NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|530423527|ref|XP_005255827|]

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cadherin-16 isoform X3 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH: 2.60.40.60

Gene Ontology: GO:0007156|GO:0005509

PubMed: 17158740|28268172|27782885|11736639

SCOP: 4007535

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

164-267

1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

:

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 89.68 E-value: 1.32e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 164 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 242
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 530423527 243 DlaGAEGGFSSTCEVEVAVTDINDH 267
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

86-154

1.82e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

:

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 72.35 E-value: 1.82e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530423527  86 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 154
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

390-477

6.93e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

:

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 67.72 E-value: 6.93e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 390 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 465
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 530423527 466 PRLSASAPLVIH 477
Cdd:cd11304   80 PPLSSTATVTIT 91

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

279-380

5.13e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

:

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 62.33 E-value: 5.13e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 279 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 358
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 530423527 359 kLV-----GPGPGPGATATVTVLVERV 380
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

1-56

1.00e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

:

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 38.83 E-value: 1.00e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530423527   1 MFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATVEVSII 56
Cdd:cd11304   44 LFSIDPSTGEITTA----KPLDREEQSSYTLTVTATDGGGPP--LSSTATVTITVL 93

Name

Accession

Description

Interval

E-value

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

164-267

1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 89.68 E-value: 1.32e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 164 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 242
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 530423527 243 DlaGAEGGFSSTCEVEVAVTDINDH 267
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

86-154

1.82e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 72.35 E-value: 1.82e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530423527  86 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 154
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98

CA

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...

86-156

2.07e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 68.53 E-value: 2.07e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530423527    86 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 156
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

390-477

6.93e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 67.72 E-value: 6.93e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 390 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 465
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 530423527 466 PRLSASAPLVIH 477
Cdd:cd11304   80 PPLSSTATVTIT 91

CA

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...

181-269

1.72e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 66.22 E-value: 1.72e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527   181 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 258
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 530423527   259 VAVTDINDHAP 269
Cdd:smart00112  71 ITVLDVNDNAP 81

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

279-380

5.13e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 62.33 E-value: 5.13e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 279 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 358
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 530423527 359 kLV-----GPGPGPGATATVTVLVERV 380
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95

Cadherin

Cadherin domain;

163-262

1.60e-11

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.78 E-value: 1.60e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527  163 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 530423527  241 AMDLAGaeGGFSSTCEVEVAVT 262
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92

Cadherin

Cadherin domain;

278-378

1.99e-09

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 55.00 E-value: 1.99e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527  278 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 357
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 530423527  358 AKLVGPGPGPGATATVTVLVE 378
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92

Cadherin

Cadherin domain;

94-148

8.78e-07

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 47.30 E-value: 8.78e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530423527   94 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 148
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

1-56

1.00e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 38.83 E-value: 1.00e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530423527   1 MFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATVEVSII 56
Cdd:cd11304   44 LFSIDPSTGEITTA----KPLDREEQSSYTLTVTATDGGGPP--LSSTATVTITVL 93

Name

Accession

Description

Interval

E-value

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

164-267

1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 89.68 E-value: 1.32e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 164 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 242
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 530423527 243 DlaGAEGGFSSTCEVEVAVTDINDH 267
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

86-154

1.82e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 72.35 E-value: 1.82e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530423527  86 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 154
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98

CA

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...

86-156

2.07e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 68.53 E-value: 2.07e-14

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530423527    86 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 156
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

390-477

6.93e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 67.72 E-value: 6.93e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 390 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 465
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 530423527 466 PRLSASAPLVIH 477
Cdd:cd11304   80 PPLSSTATVTIT 91

CA

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...

181-269

1.72e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 66.22 E-value: 1.72e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527   181 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 258
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 530423527   259 VAVTDINDHAP 269
Cdd:smart00112  71 ITVLDVNDNAP 81

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

279-380

5.13e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 62.33 E-value: 5.13e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527 279 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 358
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 530423527 359 kLV-----GPGPGPGATATVTVLVERV 380
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95

Cadherin

Cadherin domain;

163-262

1.60e-11

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.78 E-value: 1.60e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527  163 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 530423527  241 AMDLAGaeGGFSSTCEVEVAVT 262
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92

Cadherin

Cadherin domain;

278-378

1.99e-09

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 55.00 E-value: 1.99e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530423527  278 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 357
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 530423527  358 AKLVGPGPGPGATATVTVLVE 378
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92

Cadherin

Cadherin domain;

94-148

8.78e-07

Cadherin domain;

Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 47.30 E-value: 8.78e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530423527   94 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 148
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91

CA_like

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

98-154

6.96e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.

Pssm-ID: 206635 Cd Length: 98 Bit Score: 42.33 E-value: 6.96e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530423527  98 PPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 154
Cdd:cd00031   41 LPSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98

Cadherin_repeat

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...

1-56

1.00e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 38.83 E-value: 1.00e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530423527   1 MFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATVEVSII 56
Cdd:cd11304   44 LFSIDPSTGEITTA----KPLDREEQSSYTLTVTATDGGGPP--LSSTATVTITVL 93

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options