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Conserved domains on  [gi|2750649816|ref|WP_353038894|]
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acetyltransferase, partial [Serratia marcescens]

Protein Classification

GNAT family protein( domain architecture ID 106742)

GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

PubMed:  15581578

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 1-143 1.00e-56

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member PRK10514:

Pssm-ID: 473072 [Multi-domain]  Cd Length: 145  Bit Score: 173.65  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADIWLRSVRATHHFLTEDNIAQLFPLVlNDYLPAVNVWVAEERPGHPCGFIGLNGNKVEMLFIDA 80
Cdd:PRK10514    1 MISIRRSRHEEGERLVAIWRRSVDATHDFLSAEDRAEIEELV-RSFLPEAPLWVAVDERDQPVGFMLLSGGHMEALFVDP 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750649816  81 DQRGKGVGKALLTHAETLHDELQLDVNEQNPQASGFYRHYGFVITGRSPLDGQGNPFPLLHMK 143
Cdd:PRK10514   80 DVRGCGVGRMLVEHALSLHPELTTDVNEQNEQAVGFYKKMGFKVTGRSEVDDQGRPYPLLHLA 142
 
Name Accession Description Interval E-value
PRK10514 PRK10514
putative acetyltransferase; Provisional
 1-143 1.00e-56

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 173.65  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADIWLRSVRATHHFLTEDNIAQLFPLVlNDYLPAVNVWVAEERPGHPCGFIGLNGNKVEMLFIDA 80
Cdd:PRK10514    1 MISIRRSRHEEGERLVAIWRRSVDATHDFLSAEDRAEIEELV-RSFLPEAPLWVAVDERDQPVGFMLLSGGHMEALFVDP 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750649816  81 DQRGKGVGKALLTHAETLHDELQLDVNEQNPQASGFYRHYGFVITGRSPLDGQGNPFPLLHMK 143
Cdd:PRK10514   80 DVRGCGVGRMLVEHALSLHPELTTDVNEQNEQAVGFYKKMGFKVTGRSEVDDQGRPYPLLHLA 142
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-129 3.62e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 73.11  E-value: 3.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADIWLRSVRATH-----HFLTEDNIAQLFPLVLNDYLPavnVWVAEERpGHPCGFIGLNGNK--- 72
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEAIAEGTatfetEPPSEEEREAWFAAILAPGRP---VLVAEED-GEVVGFASLGPFRprp 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2750649816  73 ------VEMLFIDADQRGKGVGKALLTHAETL-----HDELQLDVNEQNPQASGFYRHYGFVITGRSP 129
Cdd:COG1247    77 ayrgtaEESIYVDPDARGRGIGRALLEALIERarargYRRLVAVVLADNEASIALYEKLGFEEVGTLP 144
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 23-144 3.59e-16

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 69.61  E-value: 3.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  23 VRATHHFLTEDNIAQLFPLvlNDYLpavnVWVAEERpGHPCGFIGL-NGNKVEMLFIDADQRGKGVGKALL----THAET 97
Cdd:pfam13673  10 IETFYEFISPEALRERIDQ--GEYF----FFVAFEG-GQIVGVIALrDRGHISLLFVDPDYQGQGIGKALLeaveDYAEK 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2750649816  98 LHDEL-QLDVNEQnPQASGFYRHYGFVITGRsplDGQGNPFPLLHMKL 144
Cdd:pfam13673  83 DGIKLsELTVNAS-PYAVPFYEKLGFRATGP---EQEFNGIRFVPMEK 126
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-105 2.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 2.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2750649816  52 VWVAEERpGHPCGFIGLNGNK-------VEMLFIDADQRGKGVGKALLTHAETLHDELQLD 105
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGsggdtayIGDLAVLPEYRGKGIGSALLEAAEEEARERGAK 60
 
Name Accession Description Interval E-value
PRK10514 PRK10514
putative acetyltransferase; Provisional
 1-143 1.00e-56

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 173.65  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADIWLRSVRATHHFLTEDNIAQLFPLVlNDYLPAVNVWVAEERPGHPCGFIGLNGNKVEMLFIDA 80
Cdd:PRK10514    1 MISIRRSRHEEGERLVAIWRRSVDATHDFLSAEDRAEIEELV-RSFLPEAPLWVAVDERDQPVGFMLLSGGHMEALFVDP 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750649816  81 DQRGKGVGKALLTHAETLHDELQLDVNEQNPQASGFYRHYGFVITGRSPLDGQGNPFPLLHMK 143
Cdd:PRK10514   80 DVRGCGVGRMLVEHALSLHPELTTDVNEQNEQAVGFYKKMGFKVTGRSEVDDQGRPYPLLHLA 142
PRK10562 PRK10562
putative acetyltransferase; Provisional
 4-127 2.91e-24

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 90.90  E-value: 2.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   4 IRARAAEDNAQLADIWLRSVRATHHFLTEDNIAQLFPLVLNDYLPAVNVWVAEErPGHPCGFIG-LNGNKVEMLFIDADQ 82
Cdd:PRK10562    2 IREYQPSDLPAILQLWLESTIWAHPFIKEQYWRESAPLVRDVYLPAAQTWVWEE-DGKLLGFVSvLEGRFVGALFVAPKA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2750649816  83 RGKGVGKALLTHAETLHDELQLDVNEQNPQASGFYRHYGFVITGR 127
Cdd:PRK10562   81 VRRGIGKALMQHVQQRYPHLSLEVYQKNQRAVNFYHAQGFRIVDS 125
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-129 3.62e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 73.11  E-value: 3.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADIWLRSVRATH-----HFLTEDNIAQLFPLVLNDYLPavnVWVAEERpGHPCGFIGLNGNK--- 72
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEAIAEGTatfetEPPSEEEREAWFAAILAPGRP---VLVAEED-GEVVGFASLGPFRprp 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2750649816  73 ------VEMLFIDADQRGKGVGKALLTHAETL-----HDELQLDVNEQNPQASGFYRHYGFVITGRSP 129
Cdd:COG1247    77 ayrgtaEESIYVDPDARGRGIGRALLEALIERarargYRRLVAVVLADNEASIALYEKLGFEEVGTLP 144
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 23-144 3.59e-16

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 69.61  E-value: 3.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  23 VRATHHFLTEDNIAQLFPLvlNDYLpavnVWVAEERpGHPCGFIGL-NGNKVEMLFIDADQRGKGVGKALL----THAET 97
Cdd:pfam13673  10 IETFYEFISPEALRERIDQ--GEYF----FFVAFEG-GQIVGVIALrDRGHISLLFVDPDYQGQGIGKALLeaveDYAEK 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2750649816  98 LHDEL-QLDVNEQnPQASGFYRHYGFVITGRsplDGQGNPFPLLHMKL 144
Cdd:pfam13673  83 DGIKLsELTVNAS-PYAVPFYEKLGFRATGP---EQEFNGIRFVPMEK 126
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 2-129 5.46e-14

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 64.30  E-value: 5.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   2 ITIRARAAEDNAQLADIwlrsvrathhFLTEDNIAQLfplvlnDYLPAVNVWVAEERPGHPCGFIGLN--GNK---VEML 76
Cdd:COG0454     1 MSIRKATPEDINFILLI----------EALDAELKAM------EGSLAGAEFIAVDDKGEPIGFAGLRrlDDKvleLKRL 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2750649816  77 FIDADQRGKGVGKALLTHAETLHDE-----LQLDVNEQNPQASGFYRHYGFVITGRSP 129
Cdd:COG0454    65 YVLPEYRGKGIGKALLEALLEWARErgctaLELDTLDGNPAAIRFYERLGFKEIERYV 122
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 73-129 7.13e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 62.75  E-value: 7.13e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2750649816  73 VEMLFIDADQRGKGVGKALLTHAETL-----HDELQLDVNEQNPQASGFYRHYGFVITGRSP 129
Cdd:COG0456    16 IEDLAVDPEYRGRGIGRALLEAALERarergARRLRLEVREDNEAAIALYEKLGFEEVGERP 77
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 52-124 4.87e-12

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.85  E-value: 4.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  52 VWVAEERpGHPCGFIGLNGNKVE------MLFIDADQRGKGVGKALLTHAETLHDE--LQLDVNEQNPQASGFYRHYGFV 123
Cdd:pfam13508   5 FFVAEDD-GKIVGFAALLPLDDEgalaelRLAVHPEYRGQGIGRALLEAAEAAAKEggIKLLELETTNRAAAFYEKLGFE 83


                  .
gi 2750649816 124 I 124
Cdd:pfam13508  84 E 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 2-133 2.51e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 54.61  E-value: 2.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   2 ITIRARAAEDNAQLADIWlrsvratHHFLTEDNIAQlfplvlndylpavnVWVAEERpGHPCGFIGL---NGNKVEM--L 76
Cdd:COG1246     1 MTIRPATPDDVPAILELI-------RPYALEEEIGE--------------FWVAEED-GEIVGCAALhplDEDLAELrsL 58

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2750649816  77 FIDADQRGKGVGKALLTHAETL-----HDELQLDVneqNPQASGFYRHYGFVITGRSPLDGQ 133
Cdd:COG1246    59 AVHPDYRGRGIGRRLLEALLAEarelgLKRLFLLT---TSAAIHFYEKLGFEEIDKEDLPYA 117
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
4-132 4.95e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.62  E-value: 4.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   4 IRARAAEDNAQLADIWLRSVRATHHFLTEDNIAQLFPLVLndylpavnVWVAEERpGHPCGFIGLNGNKV---------E 74
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGL--------SLVAEDD-GEIVGHVALSPVDIdgegpalllG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750649816  75 MLFIDADQRGKGVGKALLTHAETL-----HDELQLDVneqNPQASGFYRHYGFVITGRSPLDG 132
Cdd:COG3153    72 PLAVDPEYRGQGIGRALMRAALEAarergARAVVLLG---DPSLLPFYERFGFRPAGELGLTL 131
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 53-122 8.15e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 47.51  E-value: 8.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  53 WVAEERpGHPCGFIGLNGN-------KVEMLFIDADQRGKGVGKALLTHAETL-----HDELQLDVNEQNPQASGFYRHY 120
Cdd:pfam00583  36 FVAEED-GELVGFASLSIIddeppvgEIEGLAVAPEYRGKGIGTALLQALLEWarergCERIFLEVAADNLAAIALYEKL 114


                  ..
gi 2750649816 121 GF 122
Cdd:pfam00583 115 GF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
52-127 3.06e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 45.28  E-value: 3.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  52 VWVAEERPgHPCGFIGLNGnkvemLFIDADQRGKGVGKALLTHAETL-----HDELQLDVNEQNPQASGFYRHYGFVITG 126
Cdd:COG3393     3 VAMAGVRA-ESPGVAEISG-----VYTHPEYRGRGLASALVAALAREalargARTPFLYVDADNPAARRLYERLGFRPVG 76


                  .
gi 2750649816 127 R 127
Cdd:COG3393    77 E 77
PRK09831 PRK09831
GNAT family N-acetyltransferase;
2-143 2.55e-06

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 44.18  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   2 ITIRARAAEDNAQLADIWLRSVR--ATHHFlTEDNIA---QLFPLVLNDYLPAVNVWVAEERpGHPCGFIGLNGNKVEML 76
Cdd:PRK09831    1 IQIRNYQPGDFQQLCAIFIRAVTmtASQHY-SPQQIAawaQIDESRWKEKLAKSQVRVAVIN-AQPVGFITCIEHYIDML 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2750649816  77 FIDADQRGKGVGKALLTHAETLHDELQLDVneqNPQASGFYRHYGFVITGRSPLDGQGNPFPLLHMK 143
Cdd:PRK09831   79 FVDPEYTRRGVASALLKPLIKSESELTVDA---SITAKPFFERYGFQTVKQQRVECRGEWFINFYMR 142
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-144 3.21e-06

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 44.22  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   1 MITIRARAAEDNAQLADiWLRSVRATHHF----LTEDNIAQLFPLVLNDY-LPAVNVWVAEERP-GHPCGFIGLNG---- 70
Cdd:COG1670     7 RLRLRPLRPEDAEALAE-LLNDPEVARYLpgppYSLEEARAWLERLLADWaDGGALPFAIEDKEdGELIGVVGLYDidra 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816  71 -NKVEM-LFIDADQRGKGVG----KALLTHA-ETLH-DELQLDVNEQNPQASGFYRHYGFVITG--RSPLDGQGNPFPLL 140
Cdd:COG1670    86 nRSAEIgYWLAPAYWGKGYAtealRALLDYAfEELGlHRVEAEVDPDNTASIRVLEKLGFRLEGtlRDALVIDGRYRDHV 165


                  ....
gi 2750649816 141 HMKL 144
Cdd:COG1670   166 LYSL 169
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
72-131 4.69e-06

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 43.25  E-value: 4.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2750649816  72 KVEMLFIDADQRGKGVGKALLTHAETLHDELQLD---VNEQnPQASGFYRHYGFVITGRSPLD 131
Cdd:COG2153    60 KIGRVAVLPEYRGQGLGRALMEAAIEEARERGARrivLSAQ-AHAVGFYEKLGFVPVGEEFLE 121
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 52-105 2.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 2.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2750649816  52 VWVAEERpGHPCGFIGLNGNK-------VEMLFIDADQRGKGVGKALLTHAETLHDELQLD 105
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGsggdtayIGDLAVLPEYRGKGIGSALLEAAEEEARERGAK 60
Eis COG4552
Predicted acetyltransferase [General function prediction only];
2-127 3.54e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 39.11  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2750649816   2 ITIRARAAEDNAQLADIWLRSVratHHFLTEDNIAQLFPLVLNDylpavNVWVAEErPGHPCGFIGLN-------GNKVE 74
Cdd:COG4552     1 MEIRPLTEDDLDAFARLLAYAF---GPEPDDEELEAYRPLLEPG-----RVLGVFD-DGELVGTLALYpftlnvgGARVP 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2750649816  75 MLFI-----DADQRGKGVGKALLTHA-ETLHDE------LQldvneqnPQASGFYRHYGFVITGR 127
Cdd:COG4552    72 MAGItgvavAPEHRRRGVARALLREAlAELRERgqplsaLY-------PFEPGFYRRFGYELAGD 129
PRK03624 PRK03624
putative acetyltransferase; Provisional
 76-122 8.84e-04

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 37.22  E-value: 8.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2750649816  76 LFIDADQRGKGVGKALLTHAEtlhDEL--------QLDVNEQNPQASGFYRHYGF 122
Cdd:PRK03624   74 LAVHPDFRGRGIGRALVARLE---KKLiargcpkiNLQVREDNDAVLGFYEALGY 125
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 76-122 2.67e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 36.06  E-value: 2.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2750649816  76 LF---IDADQRGKGVGKALLTHaetLHDELQ--------LDVNEQNPQASGFYRHYGF 122
Cdd:PRK09491   66 LFniaVDPDYQRQGLGRALLEH---LIDELEkrgvatlwLEVRASNAAAIALYESLGF 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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