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Conserved domains on  [gi|2755244133|ref|WP_354284077|]
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MBL fold metallo-hydrolase, partial [Stenotrophomonas sp. 2619]

Protein Classification

MBL fold metallo-hydrolase( domain architecture ID 11454817)

MBL fold metallo-hydrolase similar to as Sus scrofa cytidine monophosphate-N-acetylneuraminic acid hydroxylase and Bacillus subtilis UPF0173 protein YddR; may be inactive as a hydrolase such as human inactive cytidine monophosphate-N-acetylneuraminic CMAHP

CATH:  3.60.15.30
Gene Ontology:  GO:0016787|GO:0046872
PubMed:  11471246|17597585
SCOP:  3001057

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UlaG COG2220
L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and ...
 5-114 1.24e-21

L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and metabolism];


:

Pssm-ID: 441822 [Multi-domain]  Cd Length: 224  Bit Score: 85.74  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   5 VSWVVSAAGRRIFHGGDTMWHGHWWKIARQFgPFDVAFLPINGARFgwrkpvsgqpgVLTPEQAIAAATVLGARSVVPIH 84
Cdd:COG2220   131 VGFVIETDGKTIYHAGDTGYFPEMKEIGERF-PIDVALLPIGAYPF-----------TMGPEEAAEAARDLKPKVVIPIH 198

                          90       100       110
                  ....*....|....*....|....*....|
gi 2755244133  85 YGVSGVDEyqevDDPLGALVRAARGTAIDV 114
Cdd:COG2220   199 YGTFPLLD----EDPLERFAAALAAAGVRV 224
 
Name Accession Description Interval E-value
UlaG COG2220
L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and ...
 5-114 1.24e-21

L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 441822 [Multi-domain]  Cd Length: 224  Bit Score: 85.74  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   5 VSWVVSAAGRRIFHGGDTMWHGHWWKIARQFgPFDVAFLPINGARFgwrkpvsgqpgVLTPEQAIAAATVLGARSVVPIH 84
Cdd:COG2220   131 VGFVIETDGKTIYHAGDTGYFPEMKEIGERF-PIDVALLPIGAYPF-----------TMGPEEAAEAARDLKPKVVIPIH 198

                          90       100       110
                  ....*....|....*....|....*....|
gi 2755244133  85 YGVSGVDEyqevDDPLGALVRAARGTAIDV 114
Cdd:COG2220   199 YGTFPLLD----EDPLERFAAALAAAGVRV 224
Lactamase_B_2 pfam12706
Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and ...
 5-85 7.83e-13

Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and is related to pfam00753.


Pssm-ID: 432732 [Multi-domain]  Cd Length: 196  Bit Score: 61.94  E-value: 7.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   5 VSWVVSAAGRRIFHGGDTmwhGHW-WKIARQFGPFDVAFLPINGarfgWRKPVSGQPGVLTPEQAIAAATVLGARSVVPI 83
Cdd:pfam12706 122 LGFRIEGPGKRVYYAGDT---GYFpDEIGERLGGADLLLLDGGA----WRDDEMIHMGHMTPEEAVEAAADLGARRKVLI 194


                  ..
gi 2755244133  84 HY 85
Cdd:pfam12706 195 HI 196
RomA-like_MBL-fold cd16283
Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain; ...
 6-48 2.16e-09

Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain; Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.


Pssm-ID: 293841  Cd Length: 181  Bit Score: 52.66  E-value: 2.16e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2755244133   6 SWVVSAAGRRIFHGGDTMWHGHWWKIARQFGPFDVAFLPInGA 48
Cdd:cd16283   134 GWVIEGEGFRIYFAGDTGYFPGFREIGRRFGPIDLALLPI-GA 175
PRK00685 PRK00685
metal-dependent hydrolase; Provisional
 8-86 4.45e-07

metal-dependent hydrolase; Provisional


Pssm-ID: 234811 [Multi-domain]  Cd Length: 228  Bit Score: 46.73  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   8 VVSAAGRRIFHGGDT-----MwhghwwKIARQFGPFDVAFLPInGARFgwrkpvsgqpgVLTPEQAIAAATVLGARSVVP 82
Cdd:PRK00685  129 VITFEGKTIYHAGDTglfsdM------KLIGELHKPDVALLPI-GDNF-----------TMGPEDAALAVELIKPKIVIP 190


                  ....
gi 2755244133  83 IHYG 86
Cdd:PRK00685  191 MHYN 194
 
Name Accession Description Interval E-value
UlaG COG2220
L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and ...
 5-114 1.24e-21

L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 441822 [Multi-domain]  Cd Length: 224  Bit Score: 85.74  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   5 VSWVVSAAGRRIFHGGDTMWHGHWWKIARQFgPFDVAFLPINGARFgwrkpvsgqpgVLTPEQAIAAATVLGARSVVPIH 84
Cdd:COG2220   131 VGFVIETDGKTIYHAGDTGYFPEMKEIGERF-PIDVALLPIGAYPF-----------TMGPEEAAEAARDLKPKVVIPIH 198

                          90       100       110
                  ....*....|....*....|....*....|
gi 2755244133  85 YGVSGVDEyqevDDPLGALVRAARGTAIDV 114
Cdd:COG2220   199 YGTFPLLD----EDPLERFAAALAAAGVRV 224
Lactamase_B_2 pfam12706
Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and ...
 5-85 7.83e-13

Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and is related to pfam00753.


Pssm-ID: 432732 [Multi-domain]  Cd Length: 196  Bit Score: 61.94  E-value: 7.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   5 VSWVVSAAGRRIFHGGDTmwhGHW-WKIARQFGPFDVAFLPINGarfgWRKPVSGQPGVLTPEQAIAAATVLGARSVVPI 83
Cdd:pfam12706 122 LGFRIEGPGKRVYYAGDT---GYFpDEIGERLGGADLLLLDGGA----WRDDEMIHMGHMTPEEAVEAAADLGARRKVLI 194


                  ..
gi 2755244133  84 HY 85
Cdd:pfam12706 195 HI 196
RomA-like_MBL-fold cd16283
Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain; ...
 6-48 2.16e-09

Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain; Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.


Pssm-ID: 293841  Cd Length: 181  Bit Score: 52.66  E-value: 2.16e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2755244133   6 SWVVSAAGRRIFHGGDTMWHGHWWKIARQFGPFDVAFLPInGA 48
Cdd:cd16283   134 GWVIEGEGFRIYFAGDTGYFPGFREIGRRFGPIDLALLPI-GA 175
PRK00685 PRK00685
metal-dependent hydrolase; Provisional
 8-86 4.45e-07

metal-dependent hydrolase; Provisional


Pssm-ID: 234811 [Multi-domain]  Cd Length: 228  Bit Score: 46.73  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755244133   8 VVSAAGRRIFHGGDT-----MwhghwwKIARQFGPFDVAFLPInGARFgwrkpvsgqpgVLTPEQAIAAATVLGARSVVP 82
Cdd:PRK00685  129 VITFEGKTIYHAGDTglfsdM------KLIGELHKPDVALLPI-GDNF-----------TMGPEDAALAVELIKPKIVIP 190


                  ....
gi 2755244133  83 IHYG 86
Cdd:PRK00685  191 MHYN 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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