|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
39-338 |
7.34e-78 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 241.39 E-value: 7.34e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 39 AEETTVRLTEEFTSEIEPYRENDITPAASGVhIDRILVDVGDVVREGQLLVTLDPTQYTQQLVQ-----------LKTVE 107
Cdd:COG0845 3 VERGDVPETVEATGTVEARREVEVRARVSGR-VEEVLVDEGDRVKKGQVLARLDPPDLQAALAQaqaqlaaaqaqLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 108 DDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNIE----------VRSPISGVVTARNYESGDLFSQ-QPVLH 176
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEqaranlayttIRAPFDGVVGERNVEPGQLVSAgTPLFT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 177 VMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIF 256
Cdd:COG0845 162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 257 DMGS-KQGVMVPDVAVQKQVGSAerYLYVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEVK 335
Cdd:COG0845 242 VLGErENALLVPASAVVRDGGGA--YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVV 319
|
...
gi 2544989011 336 QEQ 338
Cdd:COG0845 320 EAA 322
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
39-334 |
5.71e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 195.23 E-value: 5.71e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 39 AEETTVRLTEEFTSEIEPYRENDITPAASGVhIDRILVDVGDVVREGQLLVTLDPT----QYTQQLVQLKTVE------- 107
Cdd:TIGR01730 6 VESETLANTLTFPGSLEAVDEADLAAEVAGK-ITKISVREGQKVKKGQVLARLDDDdyqlALQAALAQLAAAEaqlelaq 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 108 DDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNI----------EVRSPISGVVTARNYESGDLFS-QQPVLH 176
Cdd:TIGR01730 85 RSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLasaqlnlrytEIRAPFDGTIGRRLVEVGAYVTaGQTLAT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 177 VMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIF 256
Cdd:TIGR01730 165 IVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFGRVTI 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2544989011 257 DMGSKQGVM-VPDVAVQKqvGSAERYLYVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEV 334
Cdd:TIGR01730 245 SLKVRSSAIvVPTQAVIE--DLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVKV 321
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
58-252 |
1.80e-32 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 120.30 E-value: 1.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 58 RENDITPAASGvHIDRILVD-VGDVVREGQLLVTLdptqYTQQLVQLktvEDDYnrlLPVYEVGGISAQQ--IEQAKAQL 134
Cdd:pfam16576 18 RLAHVHARVEG-WIEKLYVNaTGDPVKKGQPLAEL----YSPELVAA---QQEY---LLALRSGDALSKSelLRAARQRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 135 ---DIQREVVANMKK------NIEVRSPISGVVTARNYESGDLFS-QQPVLHVMQIDLLKVIVNISEQFFPNVKVGMPVT 204
Cdd:pfam16576 87 rllGMPEAQIAELERtgkvqpTVTVYAPISGVVTELNVREGMYVQpGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAE 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2544989011 205 LRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYA 252
Cdd:pfam16576 167 VTLPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
1-329 |
1.22e-24 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 102.87 E-value: 1.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 1 MKKIVMLAAWAVLLSGCGGRKSATDAAVDPRVltrGTVA-EETTVRLTEEFTSEIEPYRENDITPAASGVHIDRILVDvG 79
Cdd:PRK09859 5 RKLLIPLLFCGAMLTACDDKSAENAAAMTPEV---GVVTlSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIE-G 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 80 DVVREGQLLVTLDPTQYTQQLVQLK-----------TVEDDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNI 148
Cdd:PRK09859 81 DKVNQGDSLYQIDPAPLQAELNSAKgslakalstasNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 149 E----------VRSPISGVVTARNYESGDLFS---QQPVLHVMQIDLLKVIVNISEQFF------------PNVKVGMPV 203
Cdd:PRK09859 161 EqatinlqyanVTSPITGVSGKSSVTVGALVTanqADSLVTVQRLDPIYVDLTQSVQDFlrmkeevasgqiKQVQGSTPV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 204 TLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIFDMGSKQGV-MVPDVAVQKQVGSAERYL 282
Cdd:PRK09859 241 QLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVlLVPQEGVTHNAQGKATAL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2544989011 283 yVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDG 329
Cdd:PRK09859 321 -ILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPG 366
|
|
| YcfL |
COG5633 |
Uncharacterized conserved protein YcfL [Function unknown]; |
1-52 |
6.57e-03 |
|
Uncharacterized conserved protein YcfL [Function unknown];
Pssm-ID: 444360 Cd Length: 128 Bit Score: 36.12 E-value: 6.57e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2544989011 1 MKKIVMLAAWAVLLSGCGGRKSATDAA-------VDPRVLTRGTVAEETTVRLTEEFTS 52
Cdd:COG5633 1 MKKLLIALLAVLLLAGCSSSPTSGIPVnsqqplvMESSVLAAGISAEKPTLSQVGGLLR 59
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
39-338 |
7.34e-78 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 241.39 E-value: 7.34e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 39 AEETTVRLTEEFTSEIEPYRENDITPAASGVhIDRILVDVGDVVREGQLLVTLDPTQYTQQLVQ-----------LKTVE 107
Cdd:COG0845 3 VERGDVPETVEATGTVEARREVEVRARVSGR-VEEVLVDEGDRVKKGQVLARLDPPDLQAALAQaqaqlaaaqaqLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 108 DDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNIE----------VRSPISGVVTARNYESGDLFSQ-QPVLH 176
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEqaranlayttIRAPFDGVVGERNVEPGQLVSAgTPLFT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 177 VMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIF 256
Cdd:COG0845 162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 257 DMGS-KQGVMVPDVAVQKQVGSAerYLYVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEVK 335
Cdd:COG0845 242 VLGErENALLVPASAVVRDGGGA--YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVV 319
|
...
gi 2544989011 336 QEQ 338
Cdd:COG0845 320 EAA 322
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
39-334 |
5.71e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 195.23 E-value: 5.71e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 39 AEETTVRLTEEFTSEIEPYRENDITPAASGVhIDRILVDVGDVVREGQLLVTLDPT----QYTQQLVQLKTVE------- 107
Cdd:TIGR01730 6 VESETLANTLTFPGSLEAVDEADLAAEVAGK-ITKISVREGQKVKKGQVLARLDDDdyqlALQAALAQLAAAEaqlelaq 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 108 DDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNI----------EVRSPISGVVTARNYESGDLFS-QQPVLH 176
Cdd:TIGR01730 85 RSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLasaqlnlrytEIRAPFDGTIGRRLVEVGAYVTaGQTLAT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 177 VMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIF 256
Cdd:TIGR01730 165 IVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFGRVTI 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2544989011 257 DMGSKQGVM-VPDVAVQKqvGSAERYLYVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEV 334
Cdd:TIGR01730 245 SLKVRSSAIvVPTQAVIE--DLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVKV 321
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
58-252 |
1.80e-32 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 120.30 E-value: 1.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 58 RENDITPAASGvHIDRILVD-VGDVVREGQLLVTLdptqYTQQLVQLktvEDDYnrlLPVYEVGGISAQQ--IEQAKAQL 134
Cdd:pfam16576 18 RLAHVHARVEG-WIEKLYVNaTGDPVKKGQPLAEL----YSPELVAA---QQEY---LLALRSGDALSKSelLRAARQRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 135 ---DIQREVVANMKK------NIEVRSPISGVVTARNYESGDLFS-QQPVLHVMQIDLLKVIVNISEQFFPNVKVGMPVT 204
Cdd:pfam16576 87 rllGMPEAQIAELERtgkvqpTVTVYAPISGVVTELNVREGMYVQpGDTLFTIADLSTVWVEADVPEQDLALVKVGQPAE 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2544989011 205 LRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYA 252
Cdd:pfam16576 167 VTLPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPGMFA 214
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
58-259 |
3.24e-30 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 117.07 E-value: 3.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 58 RENDITPAASGVhIDRILVDVGDVVREGQLLVTLDPTQYTQQL------------------------------------- 100
Cdd:COG1566 44 RVVTVAAKVSGR-VTEVLVKEGDRVKKGQVLARLDPTDLQAALaqaeaqlaaaeaqlarleaelgaeaeiaaaeaqlaaa 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 101 -VQLKTVEDDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNIE------------------------------ 149
Cdd:COG1566 123 qAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQAQLAqaqaglreeeelaaaqaqvaqaeaalaqae 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 150 -------VRSPISGVVTARNYESGDLFSQ-QPVLHVMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSL 221
Cdd:COG1566 203 lnlarttIRAPVDGVVTNLNVEPGEVVSAgQPLLTIVPLDDLWVEAYVPETDLGRVKPGQPVEVRVDAYPDRVFEGKVTS 282
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2544989011 222 IYPALDATT----------RTFKVEVEVPNGDG-TLRPGMYARTIFDMG 259
Cdd:COG1566 283 ISPGAGFTSppknatgnvvQRYPVRIRLDNPDPePLRPGMSATVEIDTE 331
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
1-329 |
1.22e-24 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 102.87 E-value: 1.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 1 MKKIVMLAAWAVLLSGCGGRKSATDAAVDPRVltrGTVA-EETTVRLTEEFTSEIEPYRENDITPAASGVHIDRILVDvG 79
Cdd:PRK09859 5 RKLLIPLLFCGAMLTACDDKSAENAAAMTPEV---GVVTlSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIE-G 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 80 DVVREGQLLVTLDPTQYTQQLVQLK-----------TVEDDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNI 148
Cdd:PRK09859 81 DKVNQGDSLYQIDPAPLQAELNSAKgslakalstasNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 149 E----------VRSPISGVVTARNYESGDLFS---QQPVLHVMQIDLLKVIVNISEQFF------------PNVKVGMPV 203
Cdd:PRK09859 161 EqatinlqyanVTSPITGVSGKSSVTVGALVTanqADSLVTVQRLDPIYVDLTQSVQDFlrmkeevasgqiKQVQGSTPV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 204 TLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIFDMGSKQGV-MVPDVAVQKQVGSAERYL 282
Cdd:PRK09859 241 QLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVlLVPQEGVTHNAQGKATAL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 2544989011 283 yVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDG 329
Cdd:PRK09859 321 -ILDKDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPG 366
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
4-336 |
4.30e-16 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 78.60 E-value: 4.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 4 IVMLAAWAVLLSGCGGRKSATDAAVDPRVltrGTVAEETT-VRLTEEFTSEIEPYRENDITPAASGVHIDRILVDVGDVv 82
Cdd:PRK15030 12 VVLMLSGSLALTGCDDKQAQQGGQQMPAV---GVVTVKTEpLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDI- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 83 REGQLLVTLDPTQYTQQLVQLK-----------TVEDDYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNIE-- 149
Cdd:PRK15030 88 EAGVSLYQIDPATYQATYDSAKgdlakaqaaanIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVEta 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 150 --------VRSPISGVVTARNYESGDLFSQ---QPVLHVMQIDLLKVIVNISEQFFPNVKVGMPV-TLRVE--------- 208
Cdd:PRK15030 168 rinlaytkVTSPISGRIGKSNVTEGALVQNgqaTALATVQQLDPIYVDVTQSSNDFLRLKQELANgTLKQEngkakvsli 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 209 -----IFPErefTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIFDMGSK-QGVMVPDVAVQKqVGSAERYL 282
Cdd:PRK15030 248 tsdgiKFPQ---DGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNpNAILVPQQGVTR-TPRGDATV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2544989011 283 YVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEVKQ 336
Cdd:PRK15030 324 LVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQE 377
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
79-334 |
2.71e-15 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 76.37 E-value: 2.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 79 GDVVREGQLLVTLDPTQYTQQLVQ-----------LKTVEDDYNRLLPVYEVGGISAQQIE-------QAKAQLDIQREV 140
Cdd:PRK11556 106 GQQVKAGDLLAEIDPRPFKVALAQaqgqlakdqatLANARRDLARYQQLAKTNLVSRQELDaqqalvsETEGTIKADEAS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 141 VANMKKNIE---VRSPISGVVTARNYESGDLFSQ---QPVLHVMQIDLLKVIVNISEQFFPNV----KVGMPVTlrVEIF 210
Cdd:PRK11556 186 VASAQLQLDysrITAPISGRVGLKQVDVGNQISSgdtTGIVVITQTHPIDLVFTLPESDIATVvqaqKAGKPLV--VEAW 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 211 ----PEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMY--ARTIFDMgSKQGVMVPDVAVQkqVGSAERYLYV 284
Cdd:PRK11556 264 drtnSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFvnARMLVDT-LQNAVVIPTAALQ--MGNEGHFVWV 340
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2544989011 285 IVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEV 334
Cdd:PRK11556 341 LNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEV 390
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
62-323 |
1.94e-14 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 73.75 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 62 ITPAASGVHIDRIL-VDVGDVVREGQLLVTLDPTQYtqqlvqlktVEDDYNRLLpVYEVGGiSAQQIEQAKAQL------ 134
Cdd:PRK09783 125 IVQARAAGFIDKVYpLTVGDKVQKGTPLLDLTIPDW---------VEAQSEYLL-LRETGG-TATQTEGILERLrlagmp 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 135 --DIQREVVA-NMKKNIEVRSPISGVVTARNYESGDLFSQQPVLHVMQ-IDLLKVIVNISEQFFPNVKVGMPVTLRVEIF 210
Cdd:PRK09783 194 eaDIRRLIATrKIQTRFTLKAPIDGVITAFDLRAGMNIAKDNVVAKIQgMDPVWVTAAIPESIAWLVKDASQFTLTVPAR 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 211 PEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIFDMGSKQGVMVPDVAVQkqvgsaerylyvivgDSV 290
Cdd:PRK09783 274 PDKTFTIRKWTLLPSVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEPMLLIPSQALI---------------DTG 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2544989011 291 AERRSVEV---GRQVGDRVDILR----------GVQAGEQVAVTAL 323
Cdd:PRK09783 339 SEQRVITVdadGRFVPKRVAVFQesqgvtairsGLAEGEKVVSSGL 384
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
51-320 |
3.15e-12 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 66.72 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 51 TSEIEPYRENDITPAASGvHIDRILVDVGDVVREGQLLVTLDPTQYTQQL------------------VQLKTVEDDYNR 112
Cdd:PRK11578 53 TGKLDALRKVDVGAQVSG-QLKTLSVAIGDKVKKDQLLGVIDPEQAENQIkeveatlmelraqrqqaeAELKLARVTLSR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 113 LLPVYEVGGISAQQIEQAKAQLDIQREVVANMKKNI-----------------EVRSPISGVVTARNYESGD--LFSQQP 173
Cdd:PRK11578 132 QQRLAKTQAVSQQDLDTAATELAVKQAQIGTIDAQIkrnqasldtaktnldytRIVAPMAGEVTQITTLQGQtvIAAQQA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 174 --VLHVMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALDATTRT--FKVEVEVPNGDGTLRPG 249
Cdd:PRK11578 212 pnILTLADMSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGVLKDILPTPEKVNDAifYYARFEVPNPNGLLRLD 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2544989011 250 MYART-IFDMGSKQGVMVPDVAVQKQVGSaERYLYVIVGDSVAERRSVEVGRQVGDRVDILRGVQAGEQVAV 320
Cdd:PRK11578 292 MTAQVhIQLTDVKNVLTIPLSALGDPVGD-NRYKVKLLRNGETREREVTIGARNDTDVEIVKGLEAGDEVII 362
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
149-249 |
4.94e-12 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 61.61 E-value: 4.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 149 EVRSPISGVVTARNYESGDLFSQ-QPVLHVMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPEREFTGRVSLIYPALD 227
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAgDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVD 80
|
90 100
....*....|....*....|....
gi 2544989011 228 ATTRTFKVEVEVPNGDG--TLRPG 249
Cdd:pfam13437 81 PDTGVIPVRVSIENPKTpiPLLPG 104
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
41-320 |
1.55e-11 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 64.37 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 41 ETTVRLTEEFTSEIEPYREND-ITPAASGVhIDRILVDVGDVVREGQLLVTLDPTQYTQQLVQLK-----------TVED 108
Cdd:pfam00529 1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGI-VTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEaqlakaqaqvaRLQA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 109 DYNRLLPVYEVGGISAQQIEQAKAQLDIQREVVANMK----------KNIEVRSPISGVVTARNYESGDLFSQQ---PVL 175
Cdd:pfam00529 80 ELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQaqlaqaqidlARRRVLAPIGGISRESLVTAGALVAQAqanLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 176 HVMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIFPERE-----------------FTGRVSLIYPALDATTRTFKVEVE 238
Cdd:pfam00529 160 TVAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAelklakldlerteirapVDGTVAFLSVTVDGGTVSAGLRLM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 239 VPN-GDGTLRPGMYART-IFDMGSKQGVMVPDVAVQKQVGSaeRYLYVIVGDSVA-ERRSVEVGRQVGDRVDILRGVQAG 315
Cdd:pfam00529 240 FVVpEDNLLVPGMFVETqLDQVRVGQPVLIPFDAFPQTKTG--RFTGVVVGISPDtGPVRVVVDKAQGPYYPLRIGLSAG 317
|
....*
gi 2544989011 316 EQVAV 320
Cdd:pfam00529 318 ALVRL 322
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
2-334 |
4.36e-07 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 50.95 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 2 KKIVMLAAWAVLLSGCGGRKSATDAAVDPRVLTrgTVAEETTVRLTEEFTSEIEPYRENDITPAASGVHIDRiLVDVGDV 81
Cdd:PRK09578 8 RLLLAALVALFVLAGCGKGDSDAAAAAPREATV--VTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTAR-TYEEGQE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 82 VREGQLLVTLDPTQYTQQLVQ----LKTVE-------------DDYNRLLPVYEVGGISAQQIE-QAKAQLDIQREVVAN 143
Cdd:PRK09578 85 VKQGAVLFRIDPAPLKAARDAaagaLAKAEaahlaaldkrrryDDLVRDRAVSERDYTEAVADErQAKAAVASAKAELAR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 144 MKKNIE---VRSPISGVVTARNYESGDLFSQQ---PVLHVMQIDllKVIVNIS------EQFFPNVKVG---------MP 202
Cdd:PRK09578 165 AQLQLDyatVTAPIDGRARRALVTEGALVGQDqatPLTTVEQLD--PIYVNFSqpaadvEALRRAVKSGratgiaqqdVA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 203 VTLRVEIFPEREFTGRVSLIYPALDATTRTFKVEVEVPNGDGTLRPGMYARTIFDMG-SKQGVMVPDVAVqkqVGSAERY 281
Cdd:PRK09578 243 VTLVRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAvNPRAILVPRDAL---LRTADSA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2544989011 282 LYVIVG-DSVAERRSVEVGRQVGDRVDILRGVQAGEQVAVTALSKLYDGAPVEV 334
Cdd:PRK09578 320 SVKVVGqNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKA 373
|
|
| PRK15136 |
PRK15136 |
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA; |
73-235 |
1.47e-04 |
|
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
Pssm-ID: 185090 [Multi-domain] Cd Length: 390 Bit Score: 43.14 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 73 RILVDVGDVVREGQLLVTLDPTQYTQQLVQLKT--------------------------------VEDDYNRLLPVYEVG 120
Cdd:PRK15136 74 KVWADNTDFVKEGDVLVTLDPTDAEQAFEKAKTalansvrqthqlminskqyqanielqktalaqAQSDLNRRVPLGNAN 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 121 GI-------SAQQIEQAKAQLDIQRE-------VVANMK---------------------KNIEVRSPISGVVTARNYES 165
Cdd:PRK15136 154 LIgreelqhARDAVASAQAQLDVAIQqynanqaMILNTPledqpavqqaatevrnawlalQRTKIVSPMTGYVSRRSVQV 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 166 G-DLFSQQPVLHVMQIDLLKVIVNISEQFFPNVKVGMPVTLRVEIF-PEREFTGRV-----------SLIyPALDATTRT 232
Cdd:PRK15136 234 GaQISPTTPLMAVVPATNLWVDANFKETQLANMRIGQPATITSDIYgDDVVYTGKVvgldmgtgsafSLL-PAQNATGNW 312
|
...
gi 2544989011 233 FKV 235
Cdd:PRK15136 313 IKV 315
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
119-222 |
1.67e-03 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 40.01 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2544989011 119 VGGISAQ--QIEQAKAQLDI-QREVvanmkKNIEVRSPISGVVTARNYESGD-LFSQQPVLHVMQIDLLKVIVNISEQFF 194
Cdd:PRK10476 182 VGGVDALvaQRAAREAALAIaELHL-----EDTTVRAPFDGRVVGLKVSVGEfAAPMQPIFTLIDTDHWYAIANFRETDL 256
|
90 100
....*....|....*....|....*...
gi 2544989011 195 PNVKVGMPVTLRVEIFPEREFTGRVSLI 222
Cdd:PRK10476 257 KNIRVGDCATVYSMIDRGRPFEGKVDSI 284
|
|
| YcfL |
COG5633 |
Uncharacterized conserved protein YcfL [Function unknown]; |
1-52 |
6.57e-03 |
|
Uncharacterized conserved protein YcfL [Function unknown];
Pssm-ID: 444360 Cd Length: 128 Bit Score: 36.12 E-value: 6.57e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2544989011 1 MKKIVMLAAWAVLLSGCGGRKSATDAA-------VDPRVLTRGTVAEETTVRLTEEFTS 52
Cdd:COG5633 1 MKKLLIALLAVLLLAGCSSSPTSGIPVnsqqplvMESSVLAAGISAEKPTLSQVGGLLR 59
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
62-104 |
7.02e-03 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 34.34 E-value: 7.02e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2544989011 62 ITPAASGVhIDRILVDVGDVVREGQLLVTLDPTQYTQQLVQLK 104
Cdd:pfam13533 5 IASPVSGK-VVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAE 46
|
|
|