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Conserved domains on  [gi|2769207901|ref|WP_366146122|]
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transglycosylase domain-containing protein [Paraburkholderia sp.]

Protein Classification

penicillin-binding protein 1A( domain architecture ID 11472030)

penicillin-binding protein 1A is a bifunctional transpeptidases/transglycosylase that catalyzes synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation

CATH:  3.40.710.10|3.40.710.10|2.40.50.140
CAZY:  GT51
EC:  2.4.99.28|3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0008955|GO:0009002|GO:0006508
PubMed:  18266856|18248419
SCOP:  4005091|4002510|4002685

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
26-676 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 666.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  26 ALAAIPALFVLYVLVLIPFTPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEH 105
Cdd:COG5009    14 LLLLGALAVAGLYLYLSPDLPDVETLKDYQPPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINAFLAAEDKRFYEH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 106 HGIDWRRMGGAALRTL-SGDR-QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFL 183
Cdd:COG5009    94 PGVDPIGIARAAVVNLrTGRRvQGGSTITQQVAKNFL---LSPERTLTRKIKEAILALRIEQELSKDEILELYLNKIYLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 184 YNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRV 263
Cdd:COG5009   171 HRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQAEYEAAKAEPLTA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 264 DFERQKELPgPAPHFAQQLRKWLIgwaDR-NDYNVYSDGLVVRTTIDSRLQAMATQSVIlhgNQL------QG------- 329
Cdd:COG5009   251 RYHGASAEV-DAPYFAEMVRRELV---ERyGEDALYTGGLKVYTTLDPRLQEAAEKALR---DGLlaydrrHGyrgpeah 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 330 --IANSAWNTR-ADCAGNGDLFRAFIRETPEYHAQkdAGVSDDD----ALMQLSANRAFMHALCESKT------------ 390
Cdd:COG5009   324 ldLAEEDWDEAlAEVPDVGDLRPAVVLEVDDKSAR--VGLRDGEtgtlPLEGLKWARPYINDNRRGPApksasdvlkpgd 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 391 ------------------RVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDT 452
Cdd:COG5009   402 virvrpvadggwrlrqipEVQGALVALDPHTGAVLALVGGFDFEQSKFNRATQAKRQPGSSFKPFVYAAALDNGYTPATI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 453 FVDQPVEI-QLAGGEVWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVrDSALDAVPSLALGT 531
Cdd:COG5009   482 INDAPIVFdDGGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGI-YSKLPPNLSLALGS 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 532 SPVTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFH--------------------VSSPDQVLPVDADHILLD 591
Cdd:COG5009   561 GEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewdgaeprlPDPAEQVIDPRTAYQMTS 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 592 TMRDVVNRGTGSSIRtrfGIRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGFNDSRvTLrsDYWGQGAQSALPIVGDF 671
Cdd:COG5009   641 MLRGVVQRGTGRRAR---ALGRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDDPR-SL--GRGETGGRAALPIWIDF 714


                  ....*
gi 2769207901 672 FHRSL 676
Cdd:COG5009   715 MKAAL 719
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
26-676 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 666.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  26 ALAAIPALFVLYVLVLIPFTPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEH 105
Cdd:COG5009    14 LLLLGALAVAGLYLYLSPDLPDVETLKDYQPPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINAFLAAEDKRFYEH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 106 HGIDWRRMGGAALRTL-SGDR-QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFL 183
Cdd:COG5009    94 PGVDPIGIARAAVVNLrTGRRvQGGSTITQQVAKNFL---LSPERTLTRKIKEAILALRIEQELSKDEILELYLNKIYLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 184 YNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRV 263
Cdd:COG5009   171 HRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQAEYEAAKAEPLTA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 264 DFERQKELPgPAPHFAQQLRKWLIgwaDR-NDYNVYSDGLVVRTTIDSRLQAMATQSVIlhgNQL------QG------- 329
Cdd:COG5009   251 RYHGASAEV-DAPYFAEMVRRELV---ERyGEDALYTGGLKVYTTLDPRLQEAAEKALR---DGLlaydrrHGyrgpeah 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 330 --IANSAWNTR-ADCAGNGDLFRAFIRETPEYHAQkdAGVSDDD----ALMQLSANRAFMHALCESKT------------ 390
Cdd:COG5009   324 ldLAEEDWDEAlAEVPDVGDLRPAVVLEVDDKSAR--VGLRDGEtgtlPLEGLKWARPYINDNRRGPApksasdvlkpgd 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 391 ------------------RVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDT 452
Cdd:COG5009   402 virvrpvadggwrlrqipEVQGALVALDPHTGAVLALVGGFDFEQSKFNRATQAKRQPGSSFKPFVYAAALDNGYTPATI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 453 FVDQPVEI-QLAGGEVWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVrDSALDAVPSLALGT 531
Cdd:COG5009   482 INDAPIVFdDGGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGI-YSKLPPNLSLALGS 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 532 SPVTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFH--------------------VSSPDQVLPVDADHILLD 591
Cdd:COG5009   561 GEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewdgaeprlPDPAEQVIDPRTAYQMTS 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 592 TMRDVVNRGTGSSIRtrfGIRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGFNDSRvTLrsDYWGQGAQSALPIVGDF 671
Cdd:COG5009   641 MLRGVVQRGTGRRAR---ALGRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDDPR-SL--GRGETGGRAALPIWIDF 714


                  ....*
gi 2769207901 672 FHRSL 676
Cdd:COG5009   715 MKAAL 719
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 77-671 9.94e-176

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 516.04  E-value: 9.94e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  77 NREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYpdeIGRAPTLTRKL 154
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRvlEGGSTITQQLAKNLY---LTNERTITRKI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 155 KEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQR 234
Cdd:TIGR02074  78 QEALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 235 RNVVLAQMVKYGRLTPSAFDTLKRKPLRVDFERQKELPGPAPHFAQQLRKWLIGWAdrnDYNVYSDGLVVRTTIDSRLQA 314
Cdd:TIGR02074 158 RNLVLSNMVENGYITAEEAEEAINEPIQLYLQTKKSEQYKAPYFVDYVIQELEEEY---GEELYTGGLKIYTTLDLDAQK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 315 MATQSVilhgnqlqgiansawntradcagngdlfrafirETPEYHAQKDAGvsdddalmqlsanrafmhalceskTRVQA 394
Cdd:TIGR02074 235 AAEKVL---------------------------------NTGLRVAGRRDG------------------------DDLQA 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 395 DFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQPVEIQlaGGEVWHP-DDA 473
Cdd:TIGR02074 258 ALVAIDPDTGAVRALVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEKGLTPATIVNDEPITYN--GNGPWSPkNYG 335

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 474 ETPSGkPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVrDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGAYL 553
Cdd:TIGR02074 336 GGYRG-NVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI-TSPLDPVLSLALGTVEVSPLEMASAYAVFANGGKYV 413

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 554 EPVMVTRIEDHNGNVLADfHVSSPDQVLPVDADHILLDTMRDVVNRGTGSsiRTRFGIRgDVAGKTGTTQDNADGWFILM 633
Cdd:TIGR02074 414 EPHGIRKIVDRDGKVIYE-NKPKTTQVISPATAYIMTDMLKGVVESGTGR--SARLPGR-PVAGKTGTTQNWRDAWFVGY 489

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 2769207901 634 HPQLVAGAWVGFNDSRVTLRSdywGQGAQSALPIVGDF 671
Cdd:TIGR02074 490 TPYYVTAVWVGYDDKKTLGKS---GTGGGLAAPIWRDF 524
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 43-676 9.20e-94

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 312.45  E-value: 9.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  43 PFTPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLS 122
Cdd:PRK11636   31 PQLPDVATLKDVRLQTPMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALF 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 123 GDR--QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKS 200
Cdd:PRK11636  111 SGHasQGASTITQQLARNFF---LSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKT 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 201 ADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRVDFErQKELPGPAPHFAQ 280
Cdd:PRK11636  188 VDQLTLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLDEGYITQAQYDQARSEPIVANYH-APEIAFSAPYLSE 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 281 QLRKWLIgwaDRNDYNVYSDGLVVRTTIDSRLQAMATQSV--------ILHG-----NQLQGIANSAWNTRA------DC 341
Cdd:PRK11636  267 MVRQEMY---NRYGENAYEDGYRVYTTITRKVQQAAQQAVrnnvldydMRHGyrgpaNVLWKVGESAWDNKKitdtlkAL 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 342 AGNGDLFRAFIRET--PEYHAQKDAGVSDDDALMQLSANRAFMHALCESKT----------------------------- 390
Cdd:PRK11636  344 PTYGPLLPAVVTSAnpQEATAMLADGSSVALPMEGVRWARPYRSDTQQGPTprkvtdvvqtgqqiwvrqvddawwlaqvp 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 391 RVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQPVEIQLAG-GEVWH 469
Cdd:PRK11636  424 DVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGLTLASMLNDVPISRWDAGaGSDWR 503

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 470 PDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYGTIANN 549
Cdd:PRK11636  504 PKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANG 583

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 550 GAYLEPVMVTRIEDHNGNVL--ADFHVSSPDQVLPV------DADHILLDTMRDVVNRGTG------------------- 602
Cdd:PRK11636  584 GFLVDPYFISKIENDQGGVIfeAKPKVACPECDIPViygdtqKSNVLENDDVENVATSQEQqnssvpmpqleqanqalva 663

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 603 ---------------------SSIRTR-FG---------------IRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGF 645
Cdd:PRK11636  664 qngaqeyaphvintplaflikSALNTNiFGepgwmgtgwragrdlKRRDIGGKTGTTNSSKDAWFSGYGPGVVTSVWIGF 743

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 2769207901 646 NDSRVTL------------RSDYWGqGAQSALPIVGDFFHRSL 676
Cdd:PRK11636  744 DDHRRDLgrttasgaikdqISGYEG-GAKSAQPAWDDYMKAAL 785
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 66-243 5.10e-82

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 259.76  E-value: 5.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  66 DGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYPDe 143
Cdd:pfam00912   1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRivQGGSTITQQLAKNLFLT- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 144 igRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYN 223
Cdd:pfam00912  80 --PERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYN 157

                         170       180
                  ....*....|....*....|
gi 2769207901 224 PVINPERALQRRNVVLAQMV 243
Cdd:pfam00912 158 PLRNPERAKRRRNLVLDRMV 177
 
Name Accession Description Interval E-value
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
26-676 0e+00

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 666.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  26 ALAAIPALFVLYVLVLIPFTPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEH 105
Cdd:COG5009    14 LLLLGALAVAGLYLYLSPDLPDVETLKDYQPPTPSRVYSADGKLIAEFGEERRIPVPIEEIPPLLINAFLAAEDKRFYEH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 106 HGIDWRRMGGAALRTL-SGDR-QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFL 183
Cdd:COG5009    94 PGVDPIGIARAAVVNLrTGRRvQGGSTITQQVAKNFL---LSPERTLTRKIKEAILALRIEQELSKDEILELYLNKIYLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 184 YNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRV 263
Cdd:COG5009   171 HRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQAEYEAAKAEPLTA 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 264 DFERQKELPgPAPHFAQQLRKWLIgwaDR-NDYNVYSDGLVVRTTIDSRLQAMATQSVIlhgNQL------QG------- 329
Cdd:COG5009   251 RYHGASAEV-DAPYFAEMVRRELV---ERyGEDALYTGGLKVYTTLDPRLQEAAEKALR---DGLlaydrrHGyrgpeah 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 330 --IANSAWNTR-ADCAGNGDLFRAFIRETPEYHAQkdAGVSDDD----ALMQLSANRAFMHALCESKT------------ 390
Cdd:COG5009   324 ldLAEEDWDEAlAEVPDVGDLRPAVVLEVDDKSAR--VGLRDGEtgtlPLEGLKWARPYINDNRRGPApksasdvlkpgd 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 391 ------------------RVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDT 452
Cdd:COG5009   402 virvrpvadggwrlrqipEVQGALVALDPHTGAVLALVGGFDFEQSKFNRATQAKRQPGSSFKPFVYAAALDNGYTPATI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 453 FVDQPVEI-QLAGGEVWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVrDSALDAVPSLALGT 531
Cdd:COG5009   482 INDAPIVFdDGGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGI-YSKLPPNLSLALGS 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 532 SPVTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFH--------------------VSSPDQVLPVDADHILLD 591
Cdd:COG5009   561 GEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADparacedcdaaewdgaeprlPDPAEQVIDPRTAYQMTS 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 592 TMRDVVNRGTGSSIRtrfGIRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGFNDSRvTLrsDYWGQGAQSALPIVGDF 671
Cdd:COG5009   641 MLRGVVQRGTGRRAR---ALGRDIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDDPR-SL--GRGETGGRAALPIWIDF 714


                  ....*
gi 2769207901 672 FHRSL 676
Cdd:COG5009   715 MKAAL 719
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 26-671 0e+00

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 620.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  26 ALAAIPALFVLYVLVLipftPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEH 105
Cdd:COG0744    26 VLAALAGLVALYVADL----PDPEELEDLALPQTSTIYDRDGTLIATLGDENREWVPLDQIPPHLKDAVVAIEDRRFYEH 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 106 HGIDWRRMGGAALRTLS--GDRQGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFL 183
Cdd:COG0744   102 GGVDPKGIARALVANLTagGVVQGGSTITQQLVKNLF---LSNERTLSRKLKEALLALKLERKYSKDEILELYLNTVYFG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 184 YNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRV 263
Cdd:COG0744   179 RGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 264 DFERQKELPGPAPHFAQQLRKWLigwadRNDY---NVYSDGLVVRTTIDSRLQAMATQSVilhgnqlqgiansawntrad 340
Cdd:COG0744   259 VPPPNGAAAGKYPYFVDYVRREL-----EELLgedDLYRGGLKIYTTLDPKLQKAAEKAV-------------------- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 341 cagngdlfrafiretpeyhaqkDAGVSDDDAlmqlsanrafmhalceskTRVQADFMAIDPRNGQIRAWVGSRDFTQDPL 420
Cdd:COG0744   314 ----------------------KNVLPEGKP------------------GGLQAALVVVDPKTGEVLAMVGGRDYGKSQF 353

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 421 DHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQPVEIQlagGEVWHPDDAETPSGKPMSLRDALAYSRNRITAQLME 500
Cdd:COG0744   354 NRATQAKRQPGSTFKPFVYAAALEQGYTPATTVDDEPVTFP---GGGWSPKNYDGRYRGPVTLREALANSLNTPAVRLAQ 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 501 KVGPARVAKLARAMGVrDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFHvSSPDQV 580
Cdd:COG0744   431 EVGLDKVVDTARRLGI-TSPLDPNPSLALGTSEVSPLEMASAYATFANGGVYVEPHAITKVTDADGKVLYEAK-PKCEQV 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 581 LPVDADHILLDTMRDVVNRGTGSSIRtrfgIRG-DVAGKTGTTQDNADGWFILMHPQLVAGAWVGFNDSRVTlrsdYWGQ 659
Cdd:COG0744   509 ISPEVAYLMTDMLQDVVTSGTGRAAR----LPGrPVAGKTGTTNDNRDAWFVGYTPQLVTAVWVGNDDNSPM----GYVT 580

                         650
                  ....*....|..
gi 2769207901 660 GAQSALPIVGDF 671
Cdd:COG0744   581 GGSLPAPIWRDF 592
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 77-671 9.94e-176

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 516.04  E-value: 9.94e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  77 NREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYpdeIGRAPTLTRKL 154
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRvlEGGSTITQQLAKNLY---LTNERTITRKI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 155 KEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQR 234
Cdd:TIGR02074  78 QEALLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 235 RNVVLAQMVKYGRLTPSAFDTLKRKPLRVDFERQKELPGPAPHFAQQLRKWLIGWAdrnDYNVYSDGLVVRTTIDSRLQA 314
Cdd:TIGR02074 158 RNLVLSNMVENGYITAEEAEEAINEPIQLYLQTKKSEQYKAPYFVDYVIQELEEEY---GEELYTGGLKIYTTLDLDAQK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 315 MATQSVilhgnqlqgiansawntradcagngdlfrafirETPEYHAQKDAGvsdddalmqlsanrafmhalceskTRVQA 394
Cdd:TIGR02074 235 AAEKVL---------------------------------NTGLRVAGRRDG------------------------DDLQA 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 395 DFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQPVEIQlaGGEVWHP-DDA 473
Cdd:TIGR02074 258 ALVAIDPDTGAVRALVGGRDYGKSQFNRATQAKRQPGSTFKPFVYAAALEKGLTPATIVNDEPITYN--GNGPWSPkNYG 335

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 474 ETPSGkPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVrDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGAYL 553
Cdd:TIGR02074 336 GGYRG-NVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGI-TSPLDPVLSLALGTVEVSPLEMASAYAVFANGGKYV 413

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 554 EPVMVTRIEDHNGNVLADfHVSSPDQVLPVDADHILLDTMRDVVNRGTGSsiRTRFGIRgDVAGKTGTTQDNADGWFILM 633
Cdd:TIGR02074 414 EPHGIRKIVDRDGKVIYE-NKPKTTQVISPATAYIMTDMLKGVVESGTGR--SARLPGR-PVAGKTGTTQNWRDAWFVGY 489

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 2769207901 634 HPQLVAGAWVGFNDSRVTLRSdywGQGAQSALPIVGDF 671
Cdd:TIGR02074 490 TPYYVTAVWVGYDDKKTLGKS---GTGGGLAAPIWRDF 524
PBP_1b TIGR02071
penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) ...
 51-696 1.70e-103

penicillin-binding protein 1B; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273952 [Multi-domain]  Cd Length: 730  Bit Score: 335.54  E-value: 1.70e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  51 IRKAKIEQPAQVLSADGKLLAEFKPTNRE---WVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR-- 125
Cdd:TIGR02071 117 IENLDNNKEFGFFRLDPKLIAMLYSPNGEqrlFVPRDQFPELLVDTLLATEDRDFYEHDGISLYSIGRAVWVNLTAGRtv 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 126 QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVpFLYNA-----YGIEMAARTYFDKS 200
Cdd:TIGR02071 197 QGGSTLTQQLVKNLF---LSNERSLWRKANEAYMALILDARYSKDRILELYLNEV-YLGQSgddaiHGFPLASQYYFGRP 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 201 ADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRVdfERQKELPGPAPHFAQ 280
Cdd:TIGR02071 273 LGELSLDQVALLVGMVKGPSYYNPWRNPDRALERRNLVLRLLQEQKIIDDEEYDMLSARPLGV--QKKGGIISRQPAFLQ 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 281 QLRKWLigwadRNDY--NVYSD-GLVVRTTIDSRLQAMATQSVilhgnqlqgiansawntradcagngdlfrafiretpe 357
Cdd:TIGR02071 351 LVRREL-----RQKLgdKVKDLsGLRIFTTLDPVSQSAAEQAV------------------------------------- 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 358 yhaqkdagvsdDDALMQLSANRAFMHalcesktrVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPF 437
Cdd:TIGR02071 389 -----------QETIPALKKKKKLPD--------LEAAMVVTDRFTGEVRAMVGGSDPQFAGFNRALQARRQIGSLVKPA 449

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 438 VYGAAFAQgmrPD----DTFV-DQPVEIQLAGGEVWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLAR 512
Cdd:TIGR02071 450 VYLTALSQ---PDkyrlNTWIeDQPLSIKLSNGQVWSPQNYDRRYSGTVMLYDALAHSLNIPTVNLGMKVGLPKVSQTWN 526

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 513 AMGVRDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGaYLEPVMVTR-IEDHNGNVLADfHVSSPDQVLPVDADHILLD 591
Cdd:TIGR02071 527 KLGINKDEIPPVPSMLLGAINLTPYEVAQLYQTIASGG-NRAPLSAVRsVLDEDGKVLYQ-SDPQAEQAVPSQAAYLTLY 604

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 592 TMRDVVNRGTGSSIRTRFGiRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGFNDSRVTLRSdywgqGAQSALPIVGDF 671
Cdd:TIGR02071 605 AMQQVVQRGTARSLGADFP-SLSLAGKTGTTNDNRDSWFAGIDGKEVTIIWLGRDDNGPTKLT-----GASGALQVYARY 678

                         650       660
                  ....*....|....*....|....*....
gi 2769207901 672 FHRSLGSRLI----DARVRFDTEPQTGWF 696
Cdd:TIGR02071 679 LSYQTPEPLLlvppEGIDWFGVDPQGNGG 707
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 15-674 8.20e-96

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 316.00  E-value: 8.20e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  15 LRHPTLRGCAYALAAIP-ALFVLYVLVLIPftpgigdiRKAKIEQPAQVLSADGKLLAEFkPTN----REWVKLSDISPH 89
Cdd:COG4953     6 LRRRRLLALLLALLLLAlALWALDRLFPLP--------LLFAVPYSTVVLDRDGTLLRAF-LAAdgqwRLPVPLDEVSPR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  90 VVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYPDEigRapTLTRKLKEAITAFKIEAVY 167
Cdd:COG4953    77 YLQALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRivSGGSTLTMQVARLLEPRP--R--TLSGKLRQILRALQLERRY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 168 TKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGR 247
Cdd:COG4953   153 SKDEILELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRPDRNPERARAARDRVLARLAEAGV 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 248 LTPSAFDTLKRKPLrvdfeRQKELPGP--APHFAQQLRKwligwadrndynVYSDGLVVRTTIDSRLQAMATQSVILHGN 325
Cdd:COG4953   233 IDAEEAALALLEPV-----PARRRPLPqlAPHLARRLLR------------QLPGGTRIRTTLDAGLQRRLERLVRRYVR 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 326 QLQ--GIANSAwntradcagngdlfrafiretpeyhaqkdagvsdddALMqlsanrafmhalcesktrvqadfmaIDPRN 403
Cdd:COG4953   296 RLKqnGIHNAA------------------------------------VLV-------------------------VDNRT 314

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 404 GQIRAWVGSRDFT-QDPLDHVQ--QARRQPGSTFKPFVYGAAFAQGM-RPDDTFVDQPVEIqlaGGevWHPDDA-ETPSG 478
Cdd:COG4953   315 GEVLAYVGSADFFdASRQGQVDmvRALRSPGSTLKPFLYGLALDQGLiHPETLLADVPTSF---GG--YRPENFdGTFQG 389

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 479 kPMSLRDALAYSRNrITA-QLMEKVGPARVAKLARAMGVRDsaLDAVP-----SLALGTSPVTLKEMVSAYGTIANNGAY 552
Cdd:COG4953   390 -PVSAREALARSLN-IPAvRLLEALGPARFYARLRRAGLRL--LLPPAehyglSLILGGAEVTLEELVGLYAALARGGEA 465

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 553 LEPVMVTriedhNGNVLADFHVSSPdqvlpvDADHILLDTMRDvVNRGTGSSIRTRFGIRGDVAGKTGTTQDNADGWFIL 632
Cdd:COG4953   466 RPLRLLA-----GEPASPGRRLLSP------GAAWLVRDILSD-VPRPDGAFGWRALDSPPPIAWKTGTSYGFRDAWAVG 533

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 2769207901 633 MHPQLVAGAWVG-FNDSRVTlrsdywGQ-GAQSALPIVGDFFHR 674
Cdd:COG4953   534 FTGRYTVGVWVGnPDGTPVP------GLtGAEAAAPLLFDIFDL 571
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 43-676 9.20e-94

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 312.45  E-value: 9.20e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  43 PFTPGIGDIRKAKIEQPAQVLSADGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLS 122
Cdd:PRK11636   31 PQLPDVATLKDVRLQTPMQVYSADGELIAQYGEKRRIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALF 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 123 GDR--QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKS 200
Cdd:PRK11636  111 SGHasQGASTITQQLARNFF---LSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKT 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 201 ADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRVDFErQKELPGPAPHFAQ 280
Cdd:PRK11636  188 VDQLTLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLDEGYITQAQYDQARSEPIVANYH-APEIAFSAPYLSE 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 281 QLRKWLIgwaDRNDYNVYSDGLVVRTTIDSRLQAMATQSV--------ILHG-----NQLQGIANSAWNTRA------DC 341
Cdd:PRK11636  267 MVRQEMY---NRYGENAYEDGYRVYTTITRKVQQAAQQAVrnnvldydMRHGyrgpaNVLWKVGESAWDNKKitdtlkAL 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 342 AGNGDLFRAFIRET--PEYHAQKDAGVSDDDALMQLSANRAFMHALCESKT----------------------------- 390
Cdd:PRK11636  344 PTYGPLLPAVVTSAnpQEATAMLADGSSVALPMEGVRWARPYRSDTQQGPTprkvtdvvqtgqqiwvrqvddawwlaqvp 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 391 RVQADFMAIDPRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQPVEIQLAG-GEVWH 469
Cdd:PRK11636  424 DVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGLTLASMLNDVPISRWDAGaGSDWR 503

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 470 PDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYGTIANN 549
Cdd:PRK11636  504 PKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANG 583

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 550 GAYLEPVMVTRIEDHNGNVL--ADFHVSSPDQVLPV------DADHILLDTMRDVVNRGTG------------------- 602
Cdd:PRK11636  584 GFLVDPYFISKIENDQGGVIfeAKPKVACPECDIPViygdtqKSNVLENDDVENVATSQEQqnssvpmpqleqanqalva 663

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 603 ---------------------SSIRTR-FG---------------IRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGF 645
Cdd:PRK11636  664 qngaqeyaphvintplaflikSALNTNiFGepgwmgtgwragrdlKRRDIGGKTGTTNSSKDAWFSGYGPGVVTSVWIGF 743

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 2769207901 646 NDSRVTL------------RSDYWGqGAQSALPIVGDFFHRSL 676
Cdd:PRK11636  744 DDHRRDLgrttasgaikdqISGYEG-GAKSAQPAWDDYMKAAL 785
PBP_1c TIGR02073
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ...
 62-695 3.54e-87

penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273954 [Multi-domain]  Cd Length: 727  Bit Score: 291.63  E-value: 3.54e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  62 VLSADGKLLAEFkPTN----REWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTL-SGDR-QGGSTITQQL 135
Cdd:TIGR02073  14 VLDRHGTLLRAL-LANdgqwRLPVPLEDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLtNGRRvSGGSTLTMQL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 136 ARNLYPdEIGRapTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGM 215
Cdd:TIGR02073  93 ARLLDP-ELSR--TLTGKLRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLSLAEAALLAAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 216 LKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRvdfERQKELPGPAPHFAQQLRKwligwADRNDY 295
Cdd:TIGR02073 170 PQAPSARRLDRLPKAAKAARDRLLDRMVEQGPDDSEQVALAALEPLP---ALPEPLPQLAPHFALKLLR-----ARPEIA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 296 NVysdglvVRTTIDSRLQAMATqsvilhgnqlqgiansawntradcagngDLFRAFIRetpeyhAQKDAGVSDDDALMql 375
Cdd:TIGR02073 242 SV------IVSTLDADLQRRLE----------------------------ELARRYLS------ALRPRGISNLAILV-- 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 376 sanrafmhalcesktrvqadfmaIDPRNGQIRAWVGSRDFTQDP----LDHVQqARRQPGSTFKPFVYGAAFAQG-MRPD 450
Cdd:TIGR02073 280 -----------------------VDNRSGAVLAYVGSADFFDDSnsgqVDGVR-APRSPGSTLKPFLYALALDDGlLHPD 335

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 451 DTFVDQPVEIQlaggeVWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGV---RDSALDAVPSL 527
Cdd:TIGR02073 336 SLLKDVPLRFG-----DYAPENFDKTFHGPVPAREALARSLNIPAVRLLERVGPPRFADFLRQAGLnllKPKSDYYGLSL 410

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 528 ALGTSPVTLKEMVSAYGTIANNGAYLEPVMvtriedhngnVLADFHVSSPDQVLPVDADHILLDTMRDVVNRGTG---SS 604
Cdd:TIGR02073 411 ALGGAEITLQDLANLYAMLANQGLSGPLRF----------LQTDAKRPERERLLSPGAAWIVLDILKDRPRPDDTlplSA 480

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 605 IRTRFGIrgdvAGKTGTTQDNADGWFILMHPQLVAGAWVG-FNDSRVtlrsdyWGQ-GAQSALPIVGDFFHRsLGSRLID 682
Cdd:TIGR02073 481 LPTRLPL----AWKTGTSYGFRDAWAAGVSGRYTIGVWVGnFDGKPN------PGFfGAAAAAPLLFDILDA-LQASEAS 549

                         650
                  ....*....|...
gi 2769207901 683 ARVRFDTEPQTGW 695
Cdd:TIGR02073 550 TLPRPLKEVPGCL 562
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 66-243 5.10e-82

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 259.76  E-value: 5.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  66 DGKLLAEFKPTNREWVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYPDe 143
Cdd:pfam00912   1 DGTLLAELGEENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRivQGGSTITQQLAKNLFLT- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 144 igRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYN 223
Cdd:pfam00912  80 --PERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYN 157

                         170       180
                  ....*....|....*....|
gi 2769207901 224 PVINPERALQRRNVVLAQMV 243
Cdd:pfam00912 158 PLRNPERAKRRRNLVLDRMV 177
mrcB PRK09506
bifunctional glycosyl transferase/transpeptidase; Reviewed
 91-644 4.11e-68

bifunctional glycosyl transferase/transpeptidase; Reviewed


Pssm-ID: 236544 [Multi-domain]  Cd Length: 830  Bit Score: 241.60  E-value: 4.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  91 VDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYT 168
Cdd:PRK09506  224 VDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRtvQGGSTLTQQLVKNLF---LSNERSLWRKANEAYMALIMDARYS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 169 KPEILETYLNTVPFLYNA----YGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMVK 244
Cdd:PRK09506  301 KDRILELYLNEVYLGQSGddqiRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALERRNLVLRLLQQ 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 245 YGRLTPSAFDTLKRKPLRVdfERQKELPGPAPHFAQQLRKWL---IGwaDR-NDYNvysdGLVVRTTIDSRLQAMATQSV 320
Cdd:PRK09506  381 QQIIDQELYDMLSARPLGV--QPKGGVISPQPAFMQMVRQELqakLG--DKvKDLS----GVKIFTTLDPVSQDAAEKAV 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 321 IlhgnqlQGIansawntradcagngdlfrafiretPEYHAQKdaGVSDDDALMqlsanrafmhalcesktrvqadfMAID 400
Cdd:PRK09506  453 E------EGI-------------------------PALKKQR--KLSDLETAM-----------------------VVVD 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 401 PRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQgmrPD----DTFV-DQPVEIQLAGGEVWHP-DDAE 474
Cdd:PRK09506  477 RFSGEVRAMVGGSEPQFAGYNRAMQARRSIGSLAKPATYLTALSQ---PDkyrlNTWIaDAPISLRQPNGQVWSPqNDDR 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 475 TPSGKPMsLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGAYLE 554
Cdd:PRK09506  554 RFSGRVM-LVDALTRSMNVPTVNLGMALGLPAVTDTWIKLGVPKDQLNPVPAMLLGALNLTPIEVAQAFQTIASGGNRAP 632

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 555 PVMVTRIEDHNGNVLadfHVSSP--DQVLPVDADHILLDTMRDVVNRGTGSSIRTRFGiRGDVAGKTGTTQDNADGWFIL 632
Cdd:PRK09506  633 LSALRSVIAEDGKVL---YQSFPqaERAVPAQAAYLTLYTMQQVVQRGTGRQLGAKYP-NLHLAGKTGTTNDLVDSWFAG 708

                         570
                  ....*....|..
gi 2769207901 633 MHPQLVAGAWVG 644
Cdd:PRK09506  709 IDGKEVTITWVG 720
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 90-651 1.92e-56

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 207.39  E-value: 1.92e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  90 VVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVY 167
Cdd:PRK14850  169 LIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHtiQGGSTLTQQLVKNLF---LTNTRSLWRKINEIYMALILDRFY 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 168 TKPEILETYLNTVPFLYNA----YGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQMV 243
Cdd:PRK14850  246 SKDRILELYLNEVYLGQDGneqiRGFPLASIYYFGRPINELNLDQYALLVGMVKGASLYNPWTNPNLTLKRRNLVLFLLY 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 244 KYGRLTPSAFDTLKRKPLRVdfERQKELPGPAPHFAQQLRKWL---IGWADRNdynvySDGLVVRTTIDSRLQAMATQSV 320
Cdd:PRK14850  326 KQKVITRKLYKDLCSRPLNV--QSKGNIISSHPAFIQLVCEEFhkkIHYPFKN-----FSGTKIFTTLDYISQNAAEQAV 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 321 ilhgnqlqgiansawntradcagngdlfRAFIRETPEYHAQKDagvsdddalmqlsanrafmhalcesktrVQADFMAID 400
Cdd:PRK14850  399 ----------------------------KIGIPILKRKKRLKD----------------------------LEVAMVIID 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 401 PRNGQIRAWVGSRDFTQDPLDHVQQARRQPGSTFKPFVYGAAFAQgmrPD----DTFV-DQPVEIQLAGGEVWHPDDAET 475
Cdd:PRK14850  423 RFSGEVRALIGSSKPEFNGYNRALKARRSIGSLSKPITYLTALSQ---PEkyhlNTWIsDTPISIKLDNGQYWTPKNNNF 499

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 476 PSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYGTIANNGAYLEP 555
Cdd:PRK14850  500 SFSGKVMLIDALIHSINIPTVHLSINLGLKKLVDSWILLGISSNYITPLPSISLGAINLTPMEVAQVFQIIGSGGYKSSL 579

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 556 VMVTRIEDHNGNVLADFHVSSpDQVLPVDADHILLDTMRDVVNRGTGSSIRTRFGiRGDVAGKTGTTQDNADGWFILMHP 635
Cdd:PRK14850  580 SSIRSIISDDNKVLYQNFPQS-KHVESSQASYLTLYAMQQVVKSGTAKSLGTIFK-EFSLAGKTGTTNNLVDSWFVGIDG 657

                         570
                  ....*....|....*.
gi 2769207901 636 QLVAGAWVGFNDSRVT 651
Cdd:PRK14850  658 KQVVITWIGRDNNHTT 673
PRK11240 PRK11240
penicillin-binding protein 1C; Provisional
 58-647 5.30e-38

penicillin-binding protein 1C; Provisional


Pssm-ID: 183049 [Multi-domain]  Cd Length: 772  Bit Score: 152.16  E-value: 5.30e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  58 QPAQ-VLSADGKLLAEFKPTNREW---VKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTI 131
Cdd:PRK11240   38 NPARvVVAEDGTPLWRFADADGIWrypVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRviSGGSTL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 132 TQQLARNLYPdeigRAPTLTRKLKEAITAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESAT 211
Cdd:PRK11240  118 TMQVARLLDP----HPRTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYAEAAL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 212 LTGMLKGNSYYNPVINPERALQRRNVVLAQMVKYGRLTPSAFDTLKRKPLRVdFERQkeLPGPAPHFAQQLRKwligwAD 291
Cdd:PRK11240  194 LAVLPQAPSRLRPDRWPERAEAARNKVLERMAEQGVWSAEQVKESREEPVWL-APRQ--MPQLAPLFARMMLG-----KS 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 292 RNDynvysdglVVRTTIDSRLQamatqsvilhgNQLQGIAnSAWNTRadcagngdlfrafireTPEyhaqkdagvsddda 371
Cdd:PRK11240  266 KSD--------KIVTTLDAGLQ-----------RRLEDLA-LNWKGR----------------LPP-------------- 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 372 lmqlsanrafmhalcesktRVQADFMAIDPRNGQIRAWVGSRDFTQDP-LDHVQ--QARRQPGSTFKPFVYGAAFAQGM- 447
Cdd:PRK11240  296 -------------------RSSLAMIVVDHTDMAVRGWVGSVDLNDDSrFGHVDmvNAIRSPGSVLKPFVYGLALDDGLi 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 448 RPDDTFVDQPVEIqlagGEvWHPDDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGV--RDSALdAVP 525
Cdd:PRK11240  357 HPASLLQDVPRRT----GD-YRPGNFDSGFHGPVSMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLplYLPAG-AEP 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 526 SLA--LGTSPVTLKEMVSAYGTIANNGaylepvMVTRIEDHNGNVLADFHVSSP-----------DQVLPvDADHILLDt 592
Cdd:PRK11240  431 NLSliLGGAGARLEDMVAAYSAFARHG------KAAKLRLQPDDPLLERPLMSPgaawiirrimaDEAQP-LPDAALPR- 502

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2769207901 593 mrdvvnrgtgssirtrfgiRGDVAGKTGTTQDNADGWFILMHPQLVAGAWVGFND 647
Cdd:PRK11240  503 -------------------VVPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPD 538
PRK13481 PRK13481
glycosyltransferase; Provisional
 80-223 1.98e-31

glycosyltransferase; Provisional


Pssm-ID: 184078 [Multi-domain]  Cd Length: 232  Bit Score: 122.99  E-value: 1.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  80 WVKLSDISPHVVDALVSTEDHRFYEHHGIDWRRMGGAALRTLS-GDRQGGSTITQQLARNLYPDEigrAPTLTRKLKEAI 158
Cdd:PRK13481   47 FVSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTISdRDVQGGSTITQQVVKNYFYDN---ERSFTRKVKELF 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2769207901 159 TAFKIEAVYTKPEILETYLNTVPFLYNAYGIEMAARTYFDKSAD-------QLNVLESATLTGMLKGNSYYN 223
Cdd:PRK13481  124 VAHRVEKQYSKNEILSFYLNNIYFGDNQYTLEGAANHYFGTTVNknsttmsHITVLQSAILASKVNAPSVYN 195
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 396-636 1.38e-30

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 122.52  E-value: 1.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 396 FMAIDPRNGQIRAWVGSRDF------TQDPLDHVQQaRRQPGSTFKPFVYGAAFAQGM-RPDDTFVDQPVEIQLAGG-EV 467
Cdd:pfam00905   3 AVVLDPKTGEVLAMVGKPSYdpngfiGPLRNRAVTS-RYEPGSTFKPFTALAALDNGVlKPDETIFDWPGKQQGGKSiGD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 468 WHPDDAETPsgkpmSLRDALAYSRNRITAQLMEKVGPARVAKLARA--MGVRD-SALD--------------AVPSLALG 530
Cdd:pfam00905  82 WNQDQVGIG-----TLRQALEYSSNWYMQKLAQKLGADKLRSYLKKfgYGNKTgIGLPgenagyltpywlegATASFGIG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 531 TSpVTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVladfhvssPDQVLPVDADHI--LLDTMRDVVNRGTGSSIRTR 608
Cdd:pfam00905 157 LT-ITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPK--------VLNKLPISKSTAekVKDMLRLVVNDGTGTGTAAV 227

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2769207901 609 FGIRgdVAGKTGTTQ-----------DNADGWFILMHPQ 636
Cdd:pfam00905 228 PGYK--VAGKTGTAQvagpkgggyydGAQIGWFVGYAPA 264
mono_pep_trsgly TIGR02070
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ...
 26-242 2.32e-30

monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273951 [Multi-domain]  Cd Length: 224  Bit Score: 119.49  E-value: 2.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  26 ALAAIPALFVLYVLVLI--------PFTPGIgdiRKAKIEQPAQVLSAdgkllaefKPTNREWVKLSDISPHVVDALVST 97
Cdd:TIGR02070   6 CLVAGVLLFNLAVFAALaswrfvppPSTAFM---VAEKLALWGQGDPT--------CGIQHRWRPYDQISPNLKRAVIAS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901  98 EDHRFYEHHGIDWRRMGGAALRTLSGDR--QGGSTITQQLARNLYpdeIGRAPTLTRKLKEAITAFKIEAVYTKPEILET 175
Cdd:TIGR02070  75 EDAKFVEHHGFDWEAIQDALEKNEKSGKvvRGGSTISQQLAKNLF---LWSGRSYLRKGLEAWATWMLETWWSKQRILEV 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2769207901 176 YLNTVPFLYNAYGIEMAARTYFDKSADQLNVLESATLTGMLKGNSYYNPVINPERALQRRNVVLAQM 242
Cdd:TIGR02070 152 YLNSVEWGNGVFGAEAAARYYFKRSASNLTRGQAARLAAVLPNPKYYDENRPGPYVRRKATWILKQM 218
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 370-676 4.22e-28

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 119.93  E-value: 4.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 370 DALMQLSANRAFMHALCESKTRvQADFMAIDPRNGQIRAWVGSRDFtqDPLDHVQQARRQ-----------PGSTFKPFV 438
Cdd:COG0768   226 DSDLQKIAEEALKKAVEEYKAK-SGAVVVMDPKTGEILAMASYPSF--DPNLFVGGPDEPlrnravqgtyePGSTFKPFT 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 439 YGAAFAQGM-RPDDTFVDqPVEIQLaGGEVWHpdDAETPSGKPMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMG-- 515
Cdd:COG0768   303 AAAALEEGViTPDTTFDC-PGYYRV-GGRTIR--DWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGlg 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 516 --------------VRD----SALDAVpSLALG----TSPVtlkEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFH 573
Cdd:COG0768   379 qktgidlpgeasglLPSpkrwYPGETA-TMSIGqglsVTPL---QLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEEP 454

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 574 VsSPDQVLPVDADHILLDTMRDVVN--RGTGSSIRTrFGIRgdVAGKTGTTQ--DNADG---------WFILM----HPQ 636
Cdd:COG0768   455 E-VLRRVISPETAETVREGMEGVVNepGGTARRAAI-PGYR--VAGKTGTAQvvDIGNGgyykgrhiaSFVGFapadNPR 530

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2769207901 637 LVAGawvgfndsrVTL-RSDYWGQGAQSALPIVGDFFHRSL 676
Cdd:COG0768   531 YAVA---------VVVeNPGGGAYGGTVAAPVFREIMEAYL 562
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 398-677 1.93e-22

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 102.60  E-value: 1.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 398 AIDPRNGQIRAWVGSRDF-----------------TQDP----LDHVQQARRQPGSTFKPFVYGAAFAQGMRPDDTFVDQ 456
Cdd:TIGR03423 253 VMDPRTGEILAMVSTPSFdpnlfvdgisskdykalLNDPdrplLNRAIQGVYPPGSTFKPVVALAALEEGVITPETRIYC 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 457 PVEIQLaGGEVWHPDDaetPSGK-PMSLRDALAYSRNRITAQLMEKVGPARVAKLARAMGV-RDSALDaVPSLALGTSP- 533
Cdd:TIGR03423 333 PGYFQL-GGRRFRCWK---RGGHgRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFgQKTGID-LPGEKSGLVPs 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 534 ----------------------------VTLKEMVSAYGTIANNGAYLEPVMVTRIEDHNGNVLADFHVSsPDQVLPVDA 585
Cdd:TIGR03423 408 rewkrkrfgqpwypgdtlnvsigqgyvlVTPLQLAVATAALANGGKLYKPHLVKSIEDPDGGVVRRTEPE-VLRPLPISP 486

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 586 DH--ILLDTMRDVVN--RGTGSSIRTRFGIRgdVAGKTGTTQ--------------------DNAdgWFIlmhpqlvagA 641
Cdd:TIGR03423 487 ENldVVREGMRDVVNgpGGTARRARLGLPYK--MAGKTGTAQvvslkqgekydaeqiperlrDHA--LFV---------A 553

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2769207901 642 WVGFNDSRVTLRS--DYWGQGAQSALPIVGDFFHRSLG 677
Cdd:TIGR03423 554 FAPYDNPKIAVAVivEHGGGGSSAAAPIARKIMDAYLL 591
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
430-621 7.20e-05

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 45.27  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 430 PGSTFKPFVYGAAFAQGMRPDDTFvDQPVEIQLAGGEVWHPDDAETPSGKPMSLRD----ALAYSRNriTA--QLMEKVG 503
Cdd:COG2367    58 AASTFKLPVLAAVLRQVDAGKLSL-DERVTLTPEDLVGGSGILQKLPDGTGLTLRElaelMITVSDN--TAtnLLLRLLG 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769207901 504 PARVAKLARAMGVRDSALD-------AVPSLALGTSpvTLKEMVSAYGTIANngaylepvmvtriedhngnvladfhvss 576
Cdd:COG2367   135 PDAVNAFLRSLGLTDTRLDrkepdlnELPGDGRNTT--TPRDMARLLAALYR---------------------------- 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2769207901 577 pDQVLPVDADHILLDTMRDVVNRGtgssiRTRFGIRGD--VAGKTGT 621
Cdd:COG2367   185 -GELLSPESRARLLDWLARQTGRD-----RLRAGLPEGwrVAHKTGT 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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