NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2778281551|gb|XDF45894|]
View 

AAA family ATPase [Saccharolobus solfataricus]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 9-187 2.80e-58

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member PRK01184:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 184  Bit Score: 180.53  E-value: 2.80e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   9 KVILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKP--GERLMDFAKRLREIYGEGVVARLCVEELGTGSYD 86
Cdd:PRK01184    2 KIIGVVGMPGSGKGEFSKIAREMGIPVVVMGDVIREEVKKRGLEptDENIGKVAIDLRKELGMDAVAKRTVPKIREKGDE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  87 LVGFDGVRSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIERMRSDDSKEISELMRRDREELKLGIGEVIAMADYVITN 166
Cdd:PRK01184   82 VVVIDGVRGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKRGRSDDPKSWEELEERDERELSWGIGEVIALADYMIVN 161

                         170       180
                  ....*....|....*....|.
gi 2778281551 167 DSNYEEFKKRSEEVINRVLKN 187
Cdd:PRK01184  162 DSTLEEFRARVRKLLERILRS 182
 
Name Accession Description Interval E-value
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
9-187 2.80e-58

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 180.53  E-value: 2.80e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   9 KVILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKP--GERLMDFAKRLREIYGEGVVARLCVEELGTGSYD 86
Cdd:PRK01184    2 KIIGVVGMPGSGKGEFSKIAREMGIPVVVMGDVIREEVKKRGLEptDENIGKVAIDLRKELGMDAVAKRTVPKIREKGDE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  87 LVGFDGVRSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIERMRSDDSKEISELMRRDREELKLGIGEVIAMADYVITN 166
Cdd:PRK01184   82 VVVIDGVRGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKRGRSDDPKSWEELEERDERELSWGIGEVIALADYMIVN 161

                         170       180
                  ....*....|....*....|.
gi 2778281551 167 DSNYEEFKKRSEEVINRVLKN 187
Cdd:PRK01184  162 DSTLEEFRARVRKLLERILRS 182
DPCK cd02022
Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of ...
 10-172 8.22e-17

Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.


Pssm-ID: 238980  Cd Length: 179  Bit Score: 74.09  E-value: 8.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERLMDFA---------KRLREIYGEGVVAR-LCVEE 79
Cdd:cd02022     1 IIGLTGGIGSGKSTVAKLLKELGIPVIDADKIAHEVYEPGGPALQAIVEAFgpdilledgELDRKKLGEIVFADpEKRKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  80 LGTGSYDLVGFDGVRSLAEVEEFKRLLGD-------NVY-----IVAVHSPPKIRYKRIIERmrsDDSKEISELMRRDRE 147
Cdd:cd02022    81 LEAITHPLIRKEIEEQLAEARKEKVVVLDipllfetGLEklvdrVIVVDAPPEIQIERLMKR---DGLSEEEAEARIASQ 157

                         170       180
                  ....*....|....*....|....*
gi 2778281551 148 elkLGIGEVIAMADYVITNDSNYEE 172
Cdd:cd02022   158 ---MPLEEKRARADFVIDNSGSLEE 179
AAA_18 pfam13238
AAA domain;
11-129 5.20e-11

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 57.44  E-value: 5.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  11 ILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERlmDFAKRLREIYGEGVVARLcVEELGTGSYDLVGF 90
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPET--RESKRLDEDKLDRLLDLL-EENAALEEGGNLII 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2778281551  91 DGVRSLAEVEEFKrllgDNVYIVaVHSPPKIRYKRIIER 129
Cdd:pfam13238  78 DGHLAELEPERAK----DLVGIV-LRASPEELLERLEKR 111
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-149 2.01e-10

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 56.85  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAK-LLREKGARVIVmSDVVKKR-YSSEAKPGERLMDFAKRLREiygegVVARLCVEELGTGsYDL 87
Cdd:COG0645     1 LILVCGLPGSGKSTLARaLAERLGAVRLR-SDVVRKRlFGAGLAPLERSPEATARTYA-----RLLALARELLAAG-RSV 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  88 VgFDGV-RSLAEVEEFKRL---LGDNVYIVAVHSPPKIRYKRIIERMR----SDDSKEISELMRRDREEL 149
Cdd:COG0645    74 I-LDATfLRRAQREAFRALaeeAGAPFVLIWLDAPEEVLRERLEARNAeggdSDATWEVLERQLAFEEPL 142
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 8-137 7.43e-04

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 38.64  E-value: 7.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   8 IKVILITGMPGSGK-SEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERLMDFAKRlREIYGEGVVARLCVEELGTGSYD 86
Cdd:TIGR01360   3 CKIIFIVGGPGSGKgTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMES-GDLVPLDTVLDLLKDAMVAALGT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2778281551  87 LVGF--DGV-RSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIER----MRSDDSKE 137
Cdd:TIGR01360  82 SKGFliDGYpREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRaetsGRVDDNEK 139
 
Name Accession Description Interval E-value
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
9-187 2.80e-58

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 180.53  E-value: 2.80e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   9 KVILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKP--GERLMDFAKRLREIYGEGVVARLCVEELGTGSYD 86
Cdd:PRK01184    2 KIIGVVGMPGSGKGEFSKIAREMGIPVVVMGDVIREEVKKRGLEptDENIGKVAIDLRKELGMDAVAKRTVPKIREKGDE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  87 LVGFDGVRSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIERMRSDDSKEISELMRRDREELKLGIGEVIAMADYVITN 166
Cdd:PRK01184   82 VVVIDGVRGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKRGRSDDPKSWEELEERDERELSWGIGEVIALADYMIVN 161

                         170       180
                  ....*....|....*....|.
gi 2778281551 167 DSNYEEFKKRSEEVINRVLKN 187
Cdd:PRK01184  162 DSTLEEFRARVRKLLERILRS 182
PRK08356 PRK08356
hypothetical protein; Provisional
 10-186 8.73e-18

hypothetical protein; Provisional


Pssm-ID: 169400  Cd Length: 195  Bit Score: 77.13  E-value: 8.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAKLLREKGARVIVMSDVV-------KKRYS------SEAKPG-ERLMDFAKRLREIYGEGVVARL 75
Cdd:PRK08356    7 IVGVVGKIAAGKTTVAKFFEEKGFCRVSCSDPLidllthnVSDYSwvpevpFKGEPTrENLIELGRYLKEKYGEDILIRL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  76 CVEELGtgSYDLVGFDGVRSLAEVEEFKRLLGDNVYIVAvhsPPKIRYKRIIERMRSDDS--KEISELMRRDREELKL-G 152
Cdd:PRK08356   87 AVDKKR--NCKNIAIDGVRSRGEVEAIKRMGGKVIYVEA---KPEIRFERLRRRGAEKDKgiKSFEDFLKFDEWEEKLyH 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2778281551 153 IGEVIAMADYVITNDSNYEEFKKRSEEVINRVLK 186
Cdd:PRK08356  162 TTKLKDKADFVIVNEGTLEELRKKVEEILRELSK 195
DPCK cd02022
Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of ...
 10-172 8.22e-17

Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.


Pssm-ID: 238980  Cd Length: 179  Bit Score: 74.09  E-value: 8.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERLMDFA---------KRLREIYGEGVVAR-LCVEE 79
Cdd:cd02022     1 IIGLTGGIGSGKSTVAKLLKELGIPVIDADKIAHEVYEPGGPALQAIVEAFgpdilledgELDRKKLGEIVFADpEKRKK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  80 LGTGSYDLVGFDGVRSLAEVEEFKRLLGD-------NVY-----IVAVHSPPKIRYKRIIERmrsDDSKEISELMRRDRE 147
Cdd:cd02022    81 LEAITHPLIRKEIEEQLAEARKEKVVVLDipllfetGLEklvdrVIVVDAPPEIQIERLMKR---DGLSEEEAEARIASQ 157

                         170       180
                  ....*....|....*....|....*
gi 2778281551 148 elkLGIGEVIAMADYVITNDSNYEE 172
Cdd:cd02022   158 ---MPLEEKRARADFVIDNSGSLEE 179
AAA_18 pfam13238
AAA domain;
11-129 5.20e-11

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 57.44  E-value: 5.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  11 ILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERlmDFAKRLREIYGEGVVARLcVEELGTGSYDLVGF 90
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPET--RESKRLDEDKLDRLLDLL-EENAALEEGGNLII 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2778281551  91 DGVRSLAEVEEFKrllgDNVYIVaVHSPPKIRYKRIIER 129
Cdd:pfam13238  78 DGHLAELEPERAK----DLVGIV-LRASPEELLERLEKR 111
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-149 2.01e-10

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 56.85  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAK-LLREKGARVIVmSDVVKKR-YSSEAKPGERLMDFAKRLREiygegVVARLCVEELGTGsYDL 87
Cdd:COG0645     1 LILVCGLPGSGKSTLARaLAERLGAVRLR-SDVVRKRlFGAGLAPLERSPEATARTYA-----RLLALARELLAAG-RSV 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  88 VgFDGV-RSLAEVEEFKRL---LGDNVYIVAVHSPPKIRYKRIIERMR----SDDSKEISELMRRDREEL 149
Cdd:COG0645    74 I-LDATfLRRAQREAFRALaeeAGAPFVLIWLDAPEEVLRERLEARNAeggdSDATWEVLERQLAFEEPL 142
CoaE COG0237
Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the ...
 9-184 1.20e-09

Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440007  Cd Length: 193  Bit Score: 55.07  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   9 KVILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKRYsseaKPGERLMDfakRLREIYGEGVVarlcveeLGTGSYD-- 86
Cdd:COG0237     2 LIIGLTGGIGSGKSTVARMFAELGAPVIDADAIARELV----EPGGPALA---AIVEAFGEEIL-------DADGSLDrk 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  87 ----LVGFDG-------------VRslAEVEEFKRLLGDNVYIVA-------------------VHSPPKIRYKRIIERM 130
Cdd:COG0237    68 alaeIVFADPealkkleaivhplVR--EEIERRLAAARGAPYVVLdipllfetgleklvdrvivVDAPEEVQIERLMARD 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2778281551 131 RSDDsKEISELMRR--DREELKlgigeviAMADYVITNDSNYEEFKKRSEEVINRV 184
Cdd:COG0237   146 GLSE-EEAEARIAAqmPDEEKR-------ARADFVIDNDGSLEELRAQVDALLEKL 193
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 10-135 1.27e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 48.46  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAKLLREKGARVIVMSDVVKKR-YSSEAKPGERLMDFAKRLREIygegvVARLCVEELGTGsYDLV 88
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRlFGEGRPSISYYTDATDRTYER-----LHELARIALRAG-RPVI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2778281551  89 ---GFDGVRSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIERMRSDDS 135
Cdd:pfam13671  75 ldaTNLRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGD 124
AAA_17 pfam13207
AAA domain;
14-137 7.84e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 46.46  E-value: 7.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  14 TGMPGSGKSEFAKLLREK-GARVIVMSDVVKkrysSEAKPGERLMDF------AKRLREIYGEGVVARLcVEELGTGSYD 86
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKlGFPHISAGDLLR----EEAKERGLVEDRdemrklPLEPQKELQKLAAERI-AEEAGEGGVI 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  87 LVGF------DGVRSLAEVEEFKRLLGDNvyIVAVHSPPKIRYKRII---ERMRSDDSKE 137
Cdd:pfam13207  76 VDGHpriktpAGYLPGLPVEVLRELKPDA--IILLEADPEEILERRLkdrTRGRDDDSEE 133
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
10-44 1.33e-04

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 40.57  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2778281551  10 VILITGMPGSGKSEFAKLLREK-GARVIVMSDVVKK 44
Cdd:COG1936     2 RIAITGTPGTGKTTVAKLLAERlGLEVIHLNDLVKE 37
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
 11-40 1.91e-04

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 40.74  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2778281551  11 ILITGMPGSGKS----EFAKLLREKGARVIVMSD 40
Cdd:pfam08433   2 VLLTGLPSSGKStrakQLAKYLEESNYDVIVISD 35
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 8-137 7.43e-04

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 38.64  E-value: 7.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   8 IKVILITGMPGSGK-SEFAKLLREKGARVIVMSDVVKKRYSSEAKPGERLMDFAKRlREIYGEGVVARLCVEELGTGSYD 86
Cdd:TIGR01360   3 CKIIFIVGGPGSGKgTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMES-GDLVPLDTVLDLLKDAMVAALGT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2778281551  87 LVGF--DGV-RSLAEVEEFKRLLGDNVYIVAVHSPPKIRYKRIIER----MRSDDSKE 137
Cdd:TIGR01360  82 SKGFliDGYpREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRaetsGRVDDNEK 139
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 10-179 5.18e-03

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 36.06  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  10 VILITGMPGSGKSEFAKLLREK-GARVIVMSDVVKKryssEAKPGERLMdfaKRLREIYGEG------VVARLCVEELGT 82
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKyGLPHISTGDLLRE----EIASGTELG---KKAKEYIDSGklvpdeIVIKLLKERLKK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551  83 GSYDlVGF--DGV-RSLAEVEEFKRLLGDNV---YIVAVHSPPKIRYKRIIERMRSDDSKEISELMRRDREELKLgigev 156
Cdd:cd01428    74 PDCK-KGFilDGFpRTVDQAEALDELLDEGIkpdKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPL----- 147

                         170       180
                  ....*....|....*....|...
gi 2778281551 157 iamadyVITNDSNYEEFKKRSEE 179
Cdd:cd01428   148 ------SQRSDDNEETIKKRLEV 164
PRK03839 PRK03839
putative kinase; Provisional
 10-61 5.89e-03

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 35.85  E-value: 5.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2778281551  10 VILITGMPGSGKSEFAKLLREK-GARVIVMSDVVKKRYSSEAKPGERLMDFAK 61
Cdd:PRK03839    2 IIAITGTPGVGKTTVSKLLAEKlGYEYVDLTEFALKKGIGEEKDDEMEIDFDK 54
MMAA-like cd03114
methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB ...
 10-37 7.19e-03

methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB and its human homolog, methylmalonic aciduria associated protein (MMAA) are metallochaperones that function as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) and reactivation of the enzyme during catalysis. A member of the family, Escherichia coli ArgK, was previously thought to be a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and ornithine (AO system) and lysine, arginine and ornithine (LAO) transport systems.


Pssm-ID: 349768  Cd Length: 252  Bit Score: 36.01  E-value: 7.19e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2778281551  10 VILITGMPGSGKS----EFAKLLREKGARVIV 37
Cdd:cd03114    48 RVGITGPPGAGKStlieALGRLLREQGHRVAV 79
YqjQ COG0300
Short-chain dehydrogenase [General function prediction only];
4-98 8.73e-03

Short-chain dehydrogenase [General function prediction only];


Pssm-ID: 440069 [Multi-domain]  Cd Length: 252  Bit Score: 36.00  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2778281551   4 MVVSIKVILITGmpGS---GKsEFAKLLREKGARVIVMsdvvkkrysseAKPGERLMDFAKRLREiYGEGVVARLCveel 80
Cdd:COG0300     1 MSLTGKTVLITG--ASsgiGR-ALARALAARGARVVLV-----------ARDAERLEALAAELRA-AGARVEVVAL---- 61

                          90
                  ....*....|....*...
gi 2778281551  81 gtgsyDLVGFDGVRSLAE 98
Cdd:COG0300    62 -----DVTDPDAVAALAE 74
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 10-49 9.54e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 35.45  E-value: 9.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2778281551  10 VILITGMPGSGKS----EFAKLLREKGARVIVM-SDVVKKRYSSE 49
Cdd:COG0529    18 VVWFTGLSGSGKStlanALERRLFERGRHVYLLdGDNVRHGLNKD 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH