excinuclease ABC subunit UvrA [Lactiplantibacillus plantarum]
Protein Classification
excinuclease ABC subunit UvrA( domain architecture ID 1000295)
excinuclease ABC subunit UvrA is a DNA-binding ATPase that recognizes DNA adducts in the nucleotide excision repair process catalyzed by the UvrABC excinuclease repair system
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||||
| UvrA super family | cl33793 | Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; |
9-831 | 0e+00 | |||||||||||||
Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; The actual alignment was detected with superfamily member COG0178: Pssm-ID: 439948 [Multi-domain] Cd Length: 941 Bit Score: 855.48 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||
| UvrA | COG0178 | Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; |
9-831 | 0e+00 | ||||||||||||||
Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; Pssm-ID: 439948 [Multi-domain] Cd Length: 941 Bit Score: 855.48 E-value: 0e+00
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| uvrA | PRK00349 | excinuclease ABC subunit UvrA; |
9-831 | 0e+00 | ||||||||||||||
excinuclease ABC subunit UvrA; Pssm-ID: 234734 [Multi-domain] Cd Length: 943 Bit Score: 747.67 E-value: 0e+00
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| uvra | TIGR00630 | excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ... |
10-815 | 0e+00 | ||||||||||||||
excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of proteins of which all members for which functions are known except the UvrA proteins are involved in the transport of material through membranes. UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 721.80 E-value: 0e+00
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| ABC_UvrA_II | cd03271 | ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair ... |
507-811 | 7.36e-96 | ||||||||||||||
ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213238 [Multi-domain] Cd Length: 261 Bit Score: 300.30 E-value: 7.36e-96
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| UvrA_DNA-bind | pfam17755 | UvrA DNA-binding domain; |
183-289 | 6.05e-14 | ||||||||||||||
UvrA DNA-binding domain; Pssm-ID: 465484 [Multi-domain] Cd Length: 110 Bit Score: 68.65 E-value: 6.05e-14
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| AztA | NF040873 | zinc ABC transporter ATP-binding protein AztA; |
713-794 | 1.13e-06 | ||||||||||||||
zinc ABC transporter ATP-binding protein AztA; Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 49.92 E-value: 1.13e-06
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| Name | Accession | Description | Interval | E-value | ||||||||||||||
| UvrA | COG0178 | Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; |
9-831 | 0e+00 | ||||||||||||||
Excinuclease UvrABC ATPase subunit [Replication, recombination and repair]; Pssm-ID: 439948 [Multi-domain] Cd Length: 941 Bit Score: 855.48 E-value: 0e+00
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| uvrA | PRK00349 | excinuclease ABC subunit UvrA; |
9-831 | 0e+00 | ||||||||||||||
excinuclease ABC subunit UvrA; Pssm-ID: 234734 [Multi-domain] Cd Length: 943 Bit Score: 747.67 E-value: 0e+00
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| uvra | TIGR00630 | excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ... |
10-815 | 0e+00 | ||||||||||||||
excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of proteins of which all members for which functions are known except the UvrA proteins are involved in the transport of material through membranes. UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 721.80 E-value: 0e+00
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| PRK00635 | PRK00635 | excinuclease ABC subunit A; Provisional |
1-835 | 6.04e-124 | ||||||||||||||
excinuclease ABC subunit A; Provisional Pssm-ID: 234806 [Multi-domain] Cd Length: 1809 Bit Score: 410.37 E-value: 6.04e-124
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| ABC_UvrA_II | cd03271 | ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair ... |
507-811 | 7.36e-96 | ||||||||||||||
ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213238 [Multi-domain] Cd Length: 261 Bit Score: 300.30 E-value: 7.36e-96
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| PRK00635 | PRK00635 | excinuclease ABC subunit A; Provisional |
2-830 | 6.48e-78 | ||||||||||||||
excinuclease ABC subunit A; Provisional Pssm-ID: 234806 [Multi-domain] Cd Length: 1809 Bit Score: 276.32 E-value: 6.48e-78
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| uvra | TIGR00630 | excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ... |
645-826 | 1.29e-55 | ||||||||||||||
excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of proteins of which all members for which functions are known except the UvrA proteins are involved in the transport of material through membranes. UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 207.17 E-value: 1.29e-55
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| PRK00635 | PRK00635 | excinuclease ABC subunit A; Provisional |
295-810 | 3.29e-52 | ||||||||||||||
excinuclease ABC subunit A; Provisional Pssm-ID: 234806 [Multi-domain] Cd Length: 1809 Bit Score: 198.51 E-value: 3.29e-52
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| uvra | TIGR00630 | excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ... |
6-468 | 1.21e-50 | ||||||||||||||
excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of proteins of which all members for which functions are known except the UvrA proteins are involved in the transport of material through membranes. UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 192.15 E-value: 1.21e-50
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| ABC_UvrA_I | cd03270 | ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair ... |
516-809 | 1.62e-48 | ||||||||||||||
ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213237 [Multi-domain] Cd Length: 226 Bit Score: 171.29 E-value: 1.62e-48
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| ABC_UvrA_II | cd03271 | ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair ... |
296-468 | 5.36e-46 | ||||||||||||||
ATP-binding cassette domain II of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213238 [Multi-domain] Cd Length: 261 Bit Score: 165.48 E-value: 5.36e-46
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| ABC_UvrA | cd03238 | ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ... |
686-809 | 4.19e-42 | ||||||||||||||
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 151.32 E-value: 4.19e-42
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| ABC_UvrA_I | cd03270 | ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair ... |
359-467 | 2.42e-40 | ||||||||||||||
ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213237 [Multi-domain] Cd Length: 226 Bit Score: 148.17 E-value: 2.42e-40
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| ABC_UvrA_I | cd03270 | ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair ... |
10-120 | 1.32e-38 | ||||||||||||||
ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213237 [Multi-domain] Cd Length: 226 Bit Score: 143.17 E-value: 1.32e-38
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| ABC_UvrA | cd03238 | ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ... |
358-467 | 8.63e-36 | ||||||||||||||
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 133.60 E-value: 8.63e-36
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| PRK00635 | PRK00635 | excinuclease ABC subunit A; Provisional |
290-486 | 1.32e-15 | ||||||||||||||
excinuclease ABC subunit A; Provisional Pssm-ID: 234806 [Multi-domain] Cd Length: 1809 Bit Score: 81.80 E-value: 1.32e-15
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| ABC_UvrA | cd03238 | ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ... |
10-85 | 9.63e-15 | ||||||||||||||
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 73.13 E-value: 9.63e-15
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| EcfA2 | COG1122 | Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ... |
517-814 | 2.70e-14 | ||||||||||||||
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 73.14 E-value: 2.70e-14
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| UvrA_DNA-bind | pfam17755 | UvrA DNA-binding domain; |
183-289 | 6.05e-14 | ||||||||||||||
UvrA DNA-binding domain; Pssm-ID: 465484 [Multi-domain] Cd Length: 110 Bit Score: 68.65 E-value: 6.05e-14
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
719-794 | 3.54e-12 | ||||||||||||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 64.96 E-value: 3.54e-12
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
688-792 | 4.50e-12 | ||||||||||||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 65.95 E-value: 4.50e-12
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
362-831 | 8.15e-12 | ||||||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 68.39 E-value: 8.15e-12
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
379-450 | 2.72e-11 | ||||||||||||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 62.65 E-value: 2.72e-11
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| ABC_Mj1267_LivG_branched | cd03219 | ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
316-477 | 4.03e-11 | ||||||||||||||
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 64.00 E-value: 4.03e-11
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| ABC_Class2 | cd03227 | ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
721-797 | 4.31e-11 | ||||||||||||||
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins. Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 61.99 E-value: 4.31e-11
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| cbiO | PRK13631 | cobalt transporter ATP-binding subunit; Provisional |
704-835 | 8.75e-11 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 64.10 E-value: 8.75e-11
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
362-455 | 4.07e-10 | ||||||||||||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 60.17 E-value: 4.07e-10
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| ABC_cobalt_CbiO_domain2 | cd03226 | Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of ... |
702-795 | 4.33e-10 | ||||||||||||||
Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The CbiMNQO family ABC transport system is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213193 [Multi-domain] Cd Length: 205 Bit Score: 60.35 E-value: 4.33e-10
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
684-820 | 8.98e-10 | ||||||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 61.84 E-value: 8.98e-10
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| ABC_Mj1267_LivG_branched | cd03219 | ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
696-818 | 1.48e-09 | ||||||||||||||
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 58.99 E-value: 1.48e-09
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| cbiO | PRK13632 | cobalt transporter ATP-binding subunit; Provisional |
721-817 | 2.59e-09 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 58.85 E-value: 2.59e-09
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| CydD | TIGR02857 | thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ... |
636-794 | 3.80e-09 | ||||||||||||||
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 59.99 E-value: 3.80e-09
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| cbiO | PRK13635 | energy-coupling factor ABC transporter ATP-binding protein; |
721-811 | 3.86e-09 | ||||||||||||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 58.49 E-value: 3.86e-09
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| CydD | COG4988 | ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ... |
517-811 | 4.13e-09 | ||||||||||||||
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 60.16 E-value: 4.13e-09
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| Rli1 | COG1245 | Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ... |
352-456 | 6.46e-09 | ||||||||||||||
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 59.41 E-value: 6.46e-09
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| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
721-792 | 1.78e-08 | ||||||||||||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 55.62 E-value: 1.78e-08
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| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
350-467 | 1.92e-08 | ||||||||||||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 55.62 E-value: 1.92e-08
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| cbiO | PRK13649 | energy-coupling factor transporter ATPase; |
704-816 | 4.21e-08 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 55.52 E-value: 4.21e-08
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| ModF | COG1119 | ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ... |
319-472 | 4.79e-08 | ||||||||||||||
ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism]; Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 54.71 E-value: 4.79e-08
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| cbiO | PRK13643 | energy-coupling factor transporter ATPase; |
692-829 | 5.20e-08 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 55.12 E-value: 5.20e-08
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| PRK13409 | PRK13409 | ribosome biogenesis/translation initiation ATPase RLI; |
363-456 | 5.64e-08 | ||||||||||||||
ribosome biogenesis/translation initiation ATPase RLI; Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 56.36 E-value: 5.64e-08
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| cbiO | PRK13646 | energy-coupling factor transporter ATPase; |
702-832 | 9.22e-08 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 54.40 E-value: 9.22e-08
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| PRK11831 | PRK11831 | phospholipid ABC transporter ATP-binding protein MlaF; |
721-826 | 9.98e-08 | ||||||||||||||
phospholipid ABC transporter ATP-binding protein MlaF; Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 54.00 E-value: 9.98e-08
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| cbiO | PRK13639 | cobalt transporter ATP-binding subunit; Provisional |
716-830 | 1.89e-07 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184199 [Multi-domain] Cd Length: 275 Bit Score: 53.54 E-value: 1.89e-07
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| ABC_RNaseL_inhibitor_domain1 | cd03236 | The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ... |
362-456 | 1.92e-07 | ||||||||||||||
The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI s are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLIs have an N-terminal Fe-S domain and two nucleotide binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology. Pssm-ID: 213203 [Multi-domain] Cd Length: 255 Bit Score: 53.14 E-value: 1.92e-07
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| PRK13651 | PRK13651 | cobalt transporter ATP-binding subunit; Provisional |
708-783 | 2.34e-07 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 53.55 E-value: 2.34e-07
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| PRK10575 | PRK10575 | Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC; |
720-819 | 2.49e-07 | ||||||||||||||
Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC; Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 52.87 E-value: 2.49e-07
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| ABCC_MRP_domain1 | cd03250 | ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
20-51 | 2.88e-07 | ||||||||||||||
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 51.70 E-value: 2.88e-07
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| ZnuC | COG1121 | ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ... |
701-814 | 5.52e-07 | ||||||||||||||
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 51.63 E-value: 5.52e-07
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| CcmA | COG1131 | ABC-type multidrug transport system, ATPase component [Defense mechanisms]; |
721-811 | 5.71e-07 | ||||||||||||||
ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 51.60 E-value: 5.71e-07
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| ABCC_MRP_Like | cd03228 | ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ... |
20-48 | 5.82e-07 | ||||||||||||||
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 50.07 E-value: 5.82e-07
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| BtuD | COG4138 | ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism]; ... |
702-814 | 9.38e-07 | ||||||||||||||
ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism]; Pssm-ID: 443313 [Multi-domain] Cd Length: 248 Bit Score: 50.99 E-value: 9.38e-07
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| cbiO | PRK13638 | energy-coupling factor ABC transporter ATP-binding protein; |
374-452 | 9.68e-07 | ||||||||||||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 51.16 E-value: 9.68e-07
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| AztA | NF040873 | zinc ABC transporter ATP-binding protein AztA; |
713-794 | 1.13e-06 | ||||||||||||||
zinc ABC transporter ATP-binding protein AztA; Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 49.92 E-value: 1.13e-06
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| COG4559 | COG4559 | ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; |
702-814 | 1.28e-06 | ||||||||||||||
ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 443620 [Multi-domain] Cd Length: 258 Bit Score: 50.50 E-value: 1.28e-06
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
721-794 | 1.52e-06 | ||||||||||||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 49.23 E-value: 1.52e-06
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| ABC_CcmA_heme_exporter | cd03231 | Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
374-438 | 1.84e-06 | ||||||||||||||
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE. Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 49.41 E-value: 1.84e-06
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| ABC_RNaseL_inhibitor_domain1 | cd03236 | The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ... |
720-793 | 2.16e-06 | ||||||||||||||
The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI s are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLIs have an N-terminal Fe-S domain and two nucleotide binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology. Pssm-ID: 213203 [Multi-domain] Cd Length: 255 Bit Score: 50.06 E-value: 2.16e-06
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| F420-0_ABC_ATP | TIGR03873 | proposed F420-0 ABC transporter, ATP-binding protein; This small clade of ABC-type transporter ... |
704-814 | 2.71e-06 | ||||||||||||||
proposed F420-0 ABC transporter, ATP-binding protein; This small clade of ABC-type transporter ATP-binding protein components is found as a three gene cassette along with a periplasmic substrate-binding protein (TIGR03868) and a permease (TIGR03869). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with a F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this ATP-binding protein is a component of an F420-0 (that is, F420 lacking only the polyglutamate tail) transporter. Pssm-ID: 163585 [Multi-domain] Cd Length: 256 Bit Score: 49.81 E-value: 2.71e-06
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| ABC_TM1139_LivF_branched | cd03224 | ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ... |
372-475 | 2.89e-06 | ||||||||||||||
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 48.97 E-value: 2.89e-06
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| hmuV | PRK13548 | hemin importer ATP-binding subunit; Provisional |
719-814 | 2.98e-06 | ||||||||||||||
hemin importer ATP-binding subunit; Provisional Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 49.38 E-value: 2.98e-06
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| YbbA | COG4181 | Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ... |
1-51 | 3.25e-06 | ||||||||||||||
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 48.97 E-value: 3.25e-06
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| fecE | PRK11231 | Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
338-468 | 3.88e-06 | ||||||||||||||
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 49.24 E-value: 3.88e-06
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
20-47 | 5.52e-06 | ||||||||||||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 48.23 E-value: 5.52e-06
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| PRK10247 | PRK10247 | putative ABC transporter ATP-binding protein YbbL; Provisional |
336-458 | 5.54e-06 | ||||||||||||||
putative ABC transporter ATP-binding protein YbbL; Provisional Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 48.17 E-value: 5.54e-06
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| ABC_RNaseL_inhibitor_domain2 | cd03237 | The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ... |
662-793 | 5.68e-06 | ||||||||||||||
The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology. Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 48.56 E-value: 5.68e-06
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| LolD | COG1136 | ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; |
20-46 | 5.83e-06 | ||||||||||||||
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 48.12 E-value: 5.83e-06
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| FtsE | COG2884 | Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning]; |
20-54 | 6.14e-06 | ||||||||||||||
Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 48.13 E-value: 6.14e-06
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| cbiO | PRK13640 | energy-coupling factor transporter ATPase; |
702-819 | 6.92e-06 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 48.64 E-value: 6.92e-06
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| cbiO | PRK13641 | energy-coupling factor transporter ATPase; |
691-826 | 7.05e-06 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 48.67 E-value: 7.05e-06
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| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
20-47 | 7.95e-06 | ||||||||||||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 49.45 E-value: 7.95e-06
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| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
719-818 | 8.13e-06 | ||||||||||||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 47.88 E-value: 8.13e-06
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| ABC_Class2 | cd03227 | ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
370-454 | 8.35e-06 | ||||||||||||||
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins. Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 46.58 E-value: 8.35e-06
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| anch_rpt_ABC | TIGR03771 | anchored repeat-type ABC transporter, ATP-binding subunit; This protein family is the ... |
721-811 | 1.21e-05 | ||||||||||||||
anchored repeat-type ABC transporter, ATP-binding subunit; This protein family is the ATP-binding cassette subunit of binding protein-dependent ABC transporter complex that strictly co-occurs with TIGR03769. TIGRFAMs model TIGR03769 describes a protein domain that occurs singly or as one of up to three repeats in proteins of a number of Actinobacteria, including Propionibacterium acnes KPA171202. The TIGR03769 domain occurs both in an adjacent gene for the substrate-binding protein and in additional (often nearby) proteins, often with LPXTG-like sortase recognition signals. Homologous ATP-binding subunits outside the scope of this family include manganese transporter MntA in Synechocystis sp. PCC 6803 and chelated iron transporter subunits. The function of this transporter complex is unknown. [Transport and binding proteins, Unknown substrate] Pssm-ID: 163483 [Multi-domain] Cd Length: 223 Bit Score: 47.15 E-value: 1.21e-05
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
8-48 | 1.26e-05 | ||||||||||||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 46.08 E-value: 1.26e-05
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| fecE | PRK11231 | Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
720-811 | 1.27e-05 | ||||||||||||||
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 47.70 E-value: 1.27e-05
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| PRK13633 | PRK13633 | energy-coupling factor transporter ATPase; |
721-811 | 1.38e-05 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 237453 [Multi-domain] Cd Length: 280 Bit Score: 47.77 E-value: 1.38e-05
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| ABC_NikE_OppD_transporters | cd03257 | ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
9-51 | 1.71e-05 | ||||||||||||||
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF. Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 46.73 E-value: 1.71e-05
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| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
704-811 | 1.81e-05 | ||||||||||||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 48.29 E-value: 1.81e-05
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| TauB | COG1116 | ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ... |
20-46 | 1.91e-05 | ||||||||||||||
ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 47.01 E-value: 1.91e-05
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| cbiO | PRK13634 | cobalt transporter ATP-binding subunit; Provisional |
362-481 | 1.95e-05 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 47.32 E-value: 1.95e-05
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| livF | PRK11614 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF; |
721-795 | 1.96e-05 | ||||||||||||||
high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF; Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 46.80 E-value: 1.96e-05
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
376-450 | 1.99e-05 | ||||||||||||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 45.77 E-value: 1.99e-05
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| ABC_MJ0796_LolCDE_FtsE | cd03255 | ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
20-46 | 2.88e-05 | ||||||||||||||
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane. Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 45.94 E-value: 2.88e-05
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| cbiO | PRK13650 | energy-coupling factor transporter ATPase; |
719-811 | 3.02e-05 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 46.65 E-value: 3.02e-05
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| PRK13409 | PRK13409 | ribosome biogenesis/translation initiation ATPase RLI; |
721-831 | 3.29e-05 | ||||||||||||||
ribosome biogenesis/translation initiation ATPase RLI; Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 47.50 E-value: 3.29e-05
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| livG | PRK11300 | leucine/isoleucine/valine transporter ATP-binding subunit; Provisional |
743-826 | 3.32e-05 | ||||||||||||||
leucine/isoleucine/valine transporter ATP-binding subunit; Provisional Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 46.14 E-value: 3.32e-05
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| DnaJ_CXXCXGXG | pfam00684 | DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four ... |
631-661 | 3.41e-05 | ||||||||||||||
DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found. Pssm-ID: 459904 [Multi-domain] Cd Length: 65 Bit Score: 42.16 E-value: 3.41e-05
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| ABC_RNaseL_inhibitor | cd03222 | ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a ... |
379-474 | 3.86e-05 | ||||||||||||||
ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins, and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains, which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology. Pssm-ID: 213189 [Multi-domain] Cd Length: 177 Bit Score: 45.26 E-value: 3.86e-05
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| ABC_DR_subfamily_A | cd03230 | ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ... |
721-792 | 4.09e-05 | ||||||||||||||
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 44.70 E-value: 4.09e-05
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| DnaJ_zf | cd10719 | Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ... |
631-661 | 4.24e-05 | ||||||||||||||
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding. Pssm-ID: 199908 [Multi-domain] Cd Length: 65 Bit Score: 42.24 E-value: 4.24e-05
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| cbiO | PRK13638 | energy-coupling factor ABC transporter ATP-binding protein; |
684-811 | 4.45e-05 | ||||||||||||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 46.15 E-value: 4.45e-05
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| ABCC_Hemolysin | cd03252 | ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ... |
675-810 | 4.78e-05 | ||||||||||||||
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy. Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 45.55 E-value: 4.78e-05
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| ABCC_MRP_Like | cd03228 | ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ... |
721-794 | 6.31e-05 | ||||||||||||||
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 44.30 E-value: 6.31e-05
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| ABC_FtsE | cd03292 | Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
377-455 | 6.40e-05 | ||||||||||||||
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 45.09 E-value: 6.40e-05
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| PRK13539 | PRK13539 | cytochrome c biogenesis protein CcmA; Provisional |
362-458 | 6.89e-05 | ||||||||||||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 44.86 E-value: 6.89e-05
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| Rli1 | COG1245 | Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ... |
721-830 | 7.01e-05 | ||||||||||||||
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 46.32 E-value: 7.01e-05
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| hmuV | PRK13548 | hemin importer ATP-binding subunit; Provisional |
362-470 | 7.41e-05 | ||||||||||||||
hemin importer ATP-binding subunit; Provisional Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 45.15 E-value: 7.41e-05
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| ssuB | PRK11247 | aliphatic sulfonates transport ATP-binding subunit; Provisional |
20-46 | 8.25e-05 | ||||||||||||||
aliphatic sulfonates transport ATP-binding subunit; Provisional Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 45.05 E-value: 8.25e-05
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| ABC_Carb_Monos_I | cd03216 | First domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
721-792 | 8.44e-05 | ||||||||||||||
First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter. Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 43.96 E-value: 8.44e-05
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
352-472 | 8.51e-05 | ||||||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 46.05 E-value: 8.51e-05
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| FetA | COG4619 | ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism]; |
701-796 | 9.94e-05 | ||||||||||||||
ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 443661 [Multi-domain] Cd Length: 209 Bit Score: 44.42 E-value: 9.94e-05
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| ABC_NrtD_SsuB_transporters | cd03293 | ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
20-46 | 1.05e-04 | ||||||||||||||
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 44.38 E-value: 1.05e-04
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| PRK10619 | PRK10619 | histidine ABC transporter ATP-binding protein HisP; |
721-830 | 1.12e-04 | ||||||||||||||
histidine ABC transporter ATP-binding protein HisP; Pssm-ID: 182592 [Multi-domain] Cd Length: 257 Bit Score: 44.57 E-value: 1.12e-04
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| NupO | COG3845 | ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
362-438 | 1.12e-04 | ||||||||||||||
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism]; Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 45.79 E-value: 1.12e-04
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| PRK03695 | PRK03695 | vitamin B12-transporter ATPase; Provisional |
713-811 | 1.30e-04 | ||||||||||||||
vitamin B12-transporter ATPase; Provisional Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 44.54 E-value: 1.30e-04
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| DnaJ_CXXCXGXG | pfam00684 | DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four ... |
631-660 | 1.31e-04 | ||||||||||||||
DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found. Pssm-ID: 459904 [Multi-domain] Cd Length: 65 Bit Score: 40.62 E-value: 1.31e-04
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| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
20-47 | 1.41e-04 | ||||||||||||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 45.54 E-value: 1.41e-04
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| ABCC_MRP_domain2 | cd03244 | ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ... |
20-47 | 1.65e-04 | ||||||||||||||
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 43.64 E-value: 1.65e-04
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| ABC_MJ0796_LolCDE_FtsE | cd03255 | ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
363-452 | 1.76e-04 | ||||||||||||||
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane. Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 43.63 E-value: 1.76e-04
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| met_CoM_red_A2 | TIGR03269 | methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
379-543 | 1.89e-04 | ||||||||||||||
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis] Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 44.79 E-value: 1.89e-04
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| artP | PRK11124 | arginine transporter ATP-binding subunit; Provisional |
721-827 | 1.97e-04 | ||||||||||||||
arginine transporter ATP-binding subunit; Provisional Pssm-ID: 182980 [Multi-domain] Cd Length: 242 Bit Score: 43.85 E-value: 1.97e-04
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| PRK11174 | PRK11174 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
678-818 | 2.40e-04 | ||||||||||||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 44.84 E-value: 2.40e-04
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| PRK03695 | PRK03695 | vitamin B12-transporter ATPase; Provisional |
363-439 | 2.60e-04 | ||||||||||||||
vitamin B12-transporter ATPase; Provisional Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 43.38 E-value: 2.60e-04
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| ABCC_Protease_Secretion | cd03246 | ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
20-47 | 2.84e-04 | ||||||||||||||
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA. Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 42.59 E-value: 2.84e-04
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| ABC_RNaseL_inhibitor_domain2 | cd03237 | The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ... |
362-460 | 2.92e-04 | ||||||||||||||
The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology. Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 43.17 E-value: 2.92e-04
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| DnaJ_bact | TIGR02349 | chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ... |
631-670 | 2.92e-04 | ||||||||||||||
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family. Pssm-ID: 274090 [Multi-domain] Cd Length: 354 Bit Score: 44.13 E-value: 2.92e-04
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
20-48 | 2.93e-04 | ||||||||||||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 41.86 E-value: 2.93e-04
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| AAA_21 | pfam13304 | AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ... |
667-786 | 3.27e-04 | ||||||||||||||
AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system. Pssm-ID: 433102 [Multi-domain] Cd Length: 303 Bit Score: 43.53 E-value: 3.27e-04
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| PRK10767 | PRK10767 | chaperone protein DnaJ; Provisional |
630-670 | 3.43e-04 | ||||||||||||||
chaperone protein DnaJ; Provisional Pssm-ID: 236757 [Multi-domain] Cd Length: 371 Bit Score: 43.59 E-value: 3.43e-04
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| ABC_ThiQ_thiamine_transporter | cd03298 | ATP-binding cassette domain of the thiamine transport system; Part of the ... |
364-467 | 3.46e-04 | ||||||||||||||
ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 42.87 E-value: 3.46e-04
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| Rli1 | COG1245 | Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ... |
362-443 | 3.51e-04 | ||||||||||||||
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 44.00 E-value: 3.51e-04
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| PRK10535 | PRK10535 | macrolide ABC transporter ATP-binding protein/permease MacB; |
709-820 | 3.81e-04 | ||||||||||||||
macrolide ABC transporter ATP-binding protein/permease MacB; Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 43.94 E-value: 3.81e-04
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| ABC_putative_ATPase | cd03269 | ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ... |
378-467 | 3.82e-04 | ||||||||||||||
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 42.65 E-value: 3.82e-04
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| DnaJ_zf | cd10719 | Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ... |
631-660 | 3.94e-04 | ||||||||||||||
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding. Pssm-ID: 199908 [Multi-domain] Cd Length: 65 Bit Score: 39.16 E-value: 3.94e-04
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| ABC_Class2 | cd03227 | ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
12-57 | 3.95e-04 | ||||||||||||||
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins. Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 41.96 E-value: 3.95e-04
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| cbiO | PRK13648 | cobalt transporter ATP-binding subunit; Provisional |
720-811 | 4.01e-04 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 43.20 E-value: 4.01e-04
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| phnK | PRK11701 | phosphonate C-P lyase system protein PhnK; Provisional |
377-439 | 4.69e-04 | ||||||||||||||
phosphonate C-P lyase system protein PhnK; Provisional Pssm-ID: 183280 [Multi-domain] Cd Length: 258 Bit Score: 42.99 E-value: 4.69e-04
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| ABC_PhnC_transporter | cd03256 | ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ... |
20-113 | 4.73e-04 | ||||||||||||||
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 42.56 E-value: 4.73e-04
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| PRK02224 | PRK02224 | DNA double-strand break repair Rad50 ATPase; |
403-452 | 4.83e-04 | ||||||||||||||
DNA double-strand break repair Rad50 ATPase; Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 43.88 E-value: 4.83e-04
|
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| PRK11176 | PRK11176 | lipid A ABC transporter ATP-binding protein/permease MsbA; |
20-47 | 5.13e-04 | ||||||||||||||
lipid A ABC transporter ATP-binding protein/permease MsbA; Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 43.47 E-value: 5.13e-04
|
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| PhnL | COG4778 | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion ... |
722-797 | 5.15e-04 | ||||||||||||||
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism]; Pssm-ID: 443809 [Multi-domain] Cd Length: 229 Bit Score: 42.42 E-value: 5.15e-04
|
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| PRK10938 | PRK10938 | putative molybdenum transport ATP-binding protein ModF; Provisional |
363-774 | 5.56e-04 | ||||||||||||||
putative molybdenum transport ATP-binding protein ModF; Provisional Pssm-ID: 182852 [Multi-domain] Cd Length: 490 Bit Score: 43.46 E-value: 5.56e-04
|
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| YhaQ | COG4152 | ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ... |
721-810 | 5.72e-04 | ||||||||||||||
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Pssm-ID: 443322 [Multi-domain] Cd Length: 298 Bit Score: 42.79 E-value: 5.72e-04
|
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| ABC_HisP_GlnQ | cd03262 | ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ... |
16-71 | 5.75e-04 | ||||||||||||||
ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein. Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 42.13 E-value: 5.75e-04
|
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| cbiO | PRK13652 | cobalt transporter ATP-binding subunit; Provisional |
365-472 | 5.90e-04 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 172200 [Multi-domain] Cd Length: 277 Bit Score: 42.48 E-value: 5.90e-04
|
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| ABC_NikE_OppD_transporters | cd03257 | ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
721-809 | 6.00e-04 | ||||||||||||||
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF. Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 42.11 E-value: 6.00e-04
|
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| cbiO | PRK13644 | energy-coupling factor transporter ATPase; |
706-819 | 6.40e-04 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 42.67 E-value: 6.40e-04
|
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| PRK14291 | PRK14291 | chaperone protein DnaJ; Provisional |
631-662 | 6.53e-04 | ||||||||||||||
chaperone protein DnaJ; Provisional Pssm-ID: 237661 [Multi-domain] Cd Length: 382 Bit Score: 42.83 E-value: 6.53e-04
|
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| PRK10895 | PRK10895 | lipopolysaccharide ABC transporter ATP-binding protein; Provisional |
362-439 | 6.85e-04 | ||||||||||||||
lipopolysaccharide ABC transporter ATP-binding protein; Provisional Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 42.19 E-value: 6.85e-04
|
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
9-51 | 6.88e-04 | ||||||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 42.97 E-value: 6.88e-04
|
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| PRK11264 | PRK11264 | putative amino-acid ABC transporter ATP-binding protein YecC; Provisional |
20-113 | 7.00e-04 | ||||||||||||||
putative amino-acid ABC transporter ATP-binding protein YecC; Provisional Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 42.04 E-value: 7.00e-04
|
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| ABC_Carb_Monos_I | cd03216 | First domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
379-438 | 7.85e-04 | ||||||||||||||
First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter. Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 40.87 E-value: 7.85e-04
|
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| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
720-794 | 8.43e-04 | ||||||||||||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 41.02 E-value: 8.43e-04
|
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| PRK13409 | PRK13409 | ribosome biogenesis/translation initiation ATPase RLI; |
362-460 | 8.63e-04 | ||||||||||||||
ribosome biogenesis/translation initiation ATPase RLI; Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 42.87 E-value: 8.63e-04
|
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| ABC_FeS_Assembly | cd03217 | ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ... |
20-48 | 8.66e-04 | ||||||||||||||
ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet. Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 41.36 E-value: 8.66e-04
|
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| ABC_FtsE | cd03292 | Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
721-787 | 9.60e-04 | ||||||||||||||
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 41.62 E-value: 9.60e-04
|
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| xylG | TIGR02633 | D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ... |
362-544 | 9.60e-04 | ||||||||||||||
D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose isomerase and xylulokinase enzymes for xylose utilization. Members of this protein family are the ATP-binding cassette (ABC) subunit of the known or predicted high-affinity xylose ABC transporter for xylose import. These genes, which closely resemble other sugar transport ABC transporter genes, typically are encoded near xylose utilization enzymes and regulatory proteins. Note that this form of the transporter contains two copies of the ABC transporter domain (pfam00005). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 42.50 E-value: 9.60e-04
|
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| cbiO | PRK13647 | cobalt transporter ATP-binding subunit; Provisional |
745-811 | 9.78e-04 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 42.03 E-value: 9.78e-04
|
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| ABC_PstB_phosphate_transporter | cd03260 | ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ... |
20-46 | 1.00e-03 | ||||||||||||||
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD). Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 41.40 E-value: 1.00e-03
|
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| ABCC_MsbA | cd03251 | ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ... |
13-47 | 1.02e-03 | ||||||||||||||
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 41.45 E-value: 1.02e-03
|
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| PRK10790 | PRK10790 | SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; |
20-90 | 1.05e-03 | ||||||||||||||
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 42.40 E-value: 1.05e-03
|
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| potG | PRK11607 | putrescine ABC transporter ATP-binding subunit PotG; |
721-820 | 1.46e-03 | ||||||||||||||
putrescine ABC transporter ATP-binding subunit PotG; Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 41.74 E-value: 1.46e-03
|
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| PRK10535 | PRK10535 | macrolide ABC transporter ATP-binding protein/permease MacB; |
365-455 | 1.52e-03 | ||||||||||||||
macrolide ABC transporter ATP-binding protein/permease MacB; Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 42.02 E-value: 1.52e-03
|
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| PRK14283 | PRK14283 | chaperone protein DnaJ; Provisional |
145-182 | 1.53e-03 | ||||||||||||||
chaperone protein DnaJ; Provisional Pssm-ID: 184604 [Multi-domain] Cd Length: 378 Bit Score: 41.73 E-value: 1.53e-03
|
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| MalK | COG3839 | ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ... |
20-46 | 1.56e-03 | ||||||||||||||
ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 41.60 E-value: 1.56e-03
|
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| glnQ | PRK09493 | glutamine ABC transporter ATP-binding protein GlnQ; |
721-820 | 1.68e-03 | ||||||||||||||
glutamine ABC transporter ATP-binding protein GlnQ; Pssm-ID: 181906 [Multi-domain] Cd Length: 240 Bit Score: 40.85 E-value: 1.68e-03
|
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| cbiO | PRK13631 | cobalt transporter ATP-binding subunit; Provisional |
347-455 | 1.81e-03 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 41.37 E-value: 1.81e-03
|
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| ABC_YhbG | cd03218 | ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the ... |
349-477 | 2.05e-03 | ||||||||||||||
ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium. Pssm-ID: 213185 [Multi-domain] Cd Length: 232 Bit Score: 40.60 E-value: 2.05e-03
|
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| MsbA_lipidA | TIGR02203 | lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide ... |
13-47 | 2.29e-03 | ||||||||||||||
lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide chain transporter in the ATP-binding cassette (ABC) transporter family, MsbA, which exports lipid A. It may also act in multidrug resistance. Lipid A, a part of lipopolysaccharide, is found in the outer leaflet of the outer membrane of most Gram-negative bacteria. Members of this family are restricted to the Proteobacteria (although lipid A is more broadly distributed) and often are clustered with lipid A biosynthesis genes. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other] Pssm-ID: 131258 [Multi-domain] Cd Length: 571 Bit Score: 41.63 E-value: 2.29e-03
|
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| PRK13651 | PRK13651 | cobalt transporter ATP-binding subunit; Provisional |
362-439 | 2.33e-03 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 40.84 E-value: 2.33e-03
|
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| 3a01204 | TIGR00955 | The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ... |
702-811 | 2.66e-03 | ||||||||||||||
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 41.19 E-value: 2.66e-03
|
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| cbiO | PRK13632 | cobalt transporter ATP-binding subunit; Provisional |
13-46 | 2.71e-03 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 40.36 E-value: 2.71e-03
|
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| ABCC_ATM1_transporter | cd03253 | ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ... |
714-811 | 2.77e-03 | ||||||||||||||
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 40.29 E-value: 2.77e-03
|
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| MlaF | COG1127 | ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ... |
20-46 | 3.22e-03 | ||||||||||||||
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 39.96 E-value: 3.22e-03
|
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| ABC_Rad50 | cd03240 | ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ... |
372-454 | 3.23e-03 | ||||||||||||||
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence. Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 39.90 E-value: 3.23e-03
|
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| DnaJ_zf | cd10719 | Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ... |
145-179 | 3.43e-03 | ||||||||||||||
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding. Pssm-ID: 199908 [Multi-domain] Cd Length: 65 Bit Score: 36.85 E-value: 3.43e-03
|
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| znuC | PRK09544 | high-affinity zinc transporter ATPase; Reviewed |
721-818 | 3.62e-03 | ||||||||||||||
high-affinity zinc transporter ATPase; Reviewed Pssm-ID: 181939 [Multi-domain] Cd Length: 251 Bit Score: 40.10 E-value: 3.62e-03
|
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| ABCD_peroxisomal_ALDP | cd03223 | ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
20-121 | 3.82e-03 | ||||||||||||||
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic). Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 39.06 E-value: 3.82e-03
|
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| PRK14276 | PRK14276 | chaperone protein DnaJ; Provisional |
631-670 | 3.87e-03 | ||||||||||||||
chaperone protein DnaJ; Provisional Pssm-ID: 237653 [Multi-domain] Cd Length: 380 Bit Score: 40.46 E-value: 3.87e-03
|
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| cbiO | PRK13644 | energy-coupling factor transporter ATPase; |
20-58 | 4.17e-03 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 39.97 E-value: 4.17e-03
|
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| PRK14281 | PRK14281 | chaperone protein DnaJ; Provisional |
613-670 | 4.24e-03 | ||||||||||||||
chaperone protein DnaJ; Provisional Pssm-ID: 237657 [Multi-domain] Cd Length: 397 Bit Score: 40.56 E-value: 4.24e-03
|
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| PRK11160 | PRK11160 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
701-810 | 4.30e-03 | ||||||||||||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 40.58 E-value: 4.30e-03
|
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| PRK11160 | PRK11160 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
20-46 | 4.45e-03 | ||||||||||||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 40.58 E-value: 4.45e-03
|
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| YbjD | COG3593 | Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ... |
379-447 | 4.46e-03 | ||||||||||||||
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair]; Pssm-ID: 442812 [Multi-domain] Cd Length: 359 Bit Score: 40.37 E-value: 4.46e-03
|
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| ssuB | PRK11247 | aliphatic sulfonates transport ATP-binding subunit; Provisional |
720-792 | 4.75e-03 | ||||||||||||||
aliphatic sulfonates transport ATP-binding subunit; Provisional Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 39.66 E-value: 4.75e-03
|
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| PRK10619 | PRK10619 | histidine ABC transporter ATP-binding protein HisP; |
362-439 | 4.77e-03 | ||||||||||||||
histidine ABC transporter ATP-binding protein HisP; Pssm-ID: 182592 [Multi-domain] Cd Length: 257 Bit Score: 39.57 E-value: 4.77e-03
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| btuD | PRK09536 | corrinoid ABC transporter ATPase; Reviewed |
721-819 | 5.14e-03 | ||||||||||||||
corrinoid ABC transporter ATPase; Reviewed Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 40.21 E-value: 5.14e-03
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| NupO | COG3845 | ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
721-791 | 5.60e-03 | ||||||||||||||
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism]; Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 40.01 E-value: 5.60e-03
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| PRK10247 | PRK10247 | putative ABC transporter ATP-binding protein YbbL; Provisional |
708-799 | 5.83e-03 | ||||||||||||||
putative ABC transporter ATP-binding protein YbbL; Provisional Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 39.31 E-value: 5.83e-03
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| cbiO | PRK13637 | energy-coupling factor transporter ATPase; |
20-46 | 5.94e-03 | ||||||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 237455 [Multi-domain] Cd Length: 287 Bit Score: 39.65 E-value: 5.94e-03
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| DppF | COG1124 | ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ... |
20-47 | 5.94e-03 | ||||||||||||||
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism]; Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 39.40 E-value: 5.94e-03
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| cbiO | PRK13636 | cobalt transporter ATP-binding subunit; Provisional |
362-479 | 6.04e-03 | ||||||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184196 [Multi-domain] Cd Length: 283 Bit Score: 39.45 E-value: 6.04e-03
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| PRK14243 | PRK14243 | phosphate transporter ATP-binding protein; Provisional |
506-557 | 6.24e-03 | ||||||||||||||
phosphate transporter ATP-binding protein; Provisional Pssm-ID: 184588 [Multi-domain] Cd Length: 264 Bit Score: 39.38 E-value: 6.24e-03
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| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
10-46 | 6.58e-03 | ||||||||||||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 39.02 E-value: 6.58e-03
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| MK0520 | COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
20-46 | 6.65e-03 | ||||||||||||||
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 38.79 E-value: 6.65e-03
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| livG | PRK11300 | leucine/isoleucine/valine transporter ATP-binding subunit; Provisional |
362-475 | 6.89e-03 | ||||||||||||||
leucine/isoleucine/valine transporter ATP-binding subunit; Provisional Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 39.20 E-value: 6.89e-03
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| PRK11831 | PRK11831 | phospholipid ABC transporter ATP-binding protein MlaF; |
377-488 | 7.05e-03 | ||||||||||||||
phospholipid ABC transporter ATP-binding protein MlaF; Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 39.36 E-value: 7.05e-03
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| CydC | TIGR02868 | thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ... |
20-48 | 7.07e-03 | ||||||||||||||
thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 40.04 E-value: 7.07e-03
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| YejF | COG4172 | ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ... |
20-75 | 7.08e-03 | ||||||||||||||
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 39.67 E-value: 7.08e-03
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| livF | PRK11614 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF; |
378-439 | 8.26e-03 | ||||||||||||||
high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF; Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 38.71 E-value: 8.26e-03
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| ABC_putative_ATPase | cd03269 | ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ... |
721-809 | 8.51e-03 | ||||||||||||||
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 38.42 E-value: 8.51e-03
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| AbcC | COG1135 | ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; |
11-71 | 9.02e-03 | ||||||||||||||
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 39.29 E-value: 9.02e-03
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| ABCC_Glucan_exporter_like | cd03254 | ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ... |
20-47 | 9.06e-03 | ||||||||||||||
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 38.75 E-value: 9.06e-03
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| PRK11264 | PRK11264 | putative amino-acid ABC transporter ATP-binding protein YecC; Provisional |
721-830 | 9.16e-03 | ||||||||||||||
putative amino-acid ABC transporter ATP-binding protein YecC; Provisional Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 38.58 E-value: 9.16e-03
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
20-47 | 9.74e-03 | ||||||||||||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 38.06 E-value: 9.74e-03
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| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
20-46 | 9.96e-03 | ||||||||||||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 37.94 E-value: 9.96e-03
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