Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential ...
2-478
0e+00
Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential for cytadherence in the human pathogen Mycoplasma genitalium, which binds eukaryotic cells by means of its transmembrane adhesion complex called the Nap. Nap consists of two heteromers, each consisting of proteins P110 and P140. The extracellular region of P110 binds to sialic acid receptors and interacts only with the neuraminic acid moiety of oligosaccharides. Structural and functional data suggests that Nap alternates between open and closed conformation to sustain a mechanism for motility and guarantee infectivity by attachment and release of M. genitalium to and from the host cell receptor. P110 and P140 are also immunodominant proteins and constitute the main target of host antibodies during infection. Thus, anti-adherence molecules, aimed at preventing the establishment of infection, are attractive potential antimicrobial drugs. This family also includes Mycoplasma pneumoniae Mgp-operon protein 3 (also called Mgp3 or ORF-3 protein).
The actual alignment was detected with superfamily member cd20279:
Pssm-ID: 471169 [Multi-domain] Cd Length: 873 Bit Score: 547.25 E-value: 0e+00
Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential ...
2-478
0e+00
Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential for cytadherence in the human pathogen Mycoplasma genitalium, which binds eukaryotic cells by means of its transmembrane adhesion complex called the Nap. Nap consists of two heteromers, each consisting of proteins P110 and P140. The extracellular region of P110 binds to sialic acid receptors and interacts only with the neuraminic acid moiety of oligosaccharides. Structural and functional data suggests that Nap alternates between open and closed conformation to sustain a mechanism for motility and guarantee infectivity by attachment and release of M. genitalium to and from the host cell receptor. P110 and P140 are also immunodominant proteins and constitute the main target of host antibodies during infection. Thus, anti-adherence molecules, aimed at preventing the establishment of infection, are attractive potential antimicrobial drugs. This family also includes Mycoplasma pneumoniae Mgp-operon protein 3 (also called Mgp3 or ORF-3 protein).
Pssm-ID: 439135 [Multi-domain] Cd Length: 873 Bit Score: 547.25 E-value: 0e+00
MgpC adhesin; This family contains several Mycoplasma MgpC like-proteins. The structure of ...
221-444
5.68e-153
MgpC adhesin; This family contains several Mycoplasma MgpC like-proteins. The structure of MGP3 shows that this entry is a partial match to a large beta propeller domain that binds to sialic acid.
Pssm-ID: 461593 Cd Length: 226 Bit Score: 435.29 E-value: 5.68e-153
Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential ...
2-478
0e+00
Mycoplasma genitalium adhesin P110 and similar proteins; P110 is a virulence factor essential for cytadherence in the human pathogen Mycoplasma genitalium, which binds eukaryotic cells by means of its transmembrane adhesion complex called the Nap. Nap consists of two heteromers, each consisting of proteins P110 and P140. The extracellular region of P110 binds to sialic acid receptors and interacts only with the neuraminic acid moiety of oligosaccharides. Structural and functional data suggests that Nap alternates between open and closed conformation to sustain a mechanism for motility and guarantee infectivity by attachment and release of M. genitalium to and from the host cell receptor. P110 and P140 are also immunodominant proteins and constitute the main target of host antibodies during infection. Thus, anti-adherence molecules, aimed at preventing the establishment of infection, are attractive potential antimicrobial drugs. This family also includes Mycoplasma pneumoniae Mgp-operon protein 3 (also called Mgp3 or ORF-3 protein).
Pssm-ID: 439135 [Multi-domain] Cd Length: 873 Bit Score: 547.25 E-value: 0e+00
MgpC adhesin; This family contains several Mycoplasma MgpC like-proteins. The structure of ...
221-444
5.68e-153
MgpC adhesin; This family contains several Mycoplasma MgpC like-proteins. The structure of MGP3 shows that this entry is a partial match to a large beta propeller domain that binds to sialic acid.
Pssm-ID: 461593 Cd Length: 226 Bit Score: 435.29 E-value: 5.68e-153
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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