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Conserved domains on  [gi|195999244|ref|XP_002109490|]
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uncharacterized protein TRIADDRAFT_53583 [Trichoplax adhaerens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_TopBP1_rpt3 cd17718
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 315-397 1.51e-35

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain.


:

Pssm-ID: 349350  Cd Length: 83  Bit Score: 130.02  E-value: 1.51e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  315 EHSSFFLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSLWNPTDLKALKSQPFVVSVRWLIDSSK 394
Cdd:cd17718     1 EKAGDFLDGCKIYLSGFSGAELDKLRRIINAGGGTRFNQLNESVTHVVVGESSEELLKELAKLAGRPHVVTPSWLLECFK 80


                  ...
gi 195999244  395 NGI 397
Cdd:cd17718    81 QGK 83
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 181-256 3.97e-34

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


:

Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 125.73  E-value: 3.97e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244  181 PIFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWN-IHCVLTKWFYDSLKAK 256
Cdd:cd17731     1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 1111-1185 6.92e-29

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


:

Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 110.74  E-value: 6.92e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244 1111 QYRFLLSAMKPQEKINYAGIVENLEGVFYDTQYFTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAG 1185
Cdd:cd17738     1 KPVFLLSGFSEDEKKELISIIEKLGGKVLDSDEFDPKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKAG 75
BRCT_TopBP1_rpt8 cd17728
eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed ...
 1241-1320 5.32e-28

eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the eighth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


:

Pssm-ID: 349360  Cd Length: 80  Bit Score: 108.13  E-value: 5.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244 1241 GWKVLLSVDVTRQSGFKRLLEAGCATVMKLKPPFP-NIEGVTHAFIDTNRTKPGsIDLQQLINANIVCLKPDYIAEYLTH 1319
Cdd:cd17728     1 GWKVLLVVDIAKEDGFKRLLEAGGAKVIPSSPPYSlKLKDATHAFVDLTKDTSV-DLISLLAKAGVPCLKPEYIAEYLMK 79


                  .
gi 195999244 1320 D 1320
Cdd:cd17728    80 D 80
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 555-641 4.23e-26

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd18434:

Pssm-ID: 469589  Cd Length: 89  Bit Score: 103.15  E-value: 4.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  555 PLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVR--LPQGKLYPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:cd18434     1 PLNGCVISVSQFTGTERDCLTHLAELLGAKVQDYFVRkaNPSKGLLASTHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80


                  ....*....
gi 195999244  633 CEAAERAVE 641
Cdd:cd18434    81 ARTGKKVPE 89
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 733-831 1.72e-22

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17727:

Pssm-ID: 469589 [Multi-domain]  Cd Length: 75  Bit Score: 92.27  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  733 LKGVTISASKKLSSSHRQFEREASQLGADWRWTFEDCCTHFIYQvadvtltrvqidndkcitplpnlfekGKATENNREL 812
Cdd:cd17727     1 LKGVVICVSKKLSKRQGELNKIAASLGAEYRWTYDESCTHFIYQ--------------------------GKANDTNREY 54

                          90
                  ....*....|....*....
gi 195999244  813 KAAKKAKAILVSPSWLKAC 831
Cdd:cd17727    55 KSAKEQGKFIVSPHWLYAC 73
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 459-535 7.72e-20

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


:

Pssm-ID: 349386  Cd Length: 83  Bit Score: 85.06  E-value: 7.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  459 LFCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSLQ-------ADMIITPPCIYESEDENSSlRNLPCVTTYYLEDCLE 531
Cdd:cd18433     1 IFSGCTFYIHGFDDKKIQILRKHLLSNGGQVVSSLSEleadeskHRYVIVPHTNPPDELPPVS-ENAPLVTEWWIERCLH 79


                  ....
gi 195999244  532 VKQL 535
Cdd:cd18433    80 SKRL 83
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 133-175 1.13e-13

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17737:

Pssm-ID: 469589 [Multi-domain]  Cd Length: 72  Bit Score: 67.05  E-value: 1.13e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 195999244  133 DLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:cd17737     1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGE 43
 
Name Accession Description Interval E-value
BRCT_TopBP1_rpt3 cd17718
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 315-397 1.51e-35

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain.


Pssm-ID: 349350  Cd Length: 83  Bit Score: 130.02  E-value: 1.51e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  315 EHSSFFLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSLWNPTDLKALKSQPFVVSVRWLIDSSK 394
Cdd:cd17718     1 EKAGDFLDGCKIYLSGFSGAELDKLRRIINAGGGTRFNQLNESVTHVVVGESSEELLKELAKLAGRPHVVTPSWLLECFK 80


                  ...
gi 195999244  395 NGI 397
Cdd:cd17718    81 QGK 83
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 181-256 3.97e-34

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 125.73  E-value: 3.97e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244  181 PIFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWN-IHCVLTKWFYDSLKAK 256
Cdd:cd17731     1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 1111-1185 6.92e-29

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 110.74  E-value: 6.92e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244 1111 QYRFLLSAMKPQEKINYAGIVENLEGVFYDTQYFTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAG 1185
Cdd:cd17738     1 KPVFLLSGFSEDEKKELISIIEKLGGKVLDSDEFDPKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKAG 75
BRCT_TopBP1_rpt8 cd17728
eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed ...
 1241-1320 5.32e-28

eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the eighth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349360  Cd Length: 80  Bit Score: 108.13  E-value: 5.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244 1241 GWKVLLSVDVTRQSGFKRLLEAGCATVMKLKPPFP-NIEGVTHAFIDTNRTKPGsIDLQQLINANIVCLKPDYIAEYLTH 1319
Cdd:cd17728     1 GWKVLLVVDIAKEDGFKRLLEAGGAKVIPSSPPYSlKLKDATHAFVDLTKDTSV-DLISLLAKAGVPCLKPEYIAEYLMK 79


                  .
gi 195999244 1320 D 1320
Cdd:cd17728    80 D 80
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 555-641 4.23e-26

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 103.15  E-value: 4.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  555 PLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVR--LPQGKLYPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:cd18434     1 PLNGCVISVSQFTGTERDCLTHLAELLGAKVQDYFVRkaNPSKGLLASTHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80


                  ....*....
gi 195999244  633 CEAAERAVE 641
Cdd:cd18434    81 ARTGKKVPE 89
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 733-831 1.72e-22

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 92.27  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  733 LKGVTISASKKLSSSHRQFEREASQLGADWRWTFEDCCTHFIYQvadvtltrvqidndkcitplpnlfekGKATENNREL 812
Cdd:cd17727     1 LKGVVICVSKKLSKRQGELNKIAASLGAEYRWTYDESCTHFIYQ--------------------------GKANDTNREY 54

                          90
                  ....*....|....*....
gi 195999244  813 KAAKKAKAILVSPSWLKAC 831
Cdd:cd17727    55 KSAKEQGKFIVSPHWLYAC 73
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 459-535 7.72e-20

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


Pssm-ID: 349386  Cd Length: 83  Bit Score: 85.06  E-value: 7.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  459 LFCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSLQ-------ADMIITPPCIYESEDENSSlRNLPCVTTYYLEDCLE 531
Cdd:cd18433     1 IFSGCTFYIHGFDDKKIQILRKHLLSNGGQVVSSLSEleadeskHRYVIVPHTNPPDELPPVS-ENAPLVTEWWIERCLH 79


                  ....
gi 195999244  532 VKQL 535
Cdd:cd18433    80 SKRL 83
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 186-248 1.26e-17

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 78.01  E-value: 1.26e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195999244   186 CTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKW 248
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 133-175 1.13e-13

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 67.05  E-value: 1.13e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 195999244  133 DLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:cd17737     1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGE 43
BRCT smart00292
breast cancer carboxy-terminal domain;
181-253 2.88e-11

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 60.47  E-value: 2.88e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244    181 PIFSGCTICVTG-LDKEERGNIDKLITVNGGSYSPELDQ-RCTHLLVNVPKGDKYEY--ALQWNIHCVLTKWFYDSL 253
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLELlkAIALGIPIVKEEWLLDCL 78
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 559-628 2.37e-10

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 57.60  E-value: 2.37e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   559 CVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWKIPTVSEKW 628
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTK-------SVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
553-633 1.26e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 53.15  E-value: 1.26e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244    553 VNPLKDCVLSIS-QFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklYPSTHLLLIKPSGSKYG--AAKKWKIPTVSEKWL 629
Cdd:smart00292    1 PKLFKGKTFYITgSFDKEERDELKELIEALGGKVTSSLSS------KTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74


                    ....
gi 195999244    630 IASC 633
Cdd:smart00292   75 LDCL 78
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 456-540 1.61e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 50.06  E-value: 1.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   456 PSELFCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSLQADMIITPPciYESEDENSSLRNLPCVTTYYLEDCLEVKQL 535
Cdd:pfam16589    1 LPNLFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAP--YNKTDKLAENTKLGVVSPQWIFDCVKKGKL 78


                   ....*
gi 195999244   536 KDISE 540
Cdd:pfam16589   79 LPLEN 83
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 130-175 2.81e-07

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 49.21  E-value: 2.81e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 195999244   130 VMKDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:pfam00533    5 LFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA 50
BRCT smart00292
breast cancer carboxy-terminal domain;
320-392 3.67e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.91  E-value: 3.67e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244    320 FLDGCKILLSG-FNEIQQSQLQSVINSGGGTRFNTL-EDSVTHVVISEDSLWNPTDLKALKSQPFVVSVRWLIDS 392
Cdd:smart00292    3 LFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLDC 77
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 320-404 4.37e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 48.90  E-value: 4.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   320 FLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEdslwNPTDLKALKSQPFVVSVRWLIDSSKNGIKL 399
Cdd:pfam16589    4 LFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPY----NKTDKLAENTKLGVVSPQWIFDCVKKGKLL 79


                   ....*
gi 195999244   400 PEDDY 404
Cdd:pfam16589   80 PLENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
130-191 3.69e-06

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 46.21  E-value: 3.69e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195999244    130 VMKDLVICCT-NLSKDDRDELHSLIKMMGGKVNPHLT-TDVTHLVAGEN-----KHLCPIFSGCtICVT 191
Cdd:smart00292    3 LFKGKTFYITgSFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGSPeggklELLKAIALGI-PIVK 70
 
Name Accession Description Interval E-value
BRCT_TopBP1_rpt3 cd17718
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 315-397 1.51e-35

third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain.


Pssm-ID: 349350  Cd Length: 83  Bit Score: 130.02  E-value: 1.51e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  315 EHSSFFLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSLWNPTDLKALKSQPFVVSVRWLIDSSK 394
Cdd:cd17718     1 EKAGDFLDGCKIYLSGFSGAELDKLRRIINAGGGTRFNQLNESVTHVVVGESSEELLKELAKLAGRPHVVTPSWLLECFK 80


                  ...
gi 195999244  395 NGI 397
Cdd:cd17718    81 QGK 83
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 181-256 3.97e-34

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 125.73  E-value: 3.97e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244  181 PIFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWN-IHCVLTKWFYDSLKAK 256
Cdd:cd17731     1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 1111-1185 6.92e-29

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 110.74  E-value: 6.92e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244 1111 QYRFLLSAMKPQEKINYAGIVENLEGVFYDTQYFTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAG 1185
Cdd:cd17738     1 KPVFLLSGFSEDEKKELISIIEKLGGKVLDSDEFDPKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKAG 75
BRCT_TopBP1_rpt8 cd17728
eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed ...
 1241-1320 5.32e-28

eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the eighth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349360  Cd Length: 80  Bit Score: 108.13  E-value: 5.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244 1241 GWKVLLSVDVTRQSGFKRLLEAGCATVMKLKPPFP-NIEGVTHAFIDTNRTKPGsIDLQQLINANIVCLKPDYIAEYLTH 1319
Cdd:cd17728     1 GWKVLLVVDIAKEDGFKRLLEAGGAKVIPSSPPYSlKLKDATHAFVDLTKDTSV-DLISLLAKAGVPCLKPEYIAEYLMK 79


                  .
gi 195999244 1320 D 1320
Cdd:cd17728    80 D 80
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 555-641 4.23e-26

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 103.15  E-value: 4.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  555 PLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVR--LPQGKLYPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:cd18434     1 PLNGCVISVSQFTGTERDCLTHLAELLGAKVQDYFVRkaNPSKGLLASTHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80


                  ....*....
gi 195999244  633 CEAAERAVE 641
Cdd:cd18434    81 ARTGKKVPE 89
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 733-831 1.72e-22

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 92.27  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  733 LKGVTISASKKLSSSHRQFEREASQLGADWRWTFEDCCTHFIYQvadvtltrvqidndkcitplpnlfekGKATENNREL 812
Cdd:cd17727     1 LKGVVICVSKKLSKRQGELNKIAASLGAEYRWTYDESCTHFIYQ--------------------------GKANDTNREY 54

                          90
                  ....*....|....*....
gi 195999244  813 KAAKKAKAILVSPSWLKAC 831
Cdd:cd17727    55 KSAKEQGKFIVSPHWLYAC 73
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 459-535 7.72e-20

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


Pssm-ID: 349386  Cd Length: 83  Bit Score: 85.06  E-value: 7.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  459 LFCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSLQ-------ADMIITPPCIYESEDENSSlRNLPCVTTYYLEDCLE 531
Cdd:cd18433     1 IFSGCTFYIHGFDDKKIQILRKHLLSNGGQVVSSLSEleadeskHRYVIVPHTNPPDELPPVS-ENAPLVTEWWIERCLH 79


                  ....
gi 195999244  532 VKQL 535
Cdd:cd18433    80 SKRL 83
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 177-264 1.68e-19

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 84.60  E-value: 1.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  177 KHLCPIFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDSLKaK 256
Cdd:cd17746     1 KHILPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQ-R 79


                  ....*...
gi 195999244  257 GALSENKY 264
Cdd:cd17746    80 NAVLEPQY 87
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 186-248 1.26e-17

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 78.01  E-value: 1.26e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195999244   186 CTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKW 248
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 182-261 1.78e-17

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 78.43  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  182 IFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQ-WNIHCVLTKWFYDSLKAKGALS 260
Cdd:cd17710     1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALKhEGIKIVTPDWVTDCIKAKTLLD 80


                  .
gi 195999244  261 E 261
Cdd:cd17710    81 E 81
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 186-252 1.10e-16

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 75.48  E-value: 1.10e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195999244  186 CTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKY-EYALQWNIHCVLTKWFYDS 252
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWLLDC 68
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 188-254 2.72e-15

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 71.89  E-value: 2.72e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244  188 ICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDSLK 254
Cdd:cd17730     3 ISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILL 69
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 178-253 6.55e-14

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 68.09  E-value: 6.55e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244   178 HLCPIFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNvPKGDKYEYALQWNIHCVLTKWFYDSL 253
Cdd:pfam00533    1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVE-ARTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 133-175 1.13e-13

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 67.05  E-value: 1.13e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 195999244  133 DLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:cd17737     1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGE 43
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 555-635 8.66e-13

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 64.87  E-value: 8.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  555 PLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWK-IPTVSEKWLIASC 633
Cdd:cd17731     2 PFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSK-------NCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSI 74


                  ..
gi 195999244  634 EA 635
Cdd:cd17731    75 EA 76
BRCT smart00292
breast cancer carboxy-terminal domain;
181-253 2.88e-11

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 60.47  E-value: 2.88e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244    181 PIFSGCTICVTG-LDKEERGNIDKLITVNGGSYSPELDQ-RCTHLLVNVPKGDKYEY--ALQWNIHCVLTKWFYDSL 253
Cdd:smart00292    2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLELlkAIALGIPIVKEEWLLDCL 78
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 188-252 1.25e-10

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 58.55  E-value: 1.25e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244  188 ICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDS 252
Cdd:cd18438     3 ITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDS 67
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 559-632 1.83e-10

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 57.76  E-value: 1.83e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244  559 CVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYG-AAKKWKIPTVSEKWLIAS 632
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESLSS-------KVTHLIAKSPSGEKYYlAALAWGIPIVSPEWLLDC 68
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 559-628 2.37e-10

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 57.60  E-value: 2.37e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   559 CVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWKIPTVSEKW 628
Cdd:pfam12738    1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTK-------SVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 324-392 6.45e-10

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 56.22  E-value: 6.45e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195999244  324 CKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSlWNPTDLKALKSQPFVVSVRWLIDS 392
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPS-GEKYYLAALAWGIPIVSPEWLLDC 68
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 185-254 2.46e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 54.96  E-value: 2.46e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 195999244  185 GCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVN--VPKGDKYEYALQWNIHCVLTKWFYDSLK 254
Cdd:cd17723     1 GLSISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIVNstEKKSDKINFAKKWGIPVVSVEWLWDCLK 72
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 183-254 2.63e-09

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 54.93  E-value: 2.63e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244  183 FSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQW---NIHCVLTKWFYDSLK 254
Cdd:cd18436     1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKRpelNIKIVLPHWFDDCFK 75
BRCT_Ect2_rpt2 cd17732
second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 182-254 5.58e-09

second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the second BRCT domain.


Pssm-ID: 349364  Cd Length: 80  Bit Score: 54.20  E-value: 5.58e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195999244  182 IFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDSLK 254
Cdd:cd17732     1 PFEGCTLSFLGFSDEEKTHMEELTEENGGKVTPLGDPSCTHLVVDESTVKELPFEPSSKLHVVKQEWFWASIQ 73
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 323-400 8.76e-09

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 53.42  E-value: 8.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  323 GCKILLSGFNEIQQSQL----QSVINSGGGTRFNTLEDSVTHVVIseDSLWNPTDLKALKSQPFVVSVRWLIDSSKNGIK 398
Cdd:cd17711     1 GCVFFIADYPEQMGDQEiatwKKVIEEHGGEVVDEYSPRVTHVIC--ESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKL 78


                  ..
gi 195999244  399 LP 400
Cdd:cd17711    79 LP 80
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 554-632 9.14e-09

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 53.45  E-value: 9.14e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195999244   554 NPLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLvrlpqgklYPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:pfam00533    4 KLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSL--------SKKTTHVIVEARTKKYLKAKELGIPIVTEEWLLDC 74
BRCT smart00292
breast cancer carboxy-terminal domain;
553-633 1.26e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 53.15  E-value: 1.26e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244    553 VNPLKDCVLSIS-QFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklYPSTHLLLIKPSGSKYG--AAKKWKIPTVSEKWL 629
Cdd:smart00292    1 PKLFKGKTFYITgSFDKEERDELKELIEALGGKVTSSLSS------KTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWL 74


                    ....
gi 195999244    630 IASC 633
Cdd:smart00292   75 LDCL 78
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 560-629 2.00e-08

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 52.25  E-value: 2.00e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  560 VLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWL 629
Cdd:cd17730     2 VISVTGFDGSEREDIKRMIELMGAKYTGYLTR-------SNTHLICKRPEGEKYEKAKEWRIPVVNAQWL 64
BRCT_SLF1 cd17750
BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; ...
 1116-1190 2.85e-08

BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins; SLF1, also termed Smc5/6 localization factor 1, or ankyrin repeat domain-containing protein 32 (ANKRD32), or BRCT domain-containing protein 1 (BRCTD1), plays a role in the DNA damage response (DDR) pathway by regulating post replication repair of UV-damaged DNA and genomic stability maintenance. It is a component of the SLF1-SLF2 complex that acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand break (DSB) sites on chromatin during DNA repair in response to stalled replication forks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349381  Cd Length: 81  Bit Score: 52.13  E-value: 2.85e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244 1116 LSAMKPQEKINYAGIVENLEGVFYDTQYFTQaCTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAGRFVSE 1190
Cdd:cd17750     8 LTGFKGEEKEALVKLLLKLDCVFIKSEKYEN-CTHLIAKKPCRSEKFLAACAAGKWILTKDYIINSAKSGRWLDE 81
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 560-632 3.24e-08

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 51.62  E-value: 3.24e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195999244  560 VLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:cd18438     2 KITITNYTGAARQYLEKLILALGATYTKNLKP-------DNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDS 67
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 561-632 6.21e-08

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 51.10  E-value: 6.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244  561 LSISQFSGSLRNYLIELIRFVGGRFQEQLVrlpqgklyPSTHLLLIK---PSGSKYGAAKKWKIPTVSEKWLIAS 632
Cdd:cd17723     4 ISLTGFSGVDLLHISKLIKLLGAKYHESLT--------KDRSLLIVNsteKKSDKINFAKKWGIPVVSVEWLWDC 70
BRCT_TopBP1_rpt4 cd17749
fourth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 460-546 1.05e-07

fourth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also called DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fourth BRCT domain.


Pssm-ID: 349380  Cd Length: 84  Bit Score: 50.75  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  460 FCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSL--QADMIITPpcIYESEDENSslrNLPCVTTYYLEDCLEVKQLKD 537
Cdd:cd17749     1 FNGKRFLILGFDEEQEAQLAELIEENGGKVLKDNSraVADYAIVP--LLGCPVEAT---VGEVVTNCWLQMCIEQEELLD 75


                  ....*....
gi 195999244  538 ISESVFYKP 546
Cdd:cd17749    76 PDSNPLFTP 84
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 182-252 1.61e-07

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 50.38  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  182 IFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQR---------CTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDS 252
Cdd:cd18434     1 PLNGCVISVSQFTGTERDCLTHLAELLGAKVQDYFVRKanpskgllaSTHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 456-540 1.61e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 50.06  E-value: 1.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   456 PSELFCGKKLYICGFTEAHITQLQLIIETNGGQVLTNSLQADMIITPPciYESEDENSSLRNLPCVTTYYLEDCLEVKQL 535
Cdd:pfam16589    1 LPNLFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAP--YNKTDKLAENTKLGVVSPQWIFDCVKKGKL 78


                   ....*
gi 195999244   536 KDISE 540
Cdd:pfam16589   79 LPLEN 83
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 1112-1181 1.69e-07

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 49.67  E-value: 1.69e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244 1112 YRFLLSAMKPQEKINYAGIVENLEGVFydTQYFTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDES 1181
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKV--SESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 130-175 2.81e-07

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 49.21  E-value: 2.81e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 195999244   130 VMKDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:pfam00533    5 LFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA 50
BRCT smart00292
breast cancer carboxy-terminal domain;
320-392 3.67e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 48.91  E-value: 3.67e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244    320 FLDGCKILLSG-FNEIQQSQLQSVINSGGGTRFNTL-EDSVTHVVISEDSLWNPTDLKALKSQPFVVSVRWLIDS 392
Cdd:smart00292    3 LFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLDC 77
BRCT_PARP4_like cd17726
BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also ...
 182-256 4.33e-07

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349358 [Multi-domain]  Cd Length: 85  Bit Score: 48.82  E-value: 4.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  182 IFSGCTICV---TGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGD---KYEYALQWNIHCVLTKWFYDSLKA 255
Cdd:cd17726     1 VFSGCQIVLdlkTLPGFKEKKKLKKKITENGGIISYIINKKCTHVVVNNAKALssyKCRMAQKYGIPVVSLDYIWKCVEA 80


                  .
gi 195999244  256 K 256
Cdd:cd17726    81 G 81
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 320-404 4.37e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 48.90  E-value: 4.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   320 FLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEdslwNPTDLKALKSQPFVVSVRWLIDSSKNGIKL 399
Cdd:pfam16589    4 LFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPY----NKTDKLAENTKLGVVSPQWIFDCVKKGKLL 79


                   ....*
gi 195999244   400 PEDDY 404
Cdd:pfam16589   80 PLENY 84
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 131-175 1.48e-06

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 47.47  E-value: 1.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 195999244  131 MKDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGE 175
Cdd:cd17740     3 LSGIVLCCTSIPAEQRTEIATKASKMGAAYTADLTSDVTHLVAGQ 47
BRCT smart00292
breast cancer carboxy-terminal domain;
130-191 3.69e-06

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 46.21  E-value: 3.69e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195999244    130 VMKDLVICCT-NLSKDDRDELHSLIKMMGGKVNPHLT-TDVTHLVAGEN-----KHLCPIFSGCtICVT 191
Cdd:smart00292    3 LFKGKTFYITgSFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGSPeggklELLKAIALGI-PIVK 70
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 316-392 3.98e-06

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 45.75  E-value: 3.98e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244   316 HSSFFLDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEdslWNPTDLKALKSQPFVVSVRWLIDS 392
Cdd:pfam00533    1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA---RTKKYLKAKELGIPIVTEEWLLDC 74
BRCT_Bard1_rpt1 cd17734
first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...
 134-177 4.35e-06

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.


Pssm-ID: 349366  Cd Length: 80  Bit Score: 46.05  E-value: 4.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 195999244  134 LVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGENK 177
Cdd:cd17734     1 LVLLGSGLSSEQKKLLEKLAQLLKAKVVTEFSPEVTHVVVPADE 44
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 556-638 7.78e-06

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 45.30  E-value: 7.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  556 LKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAA-KKWKIPTVSEKWLIASCE 634
Cdd:cd17710     2 FSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDK-------KCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTDCIK 74


                  ....
gi 195999244  635 AAER 638
Cdd:cd17710    75 AKTL 78
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 1114-1180 2.51e-05

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 43.74  E-value: 2.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244 1114 FLLSAMKPQEKINYAGIVENLEGVFYDtqYFTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDE 1180
Cdd:cd17741     5 VCSSCLDSEEKKKLKQIIAKLGGKVVN--EWTEECTHLVMSKIKVTVKVICALISGKPIVTPEYLDA 69
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 321-396 3.87e-05

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 43.30  E-value: 3.87e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195999244  321 LDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSlwnpTD--LKALK-SQPFVVSVRWLIDSSKNG 396
Cdd:cd17731     3 FKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPS----GQkyEFARKwNSIHIVTPEWLYDSIEAG 77
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 184-248 4.64e-05

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 43.09  E-value: 4.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244  184 SGCTICVTGLDK-EERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKW 248
Cdd:cd17742     1 SGITVCLGPLDPpESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEW 66
BRCT_PARP1 cd17747
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ...
 321-394 7.05e-05

BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.


Pssm-ID: 349378 [Multi-domain]  Cd Length: 76  Bit Score: 42.52  E-value: 7.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244  321 LDGCKILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDSLWNPTDL--KALKSQPFVVSVRWLIDSSK 394
Cdd:cd17747     1 LTGMKFALIGKLSKSKDELKKLIEKLGGKVASKVTKKVTLCISTKAEVEKMSKKmkEAKEAGVPVVSEDFLEDCIK 76
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 185-264 1.12e-04

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 41.88  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  185 GCTICVTGLDKEERGNI-DKLITVnGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDSLKAKGALSENK 263
Cdd:cd17725     1 GVVFVLSGFQNPFRGELrDKALEM-GAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKR 79


                  .
gi 195999244  264 Y 264
Cdd:cd17725    80 Y 80
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 182-264 1.16e-04

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 41.97  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244   182 IFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYalQWNIHCVLTKWFYDSLKAKGALSE 261
Cdd:pfam16589    4 LFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDKLAE--NTKLGVVSPQWIFDCVKKGKLLPL 81


                   ...
gi 195999244   262 NKY 264
Cdd:pfam16589   82 ENY 84
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
 135-189 1.17e-04

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 41.81  E-value: 1.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  135 VICCTNLSKDDRDELHSLIKMMGG-KVNPHLTTDVTHLVAGEN----KHLCPIFSGCTIC 189
Cdd:cd17736     2 TLVMTSVHSEEQELLESVVKKLGGfRVEDSVTEKTTHVVVGSPrrtlNVLLGIARGCWIL 61
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 1113-1188 1.37e-04

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 41.45  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244 1113 RFLLSAMKPQEKINYAGIVENLEGVFYDTqyfTQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAGRFV 1188
Cdd:cd17712     3 RVLFTGFDPVQVRKLTKKVTILGGEVVES---PQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 132-173 1.73e-04

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 41.06  E-value: 1.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 195999244  132 KDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVA 173
Cdd:cd18436     2 SGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIA 43
BRCT_p53bp1_rpt1 cd17745
first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, ...
 182-256 2.05e-04

first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family also includes Schizosaccharomyces pombe Crb2, which is a checkpoint mediator required for the cellular response to DNA damage. This model corresponds to the first BRCT domain.


Pssm-ID: 349376 [Multi-domain]  Cd Length: 99  Bit Score: 41.91  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  182 IFSGCTICVTGLDK----EERGNIDKLITVNGG----SYSPELDQRCTHLLVNVPKGD---------------KYEYALQ 238
Cdd:cd17745     1 IFSGCAFLLTGAEEtdkpFDKERLESQIEANGGtvleDFDEELFNDGRSSTRKSRSKDlrfvfliadspsrtpKYLQALA 80

                          90
                  ....*....|....*...
gi 195999244  239 WNIHCVLTKWFYDSLKAK 256
Cdd:cd17745    81 LGIPCVSHKWILDCIEAG 98
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 182-264 2.12e-04

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 41.40  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  182 IFSGCTICVTGLDKEERGNIDKLITVNGGSYSPELDQ-RCTHLLV-NVPKGDKYEYALQWNIHCVLTKWFYDSLKAKGAL 259
Cdd:cd17719     1 IFKGVVIYVNGYTDPSADELKRLILLHGGQYEHYYSRsRVTHIIAtNLPGSKIKKLKKARNYKVVRPEWIVDSIKAGRLL 80


                  ....*
gi 195999244  260 SENKY 264
Cdd:cd17719    81 PEAPY 85
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 139-188 3.15e-04

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 40.63  E-value: 3.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244  139 TNLSKDDRDELHSLIKMMGGKV--NPHLTTDVTHLVAGE----NKHLCPIFSGCTI 188
Cdd:cd17738     7 SGFSEDEKKELISIIEKLGGKVldSDEFDPKCTHLICGKpsrsEKFLAACAAGKWI 62
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 323-406 4.21e-04

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 40.63  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  323 GCKILLSGFNEIQQSQLQSVINSGGGTrFNTLEDS--VTHVVISE--DSLWNptDLKALKSQPfVVSVRWLIDSSKNGIK 398
Cdd:cd17719     4 GVVIYVNGYTDPSADELKRLILLHGGQ-YEHYYSRsrVTHIIATNlpGSKIK--KLKKARNYK-VVRPEWIVDSIKAGRL 79


                  ....*...
gi 195999244  399 LPEDDYLV 406
Cdd:cd17719    80 LPEAPYLL 87
BRCT_Ect2_rpt1 cd17733
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 187-250 4.29e-04

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.


Pssm-ID: 349365 [Multi-domain]  Cd Length: 76  Bit Score: 40.00  E-value: 4.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195999244  187 TICVTGL-DKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFY 250
Cdd:cd17733     5 VLCFTGFrKKEELSRLVNLVHHMGGSIRKDFSSKVTHLVANSTQGEKYRVAVSLGTPIMTEDWIY 69
BRCT_Ect2_rpt1 cd17733
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 131-173 4.33e-04

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.


Pssm-ID: 349365 [Multi-domain]  Cd Length: 76  Bit Score: 40.00  E-value: 4.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 195999244  131 MKDLVICCTNL-SKDDRDELHSLIKMMGGKVNPHLTTDVTHLVA 173
Cdd:cd17733     1 MENLVLCFTGFrKKEELSRLVNLVHHMGGSIRKDFSSKVTHLVA 44
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 182-253 4.56e-04

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 40.59  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244  182 IFSGCTICVTGL----DKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQW-NIHCVLTKWFYDSL 253
Cdd:cd17729    13 VLKGCVIVFSGViptgIDPERSRLWKLAESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMpGIHVVHPDWLWACA 89
BRCT_BRCA1_rpt1 cd17735
first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins; ...
 326-406 4.78e-04

first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins; BRCA1, also termed RING finger protein 53 (RNF53), is a RING finger protein encoded by BRCA1, a tumor suppressor gene that regulates all DNA double-strand break (DSB) repair pathways. BRCA1 is frequently mutated in patients with hereditary breast and ovarian cancer (HBOC). Its mutation is also associated with an increased risk of pancreatic, stomach, laryngeal, fallopian tube, and prostate cancer. It plays an important role in the DNA damage response signaling, and has been implicated in various cellular processes such as cell cycle regulation, transcriptional regulation, chromatin remodeling, DNA DSBs, and apoptosis. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT (BRCA1 C-terminus domain) repeats at the C-terminus. The family corresponds to the first BRCT domain.


Pssm-ID: 349367  Cd Length: 97  Bit Score: 40.79  E-value: 4.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  326 ILLSGFNEIQQSQLQSVINSGGGTRFNTLEDSVTHVVISED-SLWNPTDLK---ALKSQPFVVSVRWLIDSSKNGIKLPE 401
Cdd:cd17735     3 MVASGLTPEELMLVQKFARKTGSTLTSQFTEETTHVIMKTDaELVCERTLKyflGIAGRKWVVSYQWITQSIKEGKILPE 82


                  ....*
gi 195999244  402 DDYLV 406
Cdd:cd17735    83 HDFEV 87
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 185-256 5.08e-04

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 39.94  E-value: 5.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195999244  185 GCTICVTGLDK----EERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKWFYDSLKAK 256
Cdd:cd17711     1 GCVFFIADYPEqmgdQEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRG 76
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
 1149-1188 5.25e-04

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 39.88  E-value: 5.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 195999244 1149 THVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAGRFV 1188
Cdd:cd17736    37 THVVVGSPRRTLNVLLGIARGCWILSPDWVLESLEAGKWL 76
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 187-248 8.02e-04

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 39.31  E-value: 8.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 195999244  187 TICVTGLDKEERGNIDKLITVNGGSYSPELDQRCTHLLVNVPKGDKYEYALQWNIHCVLTKW 248
Cdd:cd17737     3 TISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGEVGSKKYLVAASLKKPIMLPSW 64
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 353-396 1.04e-03

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 39.10  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 195999244  353 TLEDSVTHVVISEDSLwnPTDLKALKSQPFVVSVRWLIDSSKNG 396
Cdd:cd17716    34 RLTKTVTHVVFKDGSQ--STLEKAKKRNVKLVSPLWVEACKETG 75
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 555-634 1.21e-03

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 39.53  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  555 PLKDCVLSISQFSGSLRNYLIELIRFVGGRFQEQLVRlpqgklyPSTHLLLIKPSGSKYGAAKKWKIPTVSEKWLIASCE 634
Cdd:cd17746     6 TLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTR-------DVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQ 78
BRCT_BRC1_like_rpt5 cd17743
fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 1145-1181 2.28e-03

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.


Pssm-ID: 349374  Cd Length: 70  Bit Score: 38.00  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 195999244 1145 TQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDES 1181
Cdd:cd17743    30 PDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEAC 66
BRCT_DNA_ligase_IV_rpt2 cd17717
second BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ...
 315-395 2.74e-03

second BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the second one.


Pssm-ID: 349349  Cd Length: 88  Bit Score: 38.19  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  315 EHSSFFLDGCKILLSGFNEIQQSQLQS---VINSGGGTRFNTLEDSVTHVVISEDSLwNPTDLKALKSQPF----VVSVR 387
Cdd:cd17717     2 RGCTVYFDSYAVINDPSTEIEGTGLDIralELRFHGGKVVSELAEGISHVVVDSDHS-RVVDFKELRRLLKkkfkIVSES 80


                  ....*...
gi 195999244  388 WLIDSSKN 395
Cdd:cd17717    81 WVTDSIKR 88
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
 326-396 5.02e-03

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 37.18  E-value: 5.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195999244  326 ILLSGFNEIQQSQLQSVINSGGGTRF-NTLEDSVTHVVISEDSLwnpTD--LKALKSQPFVVSVRWLIDSSKNG 396
Cdd:cd17736     3 LVMTSVHSEEQELLESVVKKLGGFRVeDSVTEKTTHVVVGSPRR---TLnvLLGIARGCWILSPDWVLESLEAG 73
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 321-401 5.58e-03

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 37.51  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195999244  321 LDGCKILLSGF---NE-IQQSQLQSVINSGGGTRFNTLEDSVTHVVISEDslwnPTD--LKALKSQP-FVVSVRWLIDSS 393
Cdd:cd17729    14 LKGCVIVFSGViptGIdPERSRLWKLAESLGAKVVTDLSPRTTHLVAAKL----GTEkvKQALKMPGiHVVHPDWLWACA 89


                  ....*...
gi 195999244  394 KNGIKLPE 401
Cdd:cd17729    90 ERWERVDE 97
BRCT_PARP1 cd17747
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ...
 132-173 5.71e-03

BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.


Pssm-ID: 349378 [Multi-domain]  Cd Length: 76  Bit Score: 37.12  E-value: 5.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 195999244  132 KDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVA 173
Cdd:cd17747     2 TGMKFALIGKLSKSKDELKKLIEKLGGKVASKVTKKVTLCIS 43
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 190-256 6.17e-03

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 36.78  E-value: 6.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195999244  190 VTGLDKEERGNIDKLITVNGGSY--SPELDQRCTHLLVNVPK-GDKYEYAL---QWnihcVLTK-WFYDSLKAK 256
Cdd:cd17738     6 LSGFSEDEKKELISIIEKLGGKVldSDEFDPKCTHLICGKPSrSEKFLAACaagKW----ILHPsYIEASAKAG 75
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 132-188 6.81e-03

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 36.81  E-value: 6.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195999244  132 KDLVICCTNLSKDDRDELHSLIKMMGGKVNPHLTTDVTHLVAGEN----KHLCPIFSGCTI 188
Cdd:cd17741     1 EPLVVCSSCLDSEEKKKLKQIIAKLGGKVVNEWTEECTHLVMSKIkvtvKVICALISGKPI 61
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 1112-1188 9.49e-03

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 36.06  E-value: 9.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195999244 1112 YRFLLSAMKPQEKinYAGIVENLEGVFYDTQyftQACTHVVVGDINRNEKCLAAMASGKWLLRKSFLDESQLAGRFV 1188
Cdd:cd17744     1 PRVLFTGVSDKEE--GEKIIKKLGGSVVDSV---EDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 601-640 9.83e-03

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 36.54  E-value: 9.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 195999244  601 THLLLIKPSGSKYGAAKKWKIPTVSEKWLIAsCEAAERAV 640
Cdd:cd17742    39 THFVCTVPSGPEYEKAKEMNIPIVRPEWLRA-CEVEKKIV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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