interval E-value
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 15-281 6.71e-20

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 6.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  15 WLRPELVWIALPMLLALLWLARRQRPQRGWQQHIDAELLPYLLDDSEQRPRRLWPAALAALICWLALMGPSWEKVPSPVL 94
Cdd:COG1240   10 LLLLALALLLLALLLPLLPLLLLPLPLDLLLALPLAGLALLLGLAGLGLLALLLAALLLLLAVLLLLLALALAPLALARP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  95 EDRSGLVIVLDLSPSMLAQDvqpsRLERAKYTIRDLLR-LRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGmm 173
Cdd:COG1240   90 QRGRDVVLVVDASGSMAAEN----RLEAAKGALLDFLDdYRPRDRVGLVAFGGEAEVLLPLTRDREALKRALDELPPG-- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 174 plPGSNPLAGLTLAAELLARGGSA-NGHILLIGDG---FSASQLTGLKGFARNSQYPLSILAVGSErgapiplpeggfvk 249
Cdd:COG1240  164 --GGTPLGDALALALELLKRADPArRKVIVLLTDGrdnAGRIDPLEAAELAAAAGIRIYTIGVGTE-------------- 227

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551338846 250 dsqgktvlaSVPTGLMKSLSRDSGGQYAQLDS 281
Cdd:COG1240  228 ---------AVDEGLLREIAEATGGRYFRADD 250
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 100-278 1.67e-13

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 69.28  E-value: 1.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 100 LVIVLDLSPSMLAQD-VQPSRLERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGMMPlPGS 178
Cdd:cd01467    5 IMIALDVSGSMLAQDfVKPSRLEAAKEVLSDFIDRRENDRIGLVVFAGAAFTQAPLTLDRESLKELLEDIKIGLAG-QGT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 179 NPLAGLTLAAELLARGGSANGHILLIGDGFS-ASQLTGLKGFARNSQYPLSILAVGSERGAPIPLPEGGFVKDSQGktvl 257
Cdd:cd01467   84 AIGDAIGLAIKRLKNSEAKERVIVLLTDGENnAGEIDPATAAELAKNKGVRIYTIGVGKSGSGPKPDGSTILDEDS---- 159

                        170       180
                 ....*....|....*....|.
gi 551338846 258 asvptglMKSLSRDSGGQYAQ 278
Cdd:cd01467  160 -------LVEIADKTGGRIFR 173
VWA_2 pfam13519
von Willebrand factor type A domain;
100-204 8.63e-13

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 64.62  E-value: 8.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  100 LVIVLDLSPSMLAQDVQPSRLERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGmmpLPGSN 179
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAKDAVLALLKSLPGDRVGLVTFGDGPEVLIPLTKDRAKILRALRRLEPK---GGGTN 77

                          90       100
                  ....*....|....*....|....*
gi 551338846  180 PLAGLTLAAELLARGGSANGHILLI 204
Cdd:pfam13519  78 LAAALQLARAALKHRRKNQPRRIVL 102
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 408-441 8.09e-09

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 51.29  E-value: 8.09e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 551338846   408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPNM 441
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
408-440 9.45e-09

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 51.27  E-value: 9.45e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 551338846  408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPN 440
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
PRK13685 PRK13685
hypothetical protein; Provisional
 41-293 7.40e-08

hypothetical protein; Provisional


Pssm-ID: 184242 [Multi-domain]  Cd Length: 326  Bit Score: 54.71  E-value: 7.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  41 QRGWQQHI----DAELLPYLLDDSEQRPRRLwPAALAALICWL---ALMGPSWE-KVPspvlEDRSGLVIVLDLSPSMLA 112
Cdd:PRK13685  29 QRARRRRMlrfaNMELLESVAPKRPSRWRHV-PAALLVLSLVLltvAMAGPTHDvRIP----RNRAVVMLVIDVSQSMRA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 113 QDVQPSRLERAKYTIRDLlrlrADGQT-----ALVASAGDAFVVAPLTDDGNTLSTLLPALHPGMMPLPGSNPLAGLTLA 187
Cdd:PRK13685 104 TDVEPNRLAAAQEAAKQF----ADELTpginlGLIAFAGTATVLVSPTTNREATKNAIDKLQLADRTATGEAIFTALQAI 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 188 AELLARGGSANG----HILLIGDG--------------FSASQLtglkgfARNSQYPLSILAVGSergapiplpEGGFVk 249
Cdd:PRK13685 180 ATVGAVIGGGDTpppaRIVLMSDGketvptnpdnprgaYTAART------AKDQGVPISTISFGT---------PYGSV- 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551338846 250 DSQGKTVLASVPTGLMKSLSRDSGGQ-------------YAQLDSQLSEQTLSTLAS 293
Cdd:PRK13685 244 EINGQRQPVPVDDESLKKIAQLSGGEfytaasleelravYATLQQQIGYETIKGDAS 300
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
384-449 1.80e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 1.80e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551338846 384 WRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG0457   13 NLGLAYRRLGRYEEAIEDyekalELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLG 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
371-449 7.88e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 7.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 371 DPGSAATQFvdpmWRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAK 445
Cdd:COG0457   38 DPDDAEALY----NLGLAYLRLGRYEEALADyeqalELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113


                 ....
gi 551338846 446 ANKA 449
Cdd:COG0457  114 YNLG 117
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-613 2.66e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 709 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDsDSDSDSDSDSDSD 787

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQEQWLRNIPDS 613
Cdd:NF033609 788 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 856
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-604 3.03e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKpQDGDKSPDDSDASQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 589 DSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSA-SDSDSASDSDSDSDSDSDSDSDsDSDSDSDSDSDSD 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 668 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 369-600 4.05e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.29  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 369 DSDPGSAATQFVDPMWRGSalyragDYAAAAQAFAQRDSADAHYNRGNALArAGKLDEAIDAYQQALDWNPNMADAKANk 448
Cdd:NF033609 562 DSDPGSDSGSDSSNSDSGS------DSGSDSTSDSGSDSASDSDSASDSDS-ASDSDSASDSDSASDSDSASDSDSASD- 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 449 alLEQLKQQQEQQGDQQNSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA-SQSQND 527
Cdd:NF033609 634 --SDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSD 711

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551338846 528 SNAD---ERDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 712 SDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 787
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-600 4.30e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.91  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQD-GKPQDGDKSPDDSDASQSQNDSNAD-ERDSTEPSDDAQ 543
Cdd:NF033609 703 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDS 782

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551338846 544 SEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 783 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 839
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-591 5.46e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.91  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 741 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDsDSDSDSDSDSDSD 819

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGS 591
Cdd:NF033609 820 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-600 6.00e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 6.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA---SQSQNDSNAD-ERDSTEPSDD 541
Cdd:NF033609 719 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDsDSDSDSDSDS 798

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 542 AQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 799 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSE 857
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 100-286 6.31e-06

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 47.06  E-value: 6.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846   100 LVIVLDLSPSMLAQDVQPSRlERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTD--DGNTLSTLLPALHPGMMplPG 177
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAK-EFVLKLVEQLDIGPDGDRVGLVTFSDDARVLFPLNDsrSKDALLEALASLSYKLG--GG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846   178 SNPLAGLTLAAELL--ARGGSANGH---ILLIGDGFSASQLTGLKGFARN-SQYPLSILAVGsergapiplpeggfvkds 251
Cdd:smart00327  79 TNLGAALQYALENLfsKSAGSRRGApkvVILITDGESNDGPKDLLKAAKElKRSGVKVFVVG------------------ 140

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 551338846   252 qgktVLASVPTGLMKSLSRDSGGQYAQLDSQLSEQ 286
Cdd:smart00327 141 ----VGNDVDEEELKKLASAPGGVYVFLPELLDLL 171
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 442-600 1.09e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 442 ADAKANKALLEQLKQQQEQQGDQQNSGGSDA-QDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSD 520
Cdd:NF033609 738 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 817

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 521 A-SQSQNDSNADErDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAA----AGSSQEP 595
Cdd:NF033609 818 SdSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASnkneAKDSKEP 896


                 ....*....
gi 551338846 596 L----SEEE 600
Cdd:NF033609 897 LpdtgSEDE 905
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-604 1.45e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.37  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDgkpQDGDKSPDDSDASQSQNDSNADErDSTEPSDDAQSE 545
Cdd:NF033609 673 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDS 748

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 546 AQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 442-604 2.72e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 442 ADAKANKALLEQLKQQQEQQGDQQNSGGSDAQDSQDSqDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA 521
Cdd:NF033609 670 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 748

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 522 SQSQNDSNADERDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQ 601
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 828


                 ...
gi 551338846 602 AQE 604
Cdd:NF033609 829 DSD 831
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-614 3.77e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.83  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA-SQSQNDSNAD-ERDSTEPSDDAQ 543
Cdd:NF033609 677 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDsDSDSDSDSDSDS 756

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551338846 544 SEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQEQWLRNIPDSA 614
Cdd:NF033609 757 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 470-604 5.26e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 470 SDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNADErDSTEPSDDAQSEAQQQ 549
Cdd:NF033609 561 SDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSD-SASDSDSASDS-DSASDSDSASDSDSAS 638

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 551338846 550 AQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 639 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 469-604 5.82e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 469 GSDAQDSQDSQDSESKQNSD--SQEGADDQQGSPGDQQQDG-KPQDGDKSPDDSDASQSQNDSNAD---ERDSTEPSDDA 542
Cdd:NF033609 570 GSDSSNSDSGSDSGSDSTSDsgSDSASDSDSASDSDSASDSdSASDSDSASDSDSASDSDSASDSDsasDSDSDSDSDSD 649

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551338846 543 QSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 650 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 711
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 468-537 1.21e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 42.09  E-value: 1.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 468 GGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQdgkPQDGDKSPDDSDASQSQNDSNADERDSTE 537
Cdd:COG4547  211 LGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAE---AEDAEASGDDAEEGESEAAEAESDEMAEE 277
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 406-449 7.66e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:PRK02603  70 DRSYILYNMGIIYASNGEHDKALEYYHQALELNPKQPSALNNIA 113
 
Name Accession Description Interval E-value
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 15-281 6.71e-20

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 6.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  15 WLRPELVWIALPMLLALLWLARRQRPQRGWQQHIDAELLPYLLDDSEQRPRRLWPAALAALICWLALMGPSWEKVPSPVL 94
Cdd:COG1240   10 LLLLALALLLLALLLPLLPLLLLPLPLDLLLALPLAGLALLLGLAGLGLLALLLAALLLLLAVLLLLLALALAPLALARP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  95 EDRSGLVIVLDLSPSMLAQDvqpsRLERAKYTIRDLLR-LRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGmm 173
Cdd:COG1240   90 QRGRDVVLVVDASGSMAAEN----RLEAAKGALLDFLDdYRPRDRVGLVAFGGEAEVLLPLTRDREALKRALDELPPG-- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 174 plPGSNPLAGLTLAAELLARGGSA-NGHILLIGDG---FSASQLTGLKGFARNSQYPLSILAVGSErgapiplpeggfvk 249
Cdd:COG1240  164 --GGTPLGDALALALELLKRADPArRKVIVLLTDGrdnAGRIDPLEAAELAAAAGIRIYTIGVGTE-------------- 227

                        250       260       270
                 ....*....|....*....|....*....|..
gi 551338846 250 dsqgktvlaSVPTGLMKSLSRDSGGQYAQLDS 281
Cdd:COG1240  228 ---------AVDEGLLREIAEATGGRYFRADD 250
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 100-278 1.67e-13

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 69.28  E-value: 1.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 100 LVIVLDLSPSMLAQD-VQPSRLERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGMMPlPGS 178
Cdd:cd01467    5 IMIALDVSGSMLAQDfVKPSRLEAAKEVLSDFIDRRENDRIGLVVFAGAAFTQAPLTLDRESLKELLEDIKIGLAG-QGT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 179 NPLAGLTLAAELLARGGSANGHILLIGDGFS-ASQLTGLKGFARNSQYPLSILAVGSERGAPIPLPEGGFVKDSQGktvl 257
Cdd:cd01467   84 AIGDAIGLAIKRLKNSEAKERVIVLLTDGENnAGEIDPATAAELAKNKGVRIYTIGVGKSGSGPKPDGSTILDEDS---- 159

                        170       180
                 ....*....|....*....|.
gi 551338846 258 asvptglMKSLSRDSGGQYAQ 278
Cdd:cd01467  160 -------LVEIADKTGGRIFR 173
VWA_2 pfam13519
von Willebrand factor type A domain;
100-204 8.63e-13

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 64.62  E-value: 8.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  100 LVIVLDLSPSMLAQDVQPSRLERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTDDGNTLSTLLPALHPGmmpLPGSN 179
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAKDAVLALLKSLPGDRVGLVTFGDGPEVLIPLTKDRAKILRALRRLEPK---GGGTN 77

                          90       100
                  ....*....|....*....|....*
gi 551338846  180 PLAGLTLAAELLARGGSANGHILLI 204
Cdd:pfam13519  78 LAAALQLARAALKHRRKNQPRRIVL 102
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 100-235 6.42e-12

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 64.12  E-value: 6.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 100 LVIVLDLSPSMlaqdvQPSRLERAKYTIRDLLR----LRADGQTALVASAGDAFVVAPLTDDGN--TLSTLLPALHPGMM 173
Cdd:cd00198    3 IVFLLDVSGSM-----GGEKLDKAKEALKALVSslsaSPPGDRVGLVTFGSNARVVLPLTTDTDkaDLLEAIDALKKGLG 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551338846 174 plPGSNPLAGLTLAAELLARGGSANG--HILLIGDGFSASQLTGLKGFA---RNSQYPLSILAVGSE 235
Cdd:cd00198   78 --GGTNIGAALRLALELLKSAKRPNArrVIILLTDGEPNDGPELLAEAArelRKLGITVYTIGIGDD 142
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 50-281 1.57e-10

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 62.43  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  50 AELLPYLLDDSEQRPRRLWPAALAA--LICWLALMGPSWEKVPSPVLEdrsgLVIVLDLSPSMlaqdvQPSRLERAKYTI 127
Cdd:COG2304   46 EELVNFFPYDYPLPTGRLAQSPWNPqtRLLLVGLQPPKAAAEERPPLN----LVFVIDVSGSM-----SGDKLELAKEAA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 128 RDLL-RLRADGQTALVASAGDAFVVAPLT--DDGNTLSTLLPALHPGmmplpGSNPL-AGLTLAAELLARGGSANG--HI 201
Cdd:COG2304  117 KLLVdQLRPGDRVSIVTFAGDARVLLPPTpaTDRAKILAAIDRLQAG-----GGTALgAGLELAYELARKHFIPGRvnRV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 202 LLIGDG------FSASQLTGLKGFARNSQYPLSILAVGSErgapiplpeggfVKDSqgktvlasvptgLMKSLSRDSGGQ 275
Cdd:COG2304  192 ILLTDGdanvgiTDPEELLKLAEEAREEGITLTTLGVGSD------------YNED------------LLERLADAGGGN 247


                 ....*.
gi 551338846 276 YAQLDS 281
Cdd:COG2304  248 YYYIDD 253
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 408-441 8.09e-09

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 51.29  E-value: 8.09e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 551338846   408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPNM 441
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
408-440 9.45e-09

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 51.27  E-value: 9.45e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 551338846  408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPN 440
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 408-440 5.08e-08

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 49.06  E-value: 5.08e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 551338846  408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPN 440
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PRK13685 PRK13685
hypothetical protein; Provisional
 41-293 7.40e-08

hypothetical protein; Provisional


Pssm-ID: 184242 [Multi-domain]  Cd Length: 326  Bit Score: 54.71  E-value: 7.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  41 QRGWQQHI----DAELLPYLLDDSEQRPRRLwPAALAALICWL---ALMGPSWE-KVPspvlEDRSGLVIVLDLSPSMLA 112
Cdd:PRK13685  29 QRARRRRMlrfaNMELLESVAPKRPSRWRHV-PAALLVLSLVLltvAMAGPTHDvRIP----RNRAVVMLVIDVSQSMRA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 113 QDVQPSRLERAKYTIRDLlrlrADGQT-----ALVASAGDAFVVAPLTDDGNTLSTLLPALHPGMMPLPGSNPLAGLTLA 187
Cdd:PRK13685 104 TDVEPNRLAAAQEAAKQF----ADELTpginlGLIAFAGTATVLVSPTTNREATKNAIDKLQLADRTATGEAIFTALQAI 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 188 AELLARGGSANG----HILLIGDG--------------FSASQLtglkgfARNSQYPLSILAVGSergapiplpEGGFVk 249
Cdd:PRK13685 180 ATVGAVIGGGDTpppaRIVLMSDGketvptnpdnprgaYTAART------AKDQGVPISTISFGT---------PYGSV- 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551338846 250 DSQGKTVLASVPTGLMKSLSRDSGGQ-------------YAQLDSQLSEQTLSTLAS 293
Cdd:PRK13685 244 EINGQRQPVPVDDESLKKIAQLSGGEfytaasleelravYATLQQQIGYETIKGDAS 300
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
384-449 1.80e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 1.80e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551338846 384 WRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG0457   13 NLGLAYRRLGRYEEAIEDyekalELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLG 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
371-449 7.88e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 7.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 371 DPGSAATQFvdpmWRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAK 445
Cdd:COG0457   38 DPDDAEALY----NLGLAYLRLGRYEEALADyeqalELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113


                 ....
gi 551338846 446 ANKA 449
Cdd:COG0457  114 YNLG 117
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
357-449 2.45e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.14  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 357 LKTPDQRGAALFDSDPGSAATQFVDPMW-----RGSALYRAGDYAAAAQAFAQR-----DSADAHYNRGNALARAGKLDE 426
Cdd:COG4785   46 LALAAAALAAAALAAERIDRALALPDLAqlyyeRGVAYDSLGDYDLAIADFDQAleldpDLAEAYNNRGLAYLLLGDYDA 125

                         90       100
                 ....*....|....*....|...
gi 551338846 427 AIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4785  126 ALEDFDRALELDPDYAYAYLNRG 148
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-613 2.66e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 709 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDsDSDSDSDSDSDSD 787

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQEQWLRNIPDS 613
Cdd:NF033609 788 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 856
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-604 3.03e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.68  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKpQDGDKSPDDSDASQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 589 DSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSA-SDSDSASDSDSDSDSDSDSDSDsDSDSDSDSDSDSD 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 668 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
371-449 3.11e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 371 DPGSAATQFvdpmWRGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAK 445
Cdd:COG0457   72 DPDDAEALN----NLGLALQALGRYEEALEDydkalELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADAL 147


                 ....
gi 551338846 446 ANKA 449
Cdd:COG0457  148 YNLG 151
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 406-449 3.69e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 3.69e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG3914  110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLG 153
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 369-600 4.05e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 50.29  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 369 DSDPGSAATQFVDPMWRGSalyragDYAAAAQAFAQRDSADAHYNRGNALArAGKLDEAIDAYQQALDWNPNMADAKANk 448
Cdd:NF033609 562 DSDPGSDSGSDSSNSDSGS------DSGSDSTSDSGSDSASDSDSASDSDS-ASDSDSASDSDSASDSDSASDSDSASD- 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 449 alLEQLKQQQEQQGDQQNSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA-SQSQND 527
Cdd:NF033609 634 --SDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSD 711

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551338846 528 SNAD---ERDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 712 SDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 787
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-600 4.30e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.91  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQD-GKPQDGDKSPDDSDASQSQNDSNAD-ERDSTEPSDDAQ 543
Cdd:NF033609 703 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDS 782

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 551338846 544 SEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 783 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 839
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 406-449 4.86e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.61  E-value: 4.86e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG3914  144 DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLG 187
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-591 5.46e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.91  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNAD-ERDSTEPSDDAQS 544
Cdd:NF033609 741 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDsDSDSDSDSDSDSD 819

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 551338846 545 EAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGS 591
Cdd:NF033609 820 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-600 6.00e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 6.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA---SQSQNDSNAD-ERDSTEPSDD 541
Cdd:NF033609 719 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDsDSDSDSDSDS 798

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 542 AQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEE 600
Cdd:NF033609 799 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSE 857
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 100-286 6.31e-06

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 47.06  E-value: 6.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846   100 LVIVLDLSPSMLAQDVQPSRlERAKYTIRDLLRLRADGQTALVASAGDAFVVAPLTD--DGNTLSTLLPALHPGMMplPG 177
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAK-EFVLKLVEQLDIGPDGDRVGLVTFSDDARVLFPLNDsrSKDALLEALASLSYKLG--GG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846   178 SNPLAGLTLAAELL--ARGGSANGH---ILLIGDGFSASQLTGLKGFARN-SQYPLSILAVGsergapiplpeggfvkds 251
Cdd:smart00327  79 TNLGAALQYALENLfsKSAGSRRGApkvVILITDGESNDGPKDLLKAAKElKRSGVKVFVVG------------------ 140

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 551338846   252 qgktVLASVPTGLMKSLSRDSGGQYAQLDSQLSEQ 286
Cdd:smart00327 141 ----VGNDVDEEELKKLASAPGGVYVFLPELLDLL 171
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 442-600 1.09e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 442 ADAKANKALLEQLKQQQEQQGDQQNSGGSDA-QDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSD 520
Cdd:NF033609 738 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 817

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 521 A-SQSQNDSNADErDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAA----AGSSQEP 595
Cdd:NF033609 818 SdSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASnkneAKDSKEP 896


                 ....*....
gi 551338846 596 L----SEEE 600
Cdd:NF033609 897 LpdtgSEDE 905
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
406-449 1.18e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.39  E-value: 1.18e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIdAYQQALDWNPNMADAKANKA 449
Cdd:COG3063   24 DNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLA 66
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-604 1.45e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.37  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDgkpQDGDKSPDDSDASQSQNDSNADErDSTEPSDDAQSE 545
Cdd:NF033609 673 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDS 748

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 546 AQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 406-447 1.56e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.07  E-value: 1.56e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKAN 447
Cdd:COG3914  178 DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 442-604 2.72e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 442 ADAKANKALLEQLKQQQEQQGDQQNSGGSDAQDSQDSqDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA 521
Cdd:NF033609 670 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 748

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 522 SQSQNDSNADERDSTEPSDDAQSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQ 601
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 828


                 ...
gi 551338846 602 AQE 604
Cdd:NF033609 829 DSD 831
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 406-449 3.14e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.57  E-value: 3.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG5010   86 NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 466-614 3.77e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.83  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 466 NSGGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDA-SQSQNDSNAD-ERDSTEPSDDAQ 543
Cdd:NF033609 677 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDsDSDSDSDSDSDS 756

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551338846 544 SEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQEQWLRNIPDSA 614
Cdd:NF033609 757 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827
TPR_8 pfam13181
Tetratricopeptide repeat;
408-440 4.52e-05

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 40.84  E-value: 4.52e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 551338846  408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPN 440
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 406-449 4.89e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 4.89e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4783   70 DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLA 113
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 470-604 5.26e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 470 SDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQDGKPQDGDKSPDDSDaSQSQNDSNADErDSTEPSDDAQSEAQQQ 549
Cdd:NF033609 561 SDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSD-SASDSDSASDS-DSASDSDSASDSDSAS 638

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 551338846 550 AQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 639 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 469-604 5.82e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 469 GSDAQDSQDSQDSESKQNSD--SQEGADDQQGSPGDQQQDG-KPQDGDKSPDDSDASQSQNDSNAD---ERDSTEPSDDA 542
Cdd:NF033609 570 GSDSSNSDSGSDSGSDSTSDsgSDSASDSDSASDSDSASDSdSASDSDSASDSDSASDSDSASDSDsasDSDSDSDSDSD 649

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551338846 543 QSEAQQQAQRDAAAEHARQQEAIDTESSVAEKTSEPSDEQLDSNAAAGSSQEPLSEEEQAQE 604
Cdd:NF033609 650 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 711
vWA_subgroup cd01465
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 100-237 5.83e-05

VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.


Pssm-ID: 238742 [Multi-domain]  Cd Length: 170  Bit Score: 44.19  E-value: 5.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 100 LVIVLDLSPSMLAQdvqpsRLERAKYTIRDLL-RLRADGQTALVASAGDAFVVAPLT--DDGNTLSTLLPALHPGmmplP 176
Cdd:cd01465    3 LVFVIDRSGSMDGP-----KLPLVKSALKLLVdQLRPDDRLAIVTYDGAAETVLPATpvRDKAAILAAIDRLTAG----G 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551338846 177 GSNPLAGLTLAAELLARG--GSANGHILLIGDGF------SASQLTGLKGFARNSQYPLSILAVGSERG 237
Cdd:cd01465   74 STAGGAGIQLGYQEAQKHfvPGGVNRILLATDGDfnvgetDPDELARLVAQKRESGITLSTLGFGDNYN 142
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 15-240 1.09e-04

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 44.29  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  15 WLRPELVWIALPMLLALLWLARRQRPQRGWQQHIDAELLPYLLDDSEQRPRRLWPAALAALIC--------WLALMGPSW 86
Cdd:COG2425   28 GLLRAALALGLALALRAALLALLLLLLRAALALLTLLAGLVLLALDALLLAALLAALLDALLLavlllallLLAALLLLA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846  87 EKVPSPVLEDRSGLVIVLDLSPSMlaqdvQPSRLERAKYTIRDLLRLRADG-QTALVASAGDAFVVAPLTDDGN---TLS 162
Cdd:COG2425  108 APASAAVPLLEGPVVLCVDTSGSM-----AGSKEAAAKAAALALLRALRPNrRFGVILFDTEVVEDLPLTADDGledAIE 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 163 TLLPALHPGmmplpGSNPLAGLTLAAELLARGGSANGHILLIGDGFSASQLTGL--KGFARNSQYPLSILAVGSERGAPI 240
Cdd:COG2425  183 FLSGLFAGG-----GTDIAPALRAALELLEEPDYRNADIVLITDGEAGVSPEELlrEVRAKESGVRLFTVAIGDAGNPGL 257
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 406-449 1.25e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.30  E-value: 1.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
TPR_11 pfam13414
TPR repeat;
415-444 3.39e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 38.61  E-value: 3.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 551338846  415 GNALARAGKLDEAIDAYQQALDWNPNMADA 444
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEA 30
TerY COG4245
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];
101-207 6.38e-04

Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];


Pssm-ID: 443387 [Multi-domain]  Cd Length: 196  Bit Score: 41.45  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 101 VIVLDLSPSMLAqdvqpSRLERAKYTIRDLLR-LRADGQT------ALVASAGDAFVVAPLTDdgntlstlLPALHPGMM 173
Cdd:COG4245    9 YLLLDTSGSMSG-----EPIEALNEGLQALIDeLRQDPYAletvevSVITFDGEAKVLLPLTD--------LEDFQPPDL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 551338846 174 PLPGSNPL-AGLTLAAELLAR---GGSANGH------ILLIGDG 207
Cdd:COG4245   76 SASGGTPLgAALELLLDLIERrvqKYTAEGKgdwrpvVFLITDG 119
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 468-537 1.21e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 42.09  E-value: 1.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 468 GGSDAQDSQDSQDSESKQNSDSQEGADDQQGSPGDQQQdgkPQDGDKSPDDSDASQSQNDSNADERDSTE 537
Cdd:COG4547  211 LGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAE---AEDAEASGDDAEEGESEAAEAESDEMAEE 277
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 385-441 2.47e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 2.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551338846 385 RGSALYRAGDYAA-----AAQAFAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNM 441
Cdd:COG4783   78 LGLALLKAGDYDEalallEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 406-449 3.32e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG2956  142 ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 384-449 4.29e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 4.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551338846 384 WRGSALYRAGDYAA--------AAQAFAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG1729   35 WLGEAYYALGDYDEaaeafeklLKRYPDSPKAPDALLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEARA 108
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
406-444 4.54e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 4.54e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADA 444
Cdd:COG4785  139 DYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPER 177
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 385-449 5.93e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 5.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551338846 385 RGSALYRAGDYAAAAQA-----FAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4783   10 LAQALLLAGDYDEAEALlekalELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG 79
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 385-442 6.62e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.77  E-value: 6.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551338846  385 RGSALYRAGDYAA--------AAQAFAQRDSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMA 442
Cdd:pfam13432   3 LARAALRAGDYDDaaaaleaaLARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 408-449 6.84e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 6.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 551338846 408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLG 45
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 406-449 7.00e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 7.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG2956   40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA 83
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 408-444 7.37e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 7.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 551338846 408 ADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADA 444
Cdd:COG1729   30 PDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKA 66
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 406-449 7.66e-03

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 37.73  E-value: 7.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:PRK02603  70 DRSYILYNMGIIYASNGEHDKALEYYHQALELNPKQPSALNNIA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 406-449 9.85e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 9.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 551338846 406 DSADAHYNRGNALARAGKLDEAIDAYQQALDWNPNMADAKANKA 449
Cdd:COG4235   49 DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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