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acetyltransferase, partial [Serratia marcescens]
GNAT family protein( domain architecture ID 106742)
GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
NAT_SF super family | cl17182 | N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ... |
1-143 | 1.00e-56 | |||
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included. The actual alignment was detected with superfamily member PRK10514: Pssm-ID: 473072 [Multi-domain] Cd Length: 145 Bit Score: 173.65 E-value: 1.00e-56
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Name | Accession | Description | Interval | E-value | |||
PRK10514 | PRK10514 | putative acetyltransferase; Provisional |
1-143 | 1.00e-56 | |||
putative acetyltransferase; Provisional Pssm-ID: 182510 [Multi-domain] Cd Length: 145 Bit Score: 173.65 E-value: 1.00e-56
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MnaT | COG1247 | L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism]; |
1-129 | 3.62e-17 | |||
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism]; Pssm-ID: 440860 [Multi-domain] Cd Length: 163 Bit Score: 73.11 E-value: 3.62e-17
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Acetyltransf_10 | pfam13673 | Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ... |
23-144 | 3.59e-16 | |||
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins. Pssm-ID: 463953 [Multi-domain] Cd Length: 128 Bit Score: 69.61 E-value: 3.59e-16
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NAT_SF | cd04301 | N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ... |
52-105 | 2.22e-05 | |||
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included. Pssm-ID: 173926 [Multi-domain] Cd Length: 65 Bit Score: 39.95 E-value: 2.22e-05
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Name | Accession | Description | Interval | E-value | ||||
PRK10514 | PRK10514 | putative acetyltransferase; Provisional |
1-143 | 1.00e-56 | ||||
putative acetyltransferase; Provisional Pssm-ID: 182510 [Multi-domain] Cd Length: 145 Bit Score: 173.65 E-value: 1.00e-56
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PRK10562 | PRK10562 | putative acetyltransferase; Provisional |
4-127 | 2.91e-24 | ||||
putative acetyltransferase; Provisional Pssm-ID: 236715 [Multi-domain] Cd Length: 145 Bit Score: 90.90 E-value: 2.91e-24
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MnaT | COG1247 | L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism]; |
1-129 | 3.62e-17 | ||||
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism]; Pssm-ID: 440860 [Multi-domain] Cd Length: 163 Bit Score: 73.11 E-value: 3.62e-17
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Acetyltransf_10 | pfam13673 | Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ... |
23-144 | 3.59e-16 | ||||
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins. Pssm-ID: 463953 [Multi-domain] Cd Length: 128 Bit Score: 69.61 E-value: 3.59e-16
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PhnO | COG0454 | N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ... |
2-129 | 5.46e-14 | ||||
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only]; Pssm-ID: 440222 [Multi-domain] Cd Length: 136 Bit Score: 64.30 E-value: 5.46e-14
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RimI | COG0456 | Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ... |
73-129 | 7.13e-14 | ||||
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440224 [Multi-domain] Cd Length: 92 Bit Score: 62.75 E-value: 7.13e-14
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Acetyltransf_7 | pfam13508 | Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions. |
52-124 | 4.87e-12 | ||||
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions. Pssm-ID: 463905 [Multi-domain] Cd Length: 84 Bit Score: 57.85 E-value: 4.87e-12
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ArgA | COG1246 | N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ... |
2-133 | 2.51e-10 | ||||
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis Pssm-ID: 440859 [Multi-domain] Cd Length: 132 Bit Score: 54.61 E-value: 2.51e-10
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yhbS | COG3153 | Predicted N-acetyltransferase YhbS [General function prediction only]; |
4-132 | 4.95e-09 | ||||
Predicted N-acetyltransferase YhbS [General function prediction only]; Pssm-ID: 442387 [Multi-domain] Cd Length: 142 Bit Score: 51.62 E-value: 4.95e-09
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Acetyltransf_1 | pfam00583 | Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ... |
53-122 | 8.15e-08 | ||||
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins. Pssm-ID: 395465 [Multi-domain] Cd Length: 116 Bit Score: 47.51 E-value: 8.15e-08
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COG3393 | COG3393 | Predicted acetyltransferase, GNAT family [General function prediction only]; |
52-127 | 3.06e-07 | ||||
Predicted acetyltransferase, GNAT family [General function prediction only]; Pssm-ID: 442620 [Multi-domain] Cd Length: 86 Bit Score: 45.28 E-value: 3.06e-07
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PRK09831 | PRK09831 | GNAT family N-acetyltransferase; |
2-143 | 2.55e-06 | ||||
GNAT family N-acetyltransferase; Pssm-ID: 182099 Cd Length: 147 Bit Score: 44.18 E-value: 2.55e-06
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RimL | COG1670 | Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ... |
1-144 | 3.21e-06 | ||||
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 441276 [Multi-domain] Cd Length: 173 Bit Score: 44.22 E-value: 3.21e-06
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ElaA | COG2153 | Predicted N-acyltransferase, GNAT family [General function prediction only]; |
72-131 | 4.69e-06 | ||||
Predicted N-acyltransferase, GNAT family [General function prediction only]; Pssm-ID: 441756 [Multi-domain] Cd Length: 134 Bit Score: 43.25 E-value: 4.69e-06
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NAT_SF | cd04301 | N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ... |
52-105 | 2.22e-05 | ||||
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included. Pssm-ID: 173926 [Multi-domain] Cd Length: 65 Bit Score: 39.95 E-value: 2.22e-05
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Eis | COG4552 | Predicted acetyltransferase [General function prediction only]; |
2-127 | 3.54e-04 | ||||
Predicted acetyltransferase [General function prediction only]; Pssm-ID: 443616 [Multi-domain] Cd Length: 393 Bit Score: 39.11 E-value: 3.54e-04
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PRK03624 | PRK03624 | putative acetyltransferase; Provisional |
76-122 | 8.84e-04 | ||||
putative acetyltransferase; Provisional Pssm-ID: 235142 [Multi-domain] Cd Length: 140 Bit Score: 37.22 E-value: 8.84e-04
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rimI | PRK09491 | ribosomal-protein-alanine N-acetyltransferase; Provisional |
76-122 | 2.67e-03 | ||||
ribosomal-protein-alanine N-acetyltransferase; Provisional Pssm-ID: 181904 [Multi-domain] Cd Length: 146 Bit Score: 36.06 E-value: 2.67e-03
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Blast search parameters | ||||
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