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Conserved domains on  [gi|2560877178|ref|WP_305258417|]
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sensor histidine kinase KdpD, partial [Alistipes finegoldii]

Protein Classification

sensor histidine kinase( domain architecture ID 11454343)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
4-81 1.87e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 88.81  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG2205   157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
4-81 1.87e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 88.81  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG2205   157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 4-81 2.83e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 82.31  E-value: 2.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178    4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ---GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:smart00387  30 TLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109


                   .
gi 2560877178   81 I 81
Cdd:smart00387 110 L 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 6-80 6.88e-20

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 76.25  E-value: 6.88e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   6 ISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ-GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:pfam02518  31 LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
PRK10604 PRK10604
sensor protein RstB; Provisional
 1-81 1.63e-18

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 77.72  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   1 LAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFT 76
Cdd:PRK10604  339 VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdraTGGCGLGLAIVHSIALAMGGSVNCDESELGGARFS 418


                  ....*
gi 2560877178  77 LTIPI 81
Cdd:PRK10604  419 FSWPV 423
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-80 4.50e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 71.69  E-value: 4.50e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16939    30 RLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWP 103
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
4-81 1.87e-23

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 88.81  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS--QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG2205   157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
4-81 1.43e-22

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 88.04  E-value: 1.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP--FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG0642   248 SVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 4-81 2.83e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 82.31  E-value: 2.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178    4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ---GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:smart00387  30 TLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkigGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109


                   .
gi 2560877178   81 I 81
Cdd:smart00387 110 L 110
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
4-82 5.27e-21

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 84.60  E-value: 5.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTI 79
Cdd:COG5002   306 SLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKsrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385


                  ...
gi 2560877178  80 PIV 82
Cdd:COG5002   386 PLA 388
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 6-80 6.88e-20

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 76.25  E-value: 6.88e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   6 ISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ-GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:pfam02518  31 LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGgGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 11-82 3.19e-19

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 79.46  E-value: 3.19e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:COG4191   290 YVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
PRK10604 PRK10604
sensor protein RstB; Provisional
 1-81 1.63e-18

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 77.72  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   1 LAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFT 76
Cdd:PRK10604  339 VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSrdraTGGCGLGLAIVHSIALAMGGSVNCDESELGGARFS 418


                  ....*
gi 2560877178  77 LTIPI 81
Cdd:PRK10604  419 FSWPV 423
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-80 4.50e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 71.69  E-value: 4.50e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16939    30 RLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWP 103
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 11-82 1.57e-17

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 75.00  E-value: 1.57e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFV--KldpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:COG5000   349 RVRIEVSDNGPGIPEEVLERIFEPFFttK----PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLA 418
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 8-81 2.33e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 74.44  E-value: 2.33e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG4251   425 EGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 11-80 3.18e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 69.44  E-value: 3.18e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16922    36 QLRFSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 4-80 1.58e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 65.11  E-value: 1.58e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16920    30 TSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS--EGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
8-81 6.53e-15

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 67.18  E-value: 6.53e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDrfvkldPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG3852   283 PRLYVRIEVIDNGPGIPEEILDRIFE------PFfttkEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPL 354
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 15-79 1.52e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 63.42  E-value: 1.52e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2560877178  15 TVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTI 79
Cdd:cd16954    71 IVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
PRK09303 PRK09303
histidine kinase;
11-81 1.80e-14

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 66.13  E-value: 1.80e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK09303  305 KVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGteGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 9-80 4.31e-14

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 65.35  E-value: 4.31e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRF--VKLDP---FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:PRK11091  428 GDMLTFEVEDSGIGIPEDELDKIFAMYyqVKDSHggkPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 14-80 5.64e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 61.19  E-value: 5.64e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDP--FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16921    37 FYVRDNGIGIDPEYAEKVFGIFQRLHSreEYEGTGVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 4-82 1.90e-13

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 63.33  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEADRIFDRFV--KLdpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:COG3290   310 SIRDDGDELVIEVEDSGPGIPEELLEKIFERGFstKL---GEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386


                  .
gi 2560877178  82 V 82
Cdd:COG3290   387 E 387
PRK15347 PRK15347
two component system sensor kinase;
7-81 3.23e-13

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 62.74  E-value: 3.23e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2560877178   7 SHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK15347  540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 10-68 7.13e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 58.23  E-value: 7.13e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2560877178  10 KRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGLGLAVCRLIADALGGGVELDTS 68
Cdd:cd16950    29 NRTRIQVLDNGPGIAPEEVDELFQPFYRGDNArgTSGTGLGLAIVQRISDAHGGSLTLANR 89
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-77 9.62e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 57.85  E-value: 9.62e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTL 77
Cdd:cd16976    34 RLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTF 100
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
8-81 4.29e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 59.41  E-value: 4.29e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK10364  377 SGAGVKISVTDSGKGIAADQLEAIFTPYFTTK--AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
PRK10490 PRK10490
sensor protein KdpD; Provisional
 9-80 7.22e-12

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 58.89  E-value: 7.22e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:PRK10490  808 GERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 14-80 7.81e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 55.76  E-value: 7.81e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDPFSqGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16915    39 IEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 8-81 8.75e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 55.51  E-value: 8.75e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:cd16943    32 HVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 15-80 9.30e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 55.55  E-value: 9.30e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178  15 TVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16946    40 DVEDSAPGVSDDQLARLFERFYRVESsrnrASGGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 16-81 9.78e-12

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 58.76  E-value: 9.78e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178  16 VTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK11466  597 VEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 10-80 1.39e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 55.27  E-value: 1.39e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178  10 KRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVEL----DTSYTEGARFTLTIP 80
Cdd:cd16953    32 KMVTISVEDEGPGIPQEKLESIFDRFYTERPaneaFGQHSGLGLSISRQIIEAHGGISVAenhnQPGQVIGARFTVQLP 110
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-79 1.39e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 55.60  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   1 LAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPFS----QGMGLGLAVCRLIADALGGGVELDTSYTEGARFT 76
Cdd:cd16947    42 LGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFT 121


                  ...
gi 2560877178  77 LTI 79
Cdd:cd16947   122 VTL 124
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
12-81 3.17e-11

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 57.29  E-value: 3.17e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK10841  594 LSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 11-80 5.25e-11

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 53.65  E-value: 5.25e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ----GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16925    37 RFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 8-81 5.73e-11

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 56.39  E-value: 5.73e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDRFVKLD-PFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK11100  397 DGEQVALSVEDQGPGIPDYALPRIFERFYSLPrPANGrkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
9-81 7.31e-11

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 56.13  E-value: 7.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK11360  531 DGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA--KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 11-80 7.35e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 53.31  E-value: 7.35e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178  11 RIAFTVTDRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16944    41 RIVLIVCDNGKGFPREMRHRATEPYVTTRP--KGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
envZ PRK09467
osmolarity sensor protein; Provisional
 9-82 1.58e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 54.92  E-value: 1.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:PRK09467  359 GKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSArgSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 4-80 2.68e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 52.02  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   4 TLISHKKRIAFTVT--DRGPGIPAAEADRIFDRFVKLDPfsQGMGLGLAVCRLIADALGGGVELDTS--YTEgarFTLTI 79
Cdd:cd16918    34 TLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGRE--NGTGLGLAIAQNIVSQHGGVIECDSQpgHTV---FSVSL 108


                  .
gi 2560877178  80 P 80
Cdd:cd16918   109 P 109
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 12-82 3.26e-10

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 54.21  E-value: 3.26e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDrfvkldPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:COG5809   413 VVISVTDEGCGIPEERLKKLGE------PFyttkEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 9-80 1.23e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 50.02  E-value: 1.23e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16949    28 GDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWLP 103
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 14-77 1.34e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 50.10  E-value: 1.34e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDPFS-QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTL 77
Cdd:cd16940    47 IRVEDNGPGIDEEELEALFERFYRSDGQNyGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
3-81 8.25e-09

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 50.45  E-value: 8.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   3 YTLIShkkriaftVTDRGPGIPAAEADRIFDrfvkldPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLT 78
Cdd:PRK13837  607 YVLLR--------VSDTGAGIDEAVLPHIFE------PFfttrAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVY 672


                  ...
gi 2560877178  79 IPI 81
Cdd:PRK13837  673 LPP 675
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
15-80 1.14e-08

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 49.77  E-value: 1.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178  15 TVTDRGPGIPAAEADRIFDRFVKLDPFSQ----GMGLGLAVCRLIADALGGGVELdTSYTEGARFTLTIP 80
Cdd:PRK09835  411 VVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIVVAHKGTVAV-TSDARGTRFVISLP 479
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 12-82 1.43e-08

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 49.73  E-value: 1.43e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFvkldpFS---QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:COG5805   428 VIIRVIDEGIGIPEERLKKLGEPF-----FTtkeKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 12-80 1.52e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 47.37  E-value: 1.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
15-74 4.27e-08

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 48.09  E-value: 4.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178  15 TVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGAR 74
Cdd:PRK10815  412 VVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGAR 471
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 9-80 1.00e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 45.35  E-value: 1.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDRFV-----KLDPFSQGMGLGLAvcRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16948    35 EQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNFQESTGMGLYLV--KKLCDKLGHKIDVESEVGEGTTFTITFP 109
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
1-82 1.71e-07

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 46.55  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   1 LAYTLISHKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDP----FSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFT 76
Cdd:PRK10549  374 LHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGsrnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSIT 453


                  ....*.
gi 2560877178  77 LTIPIV 82
Cdd:PRK10549  454 VELPLE 459
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
12-81 1.78e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 46.65  E-value: 1.78e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2560877178   12 IAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQ--GMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK09959   865 IKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 15-80 7.09e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.90  E-value: 7.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178  15 TVTDRGPGIPAAEADRIFDRfvkldPFS---QGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:PRK11086  471 EVSDDGPGIAPDEIDAIFDK-----GYStkgSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-65 1.21e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 42.45  E-value: 1.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFVKLD-PFSQ--GMGLGLAVCRLIADALGGGVEL 65
Cdd:cd16945    37 IELLVFDEGSGIPDYALNRVFERFYSLPrPHSGqkSTGLGLAFVQEVAQLHGGRITL 93
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 14-80 5.70e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 40.65  E-value: 5.70e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16952    35 LSVEDTGPGIPPEHIPRLTERFYRVDIErcrnTGGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFP 105
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 12-61 1.65e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 39.29  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFVKLDPF--SQGMGLGLAVCRLIADALGG 61
Cdd:cd16923    33 VNIMFKNPSSHPLDFKLEKLFERFYRGDNSrnTEGAGLGLSIAKAIIELHGG 84
PRK10337 PRK10337
sensor protein QseC; Provisional
 13-56 2.16e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 40.40  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2560877178  13 AFTVTDRGPGIPAAEADRIFDRFVKldPFSQ---GMGLGLAVCRLIA 56
Cdd:PRK10337  382 NFTVRDNGPGVTPEALARIGERFYR--PPGQeatGSGLGLSIVRRIA 426
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
14-80 2.46e-05

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 40.38  E-value: 2.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVcrlIADALG---GGVELDTSYTEGARFTLTIP 80
Cdd:PRK11006  352 FSVEDNGPGIAPEHIPRLTERFYRVDKArsrqTGGSGLGLAI---VKHALShhdSRLEIESEVGKGTRFSFVLP 422
PRK13557 PRK13557
histidine kinase; Provisional
 12-82 3.07e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 40.04  E-value: 3.07e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2560877178  12 IAFTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:PRK13557  325 VSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAS 395
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
8-82 6.63e-05

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.15  E-value: 6.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178   8 HKKRIAFTVTDRGPGIPAAEADRIFDRFVKLDPF----SQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPIV 82
Cdd:PRK09470  380 DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEArdreSGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLY 458
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
9-81 1.12e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 38.46  E-value: 1.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178   9 KKRIAFTVTDRGPGIPAAEADRIFDrfvKLDPFSQGMGLGLA-VCRLIADALGG--GVELDTSYTEGARFTLTIPI 81
Cdd:COG2972   370 GDRLVITVEDNGVGMPEEKLEKLLE---ELSSKGEGRGIGLRnVRERLKLYYGEeyGLEIESEPGEGTTVTIRIPL 442
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 4-81 2.67e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 37.58  E-value: 2.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2560877178   4 TLISHKKRIAFTVTDRGPGIPAAEAdrifdrfvkldpFSQGMGLGLAVCRLIADALGGGVELDTSytEGARFTLTIPI 81
Cdd:COG3920   427 SWRREDGRLRLTVSDNGVGLPEDVD------------PPARKGLGLRLIRALVRQLGGTLELDRP--EGTRVRITFPL 490
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 7-81 2.88e-04

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 37.22  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178   7 SHKKRIAFTVTDRGPGIPAAEADRIfdRFVKL-----DPFSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIPI 81
Cdd:PRK10618  595 SSPDRLTIRILDTGAGVSIKELDNL--HFPFLnqtqgDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
14-56 6.20e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 36.48  E-value: 6.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2560877178  14 FTVTDRGPGIPAAEADRIFDRFVKLDPFSQGMGLGLAVCRLIA 56
Cdd:PRK10755  282 LAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRIT 324
glnL PRK11073
nitrogen regulation protein NR(II);
16-81 1.00e-03

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 35.83  E-value: 1.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2560877178  16 VTDRGPGIPAAEADRIFDRFVKldPFSQGMGLGLAVCRLIADALGGGVELdTSYTEGARFTLTIPI 81
Cdd:PRK11073  285 IEDNGPGIPPHLQDTLFYPMVS--GREGGTGLGLSIARNLIDQHSGKIEF-TSWPGHTEFSVYLPI 347
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 5-73 1.79e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 35.05  E-value: 1.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2560877178   5 LISHKKRIAFTVTDRGPGIPAAeaDRIFDRFVKLDpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGA 73
Cdd:COG4192   569 LLSNAENLRVAISDNGNGWPLV--DKLFTPFTTTK--EVGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 4-80 2.11e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 33.68  E-value: 2.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2560877178  4 TLISHKKRIAFTVTDRGPGIPAAEAdrifdrfvkldpfSQGMGLGLAVCRLIADALGGGVELDTSYTEGARFTLTIP 80
Cdd:cd16917   24 TLSYTADELTLTVVDDGVGFDGPAP-------------PGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARLP 87
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 16-82 4.19e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 34.04  E-value: 4.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2560877178  16 VTDRGPGIPAAEADRIFDRFVKL---DPFSQGMGLGLaVCRLIADAlGGGVELDTSYTEGARFTLTIPIV 82
Cdd:PRK15053  473 VADQGCGVPESLRDKIFEQGVSTradEPGEHGIGLYL-IASYVTRC-GGVITLEDNDPCGTLFSIFIPKV 540
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
11-60 7.45e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 32.58  E-value: 7.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2560877178  11 RIAFTVTDRGPGIPAAEADrifdrfvklDPFS--QGMGLGLAVCRLIADALG 60
Cdd:COG2172    69 GLEIEVRDEGPGFDPEDLP---------DPYStlAEGGRGLFLIRRLMDEVE 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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