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Conserved domains on  [gi|1092623841|ref|WP_070570812|]
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MULTISPECIES: carboxylesterase [Staphylococcus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-244 1.71e-62

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 195.93  E-value: 1.71e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841   1 MRIKTPSPSYLKGTNgHAILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEKAYQFL 80
Cdd:COG1647     1 MKILGAEPFFLEGGR-KGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  81 vNEGYESISATGVSLGGLMTLKLAQHYP-LKRIAVMSAP-KEKSDDGLIEHLVYYSQRMSNILNLDQQASSAQLAAIDDY 158
Cdd:COG1647    80 -KAGYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPAlKIDDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841 159 EVE-ITKFQHFIDDIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGSVDKELNGLKDSHHLMTHGEGRDILEENII 237
Cdd:COG1647   159 PLRaLAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEIL 238


                  ....*..
gi 1092623841 238 RFFNALT 244
Cdd:COG1647   239 DFLERLA 245
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-244 1.71e-62

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 195.93  E-value: 1.71e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841   1 MRIKTPSPSYLKGTNgHAILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEKAYQFL 80
Cdd:COG1647     1 MKILGAEPFFLEGGR-KGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  81 vNEGYESISATGVSLGGLMTLKLAQHYP-LKRIAVMSAP-KEKSDDGLIEHLVYYSQRMSNILNLDQQASSAQLAAIDDY 158
Cdd:COG1647    80 -KAGYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPAlKIDDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841 159 EVE-ITKFQHFIDDIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGSVDKELNGLKDSHHLMTHGEGRDILEENII 237
Cdd:COG1647   159 PLRaLAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEIL 238


                  ....*..
gi 1092623841 238 RFFNALT 244
Cdd:COG1647   239 DFLERLA 245
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 18-154 8.77e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.35  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHG-----LLLKDFITYNVDDWWEEVEKAYqflvneGYESISATG 92
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGkssrpKAQDDYRTDDLAEDLEYILEAL------GLEKVNLVG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092623841  93 VSLGGLMTLKLAQHYP--LKRIAVMSA--PKEKSDDGLIEHLVYYSQRMSNILNLDQQASSAQLAA 154
Cdd:pfam00561  76 HSMGGLIALAYAAKYPdrVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVA 141
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 171-241 1.07e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 39.74  E-value: 1.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1092623841 171 DIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGSVDKELNGLKDSHHLMTHGEGrdilEENIIRFFN 241
Cdd:PLN02385  270 EIEMQLEEVSLPLLILHGEADKVTDPSVSKFLYEKASSSDKKLKLYEDAYHSILEGEP----DEMIFQVLD 336
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 18-110 3.31e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 37.87  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSF----TGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEKAYQFLVNEGYESISATGV 93
Cdd:TIGR03101  27 VVIYLPPFaeemNKSRRMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTLWGL 106

                          90
                  ....*....|....*..
gi 1092623841  94 SLGGLMTLKLAQHYPLK 110
Cdd:TIGR03101 107 RLGALLALDAANPLAAK 123
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-244 1.71e-62

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 195.93  E-value: 1.71e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841   1 MRIKTPSPSYLKGTNgHAILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEKAYQFL 80
Cdd:COG1647     1 MKILGAEPFFLEGGR-KGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  81 vNEGYESISATGVSLGGLMTLKLAQHYP-LKRIAVMSAP-KEKSDDGLIEHLVYYSQRMSNILNLDQQASSAQLAAIDDY 158
Cdd:COG1647    80 -KAGYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPAlKIDDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841 159 EVE-ITKFQHFIDDIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGSVDKELNGLKDSHHLMTHGEGRDILEENII 237
Cdd:COG1647   159 PLRaLAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEIL 238


                  ....*..
gi 1092623841 238 RFFNALT 244
Cdd:COG1647   239 DFLERLA 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
18-242 2.65e-17

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 77.73  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGL---LLKDFITYnvDDWWEEVEKAYQFLVNEGYESISATGVS 94
Cdd:COG2267    30 TVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRsdgPRGHVDSF--DDYVDDLRAALDALRARPGLPVVLLGHS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  95 LGGLMTLKLAQHYPlKRIA--VMSAPKEKSDDgliehLVYYSQRMSNILNLDQQASSaqlaaiddyeveitkfqhfiddi 172
Cdd:COG2267   108 MGGLIALLYAARYP-DRVAglVLLAPAYRADP-----LLGPSARWLRALRLAEALAR----------------------- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841 173 mtnlnvVKIPANILFGGKDAPSYETSAHFIYEHLGSvDKELNGLKDSHHLMTHGEGRDILEENIIRFFNA 242
Cdd:COG2267   159 ------IDVPVLVLHGGADRVVPPEAARRLAARLSP-DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 13-243 4.43e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 68.87  E-value: 4.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  13 GTNGHAILLLHSFTGTNRDVKHLAAELNDqGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEkayQFLVNEGYESISATG 92
Cdd:COG0596    20 GPDGPPVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLA---ALLDALGLERVVLVG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  93 VSLGGLMTLKLAQHYP--LKRIAVMsapkeksdDGLIEHLvyysQRMSNILNLDQQASSAQLAAIDDyeveitkfqhfiD 170
Cdd:COG0596    96 HSMGGMVALELAARHPerVAGLVLV--------DEVLAAL----AEPLRRPGLAPEALAALLRALAR------------T 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092623841 171 DIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGsvDKELNGLKDSHHLMtHGEGRDILEENIIRFFNAL 243
Cdd:COG0596   152 DLRERLARITVPTLVIWGEKDPIVPPALARRLAELLP--NAELVVLPGAGHFP-PLEQPEAFAAALRDFLARL 221
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
18-108 1.37e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 59.26  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGT-NRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDwweeVEKAYQFLVNEGY---ESISATGV 93
Cdd:COG1506    25 VVVYVHGGPGSrDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDD----VLAAIDYLAARPYvdpDRIGIYGH 100

                          90
                  ....*....|....*
gi 1092623841  94 SLGGLMTLKLAQHYP 108
Cdd:COG1506   101 SYGGYMALLAAARHP 115
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 18-154 8.77e-08

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.35  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHG-----LLLKDFITYNVDDWWEEVEKAYqflvneGYESISATG 92
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGkssrpKAQDDYRTDDLAEDLEYILEAL------GLEKVNLVG 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092623841  93 VSLGGLMTLKLAQHYP--LKRIAVMSA--PKEKSDDGLIEHLVYYSQRMSNILNLDQQASSAQLAA 154
Cdd:pfam00561  76 HSMGGLIALAYAAKYPdrVKALVLLGAldPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVA 141
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
19-118 9.85e-08

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 51.68  E-value: 9.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  19 ILLLHSFTGTNRD--VKHLAAELNDQGFSCYAPNYPGHG----LLLKdfiTYNVDDWwEEVEKAYQFLVNE-GYESISAT 91
Cdd:COG0429    64 VVLLHGLEGSSDShyARGLARALYARGWDVVRLNFRGCGgepnLLPR---LYHSGDT-EDLVWVLAHLRARyPYAPLYAV 139

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1092623841  92 GVSLGGLMTLKLA-----QHYPLKRIAVMSAP 118
Cdd:COG0429   140 GFSLGGNLLLKYLgeqgdDAPPLKAAVAVSPP 171
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 18-227 1.85e-06

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 47.59  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGL-------------LLKDFITYnVDDWWEEVEKAYQFLVneg 84
Cdd:pfam12146   6 VVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRsdgkrghvpsfddYVDDLDTF-VDKIREEHPGLPLFLL--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  85 yesisatGVSLGGLMTLKLAQHYPLK-RIAVMSAPKEKSDDGLI-EHLVYYSQRMSNIL-------NLDQQASSAQLAAI 155
Cdd:pfam12146  82 -------GHSMGGLIAALYALRYPDKvDGLILSAPALKIKPYLApPILKLLAKLLGKLFprlrvpnNLLPDSLSRDPEVV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841 156 DDYE--------------VEITKFQhfiDDIMTNLNVVKIPANILFGGKDA-PSYETSAHFiYEHLGSVDKELNGLKDSH 220
Cdd:pfam12146 155 AAYAadplvhggisartlYELLDAG---ERLLRRAAAITVPLLLLHGGADRvVDPAGSREF-YERAGSTDKTLKLYPGLY 230


                  ....*..
gi 1092623841 221 HlMTHGE 227
Cdd:pfam12146 231 H-ELLNE 236
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 18-113 2.87e-06

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 46.83  E-value: 2.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGL---LLKDFITYNVDDwweeVEKAYQFLVNEGY---ESISAT 91
Cdd:COG1073    39 AVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGEsegEPREEGSPERRD----ARAAVDYLRTLPGvdpERIGLL 114

                          90       100
                  ....*....|....*....|..
gi 1092623841  92 GVSLGGLMTLKLAQHYPlkRIA 113
Cdd:COG1073   115 GISLGGGYALNAAATDP--RVK 134
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 19-114 3.76e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 46.31  E-value: 3.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  19 ILLLHsftGTNRDVKHLAAELNDqGFSCYAPNYPGHGLLLKDFITYN----VDDWWEEVEKAYQFLVnegyesisaTGVS 94
Cdd:pfam12697   1 VVLVH---GAGLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLDLAdladLAALLDELGAARPVVL---------VGHS 67

                          90       100
                  ....*....|....*....|
gi 1092623841  95 LGGLMTLKLAQHYPLKRIAV 114
Cdd:pfam12697  68 LGGAVALAAAAAALVVGVLV 87
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
18-114 8.05e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 45.34  E-value: 8.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKD-------FITYNVDDWWEEVEKAYQFLVNEGY---ES 87
Cdd:COG0412    31 GVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGDDpdearalMGALDPELLAADLRAALDWLKAQPEvdaGR 110

                          90       100
                  ....*....|....*....|....*..
gi 1092623841  88 ISATGVSLGGLMTLKLAQHYPLKRIAV 114
Cdd:COG0412   111 VGVVGFCFGGGLALLAAARGPDLAAAV 137
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 171-241 1.07e-03

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 39.74  E-value: 1.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1092623841 171 DIMTNLNVVKIPANILFGGKDAPSYETSAHFIYEHLGSVDKELNGLKDSHHLMTHGEGrdilEENIIRFFN 241
Cdd:PLN02385  270 EIEMQLEEVSLPLLILHGEADKVTDPSVSKFLYEKASSSDKKLKLYEDAYHSILEGEP----DEMIFQVLD 336
YpfH COG0400
Predicted esterase [General function prediction only];
13-117 2.05e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.96  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  13 GTNGHAILLLHSFTGTNRDVKHLAAELNDQGFSCYAPN------YPGHG--LLLKDFITYN----------VDDWWEEVE 74
Cdd:COG0400     2 GPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLAPRapvpegPGGRAwfDLSFLEGREDeeglaaaaeaLAAFIDELE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1092623841  75 KAYQFlvneGYESISATGVSLGGLMTLKLAQHYP--LKRIAVMSA 117
Cdd:COG0400    82 ARYGI----DPERIVLAGFSQGAAMALSLALRRPelLAGVVALSG 122
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 18-110 3.31e-03

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 37.87  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  18 AILLLHSF----TGTNRDVKHLAAELNDQGFSCYAPNYPGHGLLLKDFITYNVDDWWEEVEKAYQFLVNEGYESISATGV 93
Cdd:TIGR03101  27 VVIYLPPFaeemNKSRRMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTLWGL 106

                          90
                  ....*....|....*..
gi 1092623841  94 SLGGLMTLKLAQHYPLK 110
Cdd:TIGR03101 107 RLGALLALDAANPLAAK 123
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
17-112 3.39e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 37.94  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  17 HAILLLHSFTGTNRDV-KHLAAELNDQGFSCYAPNYPGHGL----LLKDFiTYNVDDWWEE-VEKAYQFLVNE-GYESIS 89
Cdd:COG4757    32 RAVVLINPATGVPQRFyRPFARYLAERGFAVLTYDYRGIGLsrpgSLRGF-DAGYRDWGELdLPAVLDALRARfPGLPLL 110

                          90       100
                  ....*....|....*....|...
gi 1092623841  90 ATGVSLGGLMTLKLAQHYPLKRI 112
Cdd:COG4757   111 LVGHSLGGQLLGLAPNAERVDRL 133
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 17-107 3.84e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.96  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092623841  17 HAILLLHSFTGTNRDVKHLAAELNDQGFSCYAPNYPG-------HGLLLKDFItynvddwwEEVEKAYqflvneGYESIS 89
Cdd:COG1075     6 YPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPStngsiedSAEQLAAFV--------DAVLAAT------GAEKVD 71

                          90
                  ....*....|....*...
gi 1092623841  90 ATGVSLGGLMTLKLAQHY 107
Cdd:COG1075    72 LVGHSMGGLVARYYLKRL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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