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Conserved domains on  [gi|2552867249|ref|WP_302989885|]
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acetate/propionate family kinase [Alistipes finegoldii]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-400 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 665.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDpeHGV 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMD--SEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGARGVNKIlSTPGSRVKVAVIATDEELVIATDTYNLVK 400
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVI-STPDSRVKVLVIPTNEELMIARDTLRLLK 395
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-400 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 665.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDpeHGV 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMD--SEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGARGVNKIlSTPGSRVKVAVIATDEELVIATDTYNLVK 400
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVI-STPDSRVKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-400 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 645.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDPEHGV 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMP--NEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:PRK00180   79 IKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:PRK00180  159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:PRK00180  239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EM-GGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGA-RGVNKILSTPGSRVKVAVIATDEELVIATDTYNL 398
Cdd:PRK00180  319 ALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAArFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398


                  ..
gi 2552867249 399 VK 400
Cdd:PRK00180  399 LG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 608.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   3 ILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDPEHGVir 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMP--TEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  83 SLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVNF 162
Cdd:cd24010    77 SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 163 MYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMGT 242
Cdd:cd24010   157 LYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 243 RCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAEM 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2552867249 323 GGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGARGVNKILSTPGSRVKVAVIATDEELVIATDTYNL 398
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 2.10e-177

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 499.26  E-value: 2.10e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   2 VILVLNCGSSSIKYQVIDMeaASSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTdpEHGVI 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDA--VIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLL--KHKII 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  82 RSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVN 161
Cdd:pfam00871  77 ELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 162 FMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMG 241
Cdd:pfam00871 157 YLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 242 TRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAE 321
Cdd:pfam00871 237 TRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAAS 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2552867249 322 MGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKgARGVNKILSTPGSRVKVAVIATDEELVIA 392
Cdd:pfam00871 317 LERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN-RFGKSGVISTEDSRVKVVVIPTNEELMIA 386
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-400 1.23e-173

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 490.39  E-value: 1.23e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEAaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTdpEHGV 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVN-GEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL--KDKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSI--EKVLPGTPQVTVFDTSFHQTIP 158
Cdd:TIGR00016  81 IKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAAlkLFPLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 159 AVNFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGL 238
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 239 VMGTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEY 318
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 319 AAEMGG-VDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGAR-GVNKILSTPGSRVKVAVIATDEELVIATDTY 396
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ....
gi 2552867249 397 NLVK 400
Cdd:TIGR00016 401 RLTK 404
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
1-400 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 665.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDpeHGV 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMD--SEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTD--HGI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:COG0282    77 IKDLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:COG0282   157 AYLYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGARGVNKIlSTPGSRVKVAVIATDEELVIATDTYNLVK 400
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVI-STPDSRVKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-400 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 645.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDPEHGV 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMP--NEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:PRK00180   79 IKDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:PRK00180  159 AYLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:PRK00180  239 GTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EM-GGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGA-RGVNKILSTPGSRVKVAVIATDEELVIATDTYNL 398
Cdd:PRK00180  319 ALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAArFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398


                  ..
gi 2552867249 399 VK 400
Cdd:PRK00180  399 LG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 608.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   3 ILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTDPEHGVir 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMP--TEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  83 SLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVNF 162
Cdd:cd24010    77 SLDEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 163 MYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMGT 242
Cdd:cd24010   157 LYALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 243 RCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAEM 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2552867249 323 GGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGARGVNKILSTPGSRVKVAVIATDEELVIATDTYNL 398
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-392 2.10e-177

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 499.26  E-value: 2.10e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   2 VILVLNCGSSSIKYQVIDMeaASSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTdpEHGVI 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDA--VIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLL--KHKII 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  82 RSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVN 161
Cdd:pfam00871  77 ELLAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 162 FMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMG 241
Cdd:pfam00871 157 YLYALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 242 TRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAE 321
Cdd:pfam00871 237 TRSGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAAS 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2552867249 322 MGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKgARGVNKILSTPGSRVKVAVIATDEELVIA 392
Cdd:pfam00871 317 LERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN-RFGKSGVISTEDSRVKVVVIPTNEELMIA 386
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-400 1.23e-173

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 490.39  E-value: 1.23e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   1 MVILVLNCGSSSIKYQVIDMEAaSSTLLAKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTdpEHGV 80
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVN-GEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL--KDKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  81 IRSLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSI--EKVLPGTPQVTVFDTSFHQTIP 158
Cdd:TIGR00016  81 IKLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAAlkLFPLPKAKNVAVFDTAFHQTMP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 159 AVNFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGL 238
Cdd:TIGR00016 161 EEAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 239 VMGTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEY 318
Cdd:TIGR00016 241 MMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 319 AAEMGG-VDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGAR-GVNKILSTPGSRVKVAVIATDEELVIATDTY 396
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARsGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ....
gi 2552867249 397 NLVK 400
Cdd:TIGR00016 401 RLTK 404
PRK12397 PRK12397
acetate/propionate family kinase;
3-394 4.00e-147

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 423.10  E-value: 4.00e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   3 ILVLNCGSSSIKYQVIDMEaaSSTLLAKGIVERIGLPEGDLIHKpVGKQPFELHRPIPNHTTGIKLVLDALTDpeHGVIR 82
Cdd:PRK12397    5 IMAINAGSSSLKFQLLEMP--QGDMLCQGLIERIGMADAQVTIK-THSQKWQETVPVADHRDAVTLLLEKLLG--YQIIN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  83 SLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVNF 162
Cdd:PRK12397   80 SLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 163 MYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMGT 242
Cdd:PRK12397  160 IYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 243 RCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAEM 322
Cdd:PRK12397  240 RSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQM 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2552867249 323 GGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKgaRGVNKILSTPGSrVKVAVIATDEELVIATD 394
Cdd:PRK12397  320 GGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQ--RNATFIQTENAL-VKVAVINTNEELMIAQD 388
PRK12379 PRK12379
propionate kinase;
2-400 2.27e-138

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 400.65  E-value: 2.27e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   2 VILVLNCGSSSIKYQVIDmeAASSTLLAKGIVERIGLPEGDLIHKpvGKQPFELHRPipNHTTGIKLVLDALTDpehgvi 81
Cdd:PRK12379    6 VVLVINCGSSSIKFSVLD--ASDCEVLMSGIADGINSENAFLSVN--GGEPAPLAHH--SYEGALKAIAFELEK------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  82 RSL-DEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAV 160
Cdd:PRK12379   74 RNLnDSVALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 161 NFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVM 240
Cdd:PRK12379  154 AYLYGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMM 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 241 GTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAA 320
Cdd:PRK12379  234 GTRSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 321 EMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANK--GARGvNKILSTPGSRVKVAVIATDEELVIATDTYNL 398
Cdd:PRK12379  314 SLHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNqpNSGG-ERIISSENSRVICAVIPTNEEKMIALDAIHL 392


                  ..
gi 2552867249 399 VK 400
Cdd:PRK12379  393 GK 394
PRK07157 PRK07157
acetate kinase; Provisional
 3-394 1.57e-124

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 365.60  E-value: 1.57e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   3 ILVLNCGSSSIKYQVIDMEAASstLLAKGIVERIGLPEGdLIHKPVGKQPFELHRPIPNHTTGIKLVLDALTdpEHGVIR 82
Cdd:PRK07157    5 ILVINAGSSSIKWQLFDKENLN--LIASGLAERIGLENG-LIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWE--ENKLIE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  83 SLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPAVNF 162
Cdd:PRK07157   80 DLEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 163 MYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLagLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLVMGT 242
Cdd:PRK07157  160 TYPINYEIAKKYGIKKYGFHGISHKFITNKVEKI--LNKDKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 243 RCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYAAEM 322
Cdd:PRK07157  238 RSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2552867249 323 GG-VDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANK---GARGVNKILSTPGSRVKVAVIATDEELVIATD 394
Cdd:PRK07157  318 GKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLkkiGEYGPIELISTPDSDIPVYVIRTNEELLIAKN 393
PRK12440 PRK12440
acetate/propionate family kinase;
3-399 1.39e-105

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 317.19  E-value: 1.39e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   3 ILVLNCGSSSIKYQVIDMEAASSTLlaKGIVERIGLPEGDLIHKPVGKQPFELHRPIPNHTtgiKLVLDALTdpehGVIR 82
Cdd:PRK12440    6 VLVINSGSSSLKFAVIDSVTGEAVL--SGLGECFGLEDARMSWKYQGEKTEIAIEGEDNHH---KIAIGRLV----GLTE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  83 SL---DEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTSFHQTIPA 159
Cdd:PRK12440   77 ELgftQDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 160 VNFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMGFSPVDGLV 239
Cdd:PRK12440  157 KAFTGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 240 MGTRCGNVDPSAVTFIgEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIDRAYDEGNPRAILARDMHYGRIRRFVGEYA 319
Cdd:PRK12440  237 MGTRCGDLDPGIIEFL-LKKGWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 320 AEMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANKGAR-GVNKILSTPGSRVKVA-VIATDEELVIATDTYN 397
Cdd:PRK12440  316 AALDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARfGKAGIIAKSELLNAVAmVIPTNEEFVIAQQSVE 395


                  ..
gi 2552867249 398 LV 399
Cdd:PRK12440  396 LL 397
PRK07058 PRK07058
acetate/propionate family kinase;
2-398 4.95e-98

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 297.73  E-value: 4.95e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   2 VILVLNCGSSSIKYQVIDMEAASSTLLAKGIVeriglpegDLIHKPVgkqpfELHRPIPNHTTGIKLVLDAlTDPEHGVI 81
Cdd:PRK07058    5 LLLTFNAGSSTVKIGLFEVDGNEARRIGKGDI--------DFRRAPL-----RFHLRNGGETLDIPLKASV-TDDLHTVL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  82 R----------SLDEVKAVGHRVAHGGEFFPESCIVTEEVKSKIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDT 151
Cdd:PRK07058   71 DetfdwlaahfDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 152 SFHQTIPAVNFMYALPHAYYDKyRVRKYGFHGTSHKYVAQTGAKLAgLDFENSKIITCHIGNGASVTAVLNGKSFDTSMG 231
Cdd:PRK07058  151 AFHRTQPDLVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGELRRRA-PELARGKVVAAHLGSGASLCALDAGKSRDTSMG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 232 FSPVDGLVMGTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDLSSDMRDIdraYDEGNPRAILARDMHYGRI 311
Cdd:PRK07058  229 FSTLDGIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDL---LASDAPEAREALDLFALRI 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 312 RRFVGEYAAEMGGVDMIVFTGGVGENSCEMRESVCTGLEFMGVEFDREANkgARGVNKIlSTPGSRVKVAVIATDEELVI 391
Cdd:PRK07058  306 AGEIARLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAAN--AANAFTI-SSRTSRVAAFVIPTDEEQVI 382


                  ....*..
gi 2552867249 392 ATDTYNL 398
Cdd:PRK07058  383 ADEAFSV 389
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 2-334 3.43e-20

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 90.67  E-value: 3.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249   2 VILVLNCGSSSIKYQVIDMEaasstllaKGIVERiglpegDLIHKPVGKQPFElhRPIPNHTTGIKLVLDALTdpEHGVi 81
Cdd:cd24011     1 RILVINPGSTSTKIAVFEGE--------EEVFEE------TIEHSPEELAKFP--SIIDQLEFRKEAVLDFLK--ENGI- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249  82 rSLDEVKAVghrVAHGGEFFPES---CIVTEEVkskIRSLFEIAPLHNPANLEGVLSIEKVLPGTPQVTVFDTsfhqtiP 158
Cdd:cd24011    62 -DLSDLDAI---VGRGGLLKPIPggtYRVNEAM---LEDLLSGPLGEHASNLGAPIAYELAKEYGIPAYIVDP------V 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 159 AVNFMYALPHAYYDKYRVRKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMG------F 232
Cdd:cd24011   129 VVDEMDPVARITGIPEIERRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpF 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 233 SPvdglvmgTRCGNVDPSAVTFIGEKEGMSYAELNEMMNKKSGVLGLTDlSSDMRDIDRAYDEGNPRAILARD-MHYgRI 311
Cdd:cd24011   209 SP-------ERAGTLPVGDLIKLCFSGKYTLEELKKKLKGKGGLVAYLG-TNDFREVEKRIEAGDEKAKLVLDaMAY-QI 279

                         330       340
                  ....*....|....*....|....
gi 2552867249 312 RRFVGEYAAEMGG-VDMIVFTGGV 334
Cdd:cd24011   280 AKEIGALAAVLKGkVDAIILTGGL 303
PRK03011 PRK03011
butyrate kinase; Provisional
 177-334 7.27e-16

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 78.28  E-value: 7.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 177 RKYGFHGTSHKYVAQTGAKLAGLDFENSKIITCHIGNGASVTAVLNGKSFDTSMG------FSPvdglvmgTRCGNVDPS 250
Cdd:PRK03011  149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSP-------ERAGGLPVG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2552867249 251 AVTFIGEKEGMSYAELNEMMNKKSGVLGLTDlSSDMRDIDRAYDEGNPRAILARD-MHYgRIRRFVGEYAAEMGG-VDMI 328
Cdd:PRK03011  222 DLVELCFSGKYTKEELKKKLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEaMAY-QIAKEIGAMAAVLKGkVDAI 299


                  ....*.
gi 2552867249 329 VFTGGV 334
Cdd:PRK03011  300 VLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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