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Conserved domains on  [gi|943890050|ref|WP_055528321|]
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MULTISPECIES: GNAT family N-acetyltransferase [Terrabacteria group]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
8-196 1.16e-15

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 70.50  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050   8 VRLATRDDVPRAVRTLAAAFAdypatrhtvdPDRHIERVTELQElfltrvGLDIGKVWVADDGAAVAvwttpesveaGAV 87
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG----------PGREAELVDRLRE------DPAAGLSLVAEDDGEIV----------GHV 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050  88 FAEIgprmaelsgsrlaaqqqmegllAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRN 167
Cdd:COG3153   55 ALSP----------------------VDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL 112

                        170       180
                 ....*....|....*....|....*....
gi 943890050 168 LPFYERLGFTVTADVEVPEGPRTWCMTRK 196
Cdd:COG3153  113 LPFYERFGFRPAGELGLTLGPDEVFLAKE 141
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
8-196 1.16e-15

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 70.50  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050   8 VRLATRDDVPRAVRTLAAAFAdypatrhtvdPDRHIERVTELQElfltrvGLDIGKVWVADDGAAVAvwttpesveaGAV 87
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG----------PGREAELVDRLRE------DPAAGLSLVAEDDGEIV----------GHV 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050  88 FAEIgprmaelsgsrlaaqqqmegllAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRN 167
Cdd:COG3153   55 ALSP----------------------VDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL 112

                        170       180
                 ....*....|....*....|....*....
gi 943890050 168 LPFYERLGFTVTADVEVPEGPRTWCMTRK 196
Cdd:COG3153  113 LPFYERFGFRPAGELGLTLGPDEVFLAKE 141
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 128-178 6.89e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.92  E-value: 6.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 943890050  128 VGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTV 178
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 112-159 3.48e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 3.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 943890050 112 LLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAF 159
Cdd:cd04301   15 SLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PRK07757 PRK07757
N-acetyltransferase;
130-186 1.25e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 37.87  E-value: 1.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 943890050 130 VSPDHQGKGLGSAVVLPGVEAAERAGVPA-FLETSAPRnlpFYERLGFTVTADVEVPE 186
Cdd:PRK07757  73 VSEDYRGQGIGRMLVEACLEEARELGVKRvFALTYQPE---FFEKLGFREVDKEALPQ 127
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
8-196 1.16e-15

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 70.50  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050   8 VRLATRDDVPRAVRTLAAAFAdypatrhtvdPDRHIERVTELQElfltrvGLDIGKVWVADDGAAVAvwttpesveaGAV 87
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG----------PGREAELVDRLRE------DPAAGLSLVAEDDGEIV----------GHV 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050  88 FAEIgprmaelsgsrlaaqqqmegllAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRN 167
Cdd:COG3153   55 ALSP----------------------VDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL 112

                        170       180
                 ....*....|....*....|....*....
gi 943890050 168 LPFYERLGFTVTADVEVPEGPRTWCMTRK 196
Cdd:COG3153  113 LPFYERFGFRPAGELGLTLGPDEVFLAKE 141
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 112-196 2.49e-11

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 57.74  E-value: 2.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050 112 LLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVP-AFLETSA--PRNLPFYERLGFTVTADVEVPEGP 188
Cdd:COG0456    3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARrLRLEVREdnEAAIALYEKLGFEEVGERPNYYGD 82


                 ....*...
gi 943890050 189 RTWCMTRK 196
Cdd:COG0456   83 DALVMEKE 90
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 128-178 6.89e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.92  E-value: 6.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 943890050  128 VGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTV 178
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 116-192 7.93e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 51.92  E-value: 7.93e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943890050 116 HRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPA-FLETSaPRNLPFYERLGFTVTADVEVPEGPRTWC 192
Cdd:COG1246   46 HPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRlFLLTT-SAAIHFYEKLGFEEIDKEDLPYAKVWQR 122
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 111-176 2.21e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.21  E-value: 2.21e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 943890050  111 GLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPA-FLETSAP--RNLPFYERLGF 176
Cdd:pfam00583  48 ASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERiFLEVAADnlAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
7-183 6.92e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.99  E-value: 6.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050   7 TVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRhiervtELQELFLTRVGLDIGKVWVA-DDGAAVAvwttpesveag 85
Cdd:COG1247    3 TIRPATPEDAPAIAAIYNEAIAEGTATFETEPPSE------EEREAWFAAILAPGRPVLVAeEDGEVVG----------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050  86 avFAEIGPRmaelsgsrlaaqqqmegllaPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAP 165
Cdd:COG1247   66 --FASLGPF--------------------RPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLA 123

                        170       180
                 ....*....|....*....|.
gi 943890050 166 RN---LPFYERLGFTVTADVE 183
Cdd:COG1247  124 DNeasIALYEKLGFEEVGTLP 144
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 124-188 1.39e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.51  E-value: 1.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 943890050 124 FLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAF-LETSA--PRNLPFYERLGFTVTADVEVPEGP 188
Cdd:COG0454   60 ELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALeLDTLDgnPAAIRFYERLGFKEIERYVAYVGG 127
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
128-181 2.30e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 44.13  E-value: 2.30e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 943890050 128 VGVSPDHQGKGLGSAVVLPGVEAAERAGVP-AFLETSA--PRNLPFYERLGFTVTAD 181
Cdd:COG3393   21 VYTHPEYRGRGLASALVAALAREALARGARtPFLYVDAdnPAARRLYERLGFRPVGE 77
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
128-182 1.34e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 42.86  E-value: 1.34e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 943890050 128 VGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADV 182
Cdd:COG2153   64 VAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEE 118
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 130-187 1.16e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 40.33  E-value: 1.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 943890050  130 VSPDHQGKGLGSAVVLPGVEAAERAG--VPAFLETSAPRNLPFYERLGFTVTADVEVPEG 187
Cdd:pfam13673  59 VDPDYQGQGIGKALLEAVEDYAEKDGikLSELTVNASPYAVPFYEKLGFRATGPEQEFNG 118
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 112-159 3.48e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 37.64  E-value: 3.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 943890050 112 LLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAF 159
Cdd:cd04301   15 SLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PRK07757 PRK07757
N-acetyltransferase;
130-186 1.25e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 37.87  E-value: 1.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 943890050 130 VSPDHQGKGLGSAVVLPGVEAAERAGVPA-FLETSAPRnlpFYERLGFTVTADVEVPE 186
Cdd:PRK07757  73 VSEDYRGQGIGRMLVEACLEEARELGVKRvFALTYQPE---FFEKLGFREVDKEALPQ 127
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 128-177 1.97e-03

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 37.38  E-value: 1.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 943890050 128 VGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFT 177
Cdd:PLN02706  91 VVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYV 140
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 124-178 7.57e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 34.23  E-value: 7.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 943890050  124 FLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETsAPRNLP---FYERLGFTV 178
Cdd:pfam08445  23 ELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVV-VAGNTPsrrLYEKLGFRK 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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