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Conserved domains on  [gi|2082276821|ref|XP_001897456|]
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Apoptosis regulator proteins, Bcl-2 family protein [Brugia malayi]

Protein Classification

Bcl-2 family protein( domain architecture ID 10160139)

Bcl-2 (B-cell lymphoma 2) family protein is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bcl-2_like cd06845
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This ...
 24-178 1.33e-25

Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.


:

Pssm-ID: 132900 [Multi-domain]  Cd Length: 144  Bit Score: 97.40  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821  24 CEDGMYLIQDFVADYIQYRIRIHGNrkvqnLFYPCRQECENGLIRSVALIFEEKHKEELQKMVEMLCENESFSCSRYIEI 103
Cdd:cd06845     1 DEITRRLARDYLRYRLGEPETPNSP-----LPSGSPPSEVAETLRRVGDELEEKHRRLFENMCRQLNISPDNAYEVFQEV 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2082276821 104 MEQFVCIhnespSQMSYGRLIALIAFAGLIATRLIDMKYFAEVSMVMSYTSKFLHKRIAlTWPYHKRSWSKFFDL 178
Cdd:cd06845    76 ARELFED-----GGINWGRIVALFAFGGRLAVKCVEQGLPELVRSIAEWTSDFLEENLA-DWIQENGGWDGFVEF 144
 
Name Accession Description Interval E-value
Bcl-2_like cd06845
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This ...
 24-178 1.33e-25

Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.


Pssm-ID: 132900 [Multi-domain]  Cd Length: 144  Bit Score: 97.40  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821  24 CEDGMYLIQDFVADYIQYRIRIHGNrkvqnLFYPCRQECENGLIRSVALIFEEKHKEELQKMVEMLCENESFSCSRYIEI 103
Cdd:cd06845     1 DEITRRLARDYLRYRLGEPETPNSP-----LPSGSPPSEVAETLRRVGDELEEKHRRLFENMCRQLNISPDNAYEVFQEV 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2082276821 104 MEQFVCIhnespSQMSYGRLIALIAFAGLIATRLIDMKYFAEVSMVMSYTSKFLHKRIAlTWPYHKRSWSKFFDL 178
Cdd:cd06845    76 ARELFED-----GGINWGRIVALFAFGGRLAVKCVEQGLPELVRSIAEWTSDFLEENLA-DWIQENGGWDGFVEF 144
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
67-172 1.31e-13

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 64.59  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821  67 IRSVALIFEEKHKEELQKMVEMLCEN-ESFSCSRYIEIMEQFVcihneSPSQMSYGRLIALIAFAGLIATRLIDMKYFAE 145
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNQLLLTpEDTAYELFREVADELF-----SDGVINWGRVVALFAFAGALAVKLVRQGHPEL 75

                          90       100
                  ....*....|....*....|....*..
gi 2082276821 146 VSMVMSYTSKFLHKRIAlTWPYHKRSW 172
Cdd:pfam00452  76 VRRLAEWLVDYLEERLA-DWIIQQGGW 101
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 67-172 4.23e-05

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 41.15  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821   67 IRSVALIFEEKHKEELQKMVEMLCENESFSCSRYIEIMEQFvcihnESPSQMSYGRLIALIAFAGLIATRLIDMKYFAEV 146
Cdd:smart00337   1 LRRVGDELNKRYERAFSSFSAQLHVTPGTAIELFGEVATEL-----FSDGNINWGRVVALLSFGGALAVKLVQKEDPDLV 75

                           90       100
                   ....*....|....*....|....*.
gi 2082276821  147 SMVMSYTSKFLHKRIAlTWPYHKRSW 172
Cdd:smart00337  76 SRLASWLSEFLRETLR-SWIRENGGW 100
 
Name Accession Description Interval E-value
Bcl-2_like cd06845
Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This ...
 24-178 1.33e-25

Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane segment. Some homologous proteins, which are not included in this model, may miss either the BH4 (Bax, Bak) or the BH2 (Bcl-X(S)) region, and some appear to only share the BH3 region (Bik, Bim, Bad, Bid, Egl-1). This family is involved in the regulation of the outer mitochondrial membrane's permeability and in promoting or preventing the release of apoptogenic factors, which in turn may trigger apoptosis by activating caspases. Bcl-2 and the closely related Bcl-X(L) are anti-apoptotic key regulators of programmed cell death. They are assumed to function via heterodimeric protein-protein interactions, binding pro-apoptotic proteins such as Bad (BCL2-antagonist of cell death), Bid, and Bim, by specifically interacting with their BH3 regions. Interfering with this heterodimeric interaction via small-molecule inhibitors may prove effective in targeting various cancers. This family also includes the Caenorhabditis elegans Bcl-2 homolog CED-9, which binds to CED-4, the C. Elegans homolog of mammalian Apaf-1. Apaf-1, however, does not seem to be inhibited by Bcl-2 directly.


Pssm-ID: 132900 [Multi-domain]  Cd Length: 144  Bit Score: 97.40  E-value: 1.33e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821  24 CEDGMYLIQDFVADYIQYRIRIHGNrkvqnLFYPCRQECENGLIRSVALIFEEKHKEELQKMVEMLCENESFSCSRYIEI 103
Cdd:cd06845     1 DEITRRLARDYLRYRLGEPETPNSP-----LPSGSPPSEVAETLRRVGDELEEKHRRLFENMCRQLNISPDNAYEVFQEV 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2082276821 104 MEQFVCIhnespSQMSYGRLIALIAFAGLIATRLIDMKYFAEVSMVMSYTSKFLHKRIAlTWPYHKRSWSKFFDL 178
Cdd:cd06845    76 ARELFED-----GGINWGRIVALFAFGGRLAVKCVEQGLPELVRSIAEWTSDFLEENLA-DWIQENGGWDGFVEF 144
Bcl-2 pfam00452
Apoptosis regulator proteins, Bcl-2 family;
67-172 1.31e-13

Apoptosis regulator proteins, Bcl-2 family;


Pssm-ID: 459816  Cd Length: 101  Bit Score: 64.59  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821  67 IRSVALIFEEKHKEELQKMVEMLCEN-ESFSCSRYIEIMEQFVcihneSPSQMSYGRLIALIAFAGLIATRLIDMKYFAE 145
Cdd:pfam00452   1 LRRLGDELERKHPELFQNMLNQLLLTpEDTAYELFREVADELF-----SDGVINWGRVVALFAFAGALAVKLVRQGHPEL 75

                          90       100
                  ....*....|....*....|....*..
gi 2082276821 146 VSMVMSYTSKFLHKRIAlTWPYHKRSW 172
Cdd:pfam00452  76 VRRLAEWLVDYLEERLA-DWIIQQGGW 101
BCL smart00337
BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not ...
 67-172 4.23e-05

BCL (B-Cell lymphoma); contains BH1, BH2 regions; (BH1, BH2, (BH3 (one helix only)) and not BH4(one helix only)). Involved in apoptosis regulation


Pssm-ID: 214626  Cd Length: 100  Bit Score: 41.15  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082276821   67 IRSVALIFEEKHKEELQKMVEMLCENESFSCSRYIEIMEQFvcihnESPSQMSYGRLIALIAFAGLIATRLIDMKYFAEV 146
Cdd:smart00337   1 LRRVGDELNKRYERAFSSFSAQLHVTPGTAIELFGEVATEL-----FSDGNINWGRVVALLSFGGALAVKLVQKEDPDLV 75

                           90       100
                   ....*....|....*....|....*.
gi 2082276821  147 SMVMSYTSKFLHKRIAlTWPYHKRSW 172
Cdd:smart00337  76 SRLASWLSEFLRETLR-SWIRENGGW 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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