NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2735789188|ref|WP_347012613|]
View 

Cna B-type domain-containing protein [Bifidobacterium dentium]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 605-694 9.01e-28

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 106.95  E-value: 9.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 605 VSVSKVWKDANDKEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYVK-KGGKAISYTVKEVgTVDGYKGEVtg 683
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYdENGKEITYTVEED-AVPGYTTTV-- 77

                          90
                  ....*....|.
gi 2735789188 684 DMTSGFTVTNT 694
Cdd:pfam05738  78 DAKDGFTITNT 88
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 515-597 1.78e-23

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 95.01  E-value: 1.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 515 VAGTKTWDD----DGVRPGSIRVNLLRDGVKV-DSVQVSAgsDGSWAYAFENLPKFDyGDGHLYDYTVSEDAVKNYSTKI 589
Cdd:pfam05738   1 VSVTKVWDDnnnqDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKYD-ENGKEITYTVEEDAVPGYTTTV 77

                          90
                  ....*....|.
gi 2735789188 590 ---NGFDLTNS 597
Cdd:pfam05738  78 dakDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 423-508 5.91e-23

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


:

Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 93.51  E-value: 5.91e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 423 TKVKVSKKWIGPKGSP------VTVHLLADGVDTGKSLVLNEDSGWKGTFTDLREYNANGQKISYTVSEDSVDGYKGEVT 496
Cdd:cd00222     1 TDITVTKTWDDDDNQDgkrpesITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYTTTVT 80

                          90
                  ....*....|..
gi 2735789188 497 GDMKcGFTLTNT 508
Cdd:cd00222    81 GDDG-GFTITNT 91
Big_8 pfam17961
Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide ...
 64-162 1.12e-21

Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide range of bacterial cell surface adherence proteins.


:

Pssm-ID: 465589 [Multi-domain]  Cd Length: 102  Bit Score: 90.36  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188  64 LSMDWDASsYGINLHEGDYFDVTLPDTFKF-PNGVTAQDFDLLDPNGNVVAKAHVTPGsdenGGTVRATFTKTVENKYNV 142
Cdd:pfam17961   8 LKLKADFS-LGDSVKEGDYFTIKLPDNLKFyGINTSDKSFDIKDDNGEVIAKGTYDPG----TGTITYTFTDYVENKSNI 82

                          90       100
                  ....*....|....*....|
gi 2735789188 143 KGTMYLVAKFNTKKVDLNKK 162
Cdd:pfam17961  83 KGSLYLPAYIDKKKVKENGK 102
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 343-409 2.74e-12

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


:

Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 62.60  E-value: 2.74e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2735789188 343 NENVKLANAVFTVTKPDGS-----TFELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLNDAEYTLTVTSSK 409
Cdd:pfam17802   1 DTGKPLAGAEFTLYDADGTvdgkvVGTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
Collagen_bind super family cl37551
Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel ...
 189-308 2.83e-07

Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.


The actual alignment was detected with superfamily member pfam05737:

Pssm-ID: 283410 [Multi-domain]  Cd Length: 129  Bit Score: 50.05  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 189 EVLNKWaGKVDGE-PGNAQWYARINHMKSTLHNVVISDTLDdPTQHYIPGSFELQKVIFNKYGDVSSV-LETVNIDSKLT 266
Cdd:pfam05737   1 EAIYKV-GWVDAEnNSLIHWTVRINYALQNIENAVLTDFIG-EGQNLVFDSIEVYELNYKKDGEVVSGdKEYPLYQTIDL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2735789188 267 IDGNSFTLNLGDVNGDQYHLTYQSTYTSG---KTLKNKLMLTSDE 308
Cdd:pfam05737  79 DTDNGFTVTFGDTIDSAYIISYTTTITDGgksQSYDNKATLNGDN 123
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 605-694 9.01e-28

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 106.95  E-value: 9.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 605 VSVSKVWKDANDKEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYVK-KGGKAISYTVKEVgTVDGYKGEVtg 683
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYdENGKEITYTVEED-AVPGYTTTV-- 77

                          90
                  ....*....|.
gi 2735789188 684 DMTSGFTVTNT 694
Cdd:pfam05738  78 DAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 603-695 3.00e-27

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 105.84  E-value: 3.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 603 TSVSVSKVWKDANDKEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYV-KKGGKAISYTVKEVGtVDGYKGEV 681
Cdd:cd00222     1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKETGDTVTLTASNDWTYTFTNLPKyDENGKEITYTVKEVP-VPGYTTTV 79

                          90
                  ....*....|....
gi 2735789188 682 TGDMtSGFTVTNTI 695
Cdd:cd00222    80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 515-597 1.78e-23

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 95.01  E-value: 1.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 515 VAGTKTWDD----DGVRPGSIRVNLLRDGVKV-DSVQVSAgsDGSWAYAFENLPKFDyGDGHLYDYTVSEDAVKNYSTKI 589
Cdd:pfam05738   1 VSVTKVWDDnnnqDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKYD-ENGKEITYTVEEDAVPGYTTTV 77

                          90
                  ....*....|.
gi 2735789188 590 ---NGFDLTNS 597
Cdd:pfam05738  78 dakDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 423-508 5.91e-23

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 93.51  E-value: 5.91e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 423 TKVKVSKKWIGPKGSP------VTVHLLADGVDTGKSLVLNEDSGWKGTFTDLREYNANGQKISYTVSEDSVDGYKGEVT 496
Cdd:cd00222     1 TDITVTKTWDDDDNQDgkrpesITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYTTTVT 80

                          90
                  ....*....|..
gi 2735789188 497 GDMKcGFTLTNT 508
Cdd:cd00222    81 GDDG-GFTITNT 91
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 425-508 1.89e-22

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 91.92  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 425 VKVSKKWIGPKG------SPVTVHLLADGVDTGKSLVLNEDSGWKGTFTDLREYNANGQKISYTVSEDSVDGYKGEVtgD 498
Cdd:pfam05738   1 VSVTKVWDDNNNqdgirpESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYTTTV--D 78

                          90
                  ....*....|
gi 2735789188 499 MKCGFTLTNT 508
Cdd:pfam05738  79 AKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 513-598 3.83e-22

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 91.20  E-value: 3.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 513 TRVAGTKTWDD----DGVRPGSIRVNLLRDGVK-VDSVQVSAGSDgsWAYAFENLPKFDyGDGHLYDYTVSEDAVKNYST 587
Cdd:cd00222     1 TDITVTKTWDDddnqDGKRPESITVQLLANGKEtGDTVTLTASND--WTYTFTNLPKYD-ENGKEITYTVKEVPVPGYTT 77

                          90
                  ....*....|....*
gi 2735789188 588 KING----FDLTNSY 598
Cdd:cd00222    78 TVTGddggFTITNTH 92
Big_8 pfam17961
Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide ...
 64-162 1.12e-21

Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide range of bacterial cell surface adherence proteins.


Pssm-ID: 465589 [Multi-domain]  Cd Length: 102  Bit Score: 90.36  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188  64 LSMDWDASsYGINLHEGDYFDVTLPDTFKF-PNGVTAQDFDLLDPNGNVVAKAHVTPGsdenGGTVRATFTKTVENKYNV 142
Cdd:pfam17961   8 LKLKADFS-LGDSVKEGDYFTIKLPDNLKFyGINTSDKSFDIKDDNGEVIAKGTYDPG----TGTITYTFTDYVENKSNI 82

                          90       100
                  ....*....|....*....|
gi 2735789188 143 KGTMYLVAKFNTKKVDLNKK 162
Cdd:pfam17961  83 KGSLYLPAYIDKKKVKENGK 102
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 325-620 7.26e-16

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 81.56  E-value: 7.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 325 TGDGDLANKIKLVKVEEGNENVKLANAVFTVTKPDGSTF-ELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLNDAEYTL 403
Cdd:COG4932   351 GNNEVKTGSVTLTKVDADDGEAPLAGAEFTLTDADGTVVaTITTDADGTASFKGLAPGTYTLTETKAPEGYTLDSTPITV 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 404 TVTSSKDGAIQTVTDKPITTKVKVSKKWIGPKGSPVTVHLLADGVDT--------------GKSLVLNEDSGWKGTFTDL 469
Cdd:COG4932   431 TVTDGGTGAIDTITNERKKGSVQVTKVDAPLAGATFTLTDADGTVVTlttdadlagatfeaDGKVVTTTDASGKYTFKNL 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 470 REYNANGQKISYTVSEDSVDGYKGEVTGDMKCGFTLTNTNVQTTRVAGTKTWDDDGVRPGSIRVNLLRDGVKVDSVQVSA 549
Cdd:COG4932   511 PPGTYTDAGGSATVITDDTDGTVGDEATGTDPEVTVTGKSTTTTPDVALLTNLGTTEDALTSLAKTGDEVGKGLTLTTTT 590

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2735789188 550 GSDGSWAYAFENLPKFDYGDGHLYDYTVSEDAVKNYSTKINGFDLTNSYTPGKTSVSVSKVWKDANDKEHT 620
Cdd:COG4932   591 TVDTLDTNATEKTETVTVTAQLIGVKTTKLTDTTDPKGGTVEEATTTGGTANTGKTGTDLTDDTTVTSTTN 661
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 343-409 2.74e-12

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 62.60  E-value: 2.74e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2735789188 343 NENVKLANAVFTVTKPDGS-----TFELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLNDAEYTLTVTSSK 409
Cdd:pfam17802   1 DTGKPLAGAEFTLYDADGTvdgkvVGTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
Collagen_bind pfam05737
Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel ...
 189-308 2.83e-07

Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.


Pssm-ID: 283410 [Multi-domain]  Cd Length: 129  Bit Score: 50.05  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 189 EVLNKWaGKVDGE-PGNAQWYARINHMKSTLHNVVISDTLDdPTQHYIPGSFELQKVIFNKYGDVSSV-LETVNIDSKLT 266
Cdd:pfam05737   1 EAIYKV-GWVDAEnNSLIHWTVRINYALQNIENAVLTDFIG-EGQNLVFDSIEVYELNYKKDGEVVSGdKEYPLYQTIDL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2735789188 267 IDGNSFTLNLGDVNGDQYHLTYQSTYTSG---KTLKNKLMLTSDE 308
Cdd:pfam05737  79 DTDNGFTVTFGDTIDSAYIISYTTTITDGgksQSYDNKATLNGDN 123
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 333-435 2.24e-05

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 47.83  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 333 KIKLVKVEEGNENVKLANAVFTV--TKPDGSTF-----------ELTTGADGTVVS--------------GILEQGTYKV 385
Cdd:NF033902  373 KLKIKKVDADDTSKKLKGAEFKVyaCEADAAAAcvnaigingktTFTTGADGTVSIdglhvtdledgasvKAAAGKDYCL 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2735789188 386 KEKVAPTGYKLNDAEYTLTVTSSKDGAIQTVTDKPITTKVKVSKKWIGPK 435
Cdd:NF033902  453 VETKAPAGYVLPPKPVEVTVVKVTVTAATTADVKNTVVNNKKTVPNWFFN 502
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 605-694 9.01e-28

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 106.95  E-value: 9.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 605 VSVSKVWKDANDKEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYVK-KGGKAISYTVKEVgTVDGYKGEVtg 683
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYdENGKEITYTVEED-AVPGYTTTV-- 77

                          90
                  ....*....|.
gi 2735789188 684 DMTSGFTVTNT 694
Cdd:pfam05738  78 DAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 603-695 3.00e-27

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 105.84  E-value: 3.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 603 TSVSVSKVWKDANDKEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYV-KKGGKAISYTVKEVGtVDGYKGEV 681
Cdd:cd00222     1 TDITVTKTWDDDDNQDGKRPESITVQLLANGKETGDTVTLTASNDWTYTFTNLPKyDENGKEITYTVKEVP-VPGYTTTV 79

                          90
                  ....*....|....
gi 2735789188 682 TGDMtSGFTVTNTI 695
Cdd:cd00222    80 TGDD-GGFTITNTH 92
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 515-597 1.78e-23

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 95.01  E-value: 1.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 515 VAGTKTWDD----DGVRPGSIRVNLLRDGVKV-DSVQVSAgsDGSWAYAFENLPKFDyGDGHLYDYTVSEDAVKNYSTKI 589
Cdd:pfam05738   1 VSVTKVWDDnnnqDGIRPESITVQLLANGQKVgVTKELTA--ANNWTYTFTDLPKYD-ENGKEITYTVEEDAVPGYTTTV 77

                          90
                  ....*....|.
gi 2735789188 590 ---NGFDLTNS 597
Cdd:pfam05738  78 dakDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 423-508 5.91e-23

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 93.51  E-value: 5.91e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 423 TKVKVSKKWIGPKGSP------VTVHLLADGVDTGKSLVLNEDSGWKGTFTDLREYNANGQKISYTVSEDSVDGYKGEVT 496
Cdd:cd00222     1 TDITVTKTWDDDDNQDgkrpesITVQLLANGKETGDTVTLTASNDWTYTFTNLPKYDENGKEITYTVKEVPVPGYTTTVT 80

                          90
                  ....*....|..
gi 2735789188 497 GDMKcGFTLTNT 508
Cdd:cd00222    81 GDDG-GFTITNT 91
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 425-508 1.89e-22

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 91.92  E-value: 1.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 425 VKVSKKWIGPKG------SPVTVHLLADGVDTGKSLVLNEDSGWKGTFTDLREYNANGQKISYTVSEDSVDGYKGEVtgD 498
Cdd:pfam05738   1 VSVTKVWDDNNNqdgirpESITVQLLANGQKVGVTKELTAANNWTYTFTDLPKYDENGKEITYTVEEDAVPGYTTTV--D 78

                          90
                  ....*....|
gi 2735789188 499 MKCGFTLTNT 508
Cdd:pfam05738  79 AKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 513-598 3.83e-22

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 91.20  E-value: 3.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 513 TRVAGTKTWDD----DGVRPGSIRVNLLRDGVK-VDSVQVSAGSDgsWAYAFENLPKFDyGDGHLYDYTVSEDAVKNYST 587
Cdd:cd00222     1 TDITVTKTWDDddnqDGKRPESITVQLLANGKEtGDTVTLTASND--WTYTFTNLPKYD-ENGKEITYTVKEVPVPGYTT 77

                          90
                  ....*....|....*
gi 2735789188 588 KING----FDLTNSY 598
Cdd:cd00222    78 TVTGddggFTITNTH 92
Big_8 pfam17961
Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide ...
 64-162 1.12e-21

Bacterial Ig domain; This entry represents a bacterial Ig-fold domain that is found in a wide range of bacterial cell surface adherence proteins.


Pssm-ID: 465589 [Multi-domain]  Cd Length: 102  Bit Score: 90.36  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188  64 LSMDWDASsYGINLHEGDYFDVTLPDTFKF-PNGVTAQDFDLLDPNGNVVAKAHVTPGsdenGGTVRATFTKTVENKYNV 142
Cdd:pfam17961   8 LKLKADFS-LGDSVKEGDYFTIKLPDNLKFyGINTSDKSFDIKDDNGEVIAKGTYDPG----TGTITYTFTDYVENKSNI 82

                          90       100
                  ....*....|....*....|
gi 2735789188 143 KGTMYLVAKFNTKKVDLNKK 162
Cdd:pfam17961  83 KGSLYLPAYIDKKKVKENGK 102
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 325-620 7.26e-16

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 81.56  E-value: 7.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 325 TGDGDLANKIKLVKVEEGNENVKLANAVFTVTKPDGSTF-ELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLNDAEYTL 403
Cdd:COG4932   351 GNNEVKTGSVTLTKVDADDGEAPLAGAEFTLTDADGTVVaTITTDADGTASFKGLAPGTYTLTETKAPEGYTLDSTPITV 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 404 TVTSSKDGAIQTVTDKPITTKVKVSKKWIGPKGSPVTVHLLADGVDT--------------GKSLVLNEDSGWKGTFTDL 469
Cdd:COG4932   431 TVTDGGTGAIDTITNERKKGSVQVTKVDAPLAGATFTLTDADGTVVTlttdadlagatfeaDGKVVTTTDASGKYTFKNL 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 470 REYNANGQKISYTVSEDSVDGYKGEVTGDMKCGFTLTNTNVQTTRVAGTKTWDDDGVRPGSIRVNLLRDGVKVDSVQVSA 549
Cdd:COG4932   511 PPGTYTDAGGSATVITDDTDGTVGDEATGTDPEVTVTGKSTTTTPDVALLTNLGTTEDALTSLAKTGDEVGKGLTLTTTT 590

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2735789188 550 GSDGSWAYAFENLPKFDYGDGHLYDYTVSEDAVKNYSTKINGFDLTNSYTPGKTSVSVSKVWKDANDKEHT 620
Cdd:COG4932   591 TVDTLDTNATEKTETVTVTAQLIGVKTTKLTDTTDPKGGTVEEATTTGGTANTGKTGTDLTDDTTVTSTTN 661
SpaA pfam17802
Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety ...
 343-409 2.74e-12

Prealbumin-like fold domain; This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.


Pssm-ID: 465513 [Multi-domain]  Cd Length: 72  Bit Score: 62.60  E-value: 2.74e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2735789188 343 NENVKLANAVFTVTKPDGS-----TFELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLNDAEYTLTVTSSK 409
Cdd:pfam17802   1 DTGKPLAGAEFTLYDADGTvdgkvVGTLTTDEDGKATFDGLPPGTYTLKETKAPDGYVLDDTPIEFTVTEDG 72
Collagen_bind pfam05737
Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel ...
 189-308 2.83e-07

Collagen binding domain; The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.


Pssm-ID: 283410 [Multi-domain]  Cd Length: 129  Bit Score: 50.05  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 189 EVLNKWaGKVDGE-PGNAQWYARINHMKSTLHNVVISDTLDdPTQHYIPGSFELQKVIFNKYGDVSSV-LETVNIDSKLT 266
Cdd:pfam05737   1 EAIYKV-GWVDAEnNSLIHWTVRINYALQNIENAVLTDFIG-EGQNLVFDSIEVYELNYKKDGEVVSGdKEYPLYQTIDL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2735789188 267 IDGNSFTLNLGDVNGDQYHLTYQSTYTSG---KTLKNKLMLTSDE 308
Cdd:pfam05737  79 DTDNGFTVTFGDTIDSAYIISYTTTITDGgksQSYDNKATLNGDN 123
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 249-736 5.00e-07

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 53.05  E-value: 5.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 249 YGDVSSVLETVNIDSKLTIDGNSFTLNLGDVNGDQYHLTYQSTYTSGKTLKNKLMLTSDEETKSYEFAYRSAESGGTGDG 328
Cdd:COG4932    79 TPTETASGLGGDATVTTTANVAKVTNGAAANLTVNADGTASNAGTLAKGAETATGNLDGDAGDVTVTAAATDGVNDVDGN 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 329 --DLANKIKLVKVEEGNENVKLANAVFTVTKPDGSTF-ELTTGADGTVVSGILEQGTYKVKEKVAPTGYKLN-----DAE 400
Cdd:COG4932   159 gaSVTDSVTLKKVDDGDTGKPLPGATFTLYDSDGTLVkTVTTDADGKYTFTDLPPGTYTLTETKAPEGYVLDtkdptGAT 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 401 YTLTVTSSKDGAIqTVTDKPITTKVKVSkkwiGPKGSPVTVHLLADGVDTGKSLVLNEDSGWKGTFTDL-REYNANGQKI 479
Cdd:COG4932   239 ITVTVNAGGTVTV-TLKNTPKYTKGSVT----VTKTDADTGEPLAGATFTLTDADGNTVVTTTVTVTDAdGSYTFTDLPP 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 480 -SYTVSEDSV--------DGYKGEVTGDMKCGFTLTNTN--VQTTRVAGTKTWDDDGVRP-GSIRVNLLR-DGVKVDSVq 546
Cdd:COG4932   314 gTYTVTETKApagydldgEAVKVTITAGQTTTVTVTNGNneVKTGSVTLTKVDADDGEAPlAGAEFTLTDaDGTVVATI- 392

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 547 vSAGSDGSwaYAFENLPKFDY-------GDGhlydYTVSEDAVK---NYSTKINGFDLTNSYTPGKTSVSVSKVWKDAND 616
Cdd:COG4932   393 -TTDADGT--ASFKGLAPGTYtltetkaPEG----YTLDSTPITvtvTDGGTGAIDTITNERKKGSVQVTKVDAPLAGAT 465

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 617 KEHTRPKSVKVQLYADGAVQGAPVELSESNHWSYTWSGLYVKKGGKAISYTVKEVGTVDGYKGEVTGDMTSGFTVTNTIV 696
Cdd:COG4932   466 FTLTDADGTVVTLTTDADLAGATFEADGKVVTTTDASGKYTFKNLPPGTYTDAGGSATVITDDTDGTVGDEATGTDPEVT 545

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 2735789188 697 PTPNKPVKKTVAATGSSLVAPSVILAALVALAVLAGGIAY 736
Cdd:COG4932   546 VTGKSTTTTPDVALLTNLGTTEDALTSLAKTGDEVGKGLT 585
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 333-435 2.24e-05

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 47.83  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2735789188 333 KIKLVKVEEGNENVKLANAVFTV--TKPDGSTF-----------ELTTGADGTVVS--------------GILEQGTYKV 385
Cdd:NF033902  373 KLKIKKVDADDTSKKLKGAEFKVyaCEADAAAAcvnaigingktTFTTGADGTVSIdglhvtdledgasvKAAAGKDYCL 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2735789188 386 KEKVAPTGYKLNDAEYTLTVTSSKDGAIQTVTDKPITTKVKVSKKWIGPK 435
Cdd:NF033902  453 VETKAPAGYVLPPKPVEVTVVKVTVTAATTADVKNTVVNNKKTVPNWFFN 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH