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Conserved domains on  [gi|557022613|ref|XP_006011552|]
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protein UXT [Latimeria chalumnae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_UXT cd23158
protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in ...
 15-141 1.50e-63

protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in the cytoplasmic assembly of RNA polymerase I and can interact with other chaperone complexes, like R2TP, to form the PAQosome. UXT has an important role in the activation of the NF-kappaB pathway. UXT is also a component of the centrosome and is associated with gamma-tubulin. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


:

Pssm-ID: 467474  Cd Length: 128  Bit Score: 190.78  E-value: 1.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  15 YENFVNEVLKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQESEN-KELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFF 93
Cdd:cd23158    1 YEAFLNEVLKPDLKKVLEERDKLYEEISEYEQLKNTIETLQENDGlKPLKTLVDLGCNFYVQAKVPDTSKIFVDVGLGFY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557022613  94 VEFTLPEALKFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRELQ 141
Cdd:cd23158   81 VEMTLDEALKFIDKKEKLLEKKADKLTKKAAKIKAHIKLVLEAIRELQ 128
 
Name Accession Description Interval E-value
Prefoldin_UXT cd23158
protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in ...
 15-141 1.50e-63

protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in the cytoplasmic assembly of RNA polymerase I and can interact with other chaperone complexes, like R2TP, to form the PAQosome. UXT has an important role in the activation of the NF-kappaB pathway. UXT is also a component of the centrosome and is associated with gamma-tubulin. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467474  Cd Length: 128  Bit Score: 190.78  E-value: 1.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  15 YENFVNEVLKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQESEN-KELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFF 93
Cdd:cd23158    1 YEAFLNEVLKPDLKKVLEERDKLYEEISEYEQLKNTIETLQENDGlKPLKTLVDLGCNFYVQAKVPDTSKIFVDVGLGFY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557022613  94 VEFTLPEALKFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRELQ 141
Cdd:cd23158   81 VEMTLDEALKFIDKKEKLLEKKADKLTKKAAKIKAHIKLVLEAIRELQ 128
Prefoldin pfam02996
Prefoldin subunit; This family comprises of several prefoldin subunits. The biogenesis of the ...
 23-141 5.31e-15

Prefoldin subunit; This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT.


Pssm-ID: 427096 [Multi-domain]  Cd Length: 120  Bit Score: 66.89  E-value: 5.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613   23 LKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQEsENKELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFFVEFTLPEAL 102
Cdd:pfam02996   1 YKQEIESLQAELARLREAIEELEKSLETLKTLKK-EDEGKEVLVPLGAGLYVKAEVIDTDKVLVDLGAGYYVEKSLEEAI 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557022613  103 KFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRELQ 141
Cdd:pfam02996  80 EILDKRIEELEKQLEKLEEELEKLKDQITTLEANLQQVQ 118
 
Name Accession Description Interval E-value
Prefoldin_UXT cd23158
protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in ...
 15-141 1.50e-63

protein UXT; UXT is an alpha subunit of the prefoldin-like complex (PFDL). PFDL is involved in the cytoplasmic assembly of RNA polymerase I and can interact with other chaperone complexes, like R2TP, to form the PAQosome. UXT has an important role in the activation of the NF-kappaB pathway. UXT is also a component of the centrosome and is associated with gamma-tubulin. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related.


Pssm-ID: 467474  Cd Length: 128  Bit Score: 190.78  E-value: 1.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  15 YENFVNEVLKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQESEN-KELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFF 93
Cdd:cd23158    1 YEAFLNEVLKPDLKKVLEERDKLYEEISEYEQLKNTIETLQENDGlKPLKTLVDLGCNFYVQAKVPDTSKIFVDVGLGFY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557022613  94 VEFTLPEALKFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRELQ 141
Cdd:cd23158   81 VEMTLDEALKFIDKKEKLLEKKADKLTKKAAKIKAHIKLVLEAIRELQ 128
Prefoldin_alpha cd00584
Prefoldin alpha subunit; Alpha subunits of prefoldin, a hexameric molecular chaperone complex, ...
 17-139 1.33e-25

Prefoldin alpha subunit; Alpha subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467468 [Multi-domain]  Cd Length: 121  Bit Score: 94.22  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  17 NFVNEVLKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQESENKELkteVDLGCNFYVQAQVPDASKIFVAVGYGFFVEF 96
Cdd:cd00584    2 AEQLQELREQIEALQEEIEQLEEEQAEIDEAKEALEELKKEGSEVL---VPLGGNAYVRAEVVDIDKVIVHLGLGYYAER 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 557022613  97 TLPEALKFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRE 139
Cdd:cd00584   79 DPDGAIEILEKKEDELDKRIEELQAELAELEDEYDQLEQQAQQ 121
Prefoldin pfam02996
Prefoldin subunit; This family comprises of several prefoldin subunits. The biogenesis of the ...
 23-141 5.31e-15

Prefoldin subunit; This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT.


Pssm-ID: 427096 [Multi-domain]  Cd Length: 120  Bit Score: 66.89  E-value: 5.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613   23 LKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQEsENKELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFFVEFTLPEAL 102
Cdd:pfam02996   1 YKQEIESLQAELARLREAIEELEKSLETLKTLKK-EDEGKEVLVPLGAGLYVKAEVIDTDKVLVDLGAGYYVEKSLEEAI 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557022613  103 KFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRELQ 141
Cdd:pfam02996  80 EILDKRIEELEKQLEKLEEELEKLKDQITTLEANLQQVQ 118
Prefoldin_alpha_GimC cd23160
Prefoldin alpha subunit, archaeal; Archaeal alpha subunit of prefoldin (GimC), a hexameric ...
 21-139 3.06e-09

Prefoldin alpha subunit, archaeal; Archaeal alpha subunit of prefoldin (GimC), a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467476 [Multi-domain]  Cd Length: 127  Bit Score: 51.72  E-value: 3.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  21 EVLKRDLQQVLEQRDEVYEKIAQYLQLKSTIERVQESEnKELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFFVEFTLPE 100
Cdd:cd23160   10 QQLEQQAEALQQQIELLQASINELNRAKETLEELKKLK-EGTEILVPIGGGSFVKAKIKDTDKVLVNIGAGVVVEKTIDE 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 557022613 101 ALKFIEKKTSQLTEYSEKLTKDSAKIKAHIRMVLEGLRE 139
Cdd:cd23160   89 AIEILEKRIKELEKALEKLQEQLQQIAQRLEELEAELQE 127
Prefoldin_5 cd23157
Prefoldin subunit 5; Prefoldin subunit 5 is one of the alpha subunits of the eukaryotic ...
 27-121 9.25e-07

Prefoldin subunit 5; Prefoldin subunit 5 is one of the alpha subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467473  Cd Length: 124  Bit Score: 45.17  E-value: 9.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  27 LQQVLEQRDEVYEKIAQYL-QLKSTIERVQESEN--KELKTE-------VDLGCNFYVQAQVPDASKIFVAVGYGFFVEF 96
Cdd:cd23157    2 LQQLKQQLEQELEHLTSSLqQLKTAQAKFKESKEalEQLKKEnegkeilVPLTSSLYVPGKLSDVDKVLVDIGTGYYVEK 81

                         90       100
                 ....*....|....*....|....*
gi 557022613  97 TLPEALKFIEKKTSQLTEYSEKLTK 121
Cdd:cd23157   82 SVEDAKDYFKRKIEFLNEQIEKLQK 106
Prefoldin_3 cd23156
Prefoldin subunit 3; Prefoldin subunit 3 is one of the alpha subunits of the eukaryotic ...
 28-122 1.13e-04

Prefoldin subunit 3; Prefoldin subunit 3 is one of the alpha subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467472  Cd Length: 129  Bit Score: 39.76  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557022613  28 QQVLEQRDEVYEKIAQylqLKSTIERV-----QESENKELKTEVDLGCNFYVQAQVPDASKIFVAVGYGFFVEFTLPEAL 102
Cdd:cd23156   14 ASLLQKKARLKEKIPD---IKKTLEAVkflkkKKEEGEELETHFELADTVYAKATVPPTDKVCLWLGANVMLEYPLDEAE 90

                         90       100
                 ....*....|....*....|
gi 557022613 103 KFIEKKTSQLTEYSEKLTKD 122
Cdd:cd23156   91 ELLEKNLATAKKSLKELEED 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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