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Conserved domains on  [gi|696567187|ref|WP_033098947|]
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MULTISPECIES: PD-(D/E)XK nuclease family protein [Lactiplantibacillus]

Protein Classification

PD-(D/E)XK nuclease family protein( domain architecture ID 11467507)

PD-(D/E)XK nuclease family protein similar to ATP-dependent helicase/deoxyribonuclease subunit B (AddB), part of a heterodimer that acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
4-1180 0e+00

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


:

Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 820.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    4 QFVLGPAKMDHRRTMVAQLVATLmaKPQDQFFYLVPNHIKFDTEVDVLNRLaqafgqpDLYAQTQVQVFSFTRLAWYLMK 83
Cdd:COG3857     1 RFILGRAGSGKTTYLLEEIKEEL--KEGKPIILLVPEQMTFQAERALLKRL-------GLGGSIRAQVLSFSRLAWRVLQ 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   84 NEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANaqagdLQAKLH 163
Cdd:COG3857    72 ETGGATRPLLSDAGKRMLLRKILEEHKDELKVFARAADKPGFIEQLAELITELKRYGITPEDLEEAAEL-----LKEKLR 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  164 DLAIVYKDFVAATADKYLKPADILVQLNAYLRRQD-LHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLMLDhkv 242
Cdd:COG3857   147 DLALIYEAYEEKLAGRYIDSEDLLRLLAEKLEKSEfLEGAEIYID--GFTDFTPQELELLEALLKKAKEVTITLTLD--- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  243 vdraPENGTLFYQSGRLYYRLYQYARIRQIPVSQdiyaetpRVAPGLVALDDFWRGQPQaatgyEEPNTNVHLFRTDSRQ 322
Cdd:COG3857   222 ----PDELDLFSATGETYERLLELAKENGVEVEF-------KKSPELAHLERNLFAYPP-----EEEPEGIEIIEAANRR 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  323 TELAQVGRMIRAMVAkkhadpADDYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELINALFDIDA 402
Cdd:COG3857   286 AEVEAVAREIRRLVR------EEGYRYRDIAVVVRDLEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVR 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  403 QQYQYRDVMRVLKTELLmpningqpmdRQAYRQAVDLTENFILKSGYHGQRWVQRedwqyfqlTEGDAGVETDQNAEISR 482
Cdd:COG3857   360 SNFRYEDVFRLLKTGLL----------RPLSREEIDRLENYVLAYGIRGRRWLER--------YLEEEEELTDEEEEDLE 421
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  483 QINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRdQALDRQDVRAAAEPEQTWQTFCGMLDEYV 562
Cdd:COG3857   422 RLNELRDRLLEPLLPLRERLKKAKTVREWAEALYEFLEELGVPEKLEEWR-EAEEAGDLEEAREHEQAWNALIELLDELV 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  563 TILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNLLSDVDKENL 642
Cdd:COG3857   501 EVLGDEKLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEERERL 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  643 QptlsslDGDHYLNDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFNLREHTylgtpdPT 722
Cdd:COG3857   581 N------ELGLELPPTSRERLLEERFLFYRALTRASERLYLSYPLADEEGKALLPSPLIDRLRELFPELEER------SL 648
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  723 NADARPFVGTKRRTISHVIQVYRDvlttntdrnrvgapLQPAPVWvwlrqqltrdpqfgelarqlmaglsyrnqpvkltp 802
Cdd:COG3857   649 LEEELEYIGTPESALSELAAALRQ--------------LELAPLW----------------------------------- 679
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  803 asvEALYGYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIPLAQASDQQLG 882
Cdd:COG3857   680 ---WDVYKWLLKLSVSRLETYAACPFQFFLRYGLKLKEREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE 756
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  883 QYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEVLFgnvGKEHGLKALDFQIDAT 962
Cdd:COG3857   757 ELLEEAVEELAPELQNGILLSSARYRYLLERLKRLLKRARRWLEEEARRSGFEPVALELSF---GPEGGLPPLELELPNG 833
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  963 HSVHVRGKIDRLDQIQVaDQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNeqalvgSDQAAVKLAGALYMHI 1042
Cdd:COG3857   834 RKIRLRGRIDRIDRLES-DGRYLRIIDYKSGSKKFDLDDVYYGLALQLPLYLDAALEN------LEGKEAEPAGALYFHL 906
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187 1043 QNPTLKPKDiqggfeaaLLKKNKYKGILLDDPQLLEHLDselqqgngtskvypfaRKKDGSYSGgraASLVTNDQLERLL 1122
Cdd:COG3857   907 KNPKLKAKK--------PLKKLKMKGLLLDDPEVLEIIP----------------LKKDGSFKN---SKVLSEEEFEELL 959
                        1130      1140      1150      1160      1170
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 696567187 1123 QHNSQLIIAAAEAIFAGEIQLNPIRLNDKtTALQYSPYLSIMQFDAMLAENAYRDLPP 1180
Cdd:COG3857   960 DHVRELLKEAGEEILAGDFAINPYRTKDR-TACQYCPYKSICRFDESLEGNEYRKLKK 1016
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
4-1180 0e+00

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 820.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    4 QFVLGPAKMDHRRTMVAQLVATLmaKPQDQFFYLVPNHIKFDTEVDVLNRLaqafgqpDLYAQTQVQVFSFTRLAWYLMK 83
Cdd:COG3857     1 RFILGRAGSGKTTYLLEEIKEEL--KEGKPIILLVPEQMTFQAERALLKRL-------GLGGSIRAQVLSFSRLAWRVLQ 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   84 NEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANaqagdLQAKLH 163
Cdd:COG3857    72 ETGGATRPLLSDAGKRMLLRKILEEHKDELKVFARAADKPGFIEQLAELITELKRYGITPEDLEEAAEL-----LKEKLR 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  164 DLAIVYKDFVAATADKYLKPADILVQLNAYLRRQD-LHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLMLDhkv 242
Cdd:COG3857   147 DLALIYEAYEEKLAGRYIDSEDLLRLLAEKLEKSEfLEGAEIYID--GFTDFTPQELELLEALLKKAKEVTITLTLD--- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  243 vdraPENGTLFYQSGRLYYRLYQYARIRQIPVSQdiyaetpRVAPGLVALDDFWRGQPQaatgyEEPNTNVHLFRTDSRQ 322
Cdd:COG3857   222 ----PDELDLFSATGETYERLLELAKENGVEVEF-------KKSPELAHLERNLFAYPP-----EEEPEGIEIIEAANRR 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  323 TELAQVGRMIRAMVAkkhadpADDYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELINALFDIDA 402
Cdd:COG3857   286 AEVEAVAREIRRLVR------EEGYRYRDIAVVVRDLEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVR 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  403 QQYQYRDVMRVLKTELLmpningqpmdRQAYRQAVDLTENFILKSGYHGQRWVQRedwqyfqlTEGDAGVETDQNAEISR 482
Cdd:COG3857   360 SNFRYEDVFRLLKTGLL----------RPLSREEIDRLENYVLAYGIRGRRWLER--------YLEEEEELTDEEEEDLE 421
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  483 QINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRdQALDRQDVRAAAEPEQTWQTFCGMLDEYV 562
Cdd:COG3857   422 RLNELRDRLLEPLLPLRERLKKAKTVREWAEALYEFLEELGVPEKLEEWR-EAEEAGDLEEAREHEQAWNALIELLDELV 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  563 TILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNLLSDVDKENL 642
Cdd:COG3857   501 EVLGDEKLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEERERL 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  643 QptlsslDGDHYLNDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFNLREHTylgtpdPT 722
Cdd:COG3857   581 N------ELGLELPPTSRERLLEERFLFYRALTRASERLYLSYPLADEEGKALLPSPLIDRLRELFPELEER------SL 648
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  723 NADARPFVGTKRRTISHVIQVYRDvlttntdrnrvgapLQPAPVWvwlrqqltrdpqfgelarqlmaglsyrnqpvkltp 802
Cdd:COG3857   649 LEEELEYIGTPESALSELAAALRQ--------------LELAPLW----------------------------------- 679
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  803 asvEALYGYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIPLAQASDQQLG 882
Cdd:COG3857   680 ---WDVYKWLLKLSVSRLETYAACPFQFFLRYGLKLKEREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE 756
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  883 QYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEVLFgnvGKEHGLKALDFQIDAT 962
Cdd:COG3857   757 ELLEEAVEELAPELQNGILLSSARYRYLLERLKRLLKRARRWLEEEARRSGFEPVALELSF---GPEGGLPPLELELPNG 833
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  963 HSVHVRGKIDRLDQIQVaDQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNeqalvgSDQAAVKLAGALYMHI 1042
Cdd:COG3857   834 RKIRLRGRIDRIDRLES-DGRYLRIIDYKSGSKKFDLDDVYYGLALQLPLYLDAALEN------LEGKEAEPAGALYFHL 906
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187 1043 QNPTLKPKDiqggfeaaLLKKNKYKGILLDDPQLLEHLDselqqgngtskvypfaRKKDGSYSGgraASLVTNDQLERLL 1122
Cdd:COG3857   907 KNPKLKAKK--------PLKKLKMKGLLLDDPEVLEIIP----------------LKKDGSFKN---SKVLSEEEFEELL 959
                        1130      1140      1150      1160      1170
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 696567187 1123 QHNSQLIIAAAEAIFAGEIQLNPIRLNDKtTALQYSPYLSIMQFDAMLAENAYRDLPP 1180
Cdd:COG3857   960 DHVRELLKEAGEEILAGDFAINPYRTKDR-TACQYCPYKSICRFDESLEGNEYRKLKK 1016
addB_Gpos TIGR02773
helicase-exonuclease AddAB, AddB subunit; DNA repair is accomplished by several different ...
1-1197 0e+00

helicase-exonuclease AddAB, AddB subunit; DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 213736 [Multi-domain]  Cd Length: 1160  Bit Score: 715.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187     1 MSLQFVLGPAKMDHRRTMVAQLVATLMAKPQ-DQFFYLVPNHIKFDTEVDVLNrlaqafgQPDLYAQTQVQVFSFTRLAW 79
Cdd:TIGR02773    1 MGLRFIYGRSGTGKTTFIINEIKQKIKRNPFgKPIILLVPDQMTFQMEYALLN-------DIELNGMLRAQVLSFSRLAW 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    80 YLMKNEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANAQA-GDL 158
Cdd:TIGR02773   74 RVLQETGGLTRTFLTSTGKQMLIRKLIEEHKDELKVYQKASRKKGFTAQLSEMITEFKRYEVTPEDLRRMAESITDsEYL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   159 QAKLHDLAIVYKDFVAATADKYLKPADILVQLNAYLRR-QDLHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLM 237
Cdd:TIGR02773  154 KEKLEDLSIIYQQFEERLADQYLDSEDYLTLLAEKIPQsEDIKGAEIYID--GFHSFTPQEYSVIEALMKKAKKVTVSLT 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   238 LDhKVVDRAPENGTLFYQSGRLYYRLYQYARIRQIPVSQDIYAET--PRVAPGLVALDDFWRGQPqaATGYEEPNTNVHL 315
Cdd:TIGR02773  232 LD-KPSKREPDELSLFRATSKTYYRLKQLAKELGIDVEEPIFLNTerPTKNKELAHLEKQFDARP--AIAYAEKQESLSI 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   316 FRTDSRQTELAQVGRMIRAMVAKKHadpaddYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELIN 395
Cdd:TIGR02773  309 FQANNRRAEVEGVAREILRLVRDKG------YRYKDIAILTRDPEDYKDLVKAVFSDYEIPYFIDKKRSMLNHPLIEFIR 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   396 ALFDIDAQQYQYRDVMRVLKTELLmPNINGQPMDRqayRQAVDLTENFILKSGYHGQ-RWVQREDWQYFQLT-EGDAGVE 473
Cdd:TIGR02773  383 SSLDVIQGNWRYEAVFRYLKTGLL-FPLNEPFIDV---RELIDQLENYVLAYGIKGKkRWWKEDWFQYRRFRgLDDDFAQ 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   474 TDQNAEISRQINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRDQALDRQDVRAAAEPEQTWQT 553
Cdd:TIGR02773  459 TDEEIEMQEMLNDTRDWIVPPLFTFEKRMKKAKTVKEFAEALYEFLEELDLPDKLEKERQRAEDDGRIEEAREHEQAWDA 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   554 FCGMLDEYVTILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNL 633
Cdd:TIGR02773  539 VIQLLDEFVEVLGNEEMDLNLFQEVIDIGLEQLEFSLIPPALDQVFVGTMDRSKMYNTKCIFLLGANDGVLPARPKENGI 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   634 LSDVDKENLQPTLSSLDgdhylnDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFN-LRE 712
Cdd:TIGR02773  619 LSDEDRELLEQIGVELS------STSREKLLDEQFLVYTAFTSASDRLKVSYPLADAEGKSLRPSIIIHRLEELFPkLKE 692
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   713 HTYLGTPDPTNaDARPFvgtkrRTISHVIQVyRDVLTTNTDRNRVGAPLqpAPVWVWLRQQLTRDPQFGELARQLMAGLS 792
Cdd:TIGR02773  693 SLLLNEPEQVS-DEEQL-----SYVSNKLPT-LSELTSQLRKWKRGYPI--SDVWWDVYNWYREEDKWKQGLEYVLSGLF 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   793 YRNQPVKLTPASVEALYGYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIP 872
Cdd:TIGR02773  764 YDNETKQLQESKAKQLYGERIQASVSRLETYNACPFAHFAQYGLKLKERKIYKLEAPDLGQLFHEALKEISDELKEEKLD 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   873 LAQASDQQLGQYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEVLFGNVGKEhgL 952
Cdd:TIGR02773  844 WSDLTKEQCRLFANDAVENLAPKLQHEILLSSNRYRYVQKKLKRIVTRAVGVLSEQAKRSGFVPVGLELGFGFGKNP--L 921
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   953 KALDFQIDATHSVHVRGKIDRLDQIQVADQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNEQALVGsdqAAV 1032
Cdd:TIGR02773  922 PPLKLQLKNGEELELRGRIDRVDKAEKEDETYLRIIDYKSSSKGLDLTEVYYGLALQMLTYLDIVLTNSAKWLG---NQA 998
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1033 KLAGALYMHIQNPTLKPKD--IQGGFEAALLKKNKYKGILLDDPQLLEHLDSELQQgnGTSKVYPFARKKDGSYsgGRAA 1110
Cdd:TIGR02773  999 TPAGVLYFHIHDPMIQAKGdlTEEEIEQEIFKEYKMKGLLLSDQEVVRLMDTTLEE--GSSNIIPASLKKDGSL--GSRS 1074
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1111 SLVTNDQLERLLQHNSQLIIAAAEAIFAGEIQLNPIRLNDKtTALQYSPYLSIMQFDAMLAENAYRDLPPLSAKQVLDLL 1190
Cdd:TIGR02773 1075 KAATEEEFELLRKHVRRKFQEAGENITDGRVSIEPYKMKKQ-TPCQYCNFSSVCQFDTSLEENEYRHLEAEKDETILEWI 1153

                   ....*..
gi 696567187  1191 KTQKGGE 1197
Cdd:TIGR02773 1154 NEEVGGN 1160
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
816-1048 1.51e-19

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 89.52  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   816 SISKLEEFYRNQYAYFLKYGLKLRERdvFELSAASTGEFFHAVLDGLIKALRsdqiPLAQASDQQLGQYLETVTRQILDQ 895
Cdd:pfam12705    3 SPSRLETYLTCPLRFFLRYLLGLRED--EELDAPDLGTLVHAALERFYRWGR----LPEEDLEELLQALLEELWPELGLQ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   896 PQFTiltssNRMAYLQRQLINTVRQIAFAIRNQSKLSAA-EPKQTEVLFGNvgkehglkaldfqidatHSVHVRGKIDRL 974
Cdd:pfam12705   77 SEIL-----PRLPWLAGRLRRRLERMLRRLAEWLRARRGfRPVAVELGFGG-----------------TTVRLVGRIDRV 134
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 696567187   975 DQiqvADQSYLGIVDYKSSQHKFDFQ--EAYYGLamQMLTYLDAVLHNEQALVGSdqaavklAGALYMHIQNPTLK 1048
Cdd:pfam12705  135 DL---DGEGYLRIIDYKTGSAPPQSEdlDLYEGL--QLLLYLLALAAGEKALGGP-------AGALYLRLDDPLKK 198
 
Name Accession Description Interval E-value
AddB COG3857
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
4-1180 0e+00

ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];


Pssm-ID: 443066 [Multi-domain]  Cd Length: 1019  Bit Score: 820.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    4 QFVLGPAKMDHRRTMVAQLVATLmaKPQDQFFYLVPNHIKFDTEVDVLNRLaqafgqpDLYAQTQVQVFSFTRLAWYLMK 83
Cdd:COG3857     1 RFILGRAGSGKTTYLLEEIKEEL--KEGKPIILLVPEQMTFQAERALLKRL-------GLGGSIRAQVLSFSRLAWRVLQ 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   84 NEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANaqagdLQAKLH 163
Cdd:COG3857    72 ETGGATRPLLSDAGKRMLLRKILEEHKDELKVFARAADKPGFIEQLAELITELKRYGITPEDLEEAAEL-----LKEKLR 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  164 DLAIVYKDFVAATADKYLKPADILVQLNAYLRRQD-LHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLMLDhkv 242
Cdd:COG3857   147 DLALIYEAYEEKLAGRYIDSEDLLRLLAEKLEKSEfLEGAEIYID--GFTDFTPQELELLEALLKKAKEVTITLTLD--- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  243 vdraPENGTLFYQSGRLYYRLYQYARIRQIPVSQdiyaetpRVAPGLVALDDFWRGQPQaatgyEEPNTNVHLFRTDSRQ 322
Cdd:COG3857   222 ----PDELDLFSATGETYERLLELAKENGVEVEF-------KKSPELAHLERNLFAYPP-----EEEPEGIEIIEAANRR 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  323 TELAQVGRMIRAMVAkkhadpADDYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELINALFDIDA 402
Cdd:COG3857   286 AEVEAVAREIRRLVR------EEGYRYRDIAVVVRDLEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVR 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  403 QQYQYRDVMRVLKTELLmpningqpmdRQAYRQAVDLTENFILKSGYHGQRWVQRedwqyfqlTEGDAGVETDQNAEISR 482
Cdd:COG3857   360 SNFRYEDVFRLLKTGLL----------RPLSREEIDRLENYVLAYGIRGRRWLER--------YLEEEEELTDEEEEDLE 421
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  483 QINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRdQALDRQDVRAAAEPEQTWQTFCGMLDEYV 562
Cdd:COG3857   422 RLNELRDRLLEPLLPLRERLKKAKTVREWAEALYEFLEELGVPEKLEEWR-EAEEAGDLEEAREHEQAWNALIELLDELV 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  563 TILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNLLSDVDKENL 642
Cdd:COG3857   501 EVLGDEKLSLEEFLRILESGLEELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDGLLSDEERERL 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  643 QptlsslDGDHYLNDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFNLREHTylgtpdPT 722
Cdd:COG3857   581 N------ELGLELPPTSRERLLEERFLFYRALTRASERLYLSYPLADEEGKALLPSPLIDRLRELFPELEER------SL 648
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  723 NADARPFVGTKRRTISHVIQVYRDvlttntdrnrvgapLQPAPVWvwlrqqltrdpqfgelarqlmaglsyrnqpvkltp 802
Cdd:COG3857   649 LEEELEYIGTPESALSELAAALRQ--------------LELAPLW----------------------------------- 679
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  803 asvEALYGYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIPLAQASDQQLG 882
Cdd:COG3857   680 ---WDVYKWLLKLSVSRLETYAACPFQFFLRYGLKLKEREEYELDAPDRGTLFHAVLERFYKELKEEGLDWADLSDEELE 756
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  883 QYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEVLFgnvGKEHGLKALDFQIDAT 962
Cdd:COG3857   757 ELLEEAVEELAPELQNGILLSSARYRYLLERLKRLLKRARRWLEEEARRSGFEPVALELSF---GPEGGLPPLELELPNG 833
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  963 HSVHVRGKIDRLDQIQVaDQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNeqalvgSDQAAVKLAGALYMHI 1042
Cdd:COG3857   834 RKIRLRGRIDRIDRLES-DGRYLRIIDYKSGSKKFDLDDVYYGLALQLPLYLDAALEN------LEGKEAEPAGALYFHL 906
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187 1043 QNPTLKPKDiqggfeaaLLKKNKYKGILLDDPQLLEHLDselqqgngtskvypfaRKKDGSYSGgraASLVTNDQLERLL 1122
Cdd:COG3857   907 KNPKLKAKK--------PLKKLKMKGLLLDDPEVLEIIP----------------LKKDGSFKN---SKVLSEEEFEELL 959
                        1130      1140      1150      1160      1170
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 696567187 1123 QHNSQLIIAAAEAIFAGEIQLNPIRLNDKtTALQYSPYLSIMQFDAMLAENAYRDLPP 1180
Cdd:COG3857   960 DHVRELLKEAGEEILAGDFAINPYRTKDR-TACQYCPYKSICRFDESLEGNEYRKLKK 1016
addB_Gpos TIGR02773
helicase-exonuclease AddAB, AddB subunit; DNA repair is accomplished by several different ...
1-1197 0e+00

helicase-exonuclease AddAB, AddB subunit; DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 213736 [Multi-domain]  Cd Length: 1160  Bit Score: 715.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187     1 MSLQFVLGPAKMDHRRTMVAQLVATLMAKPQ-DQFFYLVPNHIKFDTEVDVLNrlaqafgQPDLYAQTQVQVFSFTRLAW 79
Cdd:TIGR02773    1 MGLRFIYGRSGTGKTTFIINEIKQKIKRNPFgKPIILLVPDQMTFQMEYALLN-------DIELNGMLRAQVLSFSRLAW 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    80 YLMKNEAAYQVPRLSAAGIDMLLYRILQRHADELRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANAQA-GDL 158
Cdd:TIGR02773   74 RVLQETGGLTRTFLTSTGKQMLIRKLIEEHKDELKVYQKASRKKGFTAQLSEMITEFKRYEVTPEDLRRMAESITDsEYL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   159 QAKLHDLAIVYKDFVAATADKYLKPADILVQLNAYLRR-QDLHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLM 237
Cdd:TIGR02773  154 KEKLEDLSIIYQQFEERLADQYLDSEDYLTLLAEKIPQsEDIKGAEIYID--GFHSFTPQEYSVIEALMKKAKKVTVSLT 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   238 LDhKVVDRAPENGTLFYQSGRLYYRLYQYARIRQIPVSQDIYAET--PRVAPGLVALDDFWRGQPqaATGYEEPNTNVHL 315
Cdd:TIGR02773  232 LD-KPSKREPDELSLFRATSKTYYRLKQLAKELGIDVEEPIFLNTerPTKNKELAHLEKQFDARP--AIAYAEKQESLSI 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   316 FRTDSRQTELAQVGRMIRAMVAKKHadpaddYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELIN 395
Cdd:TIGR02773  309 FQANNRRAEVEGVAREILRLVRDKG------YRYKDIAILTRDPEDYKDLVKAVFSDYEIPYFIDKKRSMLNHPLIEFIR 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   396 ALFDIDAQQYQYRDVMRVLKTELLmPNINGQPMDRqayRQAVDLTENFILKSGYHGQ-RWVQREDWQYFQLT-EGDAGVE 473
Cdd:TIGR02773  383 SSLDVIQGNWRYEAVFRYLKTGLL-FPLNEPFIDV---RELIDQLENYVLAYGIKGKkRWWKEDWFQYRRFRgLDDDFAQ 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   474 TDQNAEISRQINLIHHFVAETLPPFFKKMRQAPDGKAAVTLLVNFLTSQGVTDQLLAWRDQALDRQDVRAAAEPEQTWQT 553
Cdd:TIGR02773  459 TDEEIEMQEMLNDTRDWIVPPLFTFEKRMKKAKTVKEFAEALYEFLEELDLPDKLEKERQRAEDDGRIEEAREHEQAWDA 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   554 FCGMLDEYVTILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNL 633
Cdd:TIGR02773  539 VIQLLDEFVEVLGNEEMDLNLFQEVIDIGLEQLEFSLIPPALDQVFVGTMDRSKMYNTKCIFLLGANDGVLPARPKENGI 618
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   634 LSDVDKENLQPTLSSLDgdhylnDSAVVQLGDESCLNYLAFLSARRHLFFSAPLKDDQETDLNWSNYVRRIQRQFN-LRE 712
Cdd:TIGR02773  619 LSDEDRELLEQIGVELS------STSREKLLDEQFLVYTAFTSASDRLKVSYPLADAEGKSLRPSIIIHRLEELFPkLKE 692
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   713 HTYLGTPDPTNaDARPFvgtkrRTISHVIQVyRDVLTTNTDRNRVGAPLqpAPVWVWLRQQLTRDPQFGELARQLMAGLS 792
Cdd:TIGR02773  693 SLLLNEPEQVS-DEEQL-----SYVSNKLPT-LSELTSQLRKWKRGYPI--SDVWWDVYNWYREEDKWKQGLEYVLSGLF 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   793 YRNQPVKLTPASVEALYGYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKALRSDQIP 872
Cdd:TIGR02773  764 YDNETKQLQESKAKQLYGERIQASVSRLETYNACPFAHFAQYGLKLKERKIYKLEAPDLGQLFHEALKEISDELKEEKLD 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   873 LAQASDQQLGQYLETVTRQILDQPQFTILTSSNRMAYLQRQLINTVRQIAFAIRNQSKLSAAEPKQTEVLFGNVGKEhgL 952
Cdd:TIGR02773  844 WSDLTKEQCRLFANDAVENLAPKLQHEILLSSNRYRYVQKKLKRIVTRAVGVLSEQAKRSGFVPVGLELGFGFGKNP--L 921
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   953 KALDFQIDATHSVHVRGKIDRLDQIQVADQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVLHNEQALVGsdqAAV 1032
Cdd:TIGR02773  922 PPLKLQLKNGEELELRGRIDRVDKAEKEDETYLRIIDYKSSSKGLDLTEVYYGLALQMLTYLDIVLTNSAKWLG---NQA 998
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1033 KLAGALYMHIQNPTLKPKD--IQGGFEAALLKKNKYKGILLDDPQLLEHLDSELQQgnGTSKVYPFARKKDGSYsgGRAA 1110
Cdd:TIGR02773  999 TPAGVLYFHIHDPMIQAKGdlTEEEIEQEIFKEYKMKGLLLSDQEVVRLMDTTLEE--GSSNIIPASLKKDGSL--GSRS 1074
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1111 SLVTNDQLERLLQHNSQLIIAAAEAIFAGEIQLNPIRLNDKtTALQYSPYLSIMQFDAMLAENAYRDLPPLSAKQVLDLL 1190
Cdd:TIGR02773 1075 KAATEEEFELLRKHVRRKFQEAGENITDGRVSIEPYKMKKQ-TPCQYCNFSSVCQFDTSLEENEYRHLEAEKDETILEWI 1153

                   ....*..
gi 696567187  1191 KTQKGGE 1197
Cdd:TIGR02773 1154 NEEVGGN 1160
rexB_recomb TIGR02774
ATP-dependent nuclease subunit B; DNA repair is accomplished by several different systems in ...
13-1185 2.26e-79

ATP-dependent nuclease subunit B; DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RecAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. The partner may be designated AddB, as in Bacillus and in alphaproteobacteria, or RexB as in Streptococcus and Lactococcus. Note, however, that RexB proteins lack an N-terminal GxxGxGK[ST] ATP-binding motif found in Bacillus subtilis and related species, and this difference may be important; this model represents specifically RexB proteins as found in Streptococcus and Lactococcus. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274291 [Multi-domain]  Cd Length: 1076  Bit Score: 283.65  E-value: 2.26e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    13 DHRRTMVAQLV--ATLMAKPQDQFFYLVPNHIKFDTEVDVLNRLAQAfgqpdlyAQTQVQVFSFTRLAWYLMKNEAAYQV 90
Cdd:TIGR02774    6 DIRTSLTEILVneAEEAAAAGKRVFYIAPNSLSFEKERAVLEYLPQQ-------ASFSITVTRFAQMARYFVLNDLPAKT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187    91 PrLSAAGIDMLLYRILQRHADE-LRLFGGEISQTGFVTQLAREINELQTANLQPEDVVQLAANAQAGDLQAKLhdlAIVY 169
Cdd:TIGR02774   79 T-LDDIGLAMIFYRALAQLEPGdLKVYGRLKQDPQFIQQLVELYKELQKSQLSILDLENLTSPDKREDLLAIF---EKVT 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   170 KDFVAATADKYLKPADILVQLNAYLRRQDLHGTHVYVElaGFAQLPAQEQGIVTTMLEQGADVTISLMLDHKVVDRAPEN 249
Cdd:TIGR02774  155 AYLNQGQYAQQSKLAHFIEAIESGKLDSDLKNTVLVID--GFTRFSAEEEALVSLLHGKGVEIIIGAYASQKAYKSSFSE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   250 GTLFYQSGRLYYRLYQYARIR-----QIPVSQDIYAETPRVapgLVALDDFWRGQPQAAtgyEEPNTNVHLFRTDSRQTE 324
Cdd:TIGR02774  233 GNLYQASVKFLHDLAQKYQTKaefisSTHESKDSFDKLSRL---LEASHDFSELALDLD---DKDKDNLTIWSCLTQKEE 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   325 LAQVGRMIRAMVAkkhadpaDDYHYRDFLIMTRHLDAYQTMLAPTFHELEIPYFVDLQRSMADHPLVELINALFDIdaQQ 404
Cdd:TIGR02774  307 VEHVARSIRQKLY-------EGYRYKDILVLLGDVDSYQLQLGKIFDQYDIPFYLGKAEPMAHHPLVQFIESLERI--KR 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   405 YQYR--DVMRVLKTELLmPNINGQPMDR-QAYRQAVDLtenfilksgyhgqrwvqredwqyfqltEGDAGVETDQNAEIS 481
Cdd:TIGR02774  378 YRFRaeDVLNLLKTGLY-GDFSQSDIDAfEQYIRYADI---------------------------KGLPKFQKTFTKNHH 429
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   482 RQINL-----IHHFVAETLPPFFKKMRQapDGKAAVTLLVNFLTSQGVTDQL--LAWRDQALDRQdvraaaEPEQTWQTF 554
Cdd:TIGR02774  430 GKFDLdrlnvLRQRILAPLEELFKSRKQ--LGEKLLNKFSVFLKEIALTKNLqdLATTLSEVEQE------KQEEVWKTF 501
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   555 CGMLDEYVTILGAEPFEITDFLALLQAGFEGASYSQIPSTLDQVLISESGMVQSQDHKVVFMVGATDLVMPDRIMTNNLL 634
Cdd:TIGR02774  502 TDILEQFATIFGQEKLSLDDFLALLHSGMSLSQYRTVPATVDVVTVKSYDLIEPHTAPFVYAIGLTQSNFPKISQNSSLL 581
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   635 SDVDKENLQPtlSSLDGDHYLNDSAvvqlgDESCLNYLAFLS----ARRHLFFSAP-LKDDQETDLnwSNYV---RRIQR 706
Cdd:TIGR02774  582 TDEERQNLND--ATEEGGHFDIASQ-----ENLKKNHYTMLSlfnsATKELVLSAPqLFNESEDKE--SPYLqelIDFGV 652
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   707 QFNLREHTYLGTpdpTNADarpfVGTKRRTISHVIQVYRDVLTTNTDrnrvgaplQPAPVWV----WLRQQLTRdpqfge 782
Cdd:TIGR02774  653 PLREKGMNSLGE---DKED----IGNYKALLSRVVAYNQQGEMEMTK--------QDLTFWSvlvrYLRKKLDQ------ 711
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   783 laRQL-MAGLSYRNQPVKLTPASVEALY--GYQIYTSISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVL 859
Cdd:TIGR02774  712 --QGLeIPTITDSLSTKTLSKDVLQALYpaDQPLKLSASALTTFYNNQYSYFLRYVLGLEEEESIHPDARHHGNYLHRIF 789
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   860 DGLIKalrsdqiplaQASDQQLGQYLETVTRQILDQPQFTILTSSNRMA-YLQRQLINTVRQIAFAIRNQSKLSAAepKQ 938
Cdd:TIGR02774  790 ERLMK----------LPGEESFDQKLNQAINETSQEREFEALYQEDAEArYTLEILLDIARSTAPILRHNSAIQVI--KE 857
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   939 TEVLFGNVGKEhglkaldFQIDATHSVHVRGKIDRLDQIqvADQSYLGIVDYKSSQHKFDFQEAYYGLAMQMLTYLDAVl 1018
Cdd:TIGR02774  858 EENFGGKDNFQ-------LQIDNGRSIFVRGIIDRIDRL--SDGGSLGVVDYKSSATQFDIPHFYNGLSPQLPTYLAAL- 927
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1019 hNEQALVGSDQaavKLAGALYMHIQNPTLKPKDIQG--GFEAALLKKNKYKGIllddpqLLEHLDSELQQGNGTSKvypf 1096
Cdd:TIGR02774  928 -KRIAPHEGEQ---PIFGAMYLHMQEPVQDLMAVKNldDAVVEASKALKYQGL------FSEKEKSHLAEGYNKNK---- 993
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  1097 arkkdgsysggraASLVTNDQLERLLQHNSQLIIAAAEAIFAGEIQLNPIRLNDKTTALQysPYLSIMQFDAMLAENAYR 1176
Cdd:TIGR02774  994 -------------ANLYSDEELQLLLDYNKYLYKKAAETILSGRFAINPYTEDGRSVQGD--QLKAITGFEADRHMGQAR 1058

                   ....*....
gi 696567187  1177 DLPPLSAKQ 1185
Cdd:TIGR02774 1059 RLEKLPAKE 1067
PDDEXK_1 pfam12705
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ...
816-1048 1.51e-19

PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily


Pssm-ID: 432731 [Multi-domain]  Cd Length: 250  Bit Score: 89.52  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   816 SISKLEEFYRNQYAYFLKYGLKLRERdvFELSAASTGEFFHAVLDGLIKALRsdqiPLAQASDQQLGQYLETVTRQILDQ 895
Cdd:pfam12705    3 SPSRLETYLTCPLRFFLRYLLGLRED--EELDAPDLGTLVHAALERFYRWGR----LPEEDLEELLQALLEELWPELGLQ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187   896 PQFTiltssNRMAYLQRQLINTVRQIAFAIRNQSKLSAA-EPKQTEVLFGNvgkehglkaldfqidatHSVHVRGKIDRL 974
Cdd:pfam12705   77 SEIL-----PRLPWLAGRLRRRLERMLRRLAEWLRARRGfRPVAVELGFGG-----------------TTVRLVGRIDRV 134
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 696567187   975 DQiqvADQSYLGIVDYKSSQHKFDFQ--EAYYGLamQMLTYLDAVLHNEQALVGSdqaavklAGALYMHIQNPTLK 1048
Cdd:pfam12705  135 DL---DGEGYLRIIDYKTGSAPPQSEdlDLYEGL--QLLLYLLALAAGEKALGGP-------AGALYLRLDDPLKK 198
Slr0479 COG2887
RecB family exonuclease [Replication, recombination and repair];
816-1060 3.72e-14

RecB family exonuclease [Replication, recombination and repair];


Pssm-ID: 442133 [Multi-domain]  Cd Length: 248  Bit Score: 73.53  E-value: 3.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  816 SISKLEEFYRNQYAYFLKYGLKLRERDVFELSAASTGEFFHAVLDGLIKAlrsdqiPLAQASDQQLGQYLETVTRQILDQ 895
Cdd:COG2887     4 SPSRIETLLRCPLRYYARYILGLRDPLEPPPDAADRGTLVHAVLERFYKL------PADELPAEELLALLEEAWAELGFE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  896 PQFTiltssnRMAYLQRqlintVRQIAFA-IRNQSKLSAAEPKQTEVlfgnvgkehglkalDFQIDATHSVHVRGKIDRL 974
Cdd:COG2887    78 DPWA------AALWLER-----AERLLEAfLEWERAPAGLEPVAVEV--------------EFELELPGGVRLRGRIDRI 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696567187  975 DqiqVADQSYLGIVDYKSSQHKFDFQEAyyGLAMQMLTYldavlhneQALV--GSDQAAVKLAGALYMHIQNPTLKPKDI 1052
Cdd:COG2887   133 D---RLPDGRLVVVDYKTGKAPSTKDEA--GEDPQLALY--------ALALerGFEGLVPAGARLVYLGDLGKKKVLDPL 199

                  ....*...
gi 696567187 1053 QGGFEAAL 1060
Cdd:COG2887   200 EEELEEAE 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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