NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|507534357|ref|XP_004651234|]
View 

transcriptional activator Myb isoform X1 [Jaculus jaculus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 16115854)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a LMSTEN motif

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 397-556 1.33e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 217.61  E-value: 1.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  397 QFIDSFLNTSSSHENLDLDMPSLTSTPLNGHKLTVTTPFHRDQTMKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 476
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  477 QEIKYGPLKMLPQTPSHLEEDLQDVIKQepdESGIVAEFQENGPPLLKKIKQEVESPTDKGRNFFCSNHWEGNSLNTQLF 556
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 92-205 4.98e-29

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 115.94  E-value: 4.98e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  92 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIA 170
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507534357 171 KLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKP 205
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTHKP 139
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
40-88 4.77e-18

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 78.03  E-value: 4.77e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357    40 KTRWTREEDEKLKKLVEQHGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 88
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
LMSTEN super family cl06845
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 268-313 1.47e-17

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


The actual alignment was detected with superfamily member pfam07988:

Pssm-ID: 462332  Cd Length: 47  Bit Score: 76.45  E-value: 1.47e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 507534357  268 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKVQQ 313
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 397-556 1.33e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 217.61  E-value: 1.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  397 QFIDSFLNTSSSHENLDLDMPSLTSTPLNGHKLTVTTPFHRDQTMKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 476
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  477 QEIKYGPLKMLPQTPSHLEEDLQDVIKQepdESGIVAEFQENGPPLLKKIKQEVESPTDKGRNFFCSNHWEGNSLNTQLF 556
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 92-205 4.98e-29

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 115.94  E-value: 4.98e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  92 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIA 170
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507534357 171 KLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKP 205
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTHKP 139
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 89-202 1.83e-28

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 119.51  E-value: 1.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  89 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 168
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 507534357 169 IAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQES 202
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQR 130
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 95-153 3.89e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 78.51  E-value: 3.89e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 507534357   95 WTKEEDQRVIELVQKYGPKrWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 153
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
40-88 4.77e-18

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 78.03  E-value: 4.77e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357    40 KTRWTREEDEKLKKLVEQHGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 88
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 42-86 1.37e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 76.46  E-value: 1.37e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 507534357  42 RWTREEDEKLKKLVEQHGTDDWKVIANYLPNRTDVQCQHRWQKVL 86
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 268-313 1.47e-17

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 76.45  E-value: 1.47e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 507534357  268 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKVQQ 313
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 43-103 3.07e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 75.81  E-value: 3.07e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507534357   43 WTREEDEKLKKLVEQHGtDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRV 103
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
92-140 4.40e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.34  E-value: 4.40e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357    92 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNP 140
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 94-138 9.51e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 9.51e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 507534357  94 PWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHL 138
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 397-556 1.33e-67

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 217.61  E-value: 1.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  397 QFIDSFLNTSSSHENLDLDMPSLTSTPLNGHKLTVTTPFHRDQTMKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAA 476
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  477 QEIKYGPLKMLPQTPSHLEEDLQDVIKQepdESGIVAEFQENGPPLLKKIKQEVESPTDKGRNFFCSNHWEGNSLNTQLF 556
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKS---EIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 92-205 4.98e-29

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 115.94  E-value: 4.98e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  92 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKG-RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIA 170
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507534357 171 KLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKP 205
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTHKP 139
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 89-202 1.83e-28

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 119.51  E-value: 1.83e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  89 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAE 168
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 507534357 169 IAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQES 202
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQR 130
PLN03091 PLN03091
hypothetical protein; Provisional
 89-205 1.10e-27

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 116.62  E-value: 1.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  89 ELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKhLKG--RIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRW 166
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507534357 167 AEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKP 205
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKP 128
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 95-153 3.89e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 78.51  E-value: 3.89e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 507534357   95 WTKEEDQRVIELVQKYGPKrWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDR 153
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
40-88 4.77e-18

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 78.03  E-value: 4.77e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357    40 KTRWTREEDEKLKKLVEQHGTDDWKVIANYLPNRTDVQCQHRWQKVLNP 88
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 42-86 1.37e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 76.46  E-value: 1.37e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 507534357  42 RWTREEDEKLKKLVEQHGTDDWKVIANYLPNRTDVQCQHRWQKVL 86
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 268-313 1.47e-17

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 76.45  E-value: 1.47e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 507534357  268 NIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKVQQ 313
Cdd:pfam07988   2 NCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 92-138 2.11e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 76.00  E-value: 2.11e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 507534357   92 KGPWTKEEDQRVIELVQKYGpKRWSVIAKHLKGRIGKQCRERWHNHL 138
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 43-103 3.07e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 75.81  E-value: 3.07e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507534357   43 WTREEDEKLKKLVEQHGtDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRV 103
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
92-140 4.40e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.34  E-value: 4.40e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357    92 KGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNP 140
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 144-187 4.69e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 4.69e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 507534357  144 KTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNS 187
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 40-86 5.92e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 5.92e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 507534357   40 KTRWTREEDEKLKKLVEQHGtDDWKVIANYLPNRTDVQCQHRWQKVL 86
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 94-138 9.51e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 9.51e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 507534357  94 PWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHL 138
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
144-191 7.67e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 66.09  E-value: 7.67e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 507534357   144 KTSWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAIKNHWNSTMRR 191
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 146-186 1.11e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 1.11e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 507534357 146 SWTEEEDRIIYQAHKRLG-NRWAEIAKLLPGRTDNAIKNHWN 186
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 147-201 2.92e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.47  E-value: 2.92e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 507534357  147 WTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQE 201
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKE 55
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 42-82 1.47e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 48.33  E-value: 1.47e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 507534357  42 RWTREEDEKLKKLVEQHGTDDWKVIANYLP---NRTDVQCQHRW 82
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKW 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 94-136 4.37e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 46.79  E-value: 4.37e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 507534357  94 PWTKEEDQRVIELVQKYGPKRWSVIAKH---LKGRIGKQCRERWHN 136
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 88-134 5.90e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 46.53  E-value: 5.90e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 507534357  88 PELIKGPWTKEEDQRVIELVQKYgPKRWSVIAKhLKGRIGKQCRERW 134
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLL-PTQWRTIAP-IVGRTAQQCLERY 45
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 38-87 1.08e-06

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 45.76  E-value: 1.08e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 507534357  38 LGKTRWTREEDEKLKKLVeQHGTDDWKVIANYLpNRTDVQCQHRWQKVLN 87
Cdd:cd11659    3 IKKTEWTREEDEKLLHLA-KLLPTQWRTIAPIV-GRTAQQCLERYNKLLD 50
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 35-184 2.70e-06

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 50.17  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  35 KRHLGKTRWTREEDEKLKKLVEQHGTdDWKVIANYLPNRTDVQCQHRWQKVLNPELiKGPWTKEEDQRVIELVQ--KYGP 112
Cdd:COG5147   67 NPQLKKKNWSEEEDEQLIDLDKELGT-QWSTIADYKDRRTAQQCVERYVNTLEDLS-STHDSKLQRRNEFDKIDpfNENS 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507534357 113 KRWSVIAKhlkgrigKQCRERWHNHL------NPEVKKtSWTEEEDriiyqaHKRLGNRWAEIAKLLPGRTDNAIKNH 184
Cdd:COG5147  145 ARRPDIYE-------DELLEREVNREasyrlrVPRVSK-ADVKPRE------KGEENNPDIEDLQEMKELKSASITRH 208
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 40-218 1.20e-05

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 48.25  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  40 KTRWTREEDEKLKKLVEQHGTdDWKVIANyLPNRTDVQCQHRWQ--KVLNPELIKGPWTKEEDQRVIELV-------QKY 110
Cdd:COG5147  291 RGKWTKEEEQELAKLVVEHGG-SWTEIGK-LLGRMPNDCRDRWRdyVKCGDTLKRNRWSIEEEELLDKVVnemrleaQQS 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357 111 GPKRWSVIAKHLKGRIGKQCRerwhnhlNPEVKKTSWTEEEDRIIY-QAHKRLGNRWAEIAKLLPGRtdNAIKNHWNSTM 189
Cdd:COG5147  369 SRILWLLIAQNIRNRLQHHCR-------DKYGVLISNSSPFDAGAAiWLIERYSNRKIQNGDLIKWR--NSVLDSARRRM 439

                        170       180
                 ....*....|....*....|....*....
gi 507534357 190 RRKVEQEGYLQESSKPSQPAVASSFQKNN 218
Cdd:COG5147  440 RDLKDLPEYALLLRTPDYNKSSLERIKKS 468
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 140-179 2.25e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 42.30  E-value: 2.25e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 507534357 140 PEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLpGRTDN 179
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 43-177 3.62e-05

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 46.70  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357  43 WTREEDEKLKKLVEQHGTDDWKV-----------------IANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIE 105
Cdd:COG5147  225 ETLALEQEINEYKEKKGLSRKQFceriwstdrdedkfwpnIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAK 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507534357 106 LVQKYGpKRWSVIAKhLKGRIGKQCRERWHNHLNP--EVKKTSWT-EEEDRII-------YQAHKRLGNRWAEIAKLLPG 175
Cdd:COG5147  305 LVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDkvvnemrLEAQQSSRILWLLIAQNIRN 382


                 ..
gi 507534357 176 RT 177
Cdd:COG5147  383 RL 384
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 42-82 9.51e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 35.70  E-value: 9.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 507534357   42 RWTREEDEKLKKLVEQ-----------HGTDDWKVIANYL----PNRTDVQCQHRW 82
Cdd:pfam13837   3 KWTEEETLALIEIWGErlelrfqeskkRNKKLWEEIAEKMaelgYNRSPEQCKEKW 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH