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Conserved domains on  [gi|2560665388|ref|WP_305205961|]
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sensor histidine kinase KdpD, partial [Alistipes finegoldii]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-127 1.78e-30

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 108.84  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP 86
Cdd:COG2205   116 ELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTiTI--SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDN 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2560665388  87 FS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG2205   194 SRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-127 1.78e-30

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 108.84  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP 86
Cdd:COG2205   116 ELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTiTI--SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDN 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2560665388  87 FS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG2205   194 SRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 24-127 1.41e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.42  E-value: 1.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   24 LLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ---GMGLGLAVCR 99
Cdd:smart00387   5 RLRQVLSNLLDNAIKYTPEGGRiTV--TLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*...
gi 2560665388  100 LIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 23-126 8.27e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 90.89  E-value: 8.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAP-DGRTTLAytlISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ-GMGLGLAVCRL 100
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAkAGEITVT---LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 2.99e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 84.02  E-value: 2.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFApdgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:cd16939     1 MARALDNLLRNALRYA---HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16939    78 VALWHGGHVECDDSELGGACFRLTWP 103
PRK10604 PRK10604
sensor protein RstB; Provisional
 24-127 6.11e-22

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 89.28  E-value: 6.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARFApdgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCR 99
Cdd:PRK10604  319 LMERVLDNLLNNALRYA---HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdraTGGCGLGLAIVH 395

                          90       100
                  ....*....|....*....|....*...
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK10604  396 SIALAMGGSVNCDESELGGARFSFSWPV 423
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
8-127 1.78e-30

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 108.84  E-value: 1.78e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP 86
Cdd:COG2205   116 ELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTiTI--SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDN 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2560665388  87 FS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG2205   194 SRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 24-127 1.41e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.42  E-value: 1.41e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   24 LLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ---GMGLGLAVCR 99
Cdd:smart00387   5 RLRQVLSNLLDNAIKYTPEGGRiTV--TLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*...
gi 2560665388  100 LIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPL 110
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-127 3.35e-28

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 104.99  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   3 RKLDSRFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV 82
Cdd:COG0642   202 KGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG-GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFF 280

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2560665388  83 KLDP--FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG0642   281 RTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
8-128 4.47e-26

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 100.40  E-value: 4.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGRT-TLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP 86
Cdd:COG5002   265 ELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTiTV--SLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDK 342

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2560665388  87 ----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:COG5002   343 srsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 23-126 8.27e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 90.89  E-value: 8.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAP-DGRTTLAytlISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ-GMGLGLAVCRL 100
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAkAGEITVT---LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLP 106
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 2.99e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 84.02  E-value: 2.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFApdgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:cd16939     1 MARALDNLLRNALRYA---HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16939    78 VALWHGGHVECDDSELGGACFRLTWP 103
PRK10604 PRK10604
sensor protein RstB; Provisional
 24-127 6.11e-22

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 89.28  E-value: 6.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARFApdgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCR 99
Cdd:PRK10604  319 LMERVLDNLLNNALRYA---HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdraTGGCGLGLAIVH 395

                          90       100
                  ....*....|....*....|....*...
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK10604  396 SIALAMGGSVNCDESELGGARFSFSWPV 423
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 29-126 1.07e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 80.23  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  29 LTELLRNAARFAPDGRTTLAYTLISHKK---RIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLI 101
Cdd:cd16922     5 LLNLLGNAIKFTEEGEVTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLAISKKL 84

                          90       100
                  ....*....|....*....|....*
gi 2560665388 102 ADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16922    85 VELMGGDISVESEPGQGSTFTFTLP 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 8-128 1.30e-19

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 82.54  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQLPVNTSCLLLSKALTELLRNAARFAPDGRT-TLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP 86
Cdd:COG4191   240 ELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2560665388  87 FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:COG4191   320 VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 4-128 2.51e-19

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 81.93  E-value: 2.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   4 KLDSRFEPECAQLPVNTSclLLSKALTELLRNAARfAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV- 82
Cdd:COG5000   299 RLELDLDPDLPEVLADRD--QLEQVLINLLKNAIE-AIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFt 375

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2560665388  83 -KldpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:COG5000   376 tK----PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLA 418
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 12-127 1.25e-18

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 80.21  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  12 ECAQLP-VNTSCLLLSKALTELLRNAARFAPDGRT-TLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ 89
Cdd:COG4251   381 EVGPLPtVRGDPTLLRQVFQNLISNAIKYSRPGEPpRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDE 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2560665388  90 --GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG4251   461 yeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
PRK15347 PRK15347
two component system sensor kinase;
23-127 4.00e-17

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 75.83  E-value: 4.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAPDGRTTLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIA 102
Cdd:PRK15347  512 LRLRQILVNLLGNAVKFTETGGIRL--RVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLA 589

                          90       100
                  ....*....|....*....|....*
gi 2560665388 103 DALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK15347  590 KMMGGELTLFSTPGVGSCFSLVLPL 614
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 5.31e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 70.50  E-value: 5.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNA----ARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCRL 100
Cdd:cd16920     1 IQQVLINLVRNGieamSEGGCERRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICRS 78

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16920    79 IIEAHGGRLSVESPAGGGATFQFTLP 104
PRK09303 PRK09303
histidine kinase;
32-127 8.89e-17

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 74.60  E-value: 8.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  32 LLRNAARFAPDGRT-TLAytlISHK--KRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLIADALG 106
Cdd:PRK09303  280 LLDNAIKYTPEGGTiTLS---MLHRttQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGteGYGIGLSVCRRIVRVHY 356

                          90       100
                  ....*....|....*....|.
gi 2560665388 107 GGVELDTSYTEGARFTLTIPI 127
Cdd:PRK09303  357 GQIWVDSEPGQGSCFHFTLPV 377
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 3-127 1.52e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 74.11  E-value: 1.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   3 RKLDSRFEPECAQLPVNTscLLLSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV 82
Cdd:PRK11100  349 KGITLRLRPDDARVLGDP--FLLRQALGNLLDNAIDFSPEG-GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFY 425

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2560665388  83 KLD-PFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK11100  426 SLPrPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 1.87e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 69.52  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPaneaFGQHSGLGLSISRQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2560665388 101 IADALGGGVEL----DTSYTEGARFTLTIP 126
Cdd:cd16953    81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 32-126 3.82e-16

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 73.05  E-value: 3.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  32 LLRNAARFAPDGRTTLayTLISH-KKRIAFTVTDRGPGIPAAEADRIFDRF--VKLDP---FSQGMGLGLAVCRLIADAL 105
Cdd:PRK11091  406 LISNAVKFTQQGGVTV--RVRYEeGDMLTFEVEDSGIGIPEDELDKIFAMYyqVKDSHggkPATGTGIGLAVSKRLAQAM 483

                          90       100
                  ....*....|....*....|.
gi 2560665388 106 GGGVELDTSYTEGARFTLTIP 126
Cdd:PRK11091  484 GGDITVTSEEGKGSCFTLTIH 504
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
25-127 5.38e-16

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 72.19  E-value: 5.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDG-----RTTLAYTLISHKKR----IAFTVTDRGPGIPAAEADRIFDrfvkldPF----SQGM 91
Cdd:COG3852   245 LIQVLLNLVRNAAEAMPEGgtitiRTRVERQVTLGGLRprlyVRIEVIDNGPGIPEEILDRIFE------PFfttkEKGT 318

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2560665388  92 GLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:COG3852   319 GLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 8.08e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 67.74  E-value: 8.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRT---TLAYTLISHKKRiaFTVTDRGPGIPAAEADRIFDRFVKLDP--FSQGMGLGLAVCR 99
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPpriEVGAEDVGEEWT--FYVRDNGIGIDPEYAEKVFGIFQRLHSreEYEGTGVGLAIVR 78

                          90       100
                  ....*....|....*....|....*..
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16921    79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-125 8.82e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 68.31  E-value: 8.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTtLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS----QGMGLGLAVCRL 100
Cdd:cd16947    21 LQRILKNLISNAIKYGSDGKF-LGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRnsakQGNGLGLTITKR 99

                          90       100
                  ....*....|....*....|....*
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTI 125
Cdd:cd16947   100 LAESMGGSIYVNSKPYEKTVFTVTL 124
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 24-127 2.04e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 66.68  E-value: 2.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARfAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIAD 103
Cdd:cd16943     3 QLNQVLLNLLVNAAQ-AMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQ 81

                          90       100
                  ....*....|....*....|....
gi 2560665388 104 ALGGGVELDTSYTEGARFTLTIPI 127
Cdd:cd16943    82 KHGGTIRVASVPGGGTRFTIILPI 105
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 32-125 2.47e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 67.27  E-value: 2.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  32 LLRNAARFApDGRTTLAYTLISHKKRIAftVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVEL 111
Cdd:cd16954    45 LLDNACKWC-LEFVEVTARQTDGGLHLI--VDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSL 121

                          90
                  ....*....|....
gi 2560665388 112 DTSYTEGARFTLTI 125
Cdd:cd16954   122 SDSPLGGARFEVVF 135
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 29-126 2.64e-15

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 66.36  E-value: 2.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  29 LTELLRNAARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ----GMGLGLAVCRLIADA 104
Cdd:cd16925     9 VLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGLGLSIVKEFVEL 88

                          90       100
                  ....*....|....*....|..
gi 2560665388 105 LGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16925    89 HGGTVTVSDAPGGGALFQVELP 110
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 23-123 1.18e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 64.73  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAP-DGRTTLAytlISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS-QGMGLGLAVCRL 100
Cdd:cd16940    12 LLLFLLLRNLVDNAVRYSPqGSRVEIK---LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNyGGSGLGLSIVKR 88

                          90       100
                  ....*....|....*....|...
gi 2560665388 101 IADALGGGVELDTSYTEGARFTL 123
Cdd:cd16940    89 IVELHGGQIFLGNAQGGGLEAWV 111
PRK10490 PRK10490
sensor protein KdpD; Provisional
 24-126 1.57e-14

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 68.52  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARFAPDgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLI 101
Cdd:PRK10490  778 LFERVLINLLENAVKYAGA-QAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICRAI 856

                          90       100
                  ....*....|....*....|....*
gi 2560665388 102 ADALGGGVELDTSYTEGARFTLTIP 126
Cdd:PRK10490  857 VEVHGGTIWAENRPEGGACFRVTLP 881
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-114 2.08e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 64.01  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFapdGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGLGLAVCRLIA 102
Cdd:cd16950     1 LKRVLSNLVDNALRY---GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNArgTSGTGLGLAIVQRIS 77

                          90
                  ....*....|..
gi 2560665388 103 DALGGGVELDTS 114
Cdd:cd16950    78 DAHGGSLTLANR 89
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 25-128 3.48e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 67.57  E-value: 3.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNA---ARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV--KLdpfSQGMGLGLAVCR 99
Cdd:COG3290   282 LVTILGNLLDNAieaVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFstKL---GEGRGLGLALVK 358

                          90       100
                  ....*....|....*....|....*....
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:COG3290   359 QIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 5.71e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 62.73  E-value: 5.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPdgrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRL 100
Cdd:cd16949     1 LARALENVLRNALRYSP---SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIAER 77

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16949    78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 8.00e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 62.80  E-value: 8.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDG--------RTTLAYTLISHKKRIAFTVT--DRGPGIPAAEADRIFDRFVKLDPfsQGMGLG 94
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSggeiilrtRTQRQVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGRE--NGTGLG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2560665388  95 LAVCRLIADALGGGVELDTS--YTEgarFTLTIP 126
Cdd:cd16918    79 LAIAQNIVSQHGGVIECDSQpgHTV---FSVSLP 109
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 24-126 1.06e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 62.17  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARF---APDGRTTLAYTL-ISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCR 99
Cdd:cd16944     4 QISQVLTNILKNAAEAiegRPSDVGEVRIRVeADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGLAIVK 81

                          90       100
                  ....*....|....*....|....*..
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16944    82 KIMEEHGGRISLSNREAGGACIRIILP 108
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-123 2.44e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 61.32  E-value: 2.44e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFA---PDGRTTLAYTLIShkKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLI 101
Cdd:cd16976     1 IQQVLMNLLQNALDAMgkvENPRIRIAARRLG--GRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGI 78

                          90       100
                  ....*....|....*....|..
gi 2560665388 102 ADALGGGVELDTSYTEGARFTL 123
Cdd:cd16976    79 VEEHGGRLSVANEEGAGARFTF 100
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
25-127 7.16e-13

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 63.65  E-value: 7.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDpfSQGMGLGLAVCRLIADA 104
Cdd:PRK10364  349 LTQVLLNLYLNAIQAIGQH-GVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQ 425

                          90       100
                  ....*....|....*....|...
gi 2560665388 105 LGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK10364  426 HGGTIQVASQEGKGATFTLWLPV 448
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
23-126 7.83e-13

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 63.64  E-value: 7.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAPDGRTtLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ----GMGLGLAVC 98
Cdd:PRK09835  374 LMLRRAISNLLSNALRYTPAGEA-ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIV 452

                          90       100
                  ....*....|....*....|....*...
gi 2560665388  99 RLIADALGGGVELdTSYTEGARFTLTIP 126
Cdd:PRK09835  453 KSIVVAHKGTVAV-TSDARGTRFVISLP 479
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 29-127 1.72e-12

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 62.62  E-value: 1.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  29 LTELLRNAARFAPDGRTTLAYTLISHKKRIAftVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGG 108
Cdd:PRK11466  566 ITNLLSNALRFTDEGSIVLRSRTDGEQWLVE--VEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGE 643

                          90
                  ....*....|....*....
gi 2560665388 109 VELDTSYTEGARFTLTIPI 127
Cdd:PRK11466  644 LSATSTPEVGSCFCLRLPL 662
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 35-126 2.32e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 58.84  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  35 NAARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSqGMGLGLAVCRLIADALGGGVELDTS 114
Cdd:cd16915    14 DALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVERLGGSITVESE 92

                          90
                  ....*....|..
gi 2560665388 115 YTEGARFTLTIP 126
Cdd:cd16915    93 PGGGTTFSIRIP 104
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 3.50e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 58.63  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:cd16946     5 LQQLFVNLLENSLRYTDTG-GKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrnrASGGSGLGLAICHN 83

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16946    84 IALAHGGTISAEHSPLGGLRLVLTLP 109
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
25-127 3.70e-12

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 61.91  E-value: 3.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTTLayTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:PRK10841  563 LQQVISNLLSNAIKFTDTGCIVL--HVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrNFQGTGLGLAICEK 640

                          90       100
                  ....*....|....*....|....*..
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK10841  641 LINMMDGDISVDSEPGMGSQFTIRIPL 667
envZ PRK09467
osmolarity sensor protein; Provisional
 16-128 7.74e-12

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 60.69  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  16 LPVNTSCLLLSKALTELLRNAARFapdGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGL 93
Cdd:PRK09467  323 IEVPMNPIAIKRALANLVVNAARY---GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSArgSSGTGL 399

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2560665388  94 GLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:PRK09467  400 GLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 24-111 9.57e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 57.09  E-value: 9.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKL-DPFSQ--GMGLGLAVCRL 100
Cdd:cd16945     4 LLRQAINNLLDNAIDFSPEG-GLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLpRPHSGqkSTGLGLAFVQE 82

                          90
                  ....*....|.
gi 2560665388 101 IADALGGGVEL 111
Cdd:cd16945    83 VAQLHGGRITL 93
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
8-127 2.03e-11

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 59.60  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   8 RFEPECAQ-LP-VNTSCLLLSKALTELLRNAARFAP-DGRTTLAyTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKL 84
Cdd:PRK11360  482 DFETELDNeLPpIWADPELLKQVLLNILINAVQAISaRGKIRIR-TWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT 560

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2560665388  85 DPfsQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK11360  561 KA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 32-128 4.59e-11

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 58.45  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  32 LLRNAARFAPDGRT-TLAYTLISHKKrIAFTVTDRGPGIPAAEADRIFDrfvkldPF----SQGMGLGLAVCRLIADALG 106
Cdd:COG5809   387 LLKNAIEAMPEGGNiTIETKAEDDDK-VVISVTDEGCGIPEERLKKLGE------PFyttkEKGTGLGLMVSYKIIEEHG 459

                          90       100
                  ....*....|....*....|..
gi 2560665388 107 GGVELDTSYTEGARFTLTIPIV 128
Cdd:COG5809   460 GKITVESEVGKGTTFSITLPIK 481
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
25-127 1.92e-10

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 57.05  E-value: 1.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   25 LSKALTELLRNAARFAPDGRTTLAYTLI---SHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCR 99
Cdd:PRK09959   829 FKQVLSNLLSNALKFTTEGAVKITTSLGhidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMICK 908

                           90       100
                   ....*....|....*....|....*...
gi 2560665388  100 LIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK09959   909 ELIKNMQGDLSLESHPGIGTTFTITIPV 936
PRK10337 PRK10337
sensor protein QseC; Provisional
 23-102 2.76e-09

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 53.50  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAPDGrTTLAYTLISHkkriAFTVTDRGPGIPAAEADRIFDRFVKldPFSQ---GMGLGLAVCR 99
Cdd:PRK10337  351 LLLSLLVRNLLDNAIRYSPQG-SVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYR--PPGQeatGSGLGLSIVR 423


                  ...
gi 2560665388 100 LIA 102
Cdd:PRK10337  424 RIA 426
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
13-102 3.98e-09

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 53.05  E-value: 3.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  13 CAQLPVNTSCLLLSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMG 92
Cdd:PRK10755  236 AADITVQGDATLLRLLLRNLVENAHRYSPEG-STITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIG 314

                          90
                  ....*....|
gi 2560665388  93 LGLAVCRLIA 102
Cdd:PRK10755  315 LGLSIVSRIT 324
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-107 4.06e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 50.46  E-value: 4.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDgRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGLGLAVCRLIA 102
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPE-NTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSrnTEGAGLGLSIAKAII 79


                  ....*
gi 2560665388 103 DALGG 107
Cdd:cd16923    80 ELHGG 84
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
25-128 7.75e-09

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 52.33  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGrTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRL 100
Cdd:PRK10549  353 LMQLFNNLLENSLRYTDSG-GSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGsrnrASGGSGLGLAICLN 431

                          90       100
                  ....*....|....*....|....*...
gi 2560665388 101 IADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:PRK10549  432 IVEAHNGRIIAAHSPFGGVSITVELPLE 459
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 1.08e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 49.51  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRT-TLAYTLISHKKRiaFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCR 99
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTiTVRWSQEESGAR--LSVEDTGPGIPPEHIPRLTERFYRVDIErcrnTGGTGLGLAIVK 78

                          90       100
                  ....*....|....*....|....*..
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16952    79 HVMSRHDARLLIASELGKGSRFTCLFP 105
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 32-128 1.53e-08

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 51.27  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  32 LLRNAARFAPDG-----RTTLAYTlishkkRIAFTVTDRGPGIPAAEADRIFDRFvkldpFS---QGMGLGLAVCRLIAD 103
Cdd:COG5805   403 LIKNAIEAMPNGgtitiHTEEEDN------SVIIRVIDEGIGIPEERLKKLGEPF-----FTtkeKGTGLGLMVSYKIIE 471

                          90       100
                  ....*....|....*....|....*
gi 2560665388 104 ALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:COG5805   472 NHNGTIDIDSKVGKGTTFTITLPLS 496
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 58-126 1.62e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 48.92  E-value: 1.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560665388  58 IAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
62-127 1.02e-07

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 48.91  E-value: 1.02e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  62 VTDRGPGIPAAEADRIFDrfvkldPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK13837  612 VSDTGAGIDEAVLPHIFE------PFfttrAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
6-128 1.71e-07

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 48.39  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   6 DSRFEPE-----------CAQLPVNTSCLLLSKALTELLRNAARFapdGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEA 74
Cdd:PRK09470  324 DAKFEAEqmgksltvsapPGPWPINGNPNALASALENIVRNALRY---SHTKIEVAFSVDKDGLTITVDDDGPGVPEEER 400

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2560665388  75 DRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:PRK09470  401 EQIFRPFYRVDEArdreSGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLY 458
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
61-120 1.93e-07

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 48.09  E-value: 1.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  61 TVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGAR 120
Cdd:PRK10815  412 VVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGAR 471
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
28-106 2.34e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 46.06  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  28 ALTELLRNAARFA----PDGRTTLAYTLisHKKRIAFTVTDRGPGIPAAEADrifdrfvklDPFS--QGMGLGLAVCRLI 101
Cdd:COG2172    38 AVSEAVTNAVRHAyggdPDGPVEVELEL--DPDGLEIEVRDEGPGFDPEDLP---------DPYStlAEGGRGLFLIRRL 106


                  ....*
gi 2560665388 102 ADALG 106
Cdd:COG2172   107 MDEVE 111
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 25-126 2.48e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 45.74  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTtLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV-----KLDPFSQGMGLGLAvcR 99
Cdd:cd16948     6 LSFIIGQIVSNALKYSKQGGK-IEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNFQESTGMGLYLV--K 82

                          90       100
                  ....*....|....*....|....*..
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:cd16948    83 KLCDKLGHKIDVESEVGEGTTFTITFP 109
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
25-126 7.56e-07

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 46.54  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDG-RTTLAYTLISHKKRiaFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVcr 99
Cdd:PRK11006  318 LRSAISNLVYNAVNHTPEGtHITVRWQRVPQGAE--FSVEDNGPGIAPEHIPRLTERFYRVDKArsrqTGGSGLGLAI-- 393

                          90       100       110
                  ....*....|....*....|....*....|
gi 2560665388 100 lIADALG---GGVELDTSYTEGARFTLTIP 126
Cdd:PRK11006  394 -VKHALShhdSRLEIESEVGKGTRFSFVLP 422
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 28-127 1.22e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 46.05  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  28 ALTELLRNAARFA-PDGRT-TLAYTLISHKKRIAFTVTDRGPGIPAAEAdrifdrfvkldpFSQGMGLGLAVCRLIADAL 105
Cdd:COG3920   403 ILNELVTNALKHAfLSGEGgRIRVSWRREDGRLRLTVSDNGVGLPEDVD------------PPARKGLGLRLIRALVRQL 470

                          90       100
                  ....*....|....*....|..
gi 2560665388 106 GGGVELDTSytEGARFTLTIPI 127
Cdd:COG3920   471 GGTLELDRP--EGTRVRITFPL 490
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 61-126 1.50e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 45.67  E-value: 1.50e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560665388  61 TVTDRGPGIPAAEADRIFDRfvkldPFS---QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 126
Cdd:PRK11086  471 EVSDDGPGIAPDEIDAIFDK-----GYStkgSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 29-126 1.74e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 42.93  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  29 LTELLRNAARFAPDGRTTLayTLISHKKRIAFTVTDRGPGIPAAEAdrifdrfvkldpfSQGMGLGLAVCRLIADALGGG 108
Cdd:cd16917     5 VQEALTNALKHAGASRVRV--TLSYTADELTLTVVDDGVGFDGPAP-------------PGGGGFGLLGMRERAELLGGT 69

                          90
                  ....*....|....*...
gi 2560665388 109 VELDTSYTEGARFTLTIP 126
Cdd:cd16917    70 LTIGSRPGGGTRVTARLP 87
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 28-103 4.69e-05

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 40.05  E-value: 4.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2560665388  28 ALTELLRNAARFAPDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEAdrifdrfVKLDPFSQ--GMGLGLAVCRLIAD 103
Cdd:cd16934    29 AVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDE-------ALRDGFSTggGLGLGLGGVRRLAD 99
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 23-125 5.78e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 39.37  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  23 LLLSKALTELLRNAARFAPDGRTtLAYTLISHKKRIAFTVTDRGPGIPAAE---ADRIFDRFVKLDPFSQGMGLGLAVCR 99
Cdd:cd16975     3 LLLSRALINIISNACQYAPEGGT-VSISIYDEEEYLYFEIWDNGHGFSEQDlkkALELFYRDDTSRRSGGHYGMGLYIAK 81

                          90       100
                  ....*....|....*....|....*.
gi 2560665388 100 LIADALGGGVELDTSYTEGARFTLTI 125
Cdd:cd16975    82 NLVEKHGGSLIIENSQKGGAEVTVKI 107
HATPase_Phy-like cd16932
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ...
 25-115 9.24e-05

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.


Pssm-ID: 340409 [Multi-domain]  Cd Length: 113  Bit Score: 39.18  E-value: 9.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTTLAYTLISHKKRIA---------FTVTDRGPGIPAAEADRIFDRfvkldpfSQGM---G 92
Cdd:cd16932     7 LQQVLADFLLNAVRFTPSPGGWVEIKVSPTKKQIGdgvhvihleFRITHPGQGLPEELVQEMFEE-------NQWTtqeG 79

                          90       100
                  ....*....|....*....|....*..
gi 2560665388  93 LGLAVCRLIADALGGGV----ELDTSY 115
Cdd:cd16932    80 LGLSISRKLVKLMNGDVrylrEAGRSY 106
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 29-126 1.19e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 38.94  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  29 LTELLRNAARFAPDGRTTLAYTLISHK--KRIAFTVTDRGPGIPAAEadrifdrfvklDPFSQGmGLGLAVCRLIADALG 106
Cdd:cd16951    44 VNELLQNALKHAFSDREGGTITIRSVVdgDYLRITVIDDGVGLPQDE-----------DWPNKG-SLGLQIVRSLVEGEL 111

                          90       100
                  ....*....|....*....|
gi 2560665388 107 GGVELDTSYTEGARFTLTIP 126
Cdd:cd16951   112 KAFLEVQSAENGTRVNIDIP 131
PRK13557 PRK13557
histidine kinase; Provisional
 58-128 1.22e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 40.04  E-value: 1.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2560665388  58 IAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 128
Cdd:PRK13557  325 VSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395
glnL PRK11073
nitrogen regulation protein NR(II);
25-127 1.39e-04

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 40.06  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAAR-FAPDG-----RTTLAYTLISHKKRIAFT----VTDRGPGIPAAEADRIFDRFVKldPFSQGMGLG 94
Cdd:PRK11073  238 IEQVLLNIVRNALQaLGPEGgtitlRTRTAFQLTLHGERYRLAaridIEDNGPGIPPHLQDTLFYPMVS--GREGGTGLG 315

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2560665388  95 LAVCRLIADALGGGVELdTSYTEGARFTLTIPI 127
Cdd:PRK11073  316 LSIARNLIDQHSGKIEF-TSWPGHTEFSVYLPI 347
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 25-111 1.64e-04

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 39.25  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAAR-----------FAPDGRTTLAYtlisHKKRIAFTVTDRGPGIPAAEADRIF------------DRF 81
Cdd:cd16929    44 LYYILFELLKNAMRatveshgddsdDLPPIKVTVAK----GDEDLTIKISDRGGGIPREDLARLFsymystapqpslDDF 119

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2560665388  82 VKLDPFSQ-----GMGLGLAVCRLIADALGGGVEL 111
Cdd:cd16929   120 SDLISGTQpsplaGFGYGLPMSRLYAEYFGGDLDL 154
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
55-127 1.99e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 39.62  E-value: 1.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560665388  55 KKRIAFTVTDRGPGIPAAEADRIFDrfvKLDPFSQGMGLGLA-VCRLIADALGG--GVELDTSYTEGARFTLTIPI 127
Cdd:COG2972   370 GDRLVITVEDNGVGMPEEKLEKLLE---ELSSKGEGRGIGLRnVRERLKLYYGEeyGLEIESEPGEGTTVTIRIPL 442
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 28-106 2.37e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 37.63  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  28 ALTELLRNAARFA----PDGRTTLAYTLISHkkRIAFTVTDRGPGipaaeadriFDRFVKLDP--FSQGMGLGLAVCRLI 101
Cdd:cd16936     4 AVSEAVTNAVRHAyrhdGPGPVRLELDLDPD--RLRVEVTDSGPG---------FDPLRPADPdaGLREGGRGLALIRAL 72


                  ....*
gi 2560665388 102 ADALG 106
Cdd:cd16936    73 MDEVG 77
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 24-127 2.94e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 39.15  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  24 LLSKALTELLRNAArfapdgrTTLAYTLIS--------HKKRIAFTVTDRGPGIPAAEADRIfdRFVKL-----DPFSQG 90
Cdd:PRK10618  565 ALRKILLLLLNYAI-------TTTAYGKITlevdqdesSPDRLTIRILDTGAGVSIKELDNL--HFPFLnqtqgDRYGKA 635

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2560665388  91 MGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK10618  636 SGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 15-128 4.11e-04

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 38.66  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  15 QLPVNTSCLLLSKALTELLRNAARFA---PDGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKL---DPFS 88
Cdd:PRK15053  423 QLPPGLDSTEFAAIVGNLLDNAFEASlrsDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTradEPGE 502

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2560665388  89 QGMGLGLaVCRLIADAlGGGVELDTSYTEGARFTLTIPIV 128
Cdd:PRK15053  503 HGIGLYL-IASYVTRC-GGVITLEDNDPCGTLFSIFIPKV 540
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
28-127 4.27e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.45  E-value: 4.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  28 ALTELLRNAARFApdGRTTLAYTLISHKKRIAFTVTDRGPGIPAAEAdrifdrfvkldpfsQGMGLGLAVCRLIADALGG 107
Cdd:COG4585   166 IVQEALTNALKHA--GATRVTVTLEVDDGELTLTVRDDGVGFDPEAA--------------PGGGLGLRGMRERAEALGG 229

                          90       100
                  ....*....|....*....|
gi 2560665388 108 GVELDTSYTEGARFTLTIPI 127
Cdd:COG4585   230 TLTIGSAPGGGTRVRATLPL 249
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 5-119 6.69e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.13  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388   5 LDSRFEPECAQL------PVNTSCLLLSKALTELLRNAARFAPD-GRTTLAYTLISHKKRIAftVTDRGPGIPAAeaDRI 77
Cdd:COG4192   518 VESRAKPQQITLhipddlMVQGDQVLLEQVLVNLLVNALDAVATqPQISVDLLSNAENLRVA--ISDNGNGWPLV--DKL 593

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2560665388  78 FDRFVKLDpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGA 119
Cdd:COG4192   594 FTPFTTTK--EVGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 25-127 2.36e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 36.37  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAARFAPDGRTTLAYTLIS---HKKRIAFTVTDRGPGIPAAEADRIFdrfvklDPFSQ----------GM 91
Cdd:PRK11107  409 LQQIITNLVGNAIKFTESGNIDILVELRAlsnTKVQLEVQIRDTGIGISERQQSQLF------QAFRQadasisrrhgGT 482

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2560665388  92 GLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 127
Cdd:PRK11107  483 GLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 25-125 3.01e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 35.38  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560665388  25 LSKALTELLRNAArfapDGRTTLAYTLISHKKRI--AFTVTDRGPGIPAAEADRIFdRFVKLDPFSQ---------GMGL 93
Cdd:pfam13589   1 LEGALAELIDNSI----DADATNIKIEVNKNRGGgtEIVIEDDGHGMSPEELINAL-RLATSAKEAKrgstdlgryGIGL 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2560665388  94 GLAVCRLIADAlgggveLDTSYTEGARFTLTI 125
Cdd:pfam13589  76 KLASLSLGAKL------TVTSKKEGKSSTLTL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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