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Conserved domains on  [gi|1934377683|ref|WP_195579603|]
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hypothetical protein [Alistipes shahii]

Protein Classification

OmpA family protein( domain architecture ID 1000806)

OmpA family membrane protein acts as a porin with low permeability that allows slow penetration of small solutes, similar to peptidoglycan-associated lipoprotein that is involved in maintenance of the integrity of the cell cell envelope

CATH:  3.30.1330.60
Gene Ontology:  GO:0042834|GO:0015288
SCOP:  4001470
TCDB:  1.B.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpI super family cl34822
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
387-540 1.08e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG4785:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.83  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 387 AILELIVAEKNPDRREQAIRQRFPKEYAYIRSVI------YPQLRAVNFRYSLRRKGMVKDTIHTTELDTAYARGVQLLQ 460
Cdd:COG4785     6 LALLLALALAAAAASKAAILLAALLFAAVLALAIaladlaLALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 461 KRKYAKALYILND-----------YNDRNtvVAHLSLDHNERAMELLATM----PKDAVTEYLRAIACSRLGRKAEGREH 525
Cdd:COG4785    86 LGDYDLAIADFDQaleldpdlaeaYNNRG--LAYLLLGDYDAALEDFDRAleldPDYAYAYLNRGIALYYLGRYELAIAD 163

                         170
                  ....*....|....*
gi 1934377683 526 FLEACRLDGRMEYRG 540
Cdd:COG4785   164 LEKALELDPNDPERA 178
OmpA_C-like super family cl30079
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 292-368 8.70e-04

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


The actual alignment was detected with superfamily member cd07185:

Pssm-ID: 453091 [Multi-domain]  Cd Length: 106  Bit Score: 39.07  E-value: 8.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1934377683 292 DNRRQLDKITGLMRQIVEQqefwvdTITLTAASSPEGAYAFNDRLSQGRAAALKRYLVRRYGrsIDTMLTVRWVAED 368
Cdd:cd07185    16 EAKPLLDKLAEVLKKNPDA------KIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGV--DASRITAVGYGES 84
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
387-540 1.08e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.83  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 387 AILELIVAEKNPDRREQAIRQRFPKEYAYIRSVI------YPQLRAVNFRYSLRRKGMVKDTIHTTELDTAYARGVQLLQ 460
Cdd:COG4785     6 LALLLALALAAAAASKAAILLAALLFAAVLALAIaladlaLALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 461 KRKYAKALYILND-----------YNDRNtvVAHLSLDHNERAMELLATM----PKDAVTEYLRAIACSRLGRKAEGREH 525
Cdd:COG4785    86 LGDYDLAIADFDQaleldpdlaeaYNNRG--LAYLLLGDYDAALEDFDRAleldPDYAYAYLNRGIALYYLGRYELAIAD 163

                         170
                  ....*....|....*
gi 1934377683 526 FLEACRLDGRMEYRG 540
Cdd:COG4785   164 LEKALELDPNDPERA 178
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 292-368 8.70e-04

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 39.07  E-value: 8.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1934377683 292 DNRRQLDKITGLMRQIVEQqefwvdTITLTAASSPEGAYAFNDRLSQGRAAALKRYLVRRYGrsIDTMLTVRWVAED 368
Cdd:cd07185    16 EAKPLLDKLAEVLKKNPDA------KIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGV--DASRITAVGYGES 84
 
Name Accession Description Interval E-value
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
387-540 1.08e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.83  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 387 AILELIVAEKNPDRREQAIRQRFPKEYAYIRSVI------YPQLRAVNFRYSLRRKGMVKDTIHTTELDTAYARGVQLLQ 460
Cdd:COG4785     6 LALLLALALAAAAASKAAILLAALLFAAVLALAIaladlaLALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934377683 461 KRKYAKALYILND-----------YNDRNtvVAHLSLDHNERAMELLATM----PKDAVTEYLRAIACSRLGRKAEGREH 525
Cdd:COG4785    86 LGDYDLAIADFDQaleldpdlaeaYNNRG--LAYLLLGDYDAALEDFDRAleldPDYAYAYLNRGIALYYLGRYELAIAD 163

                         170
                  ....*....|....*
gi 1934377683 526 FLEACRLDGRMEYRG 540
Cdd:COG4785   164 LEKALELDPNDPERA 178
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 292-368 8.70e-04

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 39.07  E-value: 8.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1934377683 292 DNRRQLDKITGLMRQIVEQqefwvdTITLTAASSPEGAYAFNDRLSQGRAAALKRYLVRRYGrsIDTMLTVRWVAED 368
Cdd:cd07185    16 EAKPLLDKLAEVLKKNPDA------KIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGV--DASRITAVGYGES 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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