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Conserved domains on  [gi|1949779987|ref|WP_198592425|]
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MoxR family ATPase [Vibrio lentus]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 65-188 4.52e-08

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 51.14  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  65 LIQGTHGTGKSSHIEQIAARL-NWPCLRINLDGHLSRLDFIGkdSIVIKDGMqvTEFKEGILPQSIQQPIALVLDEYDAG 143
Cdd:pfam07728   3 LLVGPPGTGKTELAERLAAALsNRPVFYVQLTRDTTEEDLFG--RRNIDPGG--ASWVDGPLVRAAREGEIAVLDEINRA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1949779987 144 RPDVMFVIQQLLEqDGKYTSLEQNRVI-TPHPSFRLFATCNTLGLG 188
Cdd:pfam07728  79 NPDVLNSLLSLLD-ERRLLLPDGGELVkAAPDGFRLIATMNPLDRG 123
CobS_N super family cl38358
Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is ...
 9-37 6.34e-06

Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with pfam07728. There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.


The actual alignment was detected with superfamily member pfam12556:

Pssm-ID: 432633  Cd Length: 34  Bit Score: 42.20  E-value: 6.34e-06
                          10        20
                  ....*....|....*....|....*....
gi 1949779987   9 PTQPVSVRERFGIDSNLTVMAFEHAGEYV 37
Cdd:pfam12556   6 PDTKVSVREVFGIDSDMEVPAFSERDEHV 34
 
Name Accession Description Interval E-value
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 65-188 4.52e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 51.14  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  65 LIQGTHGTGKSSHIEQIAARL-NWPCLRINLDGHLSRLDFIGkdSIVIKDGMqvTEFKEGILPQSIQQPIALVLDEYDAG 143
Cdd:pfam07728   3 LLVGPPGTGKTELAERLAAALsNRPVFYVQLTRDTTEEDLFG--RRNIDPGG--ASWVDGPLVRAAREGEIAVLDEINRA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1949779987 144 RPDVMFVIQQLLEqDGKYTSLEQNRVI-TPHPSFRLFATCNTLGLG 188
Cdd:pfam07728  79 NPDVLNSLLSLLD-ERRLLLPDGGELVkAAPDGFRLIATMNPLDRG 123
PHA02244 PHA02244
ATPase-like protein
 54-208 1.66e-06

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 49.35  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  54 ILAGFTSNRRTLIQGTHGTGKSSHIEQIAARLN---WPCLRINLDGHLSrlDFIGKDSivikdgmqvtEFKEGILPQSIQ 130
Cdd:PHA02244  112 IAKIVNANIPVFLKGGAGSGKNHIAEQIAEALDldfYFMNAIMDEFELK--GFIDANG----------KFHETPFYEAFK 179

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1949779987 131 QPIALVLDEYDAGRPDVMFVIQQLLEQdgKYTSLEQNRViTPHPSFRLFATCNTLGLGNfSGLYSGTQVLNHSQLDRW 208
Cdd:PHA02244  180 KGGLFFIDEIDASIPEALIIINSAIAN--KFFDFADERV-TAHEDFRVISAGNTLGKGA-DHIYVARNKIDGATLDRF 253
CobS_N pfam12556
Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is ...
 9-37 6.34e-06

Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with pfam07728. There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.


Pssm-ID: 432633  Cd Length: 34  Bit Score: 42.20  E-value: 6.34e-06
                          10        20
                  ....*....|....*....|....*....
gi 1949779987   9 PTQPVSVRERFGIDSNLTVMAFEHAGEYV 37
Cdd:pfam12556   6 PDTKVSVREVFGIDSDMEVPAFSERDEHV 34
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 47-226 1.55e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 39.77  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  47 DPEVTLAILAGFTSNRRTLIQGTHGTGKSSHIEQIAARLNWPCLRINLDGHLSRLDFIGkDSIVIKDGMQVtEFKEGILP 126
Cdd:COG0714    17 QEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILG-TYIYDQQTGEF-EFRPGPLF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987 127 QSIqqpiaLVLDEYDAGRPDVmfviqQ--LLE--QDGKYTsLEQNRVITPHPsFRLFATCNTLGlgnfsglYSGTQVLNH 202
Cdd:COG0714    95 ANV-----LLADEINRAPPKT-----QsaLLEamEERQVT-IPGGTYKLPEP-FLVIATQNPIE-------QEGTYPLPE 155

                         170       180
                  ....*....|....*....|....
gi 1949779987 203 SQLDRWNIIATLNYLDPQHETKIV 226
Cdd:COG0714   156 AQLDRFLLKLYIGYPDAEEEREIL 179
 
Name Accession Description Interval E-value
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 65-188 4.52e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 51.14  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  65 LIQGTHGTGKSSHIEQIAARL-NWPCLRINLDGHLSRLDFIGkdSIVIKDGMqvTEFKEGILPQSIQQPIALVLDEYDAG 143
Cdd:pfam07728   3 LLVGPPGTGKTELAERLAAALsNRPVFYVQLTRDTTEEDLFG--RRNIDPGG--ASWVDGPLVRAAREGEIAVLDEINRA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1949779987 144 RPDVMFVIQQLLEqDGKYTSLEQNRVI-TPHPSFRLFATCNTLGLG 188
Cdd:pfam07728  79 NPDVLNSLLSLLD-ERRLLLPDGGELVkAAPDGFRLIATMNPLDRG 123
PHA02244 PHA02244
ATPase-like protein
 54-208 1.66e-06

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 49.35  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  54 ILAGFTSNRRTLIQGTHGTGKSSHIEQIAARLN---WPCLRINLDGHLSrlDFIGKDSivikdgmqvtEFKEGILPQSIQ 130
Cdd:PHA02244  112 IAKIVNANIPVFLKGGAGSGKNHIAEQIAEALDldfYFMNAIMDEFELK--GFIDANG----------KFHETPFYEAFK 179

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1949779987 131 QPIALVLDEYDAGRPDVMFVIQQLLEQdgKYTSLEQNRViTPHPSFRLFATCNTLGLGNfSGLYSGTQVLNHSQLDRW 208
Cdd:PHA02244  180 KGGLFFIDEIDASIPEALIIINSAIAN--KFFDFADERV-TAHEDFRVISAGNTLGKGA-DHIYVARNKIDGATLDRF 253
CobS_N pfam12556
Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is ...
 9-37 6.34e-06

Cobaltochelatase CobS subunit N terminal; This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with pfam07728. There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.


Pssm-ID: 432633  Cd Length: 34  Bit Score: 42.20  E-value: 6.34e-06
                          10        20
                  ....*....|....*....|....*....
gi 1949779987   9 PTQPVSVRERFGIDSNLTVMAFEHAGEYV 37
Cdd:pfam12556   6 PDTKVSVREVFGIDSDMEVPAFSERDEHV 34
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 47-226 1.55e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 39.77  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987  47 DPEVTLAILAGFTSNRRTLIQGTHGTGKSSHIEQIAARLNWPCLRINLDGHLSRLDFIGkDSIVIKDGMQVtEFKEGILP 126
Cdd:COG0714    17 QEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILG-TYIYDQQTGEF-EFRPGPLF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949779987 127 QSIqqpiaLVLDEYDAGRPDVmfviqQ--LLE--QDGKYTsLEQNRVITPHPsFRLFATCNTLGlgnfsglYSGTQVLNH 202
Cdd:COG0714    95 ANV-----LLADEINRAPPKT-----QsaLLEamEERQVT-IPGGTYKLPEP-FLVIATQNPIE-------QEGTYPLPE 155

                         170       180
                  ....*....|....*....|....
gi 1949779987 203 SQLDRWNIIATLNYLDPQHETKIV 226
Cdd:COG0714   156 AQLDRFLLKLYIGYPDAEEEREIL 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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